Virginia Byers Kraus, MD, PhD

Professor of Medicine
Professor of Pathology
Professor in Orthopaedic Surgery
Member of Duke Molecular Physiology Institute
Affiliate of the Regeneration Next Initiative
Campus mail 300 N Duke St, Carmichael Building Room 15-205, Durham, NC 27701-2047
Phone (919) 681-6652
Email address kraus004@duke.edu

My special area of expertise is as a clinician scientist investigating osteoarthritis. Osteoarthritis is the most common form of joint disease in man and its incidence increases with age. It is a problem of increasing concern to the medical community due to the increasing longevity of the population. Trained as a molecular biologist and a Rheumatologist, I endeavor to study this disease from bedside to bench.

The work in this laboratory focuses on osteoarthritis and deals with the mechanisms of joint damage, and the discovery, validation and qualification of novel biochemical and genetic biomarkers for minimally invasive means of diagnosing disease, for predicting progression of disease, and for monitoring disease progression and response to therapy.

Education and Training

  • Fellow in Rheumatology, Medicine, Duke University, 1986 - 1989
  • Medical Resident, Medicine, Duke University, 1983 - 1986
  • Ph.D., Duke University, 1993
  • M.D., Duke University, 1982

Publications

Attur, Mukundan, Hwa-Ying Wang, Virginia Byers Kraus, Jack F. Bukowski, Nazneen Aziz, Svetlana Krasnokutsky, Jonathan Samuels, et al. “Radiographic severity of knee osteoarthritis is conditional on interleukin 1 receptor antagonist gene variations..” Ann Rheum Dis 69, no. 5 (May 2010): 856–61. https://doi.org/10.1136/ard.2009.113043.

PMID
19934104
Full Text

Kraus, Virginia Byers. “Waiting for action on the osteoarthritis front..” Curr Drug Targets 11, no. 5 (May 2010): 518–20.

PMID
20199398
Scholars@Duke

Kraus, Virginia B., Thomas B. Kepler, Thomas Stabler, Jordan Renner, and Joanne Jordan. “First qualification study of serum biomarkers as indicators of total body burden of osteoarthritis..” Plos One 5, no. 3 (March 17, 2010). https://doi.org/10.1371/journal.pone.0009739.

PMID
20305824
Full Text

Huebner, J. L., J. M. Williams, M. Deberg, Y. Henrotin, and V. B. Kraus. “Collagen fibril disruption occurs early in primary guinea pig knee osteoarthritis..” Osteoarthritis Cartilage 18, no. 3 (March 2010): 397–405. https://doi.org/10.1016/j.joca.2009.09.011.

PMID
19825496
Full Text

Chen, Hsiang-Cheng, Virginia Byers Kraus, Yi-Ju Li, Sarah Nelson, Carol Haynes, Jessica Johnson, Thomas Stabler, et al. “Genome-wide linkage analysis of quantitative biomarker traits of osteoarthritis in a large, multigenerational extended family..” Arthritis Rheum 62, no. 3 (March 2010): 781–90. https://doi.org/10.1002/art.27288.

PMID
20187133
Full Text

McDaniel, G., K. L. Mitchell, C. Charles, and V. B. Kraus. “A comparison of five approaches to measurement of anatomic knee alignment from radiographs..” Osteoarthritis Cartilage 18, no. 2 (February 2010): 273–77. https://doi.org/10.1016/j.joca.2009.10.005.

PMID
19897069
Full Text

Le Graverand, M-P Hellio, R. J. Buck, B. T. Wyman, E. Vignon, S. A. Mazzuca, K. D. Brandt, M. Piperno, et al. “Change in regional cartilage morphology and joint space width in osteoarthritis participants versus healthy controls: a multicentre study using 3.0 Tesla MRI and Lyon-Schuss radiography..” Ann Rheum Dis 69, no. 1 (January 2010): 155–62. https://doi.org/10.1136/ard.2008.099762.

PMID
19103634
Full Text

Catterall, Jonathan B., Thomas V. Stabler, Carl R. Flannery, and Virginia B. Kraus. “Changes in serum and synovial fluid biomarkers after acute injury (NCT00332254)..” Arthritis Res Ther 12, no. 6 (2010). https://doi.org/10.1186/ar3216.

PMID
21194441
Full Text

Griffin, Timothy M., Beverley Fermor, Janet L. Huebner, Virginia B. Kraus, Ramona M. Rodriguiz, William C. Wetsel, Li Cao, Lori A. Setton, and Farshid Guilak. “Diet-induced obesity differentially regulates behavioral, biomechanical, and molecular risk factors for osteoarthritis in mice..” Arthritis Res Ther 12, no. 4 (2010). https://doi.org/10.1186/ar3068.

PMID
20604941
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Hudelmaier, M., W. Wirth, B. Wehr, V. Kraus, B. T. Wyman, M. -. P. Hellio Le Graverand, and F. Eckstein. “Femorotibial cartilage morphology: reproducibility of different metrics and femoral regions, and sensitivity to change in disease..” Cells Tissues Organs 192, no. 5 (2010): 340–50. https://doi.org/10.1159/000318178.

PMID
20606404
Full Text

Pages