William Erle Kraus, MD

Professor of Medicine
Richard and Pat Johnson University Distinguished Professor
Professor in the School of Nursing
Member of Duke Molecular Physiology Institute
Member of the Duke Cancer Institute
Campus mail 300 N. Duke Street, Carmichael Building 51-201, Durham, NC 27701
Phone (919) 681-6733
Email address william.kraus@duke.edu

My training, expertise and research interests range from human integrative physiology and genetics to animal exercise models to cell culture models of skeletal muscle adaptation to mechanical stretch. I am trained clinically as an internist and preventive cardiologist, with particular expertise in preventive cardiology and cardiac rehabilitation.  My research training spans molecular biology and cell culture, molecular genetics, and integrative human exercise physiology and metabolism. I practice as a preventive cardiologist with a focus on cardiometabolic risk and exercise physiology for older athletes.  My research space has both a basic wet laboratory component and a human integrative physiology one.

One focus of our work is an integrative physiologic examination of exercise effects in human subjects in clinical studies of exercise training in normal individuals, in individuals at risk of disease (such as pre-diabetes and metabolic syndrome; STRRIDE), and in individuals with disease (such as coronary heart disease, congestive heart failure and cancer).

A second focus of my research group is exploration of genetic determinates of disease risk in human subjects.  We conduct studies of early onset cardiovascular disease (GENECARD; CATHGEN), congestive heart failure (HF-ACTION), peripheral arterial disease (AMNESTI), and metabolic syndrome.  We are exploring analytic models of predicting disease risk using established and innovative statistical methodology.

A third focus of my group’s work is to understand the cellular signaling mechanisms underlying the normal adaptive responses of skeletal muscle to physiologic stimuli, such as occur in exercise conditioning, and to understand the abnormal maladaptive responses that occur in response to pathophysiologic stimuli, such as occur in congestive heart failure, aging and prolonged exposure to microgravity.

Recently we have begun to investigate interactions of genes and lifestyle interventions on cardiometabolic outcomes.  We have experience with clinical lifestyle intervention studies, particularly the contributions of genetic variants to interventions responses.  We call this Lifestyle Medicopharmacogenetics.

KEY WORDS:

exercise, skeletal muscle, energy metabolism, cell signaling, gene expression, cell stretch, heart failure, aging, spaceflight, human genetics, early onset cardiovascular disease, lifestyle medicine

Education and Training

  • Fellow in Cardiology, Medicine, Duke University, 1986 - 1988
  • Medical Resident, Medicine, Duke University, 1983 - 1986
  • M.D., Duke University, 1982

Publications

Timmons, James A., Andrew Anighoro, Robert J. Brogan, Jack Stahl, Claes Wahlestedt, David Gordon Farquhar, Jake Taylor-King, Claude-Henry Volmar, William E. Kraus, and Stuart M. Phillips. “A human-based multi-gene signature enables quantitative drug repurposing for metabolic disease.” Elife 11 (January 17, 2022). https://doi.org/10.7554/eLife.68832.

PMID
35037854
Full Text

Rimbach, Rebecca, Yosuke Yamada, Hiroyuki Sagayama, Philip N. Ainslie, Lene F. Anderson, Liam J. Anderson, Lenore Arab, et al. “Total energy expenditure is repeatable in adults but not associated with short-term changes in body composition.” Nat Commun 13, no. 1 (January 10, 2022): 99. https://doi.org/10.1038/s41467-021-27246-z.

PMID
35013190
Full Text

Weaver, Anne M., Laura A. McGuinn, Lucas Neas, Robert B. Devlin, Radhika Dhingra, Cavin K. Ward-Caviness, Wayne E. Cascio, William E. Kraus, Elizabeth R. Hauser, and David Diaz-Sanchez. “Associations between neighborhood socioeconomic cluster and hypertension, diabetes, myocardial infarction, and coronary artery disease within a cohort of cardiac catheterization patients.” Am Heart J 243 (January 2022): 201–9. https://doi.org/10.1016/j.ahj.2021.09.013.

PMID
34610283
Full Text

Koontz, Bridget F., Erica Levine, Frances McSherry, Donna Niedzwiecki, Linda Sutton, Tykeytra Dale, Martin Streicher, et al. “Increasing physical activity in Cancer Survivors through a Text-messaging Exercise motivation Program (ICanSTEP).” Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer 29, no. 12 (December 2021): 7339–49. https://doi.org/10.1007/s00520-021-06281-y.

PMID
34050402
Full Text

Oliver, Catherine E., Hailee Patel, James Hong, Jonathan Carter, William E. Kraus, Kim M. Huffman, and George A. Truskey. “Tissue engineered skeletal muscle model of rheumatoid arthritis using human primary skeletal muscle cells.” Journal of Tissue Engineering and Regenerative Medicine, November 15, 2021. https://doi.org/10.1002/term.3266.

PMID
34781416
Full Text

Westerterp, Klaas R., Yosuke Yamada, Hiroyuki Sagayama, Philip N. Ainslie, Lene F. Andersen, Liam J. Anderson, Lenore Arab, et al. “Physical activity and fat-free mass during growth and in later life.” Am J Clin Nutr 114, no. 5 (November 8, 2021): 1583–89. https://doi.org/10.1093/ajcn/nqab260.

PMID
34477824
Full Text

Blumenthal, James A., Patrick J. Smith, Wei Jiang, Alan Hinderliter, Lana L. Watkins, Benson M. Hoffman, William E. Kraus, Lawrence Liao, Jonathan Davidson, and Andrew Sherwood. “Effect of Exercise, Escitalopram, or Placebo on Anxiety in Patients With Coronary Heart Disease: The Understanding the Benefits of Exercise and Escitalopram in Anxious Patients With Coronary Heart Disease (UNWIND) Randomized Clinical Trial.” Jama Psychiatry 78, no. 11 (November 1, 2021): 1270–78. https://doi.org/10.1001/jamapsychiatry.2021.2236.

PMID
34406354
Full Text

Whitson, Heather E., Donna Crabtree, Carl F. Pieper, Christine Ha, Sandra Au, Miles Berger, Harvey J. Cohen, et al. “A template for physical resilience research in older adults: Methods of the PRIME-KNEE study.” J Am Geriatr Soc 69, no. 11 (November 2021): 3232–41. https://doi.org/10.1111/jgs.17384.

PMID
34325481
Full Text

Dorling, James L., Daniel W. Belsky, Susan B. Racette, Sai Krupa Das, Eric Ravussin, Leanne M. Redman, Christoph Höchsmann, et al. “Association between the FTO rs9939609 single nucleotide polymorphism and dietary adherence during a 2-year caloric restriction intervention: Exploratory analyses from CALERIE™ phase 2.” Exp Gerontol 155 (November 2021): 111555. https://doi.org/10.1016/j.exger.2021.111555.

PMID
34543722
Full Text

Careau, Vincent, Lewis G. Halsey, Herman Pontzer, Philip N. Ainslie, Lene F. Andersen, Liam J. Anderson, Lenore Arab, et al. “Energy compensation and adiposity in humans.” Curr Biol 31, no. 20 (October 25, 2021): 4659-4666.e2. https://doi.org/10.1016/j.cub.2021.08.016.

PMID
34453886
Full Text

Pages