Uptal Dinesh Patel, MD

Adjunct Professor in the Department of Medicine
Affiliate, Duke Global Health Institute
Member in the Duke Clinical Research Institute
Campus mail 333 Lakeside Drive, Foster City, CA 94404
Phone (919) 491-5061
Email address uptal.patel@duke.edu

Uptal Patel, MD is an Adjunct Professor interested in population health with a broad range of clinical and research experience. As an adult and pediatric nephrologist with training in health services and epidemiology, his work seeks to improve population health for patients with  kidney diseases through improvements in prevention, diagnosis and treatment.

Prior efforts focused on four inter-related areas that are essential to improving kidney health: i) reducing the progression of chronic kidney disease by improving its detection and management, particularly by leveraging technology to facilitate engagement and self-management; ii) elucidating the inter-relationships between kidney disease and cardiovascular disease, which together amplify the risk of death; iii) improving the evidence in nephrology through comparative effectiveness research, including clinical trials, observational studies, and meta-analyses; and iv) promoting more optimal clinical health policy for all patients with kidney disease. These inter-disciplinary projects have been funded by a variety of public and private sources including the Robert Wood Johnson Foundation, Veterans Affairs, National Institutes of Health, Agency for Healthcare Research & Quality, Food and Drug Administration, Centers for Medicare & Medicaid Services, Renal Physicians Association, and the American Society of Nephrology. 

Current efforts seek to provide novel therapies for kidney diseases through a clinical development program that he leads at Gilead Sciences.

Education and Training

  • Fellow in Nephrology, Medicine, University of Michigan, Ann Arbor, 2002 - 2003
  • Fellow in Pediatric Nephrology, Pediatrics, University of Michigan, Ann Arbor, 2001 - 2002
  • Medicine/Pediatric Resident, Medicine/Pediatrics, University of Michigan, Ann Arbor, 1997 - 2001
  • M.D., University of California San Francisco, School of Medicine, 1997

Publications

Kobe, Elizabeth A., Clarissa J. Diamantidis, Hayden B. Bosworth, Clemontina A. Davenport, Megan Oakes, Anastasia-Stefania Alexopoulos, Jane Pendergast, Uptal D. Patel, and Matthew J. Crowley. “Racial Differences in the Effectiveness of a Multifactorial Telehealth Intervention to Slow Diabetic Kidney Disease.” Med Care 58, no. 11 (November 2020): 968–73. https://doi.org/10.1097/MLR.0000000000001387.

PMID
32833935
Full Text

Levin, Adeera, Rajiv Agarwal, William G. Herrington, Hiddo L. Heerspink, Johannes F. E. Mann, Shahnaz Shahinfar, Katherine R. Tuttle, et al. “International consensus definitions of clinical trial outcomes for kidney failure: 2020.” Kidney Int 98, no. 4 (October 2020): 849–59. https://doi.org/10.1016/j.kint.2020.07.013.

PMID
32998816
Full Text

Nelson, Cara H., Kim Etchevers, Saili Yi, David Breckenridge, Mischa Hepner, Uptal Patel, John Ling, and Anita Mathias. “Pharmacokinetics, Safety, and Tolerability of Selonsertib, an Apoptosis Signal-Regulating Kinase 1 (ASK1) Inhibitor, Following First-in-Human Single and Multiple Ascending Doses in Healthy Subjects.” Clin Pharmacokinet 59, no. 9 (September 2020): 1109–17. https://doi.org/10.1007/s40262-020-00878-y.

PMID
32333325
Full Text

Townsend, Raymond R., Paolo Guarnieri, Christos Argyropoulos, Shira Blady, Carine M. Boustany-Kari, Kishor Devalaraja-Narashimha, Lori Morton, et al. “Rationale and design of the Transformative Research in Diabetic Nephropathy (TRIDENT) Study.” Kidney Int 97, no. 1 (January 2020): 10–13. https://doi.org/10.1016/j.kint.2019.09.020.

PMID
31901339
Full Text

Chertow, Glenn M., Pablo E. Pergola, Fang Chen, Brian J. Kirby, John S. Sundy, Uptal D. Patel, and Uptal D. GS-US-223-1015 Investigators. “Effects of Selonsertib in Patients with Diabetic Kidney Disease.” J Am Soc Nephrol 30, no. 10 (October 2019): 1980–90. https://doi.org/10.1681/ASN.2018121231.

PMID
31506292
Full Text

Telford, Onala, Clarissa J. Diamantidis, Hayden B. Bosworth, Uptal D. Patel, Clemontina A. Davenport, Megan M. Oakes, and Matthew J. Crowley. “The relationship between Pittsburgh Sleep Quality Index subscales and diabetes control.” Chronic Illn 15, no. 3 (September 2019): 210–19. https://doi.org/10.1177/1742395318759587.

PMID
29466873
Full Text

Lewinski, Allison A., Uptal D. Patel, Clarissa J. Diamantidis, Megan Oakes, Khaula Baloch, Matthew J. Crowley, Jonathan Wilson, et al. “Addressing Diabetes and Poorly Controlled Hypertension: Pragmatic mHealth Self-Management Intervention.” J Med Internet Res 21, no. 4 (April 9, 2019): e12541. https://doi.org/10.2196/12541.

PMID
30964439
Full Text

Tomilo, Mark, Heather Ascani, Barbara Mirel, Maria Chiara Magnone, Carol Moreno Quinn, Anil Karihaloo, Kevin Duffin, Uptal D. Patel, and Matthias Kretzler. “Renal Pre-Competitive Consortium (RPC2): discovering therapeutic targets together.” Drug Discov Today 23, no. 10 (October 2018): 1695–99. https://doi.org/10.1016/j.drudis.2018.05.021.

PMID
29778696
Full Text

Green, J. A., P. L. Ephraim, F. F. Hill-Briggs, T. Browne, T. S. Strigo, C. L. Hauer, R. A. Stametz, et al. “Putting patients at the center of kidney care transitions: PREPARE NOW, a cluster randomized controlled trial.” Contemp Clin Trials 73 (October 2018): 98–110. https://doi.org/10.1016/j.cct.2018.09.004.

PMID
30218818
Full Text

Diamantidis, Clarissa J., Hayden B. Bosworth, Megan M. Oakes, Clemontina A. Davenport, Jane F. Pendergast, Sejal Patel, Jivan Moaddeb, et al. “Simultaneous Risk Factor Control Using Telehealth to slOw Progression of Diabetic Kidney Disease (STOP-DKD) study: Protocol and baseline characteristics of a randomized controlled trial.” Contemp Clin Trials 69 (June 2018): 28–39. https://doi.org/10.1016/j.cct.2018.04.003.

PMID
29649631
Full Text

Pages