Stuart Johnston Knechtle, MD

Professor of Surgery
William R. Kenan, Jr. Distinguished Professor
Adjunct Professor in the Department of Medicine
Member in the Duke Clinical Research Institute
Email address stuart.knechtle@duke.edu

During my career as an academic surgeon, I have had the privilege of leading and/or participating in a diverse portfolio of hypothesis-driven research projects.  These projects have centered on the immunology of surgery and transplantation, including both cellular and antibody-mediated immune responses.  During my training I studied the response of hyper-sensitized recipients to allogeneic liver transplantation, and am currently studying means of reducing immunologic memory that might allow more successful transplantation in sensitized recipients.  This immune response involves pathways of coagulation, antibody-mediated rejection, and cellular rejection and current work in my lab involves these three pathways.  The other major focuses of my work have been co-stimulation blockade and immune cell depletion as approaches to immunologic unresponsiveness or tolerance.  My research group has been involved in translational and clinical research to develop these mechanistic tools for the benefit of human organ transplant recipients.

Recent Publications

Knechtle SJ, Shaw JM, Hering BJ, Kraemer K, Madsen JC. Translational impact of NIH-funded nonhuman primate research in transplantation. Sci Transl Med. 2019 Jul 10;11(500). pii: eaau0143. Reprint | Full Text

Education and Training

  • Transplant Fellow, Surgery, University of Wisconsin - Madison, 1989 - 1991
  • Residency, Surgery, Duke University School of Medicine, 1982 - 1989
  • M.D., Cornell University, Weill Medical College, 1982

Publications

Ludwig, Johannes M., Stuart J. Knechtle, and Hyun S. Kim. “Reply to: "Percutaneous Management of Benign Biliary Strictures: Is It Time to Focus on Reducing Procedure Invasiveness?".” J Vasc Interv Radiol 27, no. 6 (June 2016): 936–37. https://doi.org/10.1016/j.jvir.2016.03.003.

PMID
27287980
Full Text

Suhre, Karsten, Joseph E. Schwartz, Vijay K. Sharma, Qiuying Chen, John R. Lee, Thangamani Muthukumar, Darshana M. Dadhania, et al. “Urine Metabolite Profiles Predictive of Human Kidney Allograft Status.” J Am Soc Nephrol 27, no. 2 (February 2016): 626–36. https://doi.org/10.1681/ASN.2015010107.

PMID
26047788
Full Text

Ludwig, Johannes M., Grant R. Webber, Stuart J. Knechtle, James R. Spivey, Minzhi Xing, and Hyun S. Kim. “Percutaneous Management of Benign Biliary Strictures with Large-Bore Catheters: Comparison between Patients with and without Orthotopic Liver Transplantation.” J Vasc Interv Radiol 27, no. 2 (February 2016): 219-225.e1. https://doi.org/10.1016/j.jvir.2015.10.021.

PMID
26710970
Full Text

Halazun, K. J., A. K. Mathur, A. A. Rana, A. B. Massie, S. Mohan, R. E. Patzer, J. P. Wedd, et al. “One Size Does Not Fit All--Regional Variation in the Impact of the Share 35 Liver Allocation Policy.” Am J Transplant 16, no. 1 (January 2016): 137–42. https://doi.org/10.1111/ajt.13500.

PMID
26561981
Full Text

Kwun, Jean, Alton B. Farris, Hyunjin Song, William T. Mahle, William J. Burlingham, and Stuart J. Knechtle. “Impact of Leukocyte Function-Associated Antigen-1 Blockade on Endogenous Allospecific T Cells to Multiple Minor Histocompatibility Antigen Mismatched Cardiac Allograft.” Transplantation 99, no. 12 (December 2015): 2485–93. https://doi.org/10.1097/TP.0000000000000805.

PMID
26102611
Full Text

Newell, K. A., A. Asare, I. Sanz, C. Wei, A. Rosenberg, Z. Gao, S. Kanaparthi, et al. “Longitudinal studies of a B cell-derived signature of tolerance in renal transplant recipients.” Am J Transplant 15, no. 11 (November 2015): 2908–20. https://doi.org/10.1111/ajt.13480.

PMID
26461968
Full Text

Burghuber, C. K., J. Kwun, E. J. Kim, F. V. Leopardi, A. C. Gibby, N. N. Iwakoshi, and S. J. Knechtle. “NEW DESENSITIZATION STRATEGY IN A KIDNEY TRANSPLANTATION MODEL WITH RHESUS MONKEYS.” In Transplant International, 28:12–12. WILEY-BLACKWELL, 2015.

Scholars@Duke

Reed, Alan, William C. Chapman, Stuart Knechtle, Kenneth Chavin, Richard Gilroy, and Goran B. G. Klintmalm. “Equalizing MELD Scores Over Broad Geographies Is Not the Most Efficacious Way to Allocate a Scarce Resource in a Value-based Environment.” Ann Surg 262, no. 2 (August 2015): 220–23. https://doi.org/10.1097/SLA.0000000000001331.

PMID
26164428
Full Text

Kokabi, Nima, Juan C. Camacho, Minzhi Xing, Bassel F. El-Rayes, James R. Spivey, Stuart J. Knechtle, and Hyun S. Kim. “Open-label prospective study of the safety and efficacy of glass-based yttrium 90 radioembolization for infiltrative hepatocellular carcinoma with portal vein thrombosis.” Cancer 121, no. 13 (July 1, 2015): 2164–74. https://doi.org/10.1002/cncr.29275.

PMID
25847227
Full Text

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