Sudarshan Rajagopal, MD, PhD

Assistant Professor of Medicine
Assistant Professor in Biochemistry
Campus mail 3126, Durham, NC 27710
Phone (919) 684-6237
Email address sudarshan.rajagopal@duke.edu
In Their Words

Education and Training

  • Clinical Fellowship, Cardiovascular Disease, Duke University School of Medicine, 2011 - 2013
  • Research Fellowship, Duke University School of Medicine, 2008 - 2011
  • Resident, Internal Medicine, Duke University School of Medicine, 2006 - 2008
  • M.D., University of Chicago, 2006
  • Ph.D., University of Chicago, 2004

Publications

Kahsai, Alem W., Kunhong Xiao, Sudarshan Rajagopal, Seungkirl Ahn, Arun K. Shukla, Jinpeng Sun, Terrence G. Oas, and Robert J. Lefkowitz. “Multiple ligand-specific conformations of the β2-adrenergic receptor..” Nat Chem Biol 7, no. 10 (August 21, 2011): 692–700. https://doi.org/10.1038/nchembio.634.

PMID
21857662
Full Text

Hara, Makoto R., Jeffrey J. Kovacs, Erin J. Whalen, Sudarshan Rajagopal, Ryan T. Strachan, Wayne Grant, Aaron J. Towers, et al. “A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1..” Nature 477, no. 7364 (August 21, 2011): 349–53. https://doi.org/10.1038/nature10368.

PMID
21857681
Full Text

Nobles, Kelly N., Kunhong Xiao, Seungkirl Ahn, Arun K. Shukla, Christopher M. Lam, Sudarshan Rajagopal, Ryan T. Strachan, et al. “Distinct phosphorylation sites on the β(2)-adrenergic receptor establish a barcode that encodes differential functions of β-arrestin..” Sci Signal 4, no. 185 (August 9, 2011). https://doi.org/10.1126/scisignal.2001707.

PMID
21868357
Full Text

Xiao, Kunhong, Jinpeng Sun, Jihee Kim, Sudarshan Rajagopal, Bo Zhai, Judit Villén, Wilhelm Haas, et al. “Global phosphorylation analysis of beta-arrestin-mediated signaling downstream of a seven transmembrane receptor (7TMR)..” Proc Natl Acad Sci U S A 107, no. 34 (August 24, 2010): 15299–304. https://doi.org/10.1073/pnas.1008461107.

PMID
20686112
Full Text

Rajagopal, Sudarshan, Keshava Rajagopal, and Robert J. Lefkowitz. “Teaching old receptors new tricks: biasing seven-transmembrane receptors..” Nat Rev Drug Discov 9, no. 5 (May 2010): 373–86. https://doi.org/10.1038/nrd3024.

PMID
20431569
Full Text

Rajagopal, Sudarshan, Jihee Kim, Seungkirl Ahn, Stewart Craig, Christopher M. Lam, Norma P. Gerard, Craig Gerard, and Robert J. Lefkowitz. “Beta-arrestin- but not G protein-mediated signaling by the "decoy" receptor CXCR7..” Proc Natl Acad Sci U S A 107, no. 2 (January 12, 2010): 628–32. https://doi.org/10.1073/pnas.0912852107.

PMID
20018651
Full Text

Rajagopal, Sudarshan, and Stephen B. H. Kent. “Total chemical synthesis and biophysical characterization of the minimal isoform of the KChIP2 potassium channel regulatory subunit..” Protein Sci 16, no. 9 (September 2007): 2056–64. https://doi.org/10.1110/ps.072876107.

PMID
17660260
Full Text

Ihee, Hyotcherl, Sudarshan Rajagopal, Vukica Srajer, Reinhard Pahl, Spencer Anderson, Marius Schmidt, Friedrich Schotte, Philip A. Anfinrud, Michael Wulff, and Keith Moffat. “Visualizing reaction pathways in photoactive yellow protein from nanoseconds to seconds..” Proc Natl Acad Sci U S A 102, no. 20 (May 17, 2005): 7145–50. https://doi.org/10.1073/pnas.0409035102.

PMID
15870207
Full Text

Rajagopal, Sudarshan, Spencer Anderson, Vukica Srajer, Marius Schmidt, Reinhard Pahl, and Keith Moffat. “A structural pathway for signaling in the E46Q mutant of photoactive yellow protein..” Structure 13, no. 1 (January 2005): 55–63. https://doi.org/10.1016/j.str.2004.10.016.

PMID
15642261
Full Text

Pages