Stuart Johnston Knechtle, MD

Professor of Surgery
William R. Kenan, Jr. Distinguished Professor
Adjunct Professor in the Department of Medicine
Member in the Duke Clinical Research Institute
Email address stuart.knechtle@duke.edu

During my career as an academic surgeon, I have had the privilege of leading and/or participating in a diverse portfolio of hypothesis-driven research projects.  These projects have centered on the immunology of surgery and transplantation, including both cellular and antibody-mediated immune responses.  During my training I studied the response of hyper-sensitized recipients to allogeneic liver transplantation, and am currently studying means of reducing immunologic memory that might allow more successful transplantation in sensitized recipients.  This immune response involves pathways of coagulation, antibody-mediated rejection, and cellular rejection and current work in my lab involves these three pathways.  The other major focuses of my work have been co-stimulation blockade and immune cell depletion as approaches to immunologic unresponsiveness or tolerance.  My research group has been involved in translational and clinical research to develop these mechanistic tools for the benefit of human organ transplant recipients.

Recent Publications

Knechtle SJ, Shaw JM, Hering BJ, Kraemer K, Madsen JC. Translational impact of NIH-funded nonhuman primate research in transplantation. Sci Transl Med. 2019 Jul 10;11(500). pii: eaau0143. Reprint | Full Text

Education and Training

  • Transplant Fellow, Surgery, University of Wisconsin - Madison, 1989 - 1991
  • Residency, Surgery, Duke University School of Medicine, 1982 - 1989
  • M.D., Cornell University, Weill Medical College, 1982

Publications

Velazquez, Victoria M., Luke S. Uebelhoer, Manoj Thapa, Chris C. Ibegbu, Cynthia Courtney, Steven E. Bosinger, Joseph F. Magliocca, et al. “Systems biological analyses reveal the hepatitis C virus (HCV)-specific regulation of hematopoietic development.” Hepatology 61, no. 3 (March 2015): 843–56. https://doi.org/10.1002/hep.27575.

PMID
25331524
Full Text

Kwun, J., E. Page, J. J. Hong, A. Gibby, J. Yoon, A. B. Farris, F. Villinger, and S. Knechtle. “Neutralizing BAFF/APRIL with atacicept prevents early DSA formation and AMR development in T cell depletion induced nonhuman primate AMR model.” Am J Transplant 15, no. 3 (March 2015): 815–22. https://doi.org/10.1111/ajt.13045.

PMID
25675879
Full Text

Shaffer, Katherine, Sungjin Kim, Anthony M. Gamboa, Jennifer A. Luke, Sunil Dacha, Andrew B. Adams, Stuart J. Knechtle, et al. “Incidence and Predictors of Lymph Nodal Metastases in Patients With Cholangiocarcinoma in the United States.” In Gastroenterology, 146:S994–S994. W B SAUNDERS CO-ELSEVIER INC, 2014.

Scholars@Duke

Medbery, Rachel L., Tatiana S. Chadid, John F. Sweeney, Stuart J. Knechtle, David A. Kooby, Shishir K. Maithel, Edward Lin, and Juan M. Sarmiento. “Laparoscopic vs open right hepatectomy: a value-based analysis.” J Am Coll Surg 218, no. 5 (May 2014): 929–39. https://doi.org/10.1016/j.jamcollsurg.2014.01.045.

PMID
24680574
Full Text

Squires, Malcolm H., Steven I. Hanish, Sarah B. Fisher, Cristen Garrett, David A. Kooby, Juan M. Sarmiento, Kenneth Cardona, et al. “Transplant versus resection for the management of hepatocellular carcinoma meeting Milan Criteria in the MELD exception era at a single institution in a UNOS region with short wait times.” J Surg Oncol 109, no. 6 (May 2014): 533–41. https://doi.org/10.1002/jso.23531.

PMID
24347475
Full Text

O’Leary, J. G., A. J. Demetris, L. S. Friedman, H. M. Gebel, P. F. Halloran, A. D. Kirk, S. J. Knechtle, et al. “The role of donor-specific HLA alloantibodies in liver transplantation.” Am J Transplant 14, no. 4 (April 2014): 779–87. https://doi.org/10.1111/ajt.12667.

PMID
24580828
Full Text

Haas, M., B. Sis, L. C. Racusen, K. Solez, D. Glotz, R. B. Colvin, M. C. R. Castro, et al. “Banff 2013 meeting report: inclusion of c4d-negative antibody-mediated rejection and antibody-associated arterial lesions.” In Am J Transplant, 14:272–83, 2014. https://doi.org/10.1111/ajt.12590.

PMID
24472190
Full Text

Thammana, Rekha V., Stuart J. Knechtle, Rene Romero, Thomas G. Heffron, Caroline T. Daniels, and Rachel E. Patzer. “Racial and socioeconomic disparities in pediatric and young adult liver transplant outcomes.” Liver Transpl 20, no. 1 (January 2014): 100–115. https://doi.org/10.1002/lt.23769.

PMID
24136785
Full Text

Pages