My training, expertise and research interests range from human integrative physiology and genetics to animal exercise models to cell culture models of skeletal muscle adaptation to mechanical stretch. I am trained clinically as an internist and preventive cardiologist, with particular expertise in preventive cardiology and cardiac rehabilitation. My research training spans molecular biology and cell culture, molecular genetics, and integrative human exercise physiology and metabolism. I practice as a preventive cardiologist with a focus on cardiometabolic risk and exercise physiology for older athletes. My research space has both a basic wet laboratory component and a human integrative physiology one.
One focus of our work is an integrative physiologic examination of exercise effects in human subjects in clinical studies of exercise training in normal individuals, in individuals at risk of disease (such as pre-diabetes and metabolic syndrome; STRRIDE), and in individuals with disease (such as coronary heart disease, congestive heart failure and cancer).
A second focus of my research group is exploration of genetic determinates of disease risk in human subjects. We conduct studies of early onset cardiovascular disease (GENECARD; CATHGEN), congestive heart failure (HF-ACTION), peripheral arterial disease (AMNESTI), and metabolic syndrome. We are exploring analytic models of predicting disease risk using established and innovative statistical methodology.
A third focus of my group’s work is to understand the cellular signaling mechanisms underlying the normal adaptive responses of skeletal muscle to physiologic stimuli, such as occur in exercise conditioning, and to understand the abnormal maladaptive responses that occur in response to pathophysiologic stimuli, such as occur in congestive heart failure, aging and prolonged exposure to microgravity.
Recently we have begun to investigate interactions of genes and lifestyle interventions on cardiometabolic outcomes. We have experience with clinical lifestyle intervention studies, particularly the contributions of genetic variants to interventions responses. We call this Lifestyle Medicopharmacogenetics.
exercise, skeletal muscle, energy metabolism, cell signaling, gene expression, cell stretch, heart failure, aging, spaceflight, human genetics, early onset cardiovascular disease, lifestyle medicine
Education and Training
- Fellow in Cardiology, Medicine, Duke University, 1986 - 1988
- Medical Resident, Medicine, Duke University, 1983 - 1986
- M.D., Duke University, 1982
- Molecular Transducers of Physical Activity and Health: NC Consortium Clinical Site
- The AMPK/ULK1/p27Kip1 axis regulates autophagy and cell survival in aged satellite cells
- Postdoctoral training in genomic medicine research
- Multidisciplinary Heart and Vascular Diseases
- Behavioral and Physiology in Aging
- Exercise and Pharmacotherapy for Anxiety in Cardiac Patients
- Biomarkers of Caloric Restriction in Humans: the CALERIE Biorepository
- Facility and Web-based Approaches to Lifestyle Change in Resistant Hypertension
- Systemic Inflammation in Microphysiological Models of Muscle and Vascular Disease
- Endocrinology and Metabolism Training Program
- Physical Resiliencies: Indicators and Mechanisms in the Elderly Collaborative
- Epigenetic Mechanisms Promoting Longevity
- Duke KURe Program
- Develoment of Behavior-Based Circadian Rhythm Index in a PAD Rehabilitation Population Pilot Project
- Circulatory system and integrated muscle tissue for drug and tissue toxicity
- Lifestyle, CVD Risk and Cognitive Impairment
- Analysis of NMR lipoprotein and metabolite data of plasma obtained from CATHGEN and STRRIDE study participants