Virginia Byers Kraus, MD, PhD

Professor of Medicine
Professor of Pathology
Professor in Orthopaedic Surgery
Member of Duke Molecular Physiology Institute
Affiliate of the Regeneration Next Initiative
Campus mail 300 N Duke St, Carmichael Building Room 15-205, Durham, NC 27701-2047
Phone (919) 681-6652
Email address kraus004@duke.edu

My special area of expertise is as a clinician scientist investigating osteoarthritis. Osteoarthritis is the most common form of joint disease in man and its incidence increases with age. It is a problem of increasing concern to the medical community due to the increasing longevity of the population. Trained as a molecular biologist and a Rheumatologist, I endeavor to study this disease from bedside to bench.

The work in this laboratory focuses on osteoarthritis and deals with the mechanisms of joint damage, and the discovery, validation and qualification of novel biochemical and genetic biomarkers for minimally invasive means of diagnosing disease, for predicting progression of disease, and for monitoring disease progression and response to therapy.

Education and Training

  • Fellow in Rheumatology, Medicine, Duke University, 1986 - 1989
  • Medical Resident, Medicine, Duke University, 1983 - 1986
  • Ph.D., Duke University, 1993
  • M.D., Duke University, 1982

Publications

Kraus, VB. "Cyclooxygenase-2 inhibitors and nonsteroidal anti-inflammatory drugs in the management of arthritis." Foot Ankle Clin 8, no. 2 (June 2003): 187-vii. (Review)

PMID
12911235
Scholars@Duke

Stabler, TV, Jordan, JM, Kraus, VB, Luta, G, Renner, JB, Dragomir, AD, Hochberg, MC, and Helmick, CG. "Serum C-reactive protein (CRP) levels and osteoarthritis." June 2003.

Scholars@Duke

Jordan, JM, Luta, G, Stabler, T, Renner, JB, Dragomir, AD, Vilim, V, Hochberg, MC, Helmick, CG, and Kraus, VB. "Ethnic and sex differences in serum levels of cartilage oligomeric matrix protein: the Johnston County Osteoarthritis Project." Arthritis and Rheumatism 48, no. 3 (March 2003): 675-681.

PMID
12632420
Full Text

Vilím, V, Vobůrka, Z, Vytásek, R, Senolt, L, Tchetverikov, I, Kraus, VB, and Pavelka, K. "Monoclonal antibodies to human cartilage oligomeric matrix protein: epitope mapping and characterization of sandwich ELISA." Clin Chim Acta 328, no. 1-2 (February 2003): 59-69.

PMID
12559599
Scholars@Duke

Huebner, JL, Hanes, MA, Beekman, B, TeKoppele, JM, and Kraus, VB. "A comparative analysis of bone and cartilage metabolism in two strains of guinea-pig with varying degrees of naturally occurring osteoarthritis." Osteoarthritis and Cartilage 10, no. 10 (October 2002): 758-767.

PMID
12359161
Full Text

Flahiff, CM, Narmoneva, DA, Huebner, JL, Kraus, VB, Guilak, F, and Setton, LA. "Osmotic loading to determine the intrinsic material properties of guinea pig knee cartilage." Journal of Biomechanics 35, no. 9 (September 2002): 1285-1290.

PMID
12163318
Full Text

Dragomir, AD, Kraus, VB, Renner, JB, Luta, G, Clark, A, Vilim, V, Hochberg, MC, Helmick, CG, and Jordan, JM. "Serum cartilage oligomeric matrix protein and clinical signs and symptoms of potential pre-radiographic hip and knee pathology." Osteoarthritis and Cartilage 10, no. 9 (September 2002): 687-691.

PMID
12202121
Full Text

Vilím, V, Olejárová, M, Machácek, S, Gatterová, J, Kraus, VB, and Pavelka, K. "Serum levels of cartilage oligomeric matrix protein (COMP) correlate with radiographic progression of knee osteoarthritis." Osteoarthritis and Cartilage 10, no. 9 (September 2002): 707-713.

PMID
12202123
Full Text

Dragomir, AD, Kraus, VB, Stabler, T, Luta, G, Renner, JB, Arab, L, Hochberg, MC, Helmick, CG, and Jordan, JM. "Lower levels of serum cartilage oligomeric matrix protein (COMP) in postmenopausal African-American and caucasian women on current hormone replacement therapy (HRT)." September 2002.

Scholars@Duke

Jordan, JM, Luta, G, Stabler, T, Renner, JB, Dragomir, AD, Hochberg, MC, Helmick, CG, and Kraus, VB. "Serum c-reactive protein (CRP) and osteoarthritis (OA)." September 2002.

Scholars@Duke

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