Virginia Byers Kraus, MD, PhD

Professor of Medicine
Professor of Pathology
Professor in Orthopaedic Surgery
Member of Duke Molecular Physiology Institute
Affiliate of the Regeneration Next Initiative
Campus mail 300 N Duke St, Carmichael Building Room 15-205, Durham, NC 27701-2047
Phone (919) 681-6652
Email address kraus004@duke.edu

My special area of expertise is as a clinician scientist investigating osteoarthritis. Osteoarthritis is the most common form of joint disease in man and its incidence increases with age. It is a problem of increasing concern to the medical community due to the increasing longevity of the population. Trained as a molecular biologist and a Rheumatologist, I endeavor to study this disease from bedside to bench.

The work in this laboratory focuses on osteoarthritis and deals with the mechanisms of joint damage, and the discovery, validation and qualification of novel biochemical and genetic biomarkers for minimally invasive means of diagnosing disease, for predicting progression of disease, and for monitoring disease progression and response to therapy.

Education and Training

  • Fellow in Rheumatology, Medicine, Duke University, 1986 - 1989
  • Medical Resident, Medicine, Duke University, 1983 - 1986
  • Ph.D., Duke University, 1993
  • M.D., Duke University, 1982

Publications

Li, Zhi-Hao, Yue-Bin Lv, Virginia Byers Kraus, Zhao-Xue Yin, Si-Min Liu, Xiao-Chang Zhang, Xiang Gao, et al. “Trends in the Incidence of Activities of Daily Living Disability Among Chinese Elderly from 2002-2014.” J Gerontol a Biol Sci Med Sci, October 11, 2019. https://doi.org/10.1093/gerona/glz221.

PMID
31603986
Full Text

Goode, Adam, David Hu, Rebecca Cleveland, Steven George, Virginia Byers Kraus, Todd Schwartz, Richard Gracely, Joanne Jordan, and Yvonne Golightly. “Transitions in Lumbar Spine Osteoarthritis: The Johnston County Osteoarthritis Project.” In Arthritis & Rheumatology, Vol. 71. WILEY, 2019.

Scholars@Duke

Hsueh, Ming-Feng, Patrik Önnerfjord, Michael P. Bolognesi, Mark E. Easley, and Virginia B. Kraus. “Analysis of "old" proteins unmasks dynamic gradient of cartilage turnover in human limbs.” Sci Adv 5, no. 10 (October 2019): eaax3203. https://doi.org/10.1126/sciadv.aax3203.

PMID
31633025
Full Text

Goode, Adam, Rebecca Cleveland, David Hu, Steven George, Virginia Byers Kraus, Todd Schwartz, Richard Gracely, Louis DeFrate, Joanne Jordan, and Yvonne Golightly. “Predictors of Incident and Worsening Lumbar Spine Degeneration: The Johnston County Osteoarthritis Project.” In Arthritis & Rheumatology, Vol. 71. WILEY, 2019.

Scholars@Duke

Huang, Rong, Xiaohua Zong, Puviindran Nadesan, Janet L. Huebner, Virginia B. Kraus, James P. White, Phillip J. White, and Gurpreet S. Baht. “Lowering circulating apolipoprotein E levels improves aged bone fracture healing.” Jci Insight 4, no. 18 (September 19, 2019). https://doi.org/10.1172/jci.insight.129144.

PMID
31534056
Full Text

Li, Zhi-Hao, Yue-Bin Lv, Wen-Fang Zhong, Xiang Gao, Virginia Byers Kraus, Meng-Chen Zou, Xi-Ru Zhang, et al. “High-Density Lipoprotein Cholesterol and All-Cause and Cause-Specific Mortality Among the Elderly.” J Clin Endocrinol Metab 104, no. 8 (August 1, 2019): 3370–78. https://doi.org/10.1210/jc.2018-02511.

PMID
30869791
Full Text

Li, Fu-Rong, Xi-Ru Zhang, Wen-Fang Zhong, Zhi-Hao Li, Xiang Gao, Virginia Byers Kraus, Yue-Bin Lv, et al. “Glycated Hemoglobin and All-Cause and Cause-Specific Mortality Among Adults With and Without Diabetes.” J Clin Endocrinol Metab 104, no. 8 (August 1, 2019): 3345–54. https://doi.org/10.1210/jc.2018-02536.

PMID
30896760
Full Text

Huang, ZeYu, Jing Chen, Qin Sheng Hu, Qiang Huang, Jun Ma, Fu Xing Pei, Bin Shen, and Virginia Byers Kraus. “Meta-analysis of pain and function placebo responses in pharmacological osteoarthritis trials.” Arthritis Res Ther 21, no. 1 (July 15, 2019): 173. https://doi.org/10.1186/s13075-019-1951-6.

PMID
31307506
Full Text

Emery, Carolyn A., Jackie L. Whittaker, Armaghan Mahmoudian, L Stefan Lohmander, Ewa M. Roos, Kim L. Bennell, Clodagh M. Toomey, et al. “Establishing outcome measures in early knee osteoarthritis.” Nat Rev Rheumatol 15, no. 7 (July 2019): 438–48. https://doi.org/10.1038/s41584-019-0237-3.

PMID
31201386
Full Text

Haraden, Collin A., Janet L. Huebner, Ming-Feng Hsueh, Yi-Ju Li, and Virginia Byers Kraus. “Synovial fluid biomarkers associated with osteoarthritis severity reflect macrophage and neutrophil related inflammation.” Arthritis Res Ther 21, no. 1 (June 13, 2019): 146. https://doi.org/10.1186/s13075-019-1923-x.

PMID
31196179
Full Text

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