My special area of expertise is as a clinician scientist investigating osteoarthritis. Osteoarthritis is the most common form of joint disease in man and its incidence increases with age. It is a problem of increasing concern to the medical community due to the increasing longevity of the population. Trained as a molecular biologist and a Rheumatologist, I endeavor to study this disease from bedside to bench.
The work in this laboratory focuses on osteoarthritis and deals with the mechanisms of joint damage, and the discovery, validation and qualification of novel biochemical and genetic biomarkers for minimally invasive means of diagnosing disease, for predicting progression of disease, and for monitoring disease progression and response to therapy.
Education and Training
- Fellow in Rheumatology, Medicine, Duke University, 1986 - 1989
- Medical Resident, Medicine, Duke University, 1983 - 1986
- Ph.D., Duke University, 1993
- M.D., Duke University, 1982
- University Training Program in Biomolecular and Tissue Engineering
- Biomarkers to Advance Clinical Phenotypes of Low Back Pain (BACk)
- Age-related alterations in the in vivo mechanical function of the spine
- Behavioral and Physiology in Aging
- Organization and Function of Cellular Structure
- Qualification of Prognostic and Diagnostic Biomarkers of Knee Osteoarthritis
- Extracellular Vesicles and Their Role in Hallmarks of Aging
- Physical Resiliencies: Indicators and Mechanisms in the Elderly Collaborative
- Evaluation of Anti-inflammatory effects of naproxen sodium on human osteoarthritis synovial cells