William Erle Kraus, MD

Professor of Medicine
Richard and Pat Johnson University Professor
Professor in the School of Nursing
Member of Duke Molecular Physiology Institute
Member of the Duke Cancer Institute
Campus mail 300 N. Duke Street, Carmichael Building 51-201, Durham, NC 27701
Phone (919) 681-6733
Email address william.kraus@duke.edu

My training, expertise and research interests range from human integrative physiology and genetics to animal exercise models to cell culture models of skeletal muscle adaptation to mechanical stretch. I am trained clinically as an internist and preventive cardiologist, with particular expertise in preventive cardiology and cardiac rehabilitation.  My research training spans molecular biology and cell culture, molecular genetics, and integrative human exercise physiology and metabolism. I practice as a preventive cardiologist with a focus on cardiometabolic risk and exercise physiology for older athletes.  My research space has both a basic wet laboratory component and a human integrative physiology one.

One focus of our work is an integrative physiologic examination of exercise effects in human subjects in clinical studies of exercise training in normal individuals, in individuals at risk of disease (such as pre-diabetes and metabolic syndrome; STRRIDE), and in individuals with disease (such as coronary heart disease, congestive heart failure and cancer).

A second focus of my research group is exploration of genetic determinates of disease risk in human subjects.  We conduct studies of early onset cardiovascular disease (GENECARD; CATHGEN), congestive heart failure (HF-ACTION), peripheral arterial disease (AMNESTI), and metabolic syndrome.  We are exploring analytic models of predicting disease risk using established and innovative statistical methodology.

A third focus of my group’s work is to understand the cellular signaling mechanisms underlying the normal adaptive responses of skeletal muscle to physiologic stimuli, such as occur in exercise conditioning, and to understand the abnormal maladaptive responses that occur in response to pathophysiologic stimuli, such as occur in congestive heart failure, aging and prolonged exposure to microgravity.

Recently we have begun to investigate interactions of genes and lifestyle interventions on cardiometabolic outcomes.  We have experience with clinical lifestyle intervention studies, particularly the contributions of genetic variants to interventions responses.  We call this Lifestyle Medicopharmacogenetics.

KEY WORDS:

exercise, skeletal muscle, energy metabolism, cell signaling, gene expression, cell stretch, heart failure, aging, spaceflight, human genetics, early onset cardiovascular disease, lifestyle medicine

In Their Words

Education and Training

  • Fellow in Cardiology, Medicine, Duke University, 1986 - 1988
  • Medical Resident, Medicine, Duke University, 1983 - 1986
  • M.D., Duke University, 1982

Publications

Zhang, S, Breitner, S, Cascio, WE, Devlin, RB, Neas, LM, Diaz-Sanchez, D, Kraus, WE, Schwartz, J, Hauser, ER, Peters, A, and Schneider, A. "Short-term effects of fine particulate matter and ozone on the cardiac conduction system in patients undergoing cardiac catheterization." Particle and Fibre Toxicology 15, no. 1 (October 11, 2018): 38-null.

PMID
30305173
Full Text

Singh, A, Babyak, MA, Brummett, BH, Kraus, WE, Siegler, IC, Hauser, ER, and Williams, RB. "Harmonizing psychosocial stress and CVD-risk variables for developing robust estimates of GxE analyses." 27th Annual Meeting of the International-Genetic-Epidemiology-Society (IGES). San Diego, CA. October 14, 2018 - October 16, 2018.: WILEY, October 1, 2018.

Scholars@Duke

Barber, JL, Kraus, WE, Church, TS, Hagberg, JM, Thompson, PD, Bartlett, DB, Beets, MW, Earnest, CP, Huffman, KM, Landers-Ramos, RQ, Leon, AS, Rao, DC, Seip, RL, Skinner, JS, Slentz, CA, Wilund, KR, Bouchard, C, and Sarzynski, MA. "Effects of regular endurance exercise on GlycA: Combined analysis of 14 exercise interventions." Atherosclerosis 277 (October 2018): 1-6.

PMID
30170218
Full Text

Saint-Maurice, P, Troiano, RP, Matthews, CE, and Kraus, WE. "Moderate-to-vigorous intensity physical activity and all-cause mortality: Do bouts matter?.": HUMAN KINETICS PUBL INC, October 1, 2018.

Scholars@Duke

Singh, A, Babyak, MA, Brummett, BH, Kraus, WE, Siegler, IC, Hauser, ER, and Williams, RB. "Harmonizing psychosocial stress and CVD-risk variables for developing robust estimates of GxE analyses." 27th Annual Meeting of the International-Genetic-Epidemiology-Society (IGES). San Diego, CA. October 14, 2018 - October 16, 2018.: WILEY, October 1, 2018.

Scholars@Duke

Cooper, LB, Yap, J, Tay, WT, Teng, T-HK, MacDonald, M, Anand, IS, Sharma, A, O'Connor, CM, Kraus, WE, Mentz, RJ, Lam, CS, and HF-ACTION and ASIAN-HF Investigators, . "Multi-ethnic comparisons of diabetes in heart failure with reduced ejection fraction: insights from the HF-ACTION trial and the ASIAN-HF registry." European Journal of Heart Failure 20, no. 9 (September 2018): 1281-1289.

PMID
29943890
Full Text

Timmons, JA, Atherton, PJ, Larsson, O, Sood, S, Blokhin, IO, Brogan, RJ, Volmar, C-H, Josse, AR, Slentz, C, Wahlestedt, C, Phillips, SM, Phillips, BE, Gallagher, IJ, and Kraus, WE. "A coding and non-coding transcriptomic perspective on the genomics of human metabolic disease." Nucleic Acids Research 46, no. 15 (September 2018): 7772-7792.

PMID
29986096
Full Text

Koeberl, DD, Case, LE, Smith, EC, Walters, C, Han, S-O, Li, Y, Chen, W, Hornik, CP, Huffman, KM, Kraus, WE, Thurberg, BL, Corcoran, DL, Bali, D, Bursac, N, and Kishnani, PS. "Correction of Biochemical Abnormalities and Improved Muscle Function in a Phase I/II Clinical Trial of Clenbuterol in Pompe Disease." Molecular Therapy : the Journal of the American Society of Gene Therapy 26, no. 9 (September 2018): 2304-2314.

PMID
30025991
Full Text

Duscha, BD, Piner, LW, Patel, MP, Crawford, LE, Jones, WS, Patel, MR, and Kraus, WE. "Effects of a 12-Week mHealth Program on FunctionalCapacity and Physical Activity in Patients With PeripheralArtery Disease." The American Journal of Cardiology 122, no. 5 (September 2018): 879-884.

PMID
30049464
Full Text

Karhausen, JA, Qi, W, Smeltz, AM, Li, Y-J, Shah, SH, Kraus, WE, Mathew, JP, Podgoreanu, MV, Kertai, MD, and Duke Perioperative Genetics Safety Outcomes (PEGASUS) Investigative Team, . "Genome-Wide Association Study Links Receptor Tyrosine Kinase Inhibitor Sprouty 2 to Thrombocytopenia after Coronary Artery Bypass Surgery." September 2018.

PMID
30103242
Full Text

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