Virginia Byers Kraus, MD, PhD

Professor of Medicine
Professor of Pathology
Professor in Orthopaedic Surgery
Member of Duke Molecular Physiology Institute
Affiliate of the Regeneration Next Initiative
Campus mail 300 N Duke St, Carmichael Building Room 15-205, Durham, NC 27701-2047
Phone (919) 681-6652
Email address kraus004@duke.edu

My special area of expertise is as a clinician scientist investigating osteoarthritis. Osteoarthritis is the most common form of joint disease in man and its incidence increases with age. It is a problem of increasing concern to the medical community due to the increasing longevity of the population. Trained as a molecular biologist and a Rheumatologist, I endeavor to study this disease from bedside to bench.

The work in this laboratory focuses on osteoarthritis and deals with the mechanisms of joint damage, and the discovery, validation and qualification of novel biochemical and genetic biomarkers for minimally invasive means of diagnosing disease, for predicting progression of disease, and for monitoring disease progression and response to therapy.

Education and Training

  • Fellow in Rheumatology, Medicine, Duke University, 1986 - 1989
  • Medical Resident, Medicine, Duke University, 1983 - 1986
  • Ph.D., Duke University, 1993
  • M.D., Duke University, 1982

Publications

Huang, ZeYu, XiaoWei Xie, LingLi Li, Qiang Huang, Jun Ma, Bin Shen, Virginia Byers Kraus, and FuXing Pei. “Intravenous and Topical Tranexamic Acid Alone Are Superior to Tourniquet Use for Primary Total Knee Arthroplasty: A Prospective, Randomized Controlled Trial..” J Bone Joint Surg Am 99, no. 24 (December 20, 2017): 2053–61. https://doi.org/10.2106/JBJS.16.01525.

PMID
29257010
Full Text

Goode, A. P., A. E. Nelson, V. B. Kraus, J. B. Renner, and J. M. Jordan. “Biomarkers reflect differences in osteoarthritis phenotypes of the lumbar spine: the Johnston County Osteoarthritis Project..” In Osteoarthritis Cartilage, 25:1672–79, 2017. https://doi.org/10.1016/j.joca.2017.07.007.

PMID
28711584
Full Text

Adams, Samuel B., Rachel M. Reilly, Janet L. Huebner, Virginia B. Kraus, and Dana L. Nettles. “Time-Dependent Effects on Synovial Fluid Composition During the Acute Phase of Human Intra-articular Ankle Fracture..” Foot Ankle Int 38, no. 10 (October 2017): 1055–63. https://doi.org/10.1177/1071100717728234.

PMID
28891711
Full Text

Feng, Sheng, Su Chen, Li Wang, Charles Peterfy, Virginia B. Kraus, Rajesh Kamath, Lanju Zhang, et al. “Biomarkers Predictive of Pain Improvement in Knee Osteoarthritis Subjects Treated with the Anti-IL-1 alpha/beta Dual Variable Domain Immunoglobulin ABT-981.” In Arthritis & Rheumatology, Vol. 69. WILEY, 2017.

Scholars@Duke

Andonian, Brian J., David Bartlett, Virginia B. Kraus, Janet Huebner, William E. Kraus, and Kim M. Huffman. “Skeletal Muscle Cytokine and Myostatin Responses to High-Intensity Interval Training in Rheumatoid Arthritis Contrasted with Prediabetes Mellitus.” In Arthritis & Rheumatology, Vol. 69. WILEY, 2017.

Scholars@Duke

Andonian, Brian J., David Bartlett, Virginia B. Kraus, Janet Huebner, William E. Kraus, and Kim M. Huffman. “Serum Galectin-3 in Rheumatoid Arthritis Compared with Healthy Controls and Subjects with Prediabetes before and after High-Intensity Interval Training.” In Arthritis & Rheumatology, Vol. 69. WILEY, 2017.

Scholars@Duke

Conaghan, Philip G., Francis Berenbaum, Virginia B. Kraus, James Johnson, and Scott Kelley. “Updating the Knee Osteoarthritis Intra-Articular Corticosteroid Meta-Analysis with Two Large Trials of Extended-Release Triamcinolone Acetonide (FX006) Versus Placebo.” In Arthritis & Rheumatology, Vol. 69. WILEY, 2017.

Scholars@Duke

Leung, Y. Y., J. L. Huebner, B. Haaland, S. B. S. Wong, and V. B. Kraus. “Synovial fluid pro-inflammatory profile differs according to the characteristics of knee pain..” Osteoarthritis Cartilage 25, no. 9 (September 2017): 1420–27. https://doi.org/10.1016/j.joca.2017.04.001.

PMID
28433814
Full Text

Wu, Chia-Lung, Jenna McNeill, Kelsey Goon, Dianne Little, Kelly Kimmerling, Janet Huebner, Virginia Kraus, and Farshid Guilak. “Conditional Macrophage Depletion Increases Inflammation and Does Not Inhibit the Development of Osteoarthritis in Obese Macrophage Fas-Induced Apoptosis-Transgenic Mice..” Arthritis Rheumatol 69, no. 9 (September 2017): 1772–83. https://doi.org/10.1002/art.40161.

PMID
28544542
Full Text

Hsueh, M. -. F., V. B. Kraus, and P. Önnerfjord. “Cartilage matrix remodelling differs by disease state and joint type..” Eur Cell Mater 34 (August 24, 2017): 70–82. https://doi.org/10.22203/eCM.v034a05.

PMID
28836259
Full Text

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