Thomas Joseph Weber, MD

Associate Professor of Medicine
Member of the Duke Cancer Institute
Campus mail 303 Baker House, Durham, NC 27710
Phone (919) 668-1367
Email address thomas.weber2@duke.edu

Osteoporosis, with current studies that focus on advances in diagnosis and natural history of male and postmenopausal osteoporosis. The study on male osteoporosis include a collaborative study with outside investigators is examining the utility of lateral spine bone densitometry in identifying men with osteoporosis and low trauma fractures.

Hypophosphatemic disorders, including X-link hypophosphatemic rickets and tumor-induced osteomalacia. My ongoing research study, in collaboration with Dr. L Darryl Quarles at the University of Kansas, seeks to further confirm and extend our understanding of the role of FGF-23 in human disorders of phosphate homeostasis, including patients with chronic kidney disease. Pending studies include primary and sub-investigator directed Phase 1 / 2 first in human studies examining the effects of a monoclonal antibody and enzyme replacement therapy for X-linked hypophosphatemic rickets and hypophosphatasia, respectively.

Education and Training

  • Fellow in Endocrinology, Medicine, Duke University, 1993 - 1997
  • Instructor, Medicine, Yale University, 1992 - 1993
  • Medical Resident, Medicine, Yale University, 1989 - 1992
  • M.D., University of Chicago, 1989

Publications

Insogna, KL, Briot, K, Imel, EA, Kamenický, P, Ruppe, MD, Portale, AA, Weber, T, Pitukcheewanont, P, Cheong, HI, Jan de Beur, S, Imanishi, Y, Ito, N, Lachmann, RH, Tanaka, H, Perwad, F, Zhang, L, Chen, C-Y, Theodore-Oklota, C, Mealiffe, M, San Martin, J, Carpenter, TO, and AXLES 1 Investigators, . "A Randomized, Double-Blind, Placebo-Controlled, Phase 3 Trial Evaluating the Efficacy of Burosumab, an Anti-FGF23 Antibody, in Adults With X-Linked Hypophosphatemia: Week 24 Primary Analysis." Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research 33, no. 8 (August 2018): 1383-1393.

PMID
29947083
Full Text

Weber, TJ, Koh, J, Thomas, SM, Hogue, JA, Scheri, RP, Roman, SA, and Sosa, JA. "Impaired calcium sensing distinguishes primary hyperparathyroidism (PHPT) patients with low bone mineral density." Metabolism: Clinical and Experimental 74 (September 2017): 22-31.

PMID
28764845
Full Text

Ruppe, MD, Zhang, X, Imel, EA, Weber, TJ, Klausner, MA, Ito, T, Vergeire, M, Humphrey, JS, Glorieux, FH, Portale, AA, Insogna, K, Peacock, M, and Carpenter, TO. "Effect of four monthly doses of a human monoclonal anti-FGF23 antibody (KRN23) on quality of life in X-linked hypophosphatemia." Bone Reports 5 (December 2016): 158-162.

PMID
28326356
Full Text

Mori, M, DeArmey, SL, Weber, TJ, and Kishnani, PS. "Case series: Odontohypophosphatasia or missed diagnosis of childhood/adult-onset hypophosphatasia? - Call for a long-term follow-up of premature loss of primary teeth." Bone Reports 5 (December 2016): 228-232.

PMID
28580391
Full Text

Weber, TJ, Sawyer, EK, Moseley, S, Odrljin, T, and Kishnani, PS. "Burden of disease in adult patients with hypophosphatasia: Results from two patient-reported surveys." Metabolism: clinical and experimental 65, no. 10 (October 2016): 1522-1530.

PMID
27621187
Full Text

Weber, TJ. "Battle of the sex steroids in the male skeleton: and the winner is...." The Journal of Clinical Investigation 126, no. 3 (March 2016): 829-832.

PMID
26901810
Full Text

Zhang, X, Imel, EA, Ruppe, MD, Weber, TJ, Klausner, MA, Ito, T, Vergeire, M, Humphrey, J, Glorieux, FH, Portale, AA, Insogna, K, Carpenter, TO, and Peacock, M. "Pharmacokinetics and pharmacodynamics of a human monoclonal anti-FGF23 antibody (KRN23) in the first multiple ascending-dose trial treating adults with X-linked hypophosphatemia." Journal of Clinical Pharmacology 56, no. 2 (February 2016): 176-185.

PMID
26073451
Full Text

Imel, EA, Zhang, X, Ruppe, MD, Weber, TJ, Klausner, MA, Ito, T, Vergeire, M, Humphrey, JS, Glorieux, FH, Portale, AA, Insogna, K, Peacock, M, and Carpenter, TO. "Prolonged Correction of Serum Phosphorus in Adults With X-Linked Hypophosphatemia Using Monthly Doses of KRN23." The Journal of Clinical Endocrinology and Metabolism 100, no. 7 (July 2015): 2565-2573.

PMID
25919461
Full Text

Carpenter, TO, Imel, EA, Ruppe, MD, Weber, TJ, Klausner, MA, Wooddell, MM, Kawakami, T, Ito, T, Zhang, X, Humphrey, J, Insogna, KL, and Peacock, M. "Randomized trial of the anti-FGF23 antibody KRN23 in X-linked hypophosphatemia." The Journal of Clinical Investigation 124, no. 4 (April 2014): 1587-1597.

PMID
24569459
Full Text

Lee, RH, Weber, T, and Colón-Emeric, C. "Comparison of cost-effectiveness of vitamin D screening with that of universal supplementation in preventing falls in community-dwelling older adults." J Am Geriatr Soc 61, no. 5 (May 2013): 707-714.

PMID
23631393
Full Text

Pages