Virginia Byers Kraus, MD, PhD

Professor of Medicine
Professor of Pathology
Professor in Orthopaedic Surgery
Member of Duke Molecular Physiology Institute
Affiliate of the Regeneration Next Initiative
Campus mail 300 N Duke St, Carmichael Building Room 15-205, Durham, NC 27701-2047
Phone (919) 681-6652
Email address kraus004@duke.edu

My special area of expertise is as a clinician scientist investigating osteoarthritis. Osteoarthritis is the most common form of joint disease in man and its incidence increases with age. It is a problem of increasing concern to the medical community due to the increasing longevity of the population. Trained as a molecular biologist and a Rheumatologist, I endeavor to study this disease from bedside to bench.

The work in this laboratory focuses on osteoarthritis and deals with the mechanisms of joint damage, and the discovery, validation and qualification of novel biochemical and genetic biomarkers for minimally invasive means of diagnosing disease, for predicting progression of disease, and for monitoring disease progression and response to therapy.

Education and Training

  • Fellow in Rheumatology, Medicine, Duke University, 1986 - 1989
  • Medical Resident, Medicine, Duke University, 1983 - 1986
  • Ph.D., Duke University, 1993
  • M.D., Duke University, 1982

Publications

Huebner, J. L., A. C. Bay Jensen, D. J. Leeming, R. E. Coleman, G. McDaniel, M. A. Karsdal, and V. B. Kraus. “048 URINARYMARKERS, ALPHA CTX AND CTXII, ARE INDICATIVE OF OA SEVERITY AND BONE TURNOVER.” In Osteoarthritis and Cartilage, 18:S29–30. Elsevier BV, 2010. https://doi.org/10.1016/s1063-4584(10)60075-1.

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Stabler, T. V., A. E. Heinrichs, K. M. Huffman, G. E. McDaniel, and V. B. Kraus. “109 INFLAMMASOME ACTIVATION IN OSTEOARTHRITIS BY URIC ACID.” In Osteoarthritis and Cartilage, 18:S55–56. Elsevier BV, 2010. https://doi.org/10.1016/s1063-4584(10)60136-7.

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Nelson, A. E., R. F. DeVellis, J. B. Renner, P. G. Conaghan, V. B. Kraus, and J. M. Jordan. “014 A COMPOSITE SCORE OFMULTI-JOINT RADIOGRAPHIC OSTEOARTHRITIS: THE JOHNSTON COUNTY OSTEOARTHRITIS PROJECT.” In Osteoarthritis and Cartilage, 18:S15–S15. Elsevier BV, 2010. https://doi.org/10.1016/s1063-4584(10)60041-6.

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Golightly, Y. M., S. W. Marshall, V. B. Kraus, J. B. Renner, A. Villaveces, C. Casteel, and J. M. Jordan. “124 SERUM CARTILAGE OLIGOMERIC MATRIX PROTEIN HYALURONAN HIGH-SENSITIVITY C-REACTIVE PROTEIN AND KERATAN SULFATE AS PREDICTORS OF INCIDENT RADIOGRAPHIC KNEE OSTEOARTHRITIS: DIFFERENCES BY CHRONIC KNEE SYMPTOMS.” In Osteoarthritis and Cartilage, 18:S62–63. Elsevier BV, 2010. https://doi.org/10.1016/s1063-4584(10)60151-3.

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Lotz, M. K., and V. B. Kraus. “Correction: Posttraumatic osteoarthritis: Pathogenesis and pharmacological treatment options.” Arthritis Research and Therapy 12, no. 6 (September 9, 2010). https://doi.org/10.1186/ar3177.

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Chuckpaiwong, Bavornrit, Hal Cecil Charles, Virginia B. Kraus, Farshid Guilak, and James A. Nunley. “Age-associated increases in the size of the infrapatellar fat pad in knee osteoarthritis as measured by 3T MRI..” J Orthop Res 28, no. 9 (September 2010): 1149–54. https://doi.org/10.1002/jor.21125.

PMID
20225314
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Kempta Lekpa, F., J. C. Piette, S. Bastuji-Garin, V. B. Kraus, T. V. Stabler, A. R. Poole, A. Marini-Portugal, and X. Chevalier. “Serum cartilage oligomeric matrix protein (COMP) level is a marker of disease activity in relapsing polychondritis..” Clin Exp Rheumatol 28, no. 4 (July 2010): 553–55.

PMID
20810035
Scholars@Duke

Nelson, A. E., Y. M. Golightly, V. B. Kraus, T. Stabler, J. B. Renner, C. G. Helmick, and J. M. Jordan. “Serum transforming growth factor-beta 1 is not a robust biomarker of incident and progressive radiographic osteoarthritis at the hip and knee: the Johnston County Osteoarthritis Project..” Osteoarthritis Cartilage 18, no. 6 (June 2010): 825–29. https://doi.org/10.1016/j.joca.2010.02.013.

PMID
20206313
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Kraus, V. B., M. Nevitt, and L. J. Sandell. “Summary of the OA biomarkers workshop 2009--biochemical biomarkers: biology, validation, and clinical studies..” Osteoarthritis Cartilage 18, no. 6 (June 2010): 742–45. https://doi.org/10.1016/j.joca.2010.02.014.

PMID
20206708
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