Virginia Byers Kraus, MD, PhD

Professor of Medicine
Professor of Pathology
Professor in Orthopaedic Surgery
Member of Duke Molecular Physiology Institute
Affiliate of the Regeneration Next Initiative
Campus mail 300 N Duke St, Carmichael Building Room 15-205, Durham, NC 27701-2047
Phone (919) 681-6652
Email address kraus004@duke.edu

My special area of expertise is as a clinician scientist investigating osteoarthritis. Osteoarthritis is the most common form of joint disease in man and its incidence increases with age. It is a problem of increasing concern to the medical community due to the increasing longevity of the population. Trained as a molecular biologist and a Rheumatologist, I endeavor to study this disease from bedside to bench.

The work in this laboratory focuses on osteoarthritis and deals with the mechanisms of joint damage, and the discovery, validation and qualification of novel biochemical and genetic biomarkers for minimally invasive means of diagnosing disease, for predicting progression of disease, and for monitoring disease progression and response to therapy.

Education and Training

  • Fellow in Rheumatology, Medicine, Duke University, 1986 - 1989
  • Medical Resident, Medicine, Duke University, 1983 - 1986
  • Ph.D., Duke University, 1993
  • M.D., Duke University, 1982

Publications

Boyd, Lawrence M., William J. Richardson, Jun Chen, Virginia B. Kraus, Alok Tewari, and Lori A. Setton. “Osmolarity regulates gene expression in intervertebral disc cells determined by gene array and real-time quantitative RT-PCR..” Ann Biomed Eng 33, no. 8 (August 2005): 1071–77. https://doi.org/10.1007/s10439-005-5775-y.

PMID
16133915
Full Text

Chang, Jane, Teresa L. Kauf, Shibani Mahajan, Joanne M. Jordan, Virginia B. Kraus, T Parker Vail, Shelby D. Reed, Mohamed A. Omar, Kristijan H. Kahler, and Kevin A. Schulman. “Impact of disease severity and gastrointestinal side effects on the health state preferences of patients with osteoarthritis..” Arthritis Rheum 52, no. 8 (August 2005): 2366–75. https://doi.org/10.1002/art.21227.

PMID
16052538
Full Text

McNulty, Amy L., Thomas P. Vail, and Virginia B. Kraus. “Chondrocyte transport and concentration of ascorbic acid is mediated by SVCT2..” Biochim Biophys Acta 1712, no. 2 (June 30, 2005): 212–21. https://doi.org/10.1016/j.bbamem.2005.04.009.

PMID
15921655
Full Text

Kraus, Virginia B., T Parker Vail, Ted Worrell, and Gary McDaniel. “A comparative assessment of alignment angle of the knee by radiographic and physical examination methods..” Arthritis Rheum 52, no. 6 (June 2005): 1730–35. https://doi.org/10.1002/art.21100.

PMID
15934069
Full Text

Dominick, Kelli L., Joanne M. Jordan, Jordan B. Renner, and Virginia B. Kraus. “Relationship of radiographic and clinical variables to pinch and grip strength among individuals with osteoarthritis..” Arthritis Rheum 52, no. 5 (May 2005): 1424–30. https://doi.org/10.1002/art.21035.

PMID
15880347
Full Text

Elliott, Alan L., Virginia B. Kraus, Gheorghe Luta, Thomas Stabler, Jordan B. Renner, Janice Woodard, Anca D. Dragomir, Charles G. Helmick, Marc C. Hochberg, and Joanne M. Jordan. “Serum hyaluronan levels and radiographic knee and hip osteoarthritis in African Americans and Caucasians in the Johnston County Osteoarthritis Project..” Arthritis Rheum 52, no. 1 (January 2005): 105–11. https://doi.org/10.1002/art.20724.

PMID
15641044
Full Text

Stabler, Thomas, Jean-Charles Piette, Xavier Chevalier, Andre Marini-Portugal, and Virginia B. Kraus. “Serum cytokine profiles in relapsing polychondritis suggest monocyte/macrophage activation..” Arthritis Rheum 50, no. 11 (November 2004): 3663–67. https://doi.org/10.1002/art.20613.

PMID
15529362
Full Text

Boyd, Lawrence M., Jun Chen, Virginia B. Kraus, and Lori A. Setton. “Conditioned medium differentially regulates matrix protein gene expression in cells of the intervertebral disc..” Spine (Phila Pa 1976) 29, no. 20 (October 15, 2004): 2217–22. https://doi.org/10.1097/01.brs.0000142747.90488.1d.

PMID
15480131
Full Text

Jordan, J. M., V. B. Kraus, J. B. Renner, G. Luta, A. D. Dragomir, M. Ionescu, T. Lobanok, L. King, and A. R. Poole. “Predictive ability of serum biomarkers of types I and II collagen cleavage and aggrecan turnover in incidence and progression of radiographic knee osteoarthritis in African Americans and Caucasians..” In Arthritis and Rheumatism, 50:S481–S481. WILEY-LISS, 2004.

Scholars@Duke

Jordan, J. M., V. B. Kraus, J. B. Renner, G. Luta, A. D. Dragomir, M. Ionescu, T. Lobanok, L. King, and A. R. Poole. “Ethnic and gender differences in serum biomarkers of types I and II collagen cleavage and aggrecan turnover in African Americans and Caucasians..” In Arthritis and Rheumatism, 50:S481–S481. WILEY-LISS, 2004.

Scholars@Duke

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