Virginia Byers Kraus, MD, PhD

Professor of Medicine
Professor of Pathology
Professor in Orthopaedic Surgery
Member of Duke Molecular Physiology Institute
Affiliate of the Regeneration Next Initiative
Campus mail 300 N Duke St, Carmichael Building Room 15-205, Durham, NC 27701-2047
Phone (919) 681-6652
Email address kraus004@duke.edu

My special area of expertise is as a clinician scientist investigating osteoarthritis. Osteoarthritis is the most common form of joint disease in man and its incidence increases with age. It is a problem of increasing concern to the medical community due to the increasing longevity of the population. Trained as a molecular biologist and a Rheumatologist, I endeavor to study this disease from bedside to bench.

The work in this laboratory focuses on osteoarthritis and deals with the mechanisms of joint damage, and the discovery, validation and qualification of novel biochemical and genetic biomarkers for minimally invasive means of diagnosing disease, for predicting progression of disease, and for monitoring disease progression and response to therapy.

Education and Training

  • Fellow in Rheumatology, Medicine, Duke University, 1986 - 1989
  • Medical Resident, Medicine, Duke University, 1983 - 1986
  • Ph.D., Duke University, 1993
  • M.D., Duke University, 1982

Publications

Taylor, AM, Hsueh, M-F, Ranganath, LR, Gallagher, JA, Dillon, JP, Huebner, JL, Catterall, JB, and Kraus, VB. "Cartilage biomarkers in the osteoarthropathy of alkaptonuria reveal low turnover and accelerated ageing." Rheumatology (Oxford, England) 56, no. 1 (January 2017): 156-164.

PMID
28028161
Full Text

Kraus, VB, Hargrove, DE, Hunter, DJ, Renner, JB, and Jordan, JM. "Establishment of reference intervals for osteoarthritis-related soluble biomarkers: the FNIH/OARSI OA Biomarkers Consortium." ANNALS OF THE RHEUMATIC DISEASES 76, no. 1 (January 2017): 179-185.

Full Text

Gupta, D, Wen, JC, Huebner, JL, Stinnett, S, Kraus, VB, Tseng, HC, and Walsh, M. "Cytokine biomarkers in tear film for primary open-angle glaucoma." Clinical Ophthalmology (Auckland, N.Z.) 11 (January 2017): 411-416.

PMID
28260854
Full Text

Karsdal, MA, Michaelis, M, Ladel, C, Siebuhr, AS, Bihlet, AR, Andersen, JR, Guehring, H, Christiansen, C, Bay-Jensen, AC, and Kraus, VB. "Disease-modifying treatments for osteoarthritis (DMOADs) of the knee and hip: lessons learned from failures and opportunities for the future." Osteoarthritis and Cartilage 24, no. 12 (December 2016): 2013-2021. (Review)

PMID
27492463
Full Text

Roemer, FW, Guermazi, A, Collins, JE, Losina, E, Nevitt, MC, Lynch, JA, Katz, JN, Kwoh, CK, Kraus, VB, and Hunter, DJ. "Semi-quantitative MRI biomarkers of knee osteoarthritis progression in the FNIH biomarkers consortium cohort - Methodologic aspects and definition of change." Bmc Musculoskeletal Disorders 17, no. 1 (November 10, 2016): 466-null.

PMID
27832771
Full Text

Kraus, WE, Pieper, CF, Huffman, KM, Thompson, DK, Kraus, VB, Morey, MC, Cohen, HJ, Ravussin, E, Redman, LM, Bain, JR, Stevens, RD, and Newgard, CB. "Association of Plasma Small-Molecule Intermediate Metabolites With Age and Body Mass Index Across Six Diverse Study Populations." The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences 71, no. 11 (November 2016): 1507-1513.

PMID
26984390
Full Text

Castaño-Betancourt, MC, Evans, DS, Ramos, YFM, Boer, CG, Metrustry, S, Liu, Y, den Hollander, W, van Rooij, J, Kraus, VB, Yau, MS, Mitchell, BD, Muir, K, Hofman, A, Doherty, M, Doherty, S, Zhang, W, Kraaij, R, Rivadeneira, F, Barrett-Connor, E, Maciewicz, RA, Arden, N, Nelissen, RGHH, Kloppenburg, M, Jordan, JM, Nevitt, MC, Slagboom, EP, Hart, DJ, Lafeber, F, Styrkarsdottir, U, Zeggini, E, Evangelou, E, Spector, TD, Uitterlinden, AG, Lane, NE, Meulenbelt, I, Valdes, AM, and van Meurs, JBJ. "Novel Genetic Variants for Cartilage Thickness and Hip Osteoarthritis." Plos Genetics 12, no. 10 (October 4, 2016): e1006260-null.

PMID
27701424
Full Text

Collins, JE, Losina, E, Nevitt, MC, Roemer, FW, Guermazi, A, Lynch, JA, Katz, JN, Kent Kwoh, C, Kraus, VB, and Hunter, DJ. "Semiquantitative Imaging Biomarkers of Knee Osteoarthritis Progression: Data From the Foundation for the National Institutes of Health Osteoarthritis Biomarkers Consortium." Arthritis & Rheumatology (Hoboken, N.J.) 68, no. 10 (October 2016): 2422-2431.

PMID
27111771
Full Text

Huang, ZY, Stabler, T, Pei, FX, and Kraus, VB. "Both systemic and local lipopolysaccharide (LPS) burden are associated with knee OA severity and inflammation." Osteoarthritis and Cartilage 24, no. 10 (October 2016): 1769-1775.

PMID
27216281
Full Text

Montell, E, Stabler, T, Verges, J, and Kraus, VB. "CHONDROITIN SULPHATE INHIBITION OF NF-kappa B ACTIVITY: ATTENTUATION OF HYALURONAN FRAGMENT INDUCED INFLAMMATORY RESPONSE IN MACROPHAGES BY CHONDROITIN SULPHATE IS MEDIATED BY REDUCTION IN NF-kappa B ACTIVITY." October 2016.

Scholars@Duke

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