Virginia Byers Kraus, MD, PhD

Professor of Medicine
Professor of Pathology
Professor in Orthopaedic Surgery
Member of Duke Molecular Physiology Institute
Affiliate of the Regeneration Next Initiative
Campus mail 300 N Duke St, Carmichael Building Room 15-205, Durham, NC 27701-2047
Phone (919) 681-6652
Email address kraus004@duke.edu

My special area of expertise is as a clinician scientist investigating osteoarthritis. Osteoarthritis is the most common form of joint disease in man and its incidence increases with age. It is a problem of increasing concern to the medical community due to the increasing longevity of the population. Trained as a molecular biologist and a Rheumatologist, I endeavor to study this disease from bedside to bench.

The work in this laboratory focuses on osteoarthritis and deals with the mechanisms of joint damage, and the discovery, validation and qualification of novel biochemical and genetic biomarkers for minimally invasive means of diagnosing disease, for predicting progression of disease, and for monitoring disease progression and response to therapy.

Education and Training

  • Fellow in Rheumatology, Medicine, Duke University, 1986 - 1989
  • Medical Resident, Medicine, Duke University, 1983 - 1986
  • Ph.D., Duke University, 1993
  • M.D., Duke University, 1982

Publications

Bowles, RD, Karikari, IO, VanDerwerken, DN, Sinclair, MS, Bell, RD, Riebe, KJ, Huebner, JL, Kraus, VB, Sempowski, GD, and Setton, LA. "In vivo luminescent imaging of NF-κB activity and NF-κB-related serum cytokine levels predict pain sensitivities in a rodent model of peripheral neuropathy." European journal of pain (London, England) 20, no. 3 (March 2016): 365-376.

PMID
26032161
Full Text

Lv, Y-B, Yin, ZX, Chei, C-L, Brasher, MS, Zhang, J, Kraus, VB, Qian, F, Shi, X-M, Matchar, DB, and Zeng, Y. "Serum Cholesterol Levels within the High Normal Range Are Associated with Better Cognitive Performance among Chinese Elderly." The journal of nutrition, health & aging 20, no. 3 (March 2016): 280-287.

PMID
26892577
Full Text

Lv, YB, Yin, ZX, Chei, CL, Brasher, MS, Zhang, J, Kraus, VB, Qian, F, Shi, X, Matchar, DB, and Zeng, Y. "Serum cholesterol levels within the high normal range are associated with better cognitive performance among Chinese elderly." Journal of Nutrition, Health and Aging 20, no. 3 (March 1, 2016): 280-287.

Full Text

Peterson, MJ, Thompson, DK, Pieper, CF, Morey, MC, Kraus, VB, Kraus, WE, Sullivan, P, Fillenbaum, G, and Cohen, HJ. "A Novel Analytic Technique to Measure Associations Between Circulating Biomarkers and Physical Performance Across the Adult Life Span." The Journals of Gerontology Series A: Biological Sciences and Medical Sciences 71, no. 2 (February 2016): 196-202.

PMID
25745025
Full Text

Catterall, JB, Zura, RD, Bolognesi, MP, and Kraus, VB. "Aspartic acid racemization reveals a high turnover state in knee compared with hip osteoarthritic cartilage." Osteoarthritis and cartilage 24, no. 2 (February 2016): 374-381.

PMID
26417696
Full Text

Huang, Z, and Kraus, VB. "Does lipopolysaccharide-mediated inflammation have a role in OA?." Nature reviews. Rheumatology 12, no. 2 (February 2016): 123-129. (Review)

PMID
26656661
Full Text

Hsueh, M-F, Khabut, A, Kjellström, S, Önnerfjord, P, and Kraus, VB. "Elucidating the Molecular Composition of Cartilage by Proteomics." Journal of proteome research 15, no. 2 (February 2016): 374-388.

PMID
26632656
Full Text

Olson, SA, Furman, BD, Kraus, VB, Huebner, JL, and Guilak, F. "Reply to "Does progranulin account for the opposite effects of etanercept and infliximab/adalimumab in osteoarthritis?" by Wei et al." Journal of orthopaedic research : official publication of the Orthopaedic Research Society 34, no. 1 (January 2016): 15-16. (Letter)

PMID
26519624
Full Text

Siebuhr, AS, Bay-Jensen, AC, Jordan, JM, Kjelgaard-Petersen, CF, Christiansen, C, Abramson, SB, Attur, M, Berenbaum, F, Kraus, V, and Karsdal, MA. "Inflammation (or synovitis)-driven osteoarthritis: an opportunity for personalizing prognosis and treatment?." Scandinavian journal of rheumatology 45, no. 2 (January 2016): 87-98. (Review)

PMID
26484849
Full Text

Huang, Z, Ma, J, Chen, J, Shen, B, Pei, F, and Kraus, VB. "The effectiveness of low-level laser therapy for nonspecific chronic low back pain: a systematic review and meta-analysis." Arthritis research & therapy 17 (December 15, 2015): 360-. (Review)

PMID
26667480
Full Text

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