Virginia Byers Kraus, MD, PhD

Professor of Medicine
Professor of Pathology
Professor in Orthopaedic Surgery
Member of Duke Molecular Physiology Institute
Affiliate of the Regeneration Next Initiative
Campus mail 300 N Duke St, Carmichael Building Room 15-205, Durham, NC 27701-2047
Phone (919) 681-6652
Email address kraus004@duke.edu

My special area of expertise is as a clinician scientist investigating osteoarthritis. Osteoarthritis is the most common form of joint disease in man and its incidence increases with age. It is a problem of increasing concern to the medical community due to the increasing longevity of the population. Trained as a molecular biologist and a Rheumatologist, I endeavor to study this disease from bedside to bench.

The work in this laboratory focuses on osteoarthritis and deals with the mechanisms of joint damage, and the discovery, validation and qualification of novel biochemical and genetic biomarkers for minimally invasive means of diagnosing disease, for predicting progression of disease, and for monitoring disease progression and response to therapy.

Education and Training

  • Fellow in Rheumatology, Medicine, Duke University, 1986 - 1989
  • Medical Resident, Medicine, Duke University, 1983 - 1986
  • Ph.D., Duke University, 1993
  • M.D., Duke University, 1982

Publications

Kraus, V. B., L. S. Simon, J. N. Katz, T. Neogi, D. Hunter, A. Guermazi, and M. A. Karsdal. “Proposed study designs for approval based on a surrogate endpoint and a post-marketing confirmatory study under FDA's accelerated approval regulations for disease modifying osteoarthritis drugs..” Osteoarthritis Cartilage 27, no. 4 (April 2019): 571–79. https://doi.org/10.1016/j.joca.2018.11.002.

PMID
30465809
Full Text

Lv, Yue-Bin, Chen Mao, Xiang Gao, Zhao-Xue Yin, Virginia Byers Kraus, Jin-Qiu Yuan, Juan Zhang, Jie-Si Luo, Yi Zeng, and Xiao-Ming Shi. “Triglycerides Paradox Among the Oldest Old: "The Lower the Better?".” J Am Geriatr Soc 67, no. 4 (April 2019): 741–48. https://doi.org/10.1111/jgs.15733.

PMID
30628728
Full Text

Yin, Zhaoxue, Melanie Sereny Brasher, Virginia B. Kraus, Yuebin Lv, Xiaoming Shi, and Yi Zeng. “Dietary Diversity Was Positively Associated with Psychological Resilience among Elders: A Population-Based Study..” Nutrients 11, no. 3 (March 18, 2019). https://doi.org/10.3390/nu11030650.

PMID
30889808
Full Text

Spitzer, Andrew I., John C. Richmond, Virginia B. Kraus, Andreas Gomoll, Deryk G. Jones, Kim M. Huffman, Charles Peterfy, Amy Cinar, Joelle Lufkin, and Scott D. Kelley. “Safety and Efficacy of Repeat Administration of Triamcinolone Acetonide Extended-release in Osteoarthritis of the Knee: A Phase 3b, Open-label Study..” Rheumatol Ther 6, no. 1 (March 2019): 109–24. https://doi.org/10.1007/s40744-019-0140-z.

PMID
30741382
Full Text

Parker, Daniel, Richard Sloane, Carl F. Pieper, Katherine S. Hall, Virginia B. Kraus, William E. Kraus, Janet L. Huebner, et al. “Age-Related Adverse Inflammatory and Metabolic Changes Begin Early in Adulthood..” In J Gerontol a Biol Sci Med Sci, 74:283–89, 2019. https://doi.org/10.1093/gerona/gly121.

PMID
29985987
Full Text

Yuan, Jin-Qiu, Yue-Bin Lv, Hua-Shuai Chen, Xiang Gao, Zhao-Xue Yin, Wen-Tao Wang, Virginia Byers Kraus, et al. “Association Between Late-Life Blood Pressure and the Incidence of Cognitive Impairment: A Community-Based Prospective Cohort Study..” J Am Med Dir Assoc 20, no. 2 (February 2019): 177-182.e2. https://doi.org/10.1016/j.jamda.2018.05.029.

PMID
30017702
Full Text

Watt, F. E., N. Corp, S. R. Kingsbury, R. Frobell, M. Englund, D. T. Felson, M. Levesque, et al. “Towards prevention of post-traumatic osteoarthritis: report from an international expert working group on considerations for the design and conduct of interventional studies following acute knee injury..” Osteoarthritis Cartilage 27, no. 1 (January 2019): 23–33. https://doi.org/10.1016/j.joca.2018.08.001.

PMID
30125638
Full Text

Andonian, Brian J., Ching-Heng Chou, Olga R. Ilkayeva, Timothy R. Koves, Margery A. Connelly, William E. Kraus, Virginia B. Kraus, and Kim M. Huffman. “Plasma MicroRNAs in Established Rheumatoid Arthritis Relate to Adiposity and Altered Plasma and Skeletal Muscle Cytokine and Metabolic Profiles..” Front Immunol 10 (2019). https://doi.org/10.3389/fimmu.2019.01475.

PMID
31316517
Full Text

Andonian, Brian J., David B. Bartlett, Janet L. Huebner, Leslie Willis, Andrew Hoselton, Virginia B. Kraus, William E. Kraus, and Kim M. Huffman. “Effect of high-intensity interval training on muscle remodeling in rheumatoid arthritis compared to prediabetes..” Arthritis Res Ther 20, no. 1 (December 27, 2018). https://doi.org/10.1186/s13075-018-1786-6.

PMID
30587230
Full Text

Huang, Z. Y., E. Perry, J. L. Huebner, B. Katz, Y. -. J. Li, and V. B. Kraus. “Biomarkers of inflammation - LBP and TLR- predict progression of knee osteoarthritis in the DOXY clinical trial..” Osteoarthritis Cartilage 26, no. 12 (December 2018): 1658–65. https://doi.org/10.1016/j.joca.2018.08.005.

PMID
30144513
Full Text

Pages