Virginia Byers Kraus, MD, PhD

Professor of Medicine
Professor of Pathology
Professor in Orthopaedic Surgery
Member of Duke Molecular Physiology Institute
Affiliate of the Regeneration Next Initiative
Campus mail 300 N Duke St, Carmichael Building Room 15-205, Durham, NC 27701-2047
Phone (919) 681-6652
Email address kraus004@duke.edu

My special area of expertise is as a clinician scientist investigating osteoarthritis. Osteoarthritis is the most common form of joint disease in man and its incidence increases with age. It is a problem of increasing concern to the medical community due to the increasing longevity of the population. Trained as a molecular biologist and a Rheumatologist, I endeavor to study this disease from bedside to bench.

The work in this laboratory focuses on osteoarthritis and deals with the mechanisms of joint damage, and the discovery, validation and qualification of novel biochemical and genetic biomarkers for minimally invasive means of diagnosing disease, for predicting progression of disease, and for monitoring disease progression and response to therapy.

Education and Training

  • Fellow in Rheumatology, Medicine, Duke University, 1986 - 1989
  • Medical Resident, Medicine, Duke University, 1983 - 1986
  • Ph.D., Duke University, 1993
  • M.D., Duke University, 1982

Publications

Boyd, LM, Chen, J, Kraus, VB, and Setton, LA. "Conditioned medium differentially regulates matrix protein gene expression in cells of the intervertebral disc." Spine 29, no. 20 (October 2004): 2217-2222.

PMID
15480131
Full Text

Jordan, JM, Kraus, VB, Renner, JB, Luta, G, Dragomir, AD, Ionescu, M, Lobanok, T, King, L, and Poole, AR. "Predictive ability of serum biomarkers of types I and II collagen cleavage and aggrecan turnover in incidence and progression of radiographic knee osteoarthritis in African Americans and Caucasians." September 2004.

Scholars@Duke

Jordan, JM, Kraus, VB, Renner, JB, Luta, G, Dragomir, AD, Ionescu, M, Lobanok, T, King, L, and Poole, AR. "Ethnic and gender differences in serum biomarkers of types I and II collagen cleavage and aggrecan turnover in African Americans and Caucasians." September 2004.

Scholars@Duke

Dominick, KL, Jordan, JM, Renner, JB, and Kraus, VB. "Relationships of radiographic and clinical variables to pinch and grip strength among patients with osteoarthritis." September 2004.

Scholars@Duke

McDaniel, GE, Vail, TP, and Kraus, VB. "Comparison of knee alignment angle by x-ray and goniometer." September 2004.

Scholars@Duke

Varjú, G, Pieper, CF, Renner, JB, and Kraus, VB. "Assessment of hand osteoarthritis: correlation between thermographic and radiographic methods." Rheumatology (Oxford, England) 43, no. 7 (July 2004): 915-919.

PMID
15126670
Full Text

Kraus, VB, Li, Y-J, Martin, ER, Jordan, JM, Renner, JB, Doherty, M, Wilson, AG, Moskowitz, R, Hochberg, M, Loeser, R, Hooper, M, and Sundseth, S. "Articular hypermobility is a protective factor for hand osteoarthritis." Arthritis and Rheumatism 50, no. 7 (July 2004): 2178-2183.

PMID
15248215
Full Text

Kraus, VB, Huebner, JL, Stabler, T, Flahiff, CM, Setton, LA, Fink, C, Vilim, V, and Clark, AG. "Ascorbic acid increases the severity of spontaneous knee osteoarthritis in a guinea pig model." Arthritis Rheum 50, no. 6 (June 2004): 1822-1831.

PMID
15188359
Full Text

Guilak, F, Fermor, B, Keefe, FJ, Kraus, VB, Olson, SA, Pisetsky, DS, Setton, LA, and Weinberg, JB. "The role of biomechanics and inflammation in cartilage injury and repair." Clinical Orthopaedics and Related Research, no. 423 (June 2004): 17-26. (Review)

PMID
15232421
Scholars@Duke

Flahiff, CM, Kraus, VB, Huebner, JL, and Setton, LA. "Cartilage mechanics in the guinea pig model of osteoarthritis studied with an osmotic loading method." Osteoarthritis Cartilage 12, no. 5 (May 2004): 383-388.

PMID
15094137
Full Text

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