Infectious Diseases

Thuy Le, MD, PhD

Associate Professor of Medicine
Associate Professor of Molecular Genetics and Microbiology
Affiliate, Duke Global Health Institute
Campus mail 315 Trent Drive, Room #257, Durham, NC 27710
Phone (919) 668-5053
Email address thuy.le@duke.edu

Education and Training

  • Fogarty International Clinical Research Fellowship, National Institutes of Health, 2009 - 2011
  • Infectious Disease Fellowship, Yale University School of Medicine, 2006 - 2009
  • Internal Medicine Residency, Tufts University School of Medicine, 2002 - 2005
  • D.Phil., University of Oxford (United Kingdom), 2016
  • M.D., University of Arizona, College of Medicine, 2002

Grants

Publications

Wei, Wudi, Chuanyi Ning, Jiegang Huang, Gang Wang, Jingzhen Lai, Jing Han, Jinhao He, et al. “Talaromyces marneffei promotes M2-like polarization of human macrophages by downregulating SOCS3 expression and activating the TLR9 pathway.” Virulence 12, no. 1 (December 2021): 1997–2012. https://doi.org/10.1080/21505594.2021.1958470.

PMID
34339354
Full Text

Thompson, George R., Thuy Le, Ariya Chindamporn, Carol A. Kauffman, Ana Alastruey-Izquierdo, Neil M. Ampel, David R. Andes, et al. “Global guideline for the diagnosis and management of the endemic mycoses: an initiative of the European Confederation of Medical Mycology in cooperation with the International Society for Human and Animal Mycology.” The Lancet. Infectious Diseases 21, no. 12 (December 2021): e364–74. https://doi.org/10.1016/s1473-3099(21)00191-2.

PMID
34364529
Full Text

Narayanasamy, Shanti, Vu Quoc Dat, Nguyen Tat Thanh, Vo Trieu Ly, Jasper Fuk-Woo Chan, Kwok-Yung Yuen, Chuanyi Ning, et al. “A global call for talaromycosis to be recognised as a neglected tropical disease.” Lancet Glob Health 9, no. 11 (November 2021): e1618–22. https://doi.org/10.1016/S2214-109X(21)00350-8.

PMID
34678201
Full Text

Stott, Katharine E., Thuy Le, Thu Nguyen, Sarah Whalley, Jennifer Unsworth, Vo Trieu Ly, Ruwanthi Kolamunnage-Dona, and William Hope. “Population Pharmacokinetics and Pharmacodynamics of Itraconazole for Disseminated Infection Caused by Talaromyces marneffei.” Antimicrob Agents Chemother 65, no. 11 (October 18, 2021): e0063621. https://doi.org/10.1128/AAC.00636-21.

PMID
34370587
Full Text

Narayanasamy, Shanti, John Dougherty, H Rogier van Doorn, and Thuy Le. “Pulmonary Talaromycosis: A Window into the Immunopathogenesis of an Endemic Mycosis.” Mycopathologia 186, no. 5 (October 2021): 707–15. https://doi.org/10.1007/s11046-021-00570-0.

PMID
34228343
Full Text

Thu, Nguyen T. M., Jasper F. W. Chan, Vo Trieu Ly, Hoa T. Ngo, Ha T. A. Hien, Nguyen P. H. Lan, Nguyen V. V. Chau, et al. “Superiority of a Novel Mp1p Antigen Detection Enzyme Immunoassay Compared to Standard BACTEC Blood Culture in the Diagnosis of Talaromycosis.” Clin Infect Dis 73, no. 2 (July 15, 2021): e330–36. https://doi.org/10.1093/cid/ciaa826.

PMID
32564074
Full Text

Buchanan, James, James Altunkaya, Nguyen Van Kinh, Nguyen Van Vinh Chau, Vo Trieu Ly, Pham Thi Thanh Thuy, Vu Hai Vinh, et al. “Cost-Effectiveness of Amphotericin B Deoxycholate Versus Itraconazole for Induction Therapy of Talaromycosis in Human Immunodeficiency Virus-Infected Adults in Vietnam.” Open Forum Infect Dis 8, no. 7 (July 2021): ofab357. https://doi.org/10.1093/ofid/ofab357.

PMID
34337101
Full Text

Axfors, Cathrine, Andreas M. Schmitt, Perrine Janiaud, Janneke Van’t Hooft, Sherief Abd-Elsalam, Ehab F. Abdo, Benjamin S. Abella, et al. “Author Correction: Mortality outcomes with hydroxychloroquine and chloroquine in COVID-19 from an international collaborative meta-analysis of randomized trials.” Nat Commun 12, no. 1 (May 14, 2021): 3001. https://doi.org/10.1038/s41467-021-23559-1.

PMID
33990619
Full Text

Axfors, Cathrine, Andreas M. Schmitt, Perrine Janiaud, Janneke Van’t Hooft, Sherief Abd-Elsalam, Ehab F. Abdo, Benjamin S. Abella, et al. “Mortality outcomes with hydroxychloroquine and chloroquine in COVID-19 from an international collaborative meta-analysis of randomized trials.” Nat Commun 12, no. 1 (April 15, 2021): 2349. https://doi.org/10.1038/s41467-021-22446-z.

PMID
33859192
Full Text

Pages