Virginia Byers Kraus, MD, PhD

Professor of Medicine
Professor of Pathology
Professor in Orthopaedic Surgery
Member of Duke Molecular Physiology Institute
Affiliate of the Regeneration Next Initiative
Campus mail 300 N Duke St, Carmichael Building Room 15-205, Durham, NC 27701-2047
Phone (919) 681-6652
Email address kraus004@duke.edu

My special area of expertise is as a clinician scientist investigating osteoarthritis. Osteoarthritis is the most common form of joint disease in man and its incidence increases with age. It is a problem of increasing concern to the medical community due to the increasing longevity of the population. Trained as a molecular biologist and a Rheumatologist, I endeavor to study this disease from bedside to bench.

The work in this laboratory focuses on osteoarthritis and deals with the mechanisms of joint damage, and the discovery, validation and qualification of novel biochemical and genetic biomarkers for minimally invasive means of diagnosing disease, for predicting progression of disease, and for monitoring disease progression and response to therapy.

Education and Training

  • Fellow in Rheumatology, Medicine, Duke University, 1986 - 1989
  • Medical Resident, Medicine, Duke University, 1983 - 1986
  • Ph.D., Duke University, 1993
  • M.D., Duke University, 1982

Publications

Kraus, VB, Inostroza, JA, Yeung, K, Reinberg, D, and Nevins, JR. "Interaction of the Dr1 inhibitory factor with the TATA binding protein is disrupted by adenovirus E1A." Proc Natl Acad Sci U S A 91, no. 14 (July 5, 1994): 6279-6282.

PMID
8022773
Scholars@Duke

Taylor, DA, Kraus, VB, Schwarz, JJ, Olson, EN, and Kraus, WE. "E1A-mediated inhibition of myogenesis correlates with a direct physical interaction of E1A12S and basic helix-loop-helix proteins." Mol Cell Biol 13, no. 8 (August 1993): 4714-4727.

PMID
8393137
Scholars@Duke

TAYLOR, DA, KRAUS, VB, SCHWARZ, JJ, OLSON, EN, and KRAUS, WE. "E1A-MEDIATED INHIBITION OF MYOGENESIS - A DIRECT PHYSICAL INTERACTION OF E1A(12S) AND BHLH PROTEINS." JOURNAL OF CELLULAR BIOCHEMISTRY (March 13, 1993): 225-225.

Scholars@Duke

KRAUS, VB, INOSTROZA, JA, REINBERG, D, MORAN, E, and NEVINS, JR. "THE ACTIVATION OF THE HSP70-PROMOTER BY E1A COINCIDES WITH A RELEASE OF TBP FROM AN INTERACTION WITH THE INHIBITORY FACTOR DR1." JOURNAL OF CELLULAR BIOCHEMISTRY (January 9, 1993): 226-226.

Scholars@Duke

KRAUS, VB, INOSTROZA, JA, REINBERG, D, MORAN, E, and NEVINS, JR. "THE ACTIVATION OF THE HSP70 PROMOTER BY E1A COINCIDES WITH A RELEASE OF TBP FROM AN INTERACTION WITH THE INHIBITORY FACTOR-DR1." JOURNAL OF CELLULAR BIOCHEMISTRY (January 9, 1993): 60-60.

Scholars@Duke

Kraus, VB, Moran, E, and Nevins, JR. "Promoter-specific trans-activation by the adenovirus E1A12S product involves separate E1A domains." Mol Cell Biol 12, no. 10 (October 1992): 4391-4399.

PMID
1406628
Scholars@Duke

TAYLOR, DA, KRAUS, VB, and KRAUS, WE. "E1A-MEDIATED INHIBITION OF MYOGENESIS - A DIRECT PHYSICAL INTERACTION OF E1A(12S) AND BHLH PROTEINS." CIRCULATION 86, no. 4 (October 1992): 347-347.

Scholars@Duke

Chellappan, S, Kraus, VB, Kroger, B, Munger, K, Howley, PM, Phelps, WC, and Nevins, JR. "Adenovirus E1A, simian virus 40 tumor antigen, and human papillomavirus E7 protein share the capacity to disrupt the interaction between transcription factor E2F and the retinoblastoma gene product." Proc Natl Acad Sci U S A 89, no. 10 (May 15, 1992): 4549-4553.

PMID
1316611
Scholars@Duke

Raychaudhuri, P, Bagchi, S, Devoto, SH, Kraus, VB, Moran, E, and Nevins, JR. "Domains of the adenovirus E1A protein required for oncogenic activity are also required for dissociation of E2F transcription factor complexes." Genes Dev 5, no. 7 (July 1991): 1200-1211.

PMID
1829698
Scholars@Duke

Phelps, WC, Bagchi, S, Barnes, JA, Raychaudhuri, P, Kraus, V, Münger, K, Howley, PM, and Nevins, JR. "Analysis of trans activation by human papillomavirus type 16 E7 and adenovirus 12S E1A suggests a common mechanism." Journal of Virology 65, no. 12 (1991): 6922-6930.

PMID
1834862
Scholars@Duke

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