Virginia Byers Kraus, MD, PhD

Professor of Medicine
Professor of Pathology
Professor in Orthopaedic Surgery
Member of Duke Molecular Physiology Institute
Affiliate of the Regeneration Next Initiative
Campus mail 300 N Duke St, Carmichael Building Room 15-205, Durham, NC 27701-2047
Phone (919) 681-6652
Email address kraus004@duke.edu

My special area of expertise is as a clinician scientist investigating osteoarthritis. Osteoarthritis is the most common form of joint disease in man and its incidence increases with age. It is a problem of increasing concern to the medical community due to the increasing longevity of the population. Trained as a molecular biologist and a Rheumatologist, I endeavor to study this disease from bedside to bench.

The work in this laboratory focuses on osteoarthritis and deals with the mechanisms of joint damage, and the discovery, validation and qualification of novel biochemical and genetic biomarkers for minimally invasive means of diagnosing disease, for predicting progression of disease, and for monitoring disease progression and response to therapy.

Education and Training

  • Fellow in Rheumatology, Medicine, Duke University, 1986 - 1989
  • Medical Resident, Medicine, Duke University, 1983 - 1986
  • Ph.D., Duke University, 1993
  • M.D., Duke University, 1982

Publications

Huang, Z, and Kraus, VB. "Does lipopolysaccharide-mediated inflammation have a role in OA?." Nature reviews. Rheumatology 12, no. 2 (February 2016): 123-129. (Review)

PMID
26656661
Full Text

Hsueh, M-F, Khabut, A, Kjellström, S, Önnerfjord, P, and Kraus, VB. "Elucidating the Molecular Composition of Cartilage by Proteomics." Journal of proteome research 15, no. 2 (February 2016): 374-388.

PMID
26632656
Full Text

Peterson, MJ, Thompson, DK, Pieper, CF, Morey, MC, Kraus, VB, Kraus, WE, Sullivan, P, Fillenbaum, G, and Cohen, HJ. "A Novel Analytic Technique to Measure Associations Between Circulating Biomarkers and Physical Performance Across the Adult Life Span." The journals of gerontology. Series A, Biological sciences and medical sciences 71, no. 2 (February 2016): 196-202.

PMID
25745025
Full Text

Catterall, JB, Zura, RD, Bolognesi, MP, and Kraus, VB. "Aspartic acid racemization reveals a high turnover state in knee compared with hip osteoarthritic cartilage." Osteoarthritis and cartilage 24, no. 2 (February 2016): 374-381.

PMID
26417696
Full Text

Olson, SA, Furman, BD, Kraus, VB, Huebner, JL, and Guilak, F. "Reply to "Does progranulin account for the opposite effects of etanercept and infliximab/adalimumab in osteoarthritis?" by Wei et al." Journal of orthopaedic research : official publication of the Orthopaedic Research Society 34, no. 1 (January 2016): 15-16. (Letter)

PMID
26519624
Full Text

Siebuhr, AS, Bay-Jensen, AC, Jordan, JM, Kjelgaard-Petersen, CF, Christiansen, C, Abramson, SB, Attur, M, Berenbaum, F, Kraus, V, and Karsdal, MA. "Inflammation (or synovitis)-driven osteoarthritis: an opportunity for personalizing prognosis and treatment?." Scandinavian journal of rheumatology 45, no. 2 (January 2016): 87-98. (Review)

PMID
26484849
Full Text

Huang, Z, Ma, J, Chen, J, Shen, B, Pei, F, and Kraus, VB. "The effectiveness of low-level laser therapy for nonspecific chronic low back pain: a systematic review and meta-analysis." Arthritis research & therapy 17 (December 15, 2015): 360-. (Review)

PMID
26667480
Full Text

Stabler, T, Zura, RD, Hsueh, M-F, and Kraus, VB. "Xanthine oxidase injurious response in acute joint injury." CLINICA CHIMICA ACTA 451 (December 7, 2015): 170-174.

Full Text

Leung, YY, Yao Hui, LL, and Kraus, VB. "Colchicine--Update on mechanisms of action and therapeutic uses." Seminars in arthritis and rheumatism 45, no. 3 (December 2015): 341-350. (Review)

PMID
26228647
Full Text

Kraus, VB, Kilfoil, TM, Hash, TW, McDaniel, G, Renner, JB, Carrino, JA, and Adams, S. "Atlas of radiographic features of osteoarthritis of the ankle and hindfoot." Osteoarthritis and cartilage 23, no. 12 (December 2015): 2059-2085. (Review)

PMID
26318654
Full Text

Pages