Virginia Byers Kraus, MD, PhD

Professor of Medicine
Professor of Pathology
Professor in Orthopaedic Surgery
Member of Duke Molecular Physiology Institute
Affiliate of the Regeneration Next Initiative
Campus mail 300 N Duke St, Carmichael Building Room 15-205, Durham, NC 27701-2047
Phone (919) 681-6652
Email address kraus004@duke.edu

My special area of expertise is as a clinician scientist investigating osteoarthritis. Osteoarthritis is the most common form of joint disease in man and its incidence increases with age. It is a problem of increasing concern to the medical community due to the increasing longevity of the population. Trained as a molecular biologist and a Rheumatologist, I endeavor to study this disease from bedside to bench.

The work in this laboratory focuses on osteoarthritis and deals with the mechanisms of joint damage, and the discovery, validation and qualification of novel biochemical and genetic biomarkers for minimally invasive means of diagnosing disease, for predicting progression of disease, and for monitoring disease progression and response to therapy.

Education and Training

  • Fellow in Rheumatology, Medicine, Duke University, 1986 - 1989
  • Medical Resident, Medicine, Duke University, 1983 - 1986
  • Ph.D., Duke University, 1993
  • M.D., Duke University, 1982

Publications

Nwosu, L. N., M. Allen, L. Wyatt, J. L. Huebner, V. Chapman, D. A. Walsh, and V. B. Kraus. “Pain prediction by serum biomarkers of bone turnover in people with knee osteoarthritis: an observational study of TRAcP5b and cathepsin K in OA..” Osteoarthritis Cartilage 25, no. 6 (June 2017): 858–65. https://doi.org/10.1016/j.joca.2017.01.002.

PMID
28087412
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Montell, E., T. V. Stabler, and V. B. Kraus. “THU0044 Chondroitin sulphate inhibits monocyte chemoattractant protein-1 release from 3T3L1 adipocytes: a new treatment opportunity for obesity-related metabolic syndromes?.” In Poster Presentations. BMJ Publishing Group Ltd and European League Against Rheumatism, 2017. https://doi.org/10.1136/annrheumdis-2017-eular.2140.

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Liu, Betty, Adam P. Goode, Teralyn E. Carter, Gangadhar M. Utturkar, Janet L. Huebner, Dean C. Taylor, Claude T. Moorman, et al. “Matrix metalloproteinase activity and prostaglandin E2 are elevated in the synovial fluid of meniscus tear patients..” Connect Tissue Res 58, no. 3–4 (May 2017): 305–16. https://doi.org/10.1080/03008207.2016.1256391.

PMID
27813662
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Adams, Samuel B., Elizabeth M. Leimer, Lori A. Setton, Richard D. Bell, Mark E. Easley, Janet L. Huebner, Thomas V. Stabler, Virginia B. Kraus, Steven A. Olson, and Dana L. Nettles. “Inflammatory Microenvironment Persists After Bone Healing in Intra-articular Ankle Fractures..” Foot Ankle Int 38, no. 5 (May 2017): 479–84. https://doi.org/10.1177/1071100717690427.

PMID
28142266
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Furman, B. D., K. A. Kimmerling, S. Ramamoorthy, Y. -. J. Li, Y. -. H. Wu, J. L. Huebner, F. Guilak, V. B. Kraus, and S. A. Olson. “Articular fracture upregulates lipid metabolites in human synovial fluid.” In Osteoarthritis and Cartilage, 25:S381–S381. Elsevier BV, 2017. https://doi.org/10.1016/j.joca.2017.02.652.

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Conaghan, P., V. Strand, D. Hunter, V. B. Kraus, F. Berenbaum, N. P. Katz, J. Lufkin, J. R. Johnson, S. Kelley, and N. Bodick. “An intra-articular, extended release formulation of triamcinolone (FX006) affords clinically relevant improvements in pain and function of knee osteoarthritis: post-hoc pooled analyses of 3 randomized controlled trials.” In Osteoarthritis and Cartilage, 25:S432–33. Elsevier BV, 2017. https://doi.org/10.1016/j.joca.2017.02.747.

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Montell, E., T. V. Stabler, J. Vergés, and V. B. Kraus. “Chondroitin Sulphate Inhibits Monocyte Chemoattractant Protein-1 Release from 3T3L1 Adipocytes: A New Treatment Opportunity for Obesity-related Metabolic Syndromes?.” In Osteoarthritis and Cartilage, 25:S272–S272. Elsevier BV, 2017. https://doi.org/10.1016/j.joca.2017.02.460.

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Haraden, C., V Byers Kraus, D. Attarian, R. -. M. Laberge, and C. -. H. Chou. “Senescence Indicators are Positively Associated with Severity of Osteoarthritis.” In Osteoarthritis and Cartilage, 25:S311–S311. Elsevier BV, 2017. https://doi.org/10.1016/j.joca.2017.02.521.

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Attur, M., S. Ma, J. Samuels, S. Krasnokutsky Samuels, H. Zhou, J. T. Bencardino, M. C. Hochberg, et al. “Functional genetic polymorphism of IL-1rn encoding the IL-1 receptor antagonist predicts radiographic severity of symptomatic knee OA.” In Osteoarthritis and Cartilage, 25:S210–11. Elsevier BV, 2017. https://doi.org/10.1016/j.joca.2017.02.366.

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