Virginia Byers Kraus, MD, PhD

Professor of Medicine
Professor of Pathology
Professor in Orthopaedic Surgery
Member of Duke Molecular Physiology Institute
Affiliate of the Regeneration Next Initiative
Campus mail 300 N Duke St, Carmichael Building Room 15-205, Durham, NC 27701-2047
Phone (919) 681-6652
Email address kraus004@duke.edu

My special area of expertise is as a clinician scientist investigating osteoarthritis. Osteoarthritis is the most common form of joint disease in man and its incidence increases with age. It is a problem of increasing concern to the medical community due to the increasing longevity of the population. Trained as a molecular biologist and a Rheumatologist, I endeavor to study this disease from bedside to bench.

The work in this laboratory focuses on osteoarthritis and deals with the mechanisms of joint damage, and the discovery, validation and qualification of novel biochemical and genetic biomarkers for minimally invasive means of diagnosing disease, for predicting progression of disease, and for monitoring disease progression and response to therapy.

Education and Training

  • Fellow in Rheumatology, Medicine, Duke University, 1986 - 1989
  • Medical Resident, Medicine, Duke University, 1983 - 1986
  • Ph.D., Duke University, 1993
  • M.D., Duke University, 1982

Publications

McNulty, AL, Stabler, TV, Vail, TP, McDaniel, GE, and Kraus, VB. "Dehydroascorbate transport in human chondrocytes is regulated by hypoxia and is a physiologically relevant source of ascorbic acid in the joint." Arthritis and rheumatism 52, no. 9 (September 2005): 2676-2685.

PMID
16142743
Full Text

Elliott, AL, Fang, F, Kraus, VB, Renner, JB, Helmick, C, Hochberg, MC, and Jordan, JM. "Association of symptoms and signs of hand osteoarthritis with hip and knee osteoarthritis in African-Americans and Caucasians." September 2005.

Scholars@Duke

Mazzuca, SA, Kraus, VB, Jordan, JM, Brandt, KD, Katz, BP, Lane, KA, and Elliott, A. "Relationship of baseline cartilage oligomeric matrix protein (COMP) levels to joint space narrowing (JSN) in patients with knee osteoarthritis (OA)." September 2005.

Scholars@Duke

Chang, J, Kauf, TL, Mahajan, S, Jordan, JM, Kraus, VB, Vail, TP, Reed, SD, Omar, MA, Kahler, KH, and Schulman, KA. "Impact of disease severity and gastrointestinal side effects on the health state preferences of patients with osteoarthritis." Arthritis Rheum 52, no. 8 (August 2005): 2366-2375.

PMID
16052538
Full Text

Boyd, LM, Richardson, WJ, Chen, J, Kraus, VB, Tewari, A, and Setton, LA. "Osmolarity regulates gene expression in intervertebral disc cells determined by gene array and real-time quantitative RT-PCR." Annals of Biomedical Engineering 33, no. 8 (August 2005): 1071-1077.

PMID
16133915
Full Text

McNulty, AL, Vail, TP, and Kraus, VB. "Chondrocyte transport and concentration of ascorbic acid is mediated by SVCT2." Biochimica et biophysica acta 1712, no. 2 (June 2005): 212-221.

PMID
15921655
Full Text

Kraus, VB, Vail, TP, Worrell, T, and McDaniel, G. "A comparative assessment of alignment angle of the knee by radiographic and physical examination methods." Arthritis Rheum 52, no. 6 (June 2005): 1730-1735.

PMID
15934069
Full Text

Dominick, KL, Jordan, JM, Renner, JB, and Kraus, VB. "Relationship of radiographic and clinical variables to pinch and grip strength among individuals with osteoarthritis." Arthritis and Rheumatism 52, no. 5 (May 2005): 1424-1430.

PMID
15880347
Full Text

Elliott, AL, Kraus, VB, Luta, G, Stabler, T, Renner, JB, Woodard, J, Dragomir, AD, Helmick, CG, Hochberg, MC, and Jordan, JM. "Serum hyaluronan levels and radiographic knee and hip osteoarthritis in African Americans and Caucasians in the Johnston County Osteoarthritis Project." Arthritis Rheum 52, no. 1 (January 2005): 105-111.

PMID
15641044
Full Text

Stabler, T, Piette, J-C, Chevalier, X, Marini-Portugal, A, and Kraus, VB. "Serum cytokine profiles in relapsing polychondritis suggest monocyte/macrophage activation." Arthritis Rheum 50, no. 11 (November 2004): 3663-3667.

PMID
15529362
Full Text

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