Sudarshan Rajagopal, MD, PhD

Assistant Professor of Medicine
Assistant Professor in Biochemistry
Campus mail 3126, Durham, NC 27710
Phone (919) 684-6237
Email address sudarshan.rajagopal@duke.edu
In Their Words

Education and Training

  • Clinical Fellowship, Cardiovascular Disease, Duke University School of Medicine, 2011 - 2013
  • Research Fellowship, Duke University School of Medicine, 2008 - 2011
  • Resident, Internal Medicine, Duke University School of Medicine, 2006 - 2008
  • M.D., University of Chicago, 2006
  • Ph.D., University of Chicago, 2004

Publications

Kahsai, AW, Xiao, K, Rajagopal, S, Ahn, S, Shukla, AK, Sun, J, Oas, TG, and Lefkowitz, RJ. "Multiple ligand-specific conformations of the β2-adrenergic receptor." Nature Chemical Biology 7, no. 10 (August 21, 2011): 692-700.

PMID
21857662
Full Text

Hara, MR, Kovacs, JJ, Whalen, EJ, Rajagopal, S, Strachan, RT, Grant, W, Towers, AJ, Williams, B, Lam, CM, Xiao, K, Shenoy, SK, Gregory, SG, Ahn, S, Duckett, DR, and Lefkowitz, RJ. "A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1." Nature 477, no. 7364 (August 21, 2011): 349-353.

PMID
21857681
Full Text

Nobles, KN, Xiao, K, Ahn, S, Shukla, AK, Lam, CM, Rajagopal, S, Strachan, RT, Huang, T-Y, Bressler, EA, Hara, MR, Shenoy, SK, Gygi, SP, and Lefkowitz, RJ. "Distinct phosphorylation sites on the β(2)-adrenergic receptor establish a barcode that encodes differential functions of β-arrestin." Science Signaling 4, no. 185 (August 2011): ra51-null.

PMID
21868357
Full Text

Whalen, EJ, Rajagopal, S, and Lefkowitz, RJ. "Therapeutic potential of β-arrestin- and G protein-biased agonists." Trends in Molecular Medicine 17, no. 3 (March 2011): 126-139. (Review)

PMID
21183406
Full Text

Xiao, K, Sun, J, Kim, J, Rajagopal, S, Zhai, B, Villén, J, Haas, W, Kovacs, JJ, Shukla, AK, Hara, MR, Hernandez, M, Lachmann, A, Zhao, S, Lin, Y, Cheng, Y, Mizuno, K, Ma'ayan, A, Gygi, SP, and Lefkowitz, RJ. "Global phosphorylation analysis of beta-arrestin-mediated signaling downstream of a seven transmembrane receptor (7TMR)." Proceedings of the National Academy of Sciences of the United States of America 107, no. 34 (August 4, 2010): 15299-15304.

PMID
20686112
Full Text

Rajagopal, S, Rajagopal, K, and Lefkowitz, RJ. "Teaching old receptors new tricks: biasing seven-transmembrane receptors." Nature Reviews. Drug Discovery 9, no. 5 (May 2010): 373-386. (Review)

PMID
20431569
Full Text

Rajagopal, S, Kim, J, Ahn, S, Craig, S, Lam, CM, Gerard, NP, Gerard, C, and Lefkowitz, RJ. "Beta-arrestin- but not G protein-mediated signaling by the "decoy" receptor CXCR7." Proceedings of the National Academy of Sciences of the United States of America 107, no. 2 (January 2010): 628-632.

PMID
20018651
Full Text

Rajagopal, S, and Kent, SBH. "Total chemical synthesis and biophysical characterization of the minimal isoform of the KChIP2 potassium channel regulatory subunit." Protein science : a publication of the Protein Society 16, no. 9 (September 2007): 2056-2064.

PMID
17660260
Full Text

Ihee, H, Rajagopal, S, Srajer, V, Pahl, R, Anderson, S, Schmidt, M, Schotte, F, Anfinrud, PA, Wulff, M, and Moffat, K. "Visualizing reaction pathways in photoactive yellow protein from nanoseconds to seconds." Proceedings of the National Academy of Sciences of the United States of America 102, no. 20 (May 3, 2005): 7145-7150.

PMID
15870207
Full Text

Rajagopal, S, Anderson, S, Srajer, V, Schmidt, M, Pahl, R, and Moffat, K. "A structural pathway for signaling in the E46Q mutant of photoactive yellow protein." Structure (London, England : 1993) 13, no. 1 (January 2005): 55-63.

PMID
15642261
Full Text

Pages