Virginia Byers Kraus, MD, PhD

Professor of Medicine
Professor of Pathology
Professor in Orthopaedic Surgery
Member of Duke Molecular Physiology Institute
Affiliate of the Regeneration Next Initiative
Campus mail 300 N Duke St, Carmichael Building Room 15-205, Durham, NC 27701-2047
Phone (919) 681-6652
Email address kraus004@duke.edu

My special area of expertise is as a clinician scientist investigating osteoarthritis. Osteoarthritis is the most common form of joint disease in man and its incidence increases with age. It is a problem of increasing concern to the medical community due to the increasing longevity of the population. Trained as a molecular biologist and a Rheumatologist, I endeavor to study this disease from bedside to bench.

The work in this laboratory focuses on osteoarthritis and deals with the mechanisms of joint damage, and the discovery, validation and qualification of novel biochemical and genetic biomarkers for minimally invasive means of diagnosing disease, for predicting progression of disease, and for monitoring disease progression and response to therapy.

Education and Training

  • Fellow in Rheumatology, Medicine, Duke University, 1986 - 1989
  • Medical Resident, Medicine, Duke University, 1983 - 1986
  • Ph.D., Duke University, 1993
  • M.D., Duke University, 1982

Publications

Eckstein, F, Collins, JE, Nevitt, MC, Lynch, JA, Kraus, VB, Katz, JN, Losina, E, Wirth, W, Guermazi, A, Roemer, FW, Hunter, DJ, and FNIH OA Biomarkers Consortium, . "Brief Report: Cartilage Thickness Change as an Imaging Biomarker of Knee Osteoarthritis Progression: Data From the Foundation for the National Institutes of Health Osteoarthritis Biomarkers Consortium." Arthritis & rheumatology (Hoboken, N.J.) 67, no. 12 (December 2015): 3184-3189.

PMID
26316262
Full Text

Montell, E, Stabler, T, Verges Milano, J, and Kraus, VB. "ATTENTUATION OF HYALURONAN FRAGMENT INDUCED INFLAMMATORY RESPONSE IN MACROPHAGES BY CHONDROITIN SULPHATE." BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY 117 (December 2015): 11-11.

Scholars@Duke

Wu, C-L, Jain, D, McNeill, JN, Little, D, Anderson, JA, Huebner, JL, Kraus, VB, Rodriguiz, RM, Wetsel, WC, and Guilak, F. "Dietary fatty acid content regulates wound repair and the pathogenesis of osteoarthritis following joint injury." Annals of the rheumatic diseases 74, no. 11 (November 2015): 2076-2083.

PMID
25015373
Full Text

Attur, M, Krasnokutsky, S, Statnikov, A, Samuels, J, Li, Z, Friese, O, Hellio Le Graverand-Gastineau, M-P, Rybak, L, Kraus, VB, Jordan, JM, Aliferis, CF, and Abramson, SB. "Low-grade inflammation in symptomatic knee osteoarthritis: prognostic value of inflammatory plasma lipids and peripheral blood leukocyte biomarkers." Arthritis & rheumatology (Hoboken, N.J.) 67, no. 11 (November 2015): 2905-2915.

PMID
26195278
Full Text

Hsu, Y-H, Liu, Y, Hannan, MT, Maixner, W, Smith, SB, Diatchenko, L, Golightly, YM, Menz, HB, Kraus, VB, Doherty, M, Wilson, AG, and Jordan, JM. "Genome-wide association meta-analyses to identify common genetic variants associated with hallux valgus in Caucasian and African Americans." Journal of medical genetics 52, no. 11 (November 2015): 762-769.

PMID
26337638
Full Text

Adams, SB, Setton, LA, Bell, RD, Easley, ME, Huebner, JL, Stabler, T, Kraus, VB, Leimer, EM, Olson, SA, and Nettles, DL. "Inflammatory Cytokines and Matrix Metalloproteinases in the Synovial Fluid After Intra-articular Ankle Fracture." Foot & ankle international 36, no. 11 (November 2015): 1264-1271.

PMID
26449389
Full Text

Attur, M, Statnikov, A, Samuels, J, Li, Z, Alekseyenko, AV, Greenberg, JD, Krasnokutsky, S, Rybak, L, Lu, QA, Todd, J, Zhou, H, Jordan, JM, Kraus, VB, Aliferis, CF, and Abramson, SB. "Plasma levels of interleukin-1 receptor antagonist (IL1Ra) predict radiographic progression of symptomatic knee osteoarthritis." Osteoarthritis and cartilage 23, no. 11 (November 2015): 1915-1924.

PMID
26521737
Full Text

Daghestani, HN, and Kraus, VB. "Inflammatory biomarkers in osteoarthritis." Osteoarthritis and cartilage 23, no. 11 (November 2015): 1890-1896. (Review)

PMID
26521734
Full Text

Huang, Z, Chen, J, Ma, J, Shen, B, Pei, F, and Kraus, VB. "Effectiveness of low-level laser therapy in patients with knee osteoarthritis: a systematic review and meta-analysis." Osteoarthritis and cartilage 23, no. 9 (September 2015): 1437-1444. (Review)

PMID
25914044
Full Text

Olson, SA, Furman, BD, Kraus, VB, Huebner, JL, and Guilak, F. "Therapeutic opportunities to prevent post-traumatic arthritis: Lessons from the natural history of arthritis after articular fracture." Journal of orthopaedic research : official publication of the Orthopaedic Research Society 33, no. 9 (September 2015): 1266-1277.

PMID
25939531
Full Text

Pages