William Erle Kraus, MD

Professor of Medicine
Richard and Pat Johnson University Distinguished Professor
Professor in the School of Nursing
Member of Duke Molecular Physiology Institute
Member of the Duke Cancer Institute
Campus mail 300 N. Duke Street, Carmichael Building 51-201, Durham, NC 27701
Phone (919) 360-8020
Email address william.kraus@duke.edu

My training, expertise and research interests range from human integrative physiology and genetics to animal exercise models to cell culture models of skeletal muscle adaptation to mechanical stretch. I am trained clinically as an internist and preventive cardiologist, with particular expertise in preventive cardiology and cardiac rehabilitation.  My research training spans molecular biology and cell culture, molecular genetics, and integrative human exercise physiology and metabolism. I practice as a preventive cardiologist with a focus on cardiometabolic risk and exercise physiology for older athletes.  My research space has both a basic wet laboratory component and a human integrative physiology one.

One focus of our work is an integrative physiologic examination of exercise effects in human subjects in clinical studies of exercise training in normal individuals, in individuals at risk of disease (such as pre-diabetes and metabolic syndrome; STRRIDE), and in individuals with disease (such as coronary heart disease, congestive heart failure and cancer).

A second focus of my research group is exploration of genetic determinates of disease risk in human subjects.  We conduct studies of early onset cardiovascular disease (GENECARD; CATHGEN), congestive heart failure (HF-ACTION), peripheral arterial disease (AMNESTI), and metabolic syndrome.  We are exploring analytic models of predicting disease risk using established and innovative statistical methodology.

A third focus of my group’s work is to understand the cellular signaling mechanisms underlying the normal adaptive responses of skeletal muscle to physiologic stimuli, such as occur in exercise conditioning, and to understand the abnormal maladaptive responses that occur in response to pathophysiologic stimuli, such as occur in congestive heart failure, aging and prolonged exposure to microgravity.

Recently we have begun to investigate interactions of genes and lifestyle interventions on cardiometabolic outcomes.  We have experience with clinical lifestyle intervention studies, particularly the contributions of genetic variants to interventions responses.  We call this Lifestyle Medicopharmacogenetics.

KEY WORDS:

exercise, skeletal muscle, energy metabolism, cell signaling, gene expression, cell stretch, heart failure, aging, spaceflight, human genetics, early onset cardiovascular disease, lifestyle medicine

Education and Training

  • Fellow in Cardiology, Medicine, Duke University, 1986 - 1988
  • Medical Resident, Medicine, Duke University, 1983 - 1986
  • M.D., Duke University, 1982

Publications

Bonafiglia, Jacob T., Nicholas Preobrazenski, Hashim Islam, Jeremy J. Walsh, Robert Ross, Neil M. Johannsen, Corby K. Martin, et al. “Exploring Differences in Cardiorespiratory Fitness Response Rates Across Varying Doses of Exercise Training: A Retrospective Analysis of Eight Randomized Controlled Trials.” Sports Med 51, no. 8 (August 2021): 1785–97. https://doi.org/10.1007/s40279-021-01442-9.

PMID
33704698
Full Text

Barone Gibbs, Bethany, Marie-France Hivert, Gerald J. Jerome, William E. Kraus, Sara K. Rosenkranz, Erica N. Schorr, Nicole L. Spartano, Felipe Lobelo, and Felipe American Heart Association Council on Lifestyle and Cardiometabolic Health; Council on Cardiovascular and Stroke Nursing; and Council on Clinical Cardiology. “Physical Activity as a Critical Component of First-Line Treatment for Elevated Blood Pressure or Cholesterol: Who, What, and How?: A Scientific Statement From the American Heart Association.” Hypertension 78, no. 2 (August 2021): e26–37. https://doi.org/10.1161/HYP.0000000000000196.

PMID
34074137
Full Text

Andonian, Brian J., Andrew Johannemann, Monica J. Hubal, David M. Pober, Alec Koss, William E. Kraus, David B. Bartlett, and Kim M. Huffman. “Altered skeletal muscle metabolic pathways, age, systemic inflammation, and low cardiorespiratory fitness associate with improvements in disease activity following high-intensity interval training in persons with rheumatoid arthritis.” Arthritis Res Ther 23, no. 1 (July 10, 2021): 187. https://doi.org/10.1186/s13075-021-02570-3.

PMID
34246305
Full Text

Akbari, Parsa, Ankit Gilani, Olukayode Sosina, Jack A. Kosmicki, Lori Khrimian, Yi-Ya Fang, Trikaldarshi Persaud, et al. “Sequencing of 640,000 exomes identifies GPR75 variants associated with protection from obesity.” Science 373, no. 6550 (July 2, 2021). https://doi.org/10.1126/science.abf8683.

PMID
34210852
Full Text

Malian, Hannah M., Patrick J. Smith, Benson Hoffman, Wei Jiang, Katharine Ammerman, William E. Kraus, Alan Hinderliter, Andrew Sherwood, and James A. Blumenthal. “Effects of Acute Exercise on Anxiety Ratings in Patients With Coronary Heart Disease and Elevated Anxiety.” J Cardiopulm Rehabil Prev 41, no. 4 (July 1, 2021): 277–81. https://doi.org/10.1097/HCR.0000000000000579.

PMID
34158457
Full Text

Koontz, Bridget F., Erica Levine, Frances McSherry, Donna Niedzwiecki, Linda Sutton, Tykeytra Dale, Martin Streicher, et al. “Increasing physical activity in Cancer Survivors through a Text-messaging Exercise motivation Program (ICanSTEP).” Support Care Cancer, May 28, 2021. https://doi.org/10.1007/s00520-021-06281-y.

PMID
34050402
Full Text

Lekavich, Carolyn L., Dennis Abraham, Marat Fudim, Cynthia Green, Robert J. Mentz, Karol Harshaw-Ellis, Margaret Bowers, et al. “Early Identification of Patients at Risk for Incident Heart Failure With Preserved Ejection Fraction: Novel Approach to Echocardiographic Trends.” J Card Fail, May 7, 2021. https://doi.org/10.1016/j.cardfail.2021.03.013.

PMID
33965536
Full Text

Duscha, Brian D., Johanna L. Johnson, William C. Bennett, Kelsey N. Ball, Liezl B. Mae Fos, Megan A. Reaves, and William E. Kraus. “Cardiopulmonary Exercise Testing in the Coronavirus Disease - 2019 Era: Safety and Protocol Considerations.” Curr Sports Med Rep 20, no. 5 (May 1, 2021): 259–65. https://doi.org/10.1249/JSR.0000000000000843.

PMID
33908913
Full Text

Breeze, Charles E., Anna Batorsky, Mi Kyeong Lee, Mindy D. Szeto, Xiaoguang Xu, Daniel L. McCartney, Rong Jiang, et al. “Epigenome-wide association study of kidney function identifies trans-ethnic and ethnic-specific loci.” Genome Med 13, no. 1 (April 30, 2021): 74. https://doi.org/10.1186/s13073-021-00877-z.

PMID
33931109
Full Text

Zhang, Siqi, Susanne Breitner, Wayne E. Cascio, Robert B. Devlin, Lucas M. Neas, Cavin Ward-Caviness, David Diaz-Sanchez, et al. “Association between short-term exposure to ambient fine particulate matter and myocardial injury in the CATHGEN cohort.” Environ Pollut 275 (April 15, 2021): 116663. https://doi.org/10.1016/j.envpol.2021.116663.

PMID
33581627
Full Text

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