William Erle Kraus, MD

Professor of Medicine
Richard and Pat Johnson University Distinguished Professor
Professor in the School of Nursing
Member of Duke Molecular Physiology Institute
Member of the Duke Cancer Institute
Campus mail 300 N. Duke Street, Carmichael Building 51-201, Durham, NC 27701
Phone (919) 360-8020
Email address william.kraus@duke.edu

My training, expertise and research interests range from human integrative physiology and genetics to animal exercise models to cell culture models of skeletal muscle adaptation to mechanical stretch. I am trained clinically as an internist and preventive cardiologist, with particular expertise in preventive cardiology and cardiac rehabilitation.  My research training spans molecular biology and cell culture, molecular genetics, and integrative human exercise physiology and metabolism. I practice as a preventive cardiologist with a focus on cardiometabolic risk and exercise physiology for older athletes.  My research space has both a basic wet laboratory component and a human integrative physiology one.

One focus of our work is an integrative physiologic examination of exercise effects in human subjects in clinical studies of exercise training in normal individuals, in individuals at risk of disease (such as pre-diabetes and metabolic syndrome; STRRIDE), and in individuals with disease (such as coronary heart disease, congestive heart failure and cancer).

A second focus of my research group is exploration of genetic determinates of disease risk in human subjects.  We conduct studies of early onset cardiovascular disease (GENECARD; CATHGEN), congestive heart failure (HF-ACTION), peripheral arterial disease (AMNESTI), and metabolic syndrome.  We are exploring analytic models of predicting disease risk using established and innovative statistical methodology.

A third focus of my group’s work is to understand the cellular signaling mechanisms underlying the normal adaptive responses of skeletal muscle to physiologic stimuli, such as occur in exercise conditioning, and to understand the abnormal maladaptive responses that occur in response to pathophysiologic stimuli, such as occur in congestive heart failure, aging and prolonged exposure to microgravity.

Recently we have begun to investigate interactions of genes and lifestyle interventions on cardiometabolic outcomes.  We have experience with clinical lifestyle intervention studies, particularly the contributions of genetic variants to interventions responses.  We call this Lifestyle Medicopharmacogenetics.

KEY WORDS:

exercise, skeletal muscle, energy metabolism, cell signaling, gene expression, cell stretch, heart failure, aging, spaceflight, human genetics, early onset cardiovascular disease, lifestyle medicine

Education and Training

  • Fellow in Cardiology, Medicine, Duke University, 1986 - 1988
  • Medical Resident, Medicine, Duke University, 1983 - 1986
  • M.D., Duke University, 1982

Grants

Publications

Dorling, James L., Stephan van Vliet, Kim M. Huffman, William E. Kraus, Manjushri Bhapkar, Carl F. Pieper, Tiffany Stewart, et al. “Effects of caloric restriction on human physiological, psychological, and behavioral outcomes: highlights from CALERIE phase 2.” Nutr Rev 79, no. 1 (January 1, 2021): 98–113. https://doi.org/10.1093/nutrit/nuaa085.

PMID
32940695
Full Text

Erickson, Melissa L., Karyn A. Esser, William E. Kraus, Thomas W. Buford, and Leanne M. Redman. “A Role for Exercise to Counter Skeletal Muscle Clock Disruption.” Exerc Sport Sci Rev 49, no. 1 (January 2021): 35–41. https://doi.org/10.1249/JES.0000000000000235.

PMID
33044328
Full Text

Ellison, Stephen, Jawan W. Abdulrahim, Lydia Coulter Kwee, Nathan A. Bihlmeyer, Neha Pagidipati, Robert McGarrah, James R. Bain, William E. Kraus, and Svati H. Shah. “Novel plasma biomarkers improve discrimination of metabolic health independent of weight.” Sci Rep 10, no. 1 (December 7, 2020): 21365. https://doi.org/10.1038/s41598-020-78478-w.

PMID
33288813
Full Text

Ward-Caviness, Cavin K., Armistead G. Russell, Anne M. Weaver, Erik Slawsky, Radhika Dhingra, Lydia Coulter Kwee, Rong Jiang, et al. “Accelerated epigenetic age as a biomarker of cardiovascular sensitivity to traffic-related air pollution.” Aging (Albany Ny) 12, no. 23 (December 7, 2020): 24141–55. https://doi.org/10.18632/aging.202341.

PMID
33289704
Full Text

Lanfear, David E., Jasmine A. Luzum, Ruicong She, Hongsheng Gui, Mark P. Donahue, Christopher M. O’Connor, Kirkwood F. Adams, et al. “Polygenic Score for β-Blocker Survival Benefit in European Ancestry Patients With Reduced Ejection Fraction Heart Failure.” Circ Heart Fail 13, no. 12 (December 2020): e007012. https://doi.org/10.1161/CIRCHEARTFAILURE.119.007012.

PMID
33012170
Full Text

Brooksbank, Jeremy A., Stephen J. Greene, Hailey M. Harris, Amanda Stebbins, Mona Fiuzat, David J. Whellan, Brooke Alhanti, et al. “Beta-blocker and ACE-inhibitor dosing as a function of body surface area: From the HF-ACTION trial.” Am Heart J 233 (November 24, 2020): 1–4. https://doi.org/10.1016/j.ahj.2020.11.003.

PMID
33245905
Full Text

White, Phillip J., Amanda L. Lapworth, Robert W. McGarrah, Lydia Coulter Kwee, Scott B. Crown, Olga Ilkayeva, Jie An, et al. “Muscle-Liver Trafficking of BCAA-Derived Nitrogen Underlies Obesity-Related Glycine Depletion.” Cell Rep 33, no. 6 (November 10, 2020): 108375. https://doi.org/10.1016/j.celrep.2020.108375.

PMID
33176135
Full Text

Singh, Abanish, Michael A. Babyak, Mario Sims, Solomon K. Musani, Beverly H. Brummett, Rong Jiang, William E. Kraus, et al. “Evaluating the precision of EBF1 SNP x stress interaction association: sex, race, and age differences in a big harmonized data set of 28,026 participants.” Transl Psychiatry 10, no. 1 (October 20, 2020): 351. https://doi.org/10.1038/s41398-020-01028-5.

PMID
33077726
Full Text

Duscha, Brian D., William E. Kraus, William S. Jones, Jennifer L. Robbins, Lucy W. Piner, Kim M. Huffman, Jason D. Allen, and Brian H. Annex. “Skeletal muscle capillary density is related to anaerobic threshold and claudication in peripheral artery disease.” Vasc Med 25, no. 5 (October 2020): 411–18. https://doi.org/10.1177/1358863X20945794.

PMID
32841100
Full Text

Omura, John D., Susan A. Carlson, David R. Brown, David P. Hopkins, William E. Kraus, Beth A. Staffileno, Randal J. Thomas, Felipe Lobelo, Janet E. Fulton, and Janet E. American Heart Association Physical Activity Committee of the Council on Lifestyle and Cardiometabolic Health; Council on Cardiovascular and Stroke Nursing; and Council on Clinical Cardiology. “Built Environment Approaches to Increase Physical Activity: A Science Advisory From the American Heart Association.” Circulation 142, no. 11 (September 15, 2020): e160–66. https://doi.org/10.1161/CIR.0000000000000884.

PMID
32787451
Full Text

Pages