William Erle Kraus, MD

Professor of Medicine
Richard and Pat Johnson University Distinguished Professor
Professor in the School of Nursing
Member of Duke Molecular Physiology Institute
Member of the Duke Cancer Institute
Campus mail 300 N. Duke Street, Carmichael Building 51-201, Durham, NC 27701
Phone (919) 681-6733
Email address william.kraus@duke.edu

My training, expertise and research interests range from human integrative physiology and genetics to animal exercise models to cell culture models of skeletal muscle adaptation to mechanical stretch. I am trained clinically as an internist and preventive cardiologist, with particular expertise in preventive cardiology and cardiac rehabilitation.  My research training spans molecular biology and cell culture, molecular genetics, and integrative human exercise physiology and metabolism. I practice as a preventive cardiologist with a focus on cardiometabolic risk and exercise physiology for older athletes.  My research space has both a basic wet laboratory component and a human integrative physiology one.

One focus of our work is an integrative physiologic examination of exercise effects in human subjects in clinical studies of exercise training in normal individuals, in individuals at risk of disease (such as pre-diabetes and metabolic syndrome; STRRIDE), and in individuals with disease (such as coronary heart disease, congestive heart failure and cancer).

A second focus of my research group is exploration of genetic determinates of disease risk in human subjects.  We conduct studies of early onset cardiovascular disease (GENECARD; CATHGEN), congestive heart failure (HF-ACTION), peripheral arterial disease (AMNESTI), and metabolic syndrome.  We are exploring analytic models of predicting disease risk using established and innovative statistical methodology.

A third focus of my group’s work is to understand the cellular signaling mechanisms underlying the normal adaptive responses of skeletal muscle to physiologic stimuli, such as occur in exercise conditioning, and to understand the abnormal maladaptive responses that occur in response to pathophysiologic stimuli, such as occur in congestive heart failure, aging and prolonged exposure to microgravity.

Recently we have begun to investigate interactions of genes and lifestyle interventions on cardiometabolic outcomes.  We have experience with clinical lifestyle intervention studies, particularly the contributions of genetic variants to interventions responses.  We call this Lifestyle Medicopharmacogenetics.

KEY WORDS:

exercise, skeletal muscle, energy metabolism, cell signaling, gene expression, cell stretch, heart failure, aging, spaceflight, human genetics, early onset cardiovascular disease, lifestyle medicine

Education and Training

  • Fellow in Cardiology, Medicine, Duke University, 1986 - 1988
  • Medical Resident, Medicine, Duke University, 1983 - 1986
  • M.D., Duke University, 1982

Publications

Weaver, Anne M., Laura A. McGuinn, Lucas Neas, Robert B. Devlin, Radhika Dhingra, Cavin K. Ward-Caviness, Wayne E. Cascio, William E. Kraus, Elizabeth R. Hauser, and David Diaz-Sanchez. “Associations between neighborhood socioeconomic cluster and hypertension, diabetes, myocardial infarction, and coronary artery disease within a cohort of cardiac catheterization patients.” Am Heart J, October 2, 2021. https://doi.org/10.1016/j.ahj.2021.09.013.

PMID
34610283
Full Text

George, Stephanie M., Haiying Chen, Michael E. Miller, W Jack Rejeski, Cynthia L. Stowe, Christopher Webb, William E. Kraus, Nicolas Musi, and John M. Jakicic. “Rapid report on using data to make standardized decisions about enrollment during the COVID-19 pandemic: perspectives from the MoTrPAC study.” Ann Epidemiol 62 (October 2021): 19–21. https://doi.org/10.1016/j.annepidem.2021.04.016.

PMID
33957248
Full Text

Dorling, James L., Daniel W. Belsky, Susan B. Racette, Sai Krupa Das, Eric Ravussin, Leanne M. Redman, Christoph Höchsmann, et al. “Association between the FTO rs9939609 single nucleotide polymorphism and dietary adherence during a 2-year caloric restriction intervention: Exploratory analyses from CALERIE™ phase 2.” Exp Gerontol 155 (September 20, 2021): 111555. https://doi.org/10.1016/j.exger.2021.111555.

PMID
34543722
Full Text

Neshteruk, Cody D., Alexandra Zizzi, Lilianna Suarez, Elizabeth Erickson, William E. Kraus, Jennifer S. Li, Asheley C. Skinner, Mary Story, Nancy Zucker, and Sarah C. Armstrong. “Weight-Related Behaviors of Children with Obesity during the COVID-19 Pandemic.” Childhood Obesity (Print) 17, no. 6 (September 2021): 371–78. https://doi.org/10.1089/chi.2021.0038.

PMID
33902326
Full Text

Lekavich, Carolyn L., Dennis Abraham, Marat Fudim, Cynthia Green, Robert J. Mentz, Karol Harshaw-Ellis, Margaret Bowers, et al. “Early Identification of Patients at Risk for Incident Heart Failure With Preserved Ejection Fraction: Novel Approach to Echocardiographic Trends.” Journal of Cardiac Failure 27, no. 9 (September 2021): 942–48. https://doi.org/10.1016/j.cardfail.2021.03.013.

PMID
33965536
Full Text

Blumenthal, James A., Patrick J. Smith, Wei Jiang, Alan Hinderliter, Lana L. Watkins, Benson M. Hoffman, William E. Kraus, Lawrence Liao, Jonathan Davidson, and Andrew Sherwood. “Effect of Exercise, Escitalopram, or Placebo on Anxiety in Patients With Coronary Heart Disease: The Understanding the Benefits of Exercise and Escitalopram in Anxious Patients With Coronary Heart Disease (UNWIND) Randomized Clinical Trial.” Jama Psychiatry, August 18, 2021. https://doi.org/10.1001/jamapsychiatry.2021.2236.

PMID
34406354
Full Text

Pontzer, Herman, Yosuke Yamada, Hiroyuki Sagayama, Philip N. Ainslie, Lene F. Andersen, Liam J. Anderson, Lenore Arab, et al. “Daily energy expenditure through the human life course.” Science 373, no. 6556 (August 13, 2021): 808–12. https://doi.org/10.1126/science.abe5017.

PMID
34385400
Full Text

Truby, Lauren K., Jessica A. Regan, Stephanie N. Giamberardino, Olga Ilkayeva, James Bain, Christopher B. Newgard, Christopher M. O’Connor, et al. “Circulating long chain acylcarnitines and outcomes in diabetic heart failure: an HF-ACTION clinical trial substudy.” Cardiovasc Diabetol 20, no. 1 (August 3, 2021): 161. https://doi.org/10.1186/s12933-021-01353-z.

PMID
34344360
Full Text

Thompson, Paul D., Aaron L. Baggish, Michael J. Blaha, Clinton A. Brawner, JoAnn M. Eickhoff-Shemek, Tamerah N. Hunt, and William E. Kraus. “Increasing the Availability of Automated External Defibrillators at Sporting Events: A Call to Action from the American College of Sports Medicine.” Curr Sports Med Rep 20, no. 8 (August 1, 2021): 418–19. https://doi.org/10.1249/JSR.0000000000000870.

PMID
34357888
Full Text

Bonafiglia, Jacob T., Nicholas Preobrazenski, Hashim Islam, Jeremy J. Walsh, Robert Ross, Neil M. Johannsen, Corby K. Martin, et al. “Exploring Differences in Cardiorespiratory Fitness Response Rates Across Varying Doses of Exercise Training: A Retrospective Analysis of Eight Randomized Controlled Trials.” Sports Med 51, no. 8 (August 2021): 1785–97. https://doi.org/10.1007/s40279-021-01442-9.

PMID
33704698
Full Text

Pages