Uptal Dinesh Patel, MD

Adjunct Professor in the Department of Medicine
Affiliate, Duke Global Health Institute
Member in the Duke Clinical Research Institute
Campus mail 1 Medimmune Way, Gaithersburg, MD 20878-2204
Phone (650) 339-8061
Email address uptal.patel@duke.edu

Uptal Patel, MD is an Adjunct Professor interested in population health with a broad range of clinical and research experience. As an adult and pediatric nephrologist with training in health services and epidemiology, his work seeks to improve population health for patients with  kidney diseases through improvements in prevention, diagnosis and treatment.

Prior efforts focused on four inter-related areas that are essential to improving kidney health: i) reducing the progression of chronic kidney disease by improving its detection and management, particularly by leveraging technology to facilitate engagement and self-management; ii) elucidating the inter-relationships between kidney disease and cardiovascular disease, which together amplify the risk of death; iii) improving the evidence in nephrology through comparative effectiveness research, including clinical trials, observational studies, and meta-analyses; and iv) promoting more optimal clinical health policy for all patients with kidney disease. These inter-disciplinary projects have been funded by a variety of public and private sources including the Robert Wood Johnson Foundation, Veterans Affairs, National Institutes of Health, Agency for Healthcare Research & Quality, Food and Drug Administration, Centers for Medicare & Medicaid Services, Renal Physicians Association, and the American Society of Nephrology. 

Current efforts seek to advance novel therapies for kidney diseases through early clinical development that he leads at AstraZeneca.

Education and Training

  • Fellow in Nephrology, Medicine, University of Michigan, Ann Arbor, 2002 - 2003
  • Fellow in Pediatric Nephrology, Pediatrics, University of Michigan, Ann Arbor, 2001 - 2002
  • Medicine/Pediatric Resident, Medicine/Pediatrics, University of Michigan, Ann Arbor, 1997 - 2001
  • M.D., University of California San Francisco, School of Medicine, 1997

Publications

Machen, Leah, Clemontina A. Davenport, Megan Oakes, Hayden B. Bosworth, Uptal D. Patel, and Clarissa Diamantidis. “Race, Income, and Medical Care Spending Patterns in High-Risk Primary Care Patients: Results From the STOP-DKD (Simultaneous Risk Factor Control Using Telehealth to Slow Progression of Diabetic Kidney Disease) Study.” Kidney Med 4, no. 1 (January 2022): 100382. https://doi.org/10.1016/j.xkme.2021.08.016.

PMID
35072046
Full Text

Lunyera, Joseph, Clarissa J. Diamantidis, Hayden B. Bosworth, Uptal D. Patel, James Bain, Michael J. Muehlbauer, Olga Ilkayeva, et al. “Urine tricarboxylic acid cycle signatures of early-stage diabetic kidney disease.” Metabolomics 18, no. 1 (December 20, 2021): 5. https://doi.org/10.1007/s11306-021-01858-4.

PMID
34928443
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Abedini, Amin, Yuan O. Zhu, Shatakshee Chatterjee, Gabor Halasz, Kishor Devalaraja-Narashimha, Rojesh Shrestha, Michael S. Balzer, et al. “Urinary Single-Cell Profiling Captures the Cellular Diversity of the Kidney.” J Am Soc Nephrol 32, no. 3 (March 2021): 614–27. https://doi.org/10.1681/ASN.2020050757.

PMID
33531352
Full Text

Baker, Matthew, Yashaar Chaichian, Mark Genovese, Vimal Derebail, Panduranga Rao, Winn Chatham, Michael Bubb, et al. “Phase II, randomised, double-blind, multicentre study evaluating the safety and efficacy of filgotinib and lanraplenib in patients with lupus membranous nephropathy.” Rmd Open 6, no. 3 (December 2020). https://doi.org/10.1136/rmdopen-2020-001490.

PMID
33380521
Full Text

Kobe, Elizabeth A., Clarissa J. Diamantidis, Hayden B. Bosworth, Clemontina A. Davenport, Megan Oakes, Anastasia-Stefania Alexopoulos, Jane Pendergast, Uptal D. Patel, and Matthew J. Crowley. “Racial Differences in the Effectiveness of a Multifactorial Telehealth Intervention to Slow Diabetic Kidney Disease.” Med Care 58, no. 11 (November 2020): 968–73. https://doi.org/10.1097/MLR.0000000000001387.

PMID
32833935
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Levin, Adeera, Rajiv Agarwal, William G. Herrington, Hiddo L. Heerspink, Johannes F. E. Mann, Shahnaz Shahinfar, Katherine R. Tuttle, et al. “International consensus definitions of clinical trial outcomes for kidney failure: 2020.” Kidney Int 98, no. 4 (October 2020): 849–59. https://doi.org/10.1016/j.kint.2020.07.013.

PMID
32998816
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Nelson, Cara H., Kim Etchevers, Saili Yi, David Breckenridge, Mischa Hepner, Uptal Patel, John Ling, and Anita Mathias. “Pharmacokinetics, Safety, and Tolerability of Selonsertib, an Apoptosis Signal-Regulating Kinase 1 (ASK1) Inhibitor, Following First-in-Human Single and Multiple Ascending Doses in Healthy Subjects.” Clin Pharmacokinet 59, no. 9 (September 2020): 1109–17. https://doi.org/10.1007/s40262-020-00878-y.

PMID
32333325
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Townsend, Raymond R., Paolo Guarnieri, Christos Argyropoulos, Shira Blady, Carine M. Boustany-Kari, Kishor Devalaraja-Narashimha, Lori Morton, et al. “Rationale and design of the Transformative Research in Diabetic Nephropathy (TRIDENT) Study.” Kidney Int 97, no. 1 (January 2020): 10–13. https://doi.org/10.1016/j.kint.2019.09.020.

PMID
31901339
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Chertow, Glenn M., Pablo E. Pergola, Fang Chen, Brian J. Kirby, John S. Sundy, Uptal D. Patel, and Uptal D. GS-US-223-1015 Investigators. “Effects of Selonsertib in Patients with Diabetic Kidney Disease.” J Am Soc Nephrol 30, no. 10 (October 2019): 1980–90. https://doi.org/10.1681/ASN.2018121231.

PMID
31506292
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Telford, Onala, Clarissa J. Diamantidis, Hayden B. Bosworth, Uptal D. Patel, Clemontina A. Davenport, Megan M. Oakes, and Matthew J. Crowley. “The relationship between Pittsburgh Sleep Quality Index subscales and diabetes control.” Chronic Illn 15, no. 3 (September 2019): 210–19. https://doi.org/10.1177/1742395318759587.

PMID
29466873
Full Text

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