Virginia Byers Kraus, MD, PhD

Professor of Medicine
Professor of Pathology
Professor in Orthopaedic Surgery
Member of Duke Molecular Physiology Institute
Affiliate of the Regeneration Next Initiative
Campus mail 300 N Duke St, Carmichael Building Room 15-205, Durham, NC 27701-2047
Phone (919) 681-6652
Email address kraus004@duke.edu

My special area of expertise is as a clinician scientist investigating osteoarthritis. Osteoarthritis is the most common form of joint disease in man and its incidence increases with age. It is a problem of increasing concern to the medical community due to the increasing longevity of the population. Trained as a molecular biologist and a Rheumatologist, I endeavor to study this disease from bedside to bench.

The work in this laboratory focuses on osteoarthritis and deals with the mechanisms of joint damage, and the discovery, validation and qualification of novel biochemical and genetic biomarkers for minimally invasive means of diagnosing disease, for predicting progression of disease, and for monitoring disease progression and response to therapy.

Education and Training

  • Fellow in Rheumatology, Medicine, Duke University, 1986 - 1989
  • Medical Resident, Medicine, Duke University, 1983 - 1986
  • Ph.D., Duke University, 1993
  • M.D., Duke University, 1982

Publications

Clark, AG, Rohrbaugh, AL, Otterness, I, and Kraus, VB. "The effects of ascorbic acid on cartilage metabolism in guinea pig articular cartilage explants." Matrix biology : journal of the International Society for Matrix Biology 21, no. 2 (March 2002): 175-184.

PMID
11852233
Full Text

Kraus, VB, Huebner, JL, Fink, C, King, JB, Brown, S, Vail, TP, and Guilak, F. "Urea as a passive transport marker for arthritis biomarker studies." Arthritis Rheum 46, no. 2 (February 2002): 420-427.

PMID
11840444
Scholars@Duke

Carlson, CS, Guilak, F, Vail, TP, Gardin, JF, and Kraus, VB. "Synovial fluid biomarker levels predict articular cartilage damage following complete medial meniscectomy in the canine knee." Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society 20, no. 1 (January 2002): 92-100.

PMID
11853096
Full Text

Vilím, V, Vytásek, R, Olejárová, M, Machácek, S, Gatterová, J, Procházka, B, Kraus, VB, and Pavelka, K. "Serum cartilage oligomeric matrix protein reflects the presence of clinically diagnosed synovitis in patients with knee osteoarthritis." Osteoarthritis Cartilage 9, no. 7 (October 2001): 612-618.

PMID
11597173
Full Text

Wang, JY, Baer, AE, Kraus, VB, and Setton, LA. "Intervertebral disc cells exhibit differences in gene expression in alginate and monolayer culture." Spine 26, no. 16 (August 2001): 1747-1752.

PMID
11493844
Full Text

Hale, LP, Clark, AG, Li, J, Greer, PK, and Byers Kraus, V. "Age-related thymic atrophy in the guinea pig." Dev Comp Immunol 25, no. 5-6 (June 2001): 509-518.

PMID
11356230
Scholars@Duke

St Clair, EW, Wilkinson, WE, Pisetsky, DS, Sexton, DJ, Drew, R, Kraus, VB, and Greenwald, RA. "The effects of intravenous doxycycline therapy for rheumatoid arthritis: a randomized, double-blind, placebo-controlled trial." Arthritis Rheum 44, no. 5 (May 2001): 1043-1047.

PMID
11357896
Full Text

Baer, AE, Wang, JY, Kraus, VB, and Setton, LA. "Collagen gene expression and mechanical properties of intervertebral disc cell-alginate cultures." J Orthop Res 19, no. 1 (January 2001): 2-10.

PMID
11332616
Full Text

Kraus, VB, Clark, AG, Jordan, JM, Dragomir, AD, Luta, G, and Vilim, V. "Diagnosis of osteoarthritis in relation to molecular processes in cartilage: comment on the article by Clark et al - Reply." ARTHRITIS AND RHEUMATISM 43, no. 6 (June 2000): 1426-1427.

Full Text

Lindhorst, E, Vail, TP, Guilak, F, Wang, H, Setton, LA, Vilim, V, and Kraus, VB. "Longitudinal characterization of synovial fluid biomarkers in the canine meniscectomy model of osteoarthritis." Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society 18, no. 2 (March 2000): 269-280.

PMID
10815829
Full Text

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