William Erle Kraus, MD

Professor of Medicine
Richard and Pat Johnson University Professor
Professor in the School of Nursing
Member of Duke Molecular Physiology Institute
Member of the Duke Cancer Institute
Campus mail 300 N. Duke Street, Carmichael Building 51-201, Durham, NC 27701
Phone (919) 681-6733
Email address william.kraus@duke.edu

My training, expertise and research interests range from human integrative physiology and genetics to animal exercise models to cell culture models of skeletal muscle adaptation to mechanical stretch. I am trained clinically as an internist and preventive cardiologist, with particular expertise in preventive cardiology and cardiac rehabilitation.  My research training spans molecular biology and cell culture, molecular genetics, and integrative human exercise physiology and metabolism. I practice as a preventive cardiologist with a focus on cardiometabolic risk and exercise physiology for older athletes.  My research space has both a basic wet laboratory component and a human integrative physiology one.

One focus of our work is an integrative physiologic examination of exercise effects in human subjects in clinical studies of exercise training in normal individuals, in individuals at risk of disease (such as pre-diabetes and metabolic syndrome; STRRIDE), and in individuals with disease (such as coronary heart disease, congestive heart failure and cancer).

A second focus of my research group is exploration of genetic determinates of disease risk in human subjects.  We conduct studies of early onset cardiovascular disease (GENECARD; CATHGEN), congestive heart failure (HF-ACTION), peripheral arterial disease (AMNESTI), and metabolic syndrome.  We are exploring analytic models of predicting disease risk using established and innovative statistical methodology.

A third focus of my group’s work is to understand the cellular signaling mechanisms underlying the normal adaptive responses of skeletal muscle to physiologic stimuli, such as occur in exercise conditioning, and to understand the abnormal maladaptive responses that occur in response to pathophysiologic stimuli, such as occur in congestive heart failure, aging and prolonged exposure to microgravity.

Recently we have begun to investigate interactions of genes and lifestyle interventions on cardiometabolic outcomes.  We have experience with clinical lifestyle intervention studies, particularly the contributions of genetic variants to interventions responses.  We call this Lifestyle Medicopharmacogenetics.

KEY WORDS:

exercise, skeletal muscle, energy metabolism, cell signaling, gene expression, cell stretch, heart failure, aging, spaceflight, human genetics, early onset cardiovascular disease, lifestyle medicine

In Their Words

Education and Training

  • Fellow in Cardiology, Medicine, Duke University, 1986 - 1988
  • Medical Resident, Medicine, Duke University, 1983 - 1986
  • M.D., Duke University, 1982

Publications

Ward-Caviness, CK, Kraus, WE, Blach, C, Haynes, CS, Dowdy, E, Miranda, ML, Devlin, R, Diaz-Sanchez, D, Cascio, WE, Mukerjee, S, Stallings, C, Smith, LA, Gregory, SG, Shah, SH, Neas, LM, and Hauser, ER. "Associations Between Residential Proximity to Traffic and Vascular Disease in a Cardiac Catheterization Cohort." Arteriosclerosis, thrombosis, and vascular biology 38, no. 1 (January 2018): 275-282.

PMID
29191927
Full Text

Allen, JD, VanBruggen, MD, Johannsen, NM, Robbins, JL, Credeur, DP, Pieper, CF, Sloane, R, Earnest, CP, Church, TS, Ravussin, E, Kraus, WE, and Welsch, MA. "PRIME: A Novel Low-Mass, High-Repetition Approach to Improve Function in Older Adults." Medicine and science in sports and exercise (December 11, 2017).

PMID
29232316
Full Text

Belsky, DW, Huffman, KM, Pieper, CF, Shalev, I, and Kraus, WE. "Change in the Rate of Biological Aging in Response to Caloric Restriction: CALERIE Biobank Analysis." The journals of gerontology. Series A, Biological sciences and medical sciences 73, no. 1 (December 2017): 4-10.

PMID
28531269
Full Text

Mirowsky, JE, Carraway, MS, Dhingra, R, Tong, H, Neas, L, Diaz-Sanchez, D, Cascio, W, Case, M, Crooks, J, Hauser, ER, Elaine Dowdy, Z, Kraus, WE, and Devlin, RB. "Ozone exposure is associated with acute changes in inflammation, fibrinolysis, and endothelial cell function in coronary artery disease patients." Environmental health : a global access science source 16, no. 1 (November 21, 2017): 126-.

PMID
29157250
Full Text

Zillikens, MC, Demissie, S, Hsu, Y-H, Yerges-Armstrong, LM, Chou, W-C, Stolk, L, Livshits, G, Broer, L, Johnson, T, Koller, DL, Kutalik, Z, Luan, J, Malkin, I, Ried, JS, Smith, AV, Thorleifsson, G, Vandenput, L, Hua Zhao, J, Zhang, W, Aghdassi, A, Åkesson, K, Amin, N, Baier, LJ, Barroso, I, Bennett, DA, Bertram, L, Biffar, R, Bochud, M, Boehnke, M, Borecki, IB, Buchman, AS, Byberg, L, Campbell, H, Campos Obanda, N, Cauley, JA, Cawthon, PM, Cederberg, H, Chen, Z, Cho, NH, and Jin Choi, H et al. "Erratum: Large meta-analysis of genome-wide association studies identifies five loci for lean body mass." Nature communications 8, no. 1 (November 7, 2017): 1414-.

PMID
29116125
Full Text

Racette, SB, Rochon, J, Uhrich, ML, Villareal, DT, DAS, SK, Fontana, L, Bhapkar, M, Martin, CK, Redman, LM, Fuss, PJ, Roberts, SB, and Kraus, WE. "Effects of Two Years of Calorie Restriction on Aerobic Capacity and Muscle Strength." Medicine and science in sports and exercise 49, no. 11 (November 2017): 2240-2249.

PMID
29045325
Full Text

McGuinn, LA, Ward-Caviness, C, Neas, LM, Schneider, A, Di, Q, Chudnovsky, A, Schwartz, J, Koutrakis, P, Russell, AG, Garcia, V, Kraus, WE, Hauser, ER, Cascio, W, Diaz-Sanchez, D, and Devlin, RB. "Fine particulate matter and cardiovascular disease: Comparison of assessment methods for long-term exposure." Environmental research 159 (November 2017): 16-23.

PMID
28763730
Full Text

Woessner, MN, VanBruggen, MD, Pieper, CF, O'Reilly, EK, Kraus, WE, and Allen, JD. "Combined Dietary Nitrate and Exercise Intervention in Peripheral Artery Disease: Protocol Rationale and Design." JMIR research protocols 6, no. 10 (October 3, 2017): e139-.

PMID
28974486
Full Text

Sharma, A, Stevens, SR, Lucas, J, Fiuzat, M, Adams, KF, Whellan, DJ, Donahue, MP, Kitzman, DW, Piña, IL, Zannad, F, Kraus, WE, O'Connor, CM, and Felker, GM. "Utility of Growth Differentiation Factor-15, A Marker of Oxidative Stress and Inflammation, in Chronic Heart Failure: Insights From the HF-ACTION Study." JACC. Heart failure 5, no. 10 (October 2017): 724-734.

PMID
28958347
Full Text

Jessee, R, Peart, E, Beineke, P, Rosenberg, S, Wingrove, JA, Kraus, WE, and Huffman, KM. "Rheumatoid arthritis complicates noninvasive whole blood gene expression testing for coronary artery disease." American heart journal 192 (October 2017): 13-18.

PMID
28938959
Full Text

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