Virginia Byers Kraus, MD, PhD

Professor of Medicine
Professor of Pathology
Professor in Orthopaedic Surgery
Member of Duke Molecular Physiology Institute
Affiliate of the Regeneration Next Initiative
Campus mail 300 N Duke St, Carmichael Building Room 15-205, Durham, NC 27701-2047
Phone (919) 681-6652
Email address kraus004@duke.edu

My special area of expertise is as a clinician scientist investigating osteoarthritis. Osteoarthritis is the most common form of joint disease in man and its incidence increases with age. It is a problem of increasing concern to the medical community due to the increasing longevity of the population. Trained as a molecular biologist and a Rheumatologist, I endeavor to study this disease from bedside to bench.

The work in this laboratory focuses on osteoarthritis and deals with the mechanisms of joint damage, and the discovery, validation and qualification of novel biochemical and genetic biomarkers for minimally invasive means of diagnosing disease, for predicting progression of disease, and for monitoring disease progression and response to therapy.

Education and Training

  • Fellow in Rheumatology, Medicine, Duke University, 1986 - 1989
  • Medical Resident, Medicine, Duke University, 1983 - 1986
  • Ph.D., Duke University, 1993
  • M.D., Duke University, 1982

Publications

Lindhorst, E, Vail, TP, Guilak, F, Wang, H, Setton, LA, Vilim, V, and Kraus, VB. "Longitudinal characterization of synovial fluid biomarkers in the canine meniscectomy model of osteoarthritis." J Orthop Res 18, no. 2 (March 2000): 269-280.

PMID
10815829
Full Text

Månsson, B, Heinegård, D, Saxne, T, Kraus, VB, Clark, AG, Jordan, JM, Dragomir, AD, Luta, G, and Vilim, V. "Diagnosis of osteoarthritis in relation to molecular processes in cartilage: Comment on the article by Clark et al [3] (multiple letters)." Arthritis and Rheumatism 43, no. 6 (2000): 1425-1427.

PMID
10857808
Full Text

Clark, AG, Jordan, JM, Vilim, V, Renner, JB, Dragomir, AD, Luta, G, and Kraus, VB. "Serum cartilage oligomeric matrix protein reflects osteoarthritis presence and severity: the Johnston County Osteoarthritis Project." Arthritis Rheum 42, no. 11 (November 1999): 2356-2364.

PMID
10555031
Full Text

Huebner, JL, and Kraus, VB. "Expression of matrix metalloproteinase 1 in rodents: Reply." ARTHRITIS AND RHEUMATISM 42, no. 3 (March 1999): 590-590.

Full Text

Setton, LA, Baer, AE, Wang, JY, and Kraus, VB. "Biosynthesis of intervertebral disc matrix in vitro." Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings 2 (1999): 1325--.

Scholars@Duke

Selman, M, Pardo, A, Huebner, JL, and Kraus, VB. "Expression of matrix metalloproteinase 1 in rodents: Comment on the article by Huebner et al [5] (multiple letters)." Arthritis and Rheumatism 42, no. 3 (1999): 590--.

PMID
10088792
Scholars@Duke

Huebner, JL, Otterness, IG, Freund, EM, Caterson, B, and Kraus, VB. "Collagenase 1 and collagenase 3 expression in a guinea pig model of osteoarthritis." Arthritis Rheum 41, no. 5 (May 1998): 877-890.

PMID
9588741
Full Text

Bello, AE, Garrett, WE, Wang, H, Lohnes, J, DeLong, E, Caterson, B, and Kraus, VB. "Comparison of synovial fluid cartilage marker concentrations and chondral damage assessed arthroscopically in acute knee injury." Osteoarthritis Cartilage 5, no. 6 (November 1997): 419-426.

PMID
9536290
Scholars@Duke

Kraus, VB. "Pathogenesis and treatment of osteoarthritis." Med Clin North Am 81, no. 1 (January 1997): 85-112. (Review)

PMID
9012756
Scholars@Duke

Kraus, VB, Freund, EMN, Huebner, JL, and Caterson, B. "Collagenase in a guinea PK3 model of natural osteoarthrftis." Journal of Investigative Medicine 44, no. 3 (1996): 296a-.

Scholars@Duke

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