William Erle Kraus, MD

Professor of Medicine
Richard and Pat Johnson University Professor
Professor in the School of Nursing
Member of Duke Molecular Physiology Institute
Member of the Duke Cancer Institute
Campus mail 300 N. Duke Street, Carmichael Building 51-201, Durham, NC 27701
Phone (919) 681-6733
Email address william.kraus@duke.edu

My training, expertise and research interests range from human integrative physiology and genetics to animal exercise models to cell culture models of skeletal muscle adaptation to mechanical stretch. I am trained clinically as an internist and preventive cardiologist, with particular expertise in preventive cardiology and cardiac rehabilitation.  My research training spans molecular biology and cell culture, molecular genetics, and integrative human exercise physiology and metabolism. I practice as a preventive cardiologist with a focus on cardiometabolic risk and exercise physiology for older athletes.  My research space has both a basic wet laboratory component and a human integrative physiology one.

One focus of our work is an integrative physiologic examination of exercise effects in human subjects in clinical studies of exercise training in normal individuals, in individuals at risk of disease (such as pre-diabetes and metabolic syndrome; STRRIDE), and in individuals with disease (such as coronary heart disease, congestive heart failure and cancer).

A second focus of my research group is exploration of genetic determinates of disease risk in human subjects.  We conduct studies of early onset cardiovascular disease (GENECARD; CATHGEN), congestive heart failure (HF-ACTION), peripheral arterial disease (AMNESTI), and metabolic syndrome.  We are exploring analytic models of predicting disease risk using established and innovative statistical methodology.

A third focus of my group’s work is to understand the cellular signaling mechanisms underlying the normal adaptive responses of skeletal muscle to physiologic stimuli, such as occur in exercise conditioning, and to understand the abnormal maladaptive responses that occur in response to pathophysiologic stimuli, such as occur in congestive heart failure, aging and prolonged exposure to microgravity.

Recently we have begun to investigate interactions of genes and lifestyle interventions on cardiometabolic outcomes.  We have experience with clinical lifestyle intervention studies, particularly the contributions of genetic variants to interventions responses.  We call this Lifestyle Medicopharmacogenetics.

KEY WORDS:

exercise, skeletal muscle, energy metabolism, cell signaling, gene expression, cell stretch, heart failure, aging, spaceflight, human genetics, early onset cardiovascular disease, lifestyle medicine

In Their Words

Education and Training

  • Fellow in Cardiology, Medicine, Duke University, 1986 - 1988
  • Medical Resident, Medicine, Duke University, 1983 - 1986
  • M.D., Duke University, 1982

Publications

Cooper, LB, Yap, J, Tay, WT, Teng, T-HK, MacDonald, M, Anand, IS, Sharma, A, O'Connor, CM, Kraus, WE, Mentz, RJ, Lam, CS, and HF-ACTION and ASIAN-HF Investigators, . "Multi-ethnic comparisons of diabetes in heart failure with reduced ejection fraction: insights from the HF-ACTION trial and the ASIAN-HF registry." European Journal of Heart Failure 20, no. 9 (September 2018): 1281-1289.

PMID
29943890
Full Text

Timmons, JA, Atherton, PJ, Larsson, O, Sood, S, Blokhin, IO, Brogan, RJ, Volmar, C-H, Josse, AR, Slentz, C, Wahlestedt, C, Phillips, SM, Phillips, BE, Gallagher, IJ, and Kraus, WE. "A coding and non-coding transcriptomic perspective on the genomics of human metabolic disease." Nucleic Acids Research 46, no. 15 (September 2018): 7772-7792.

PMID
29986096
Full Text

Koeberl, DD, Case, LE, Smith, EC, Walters, C, Han, S-O, Li, Y, Chen, W, Hornik, CP, Huffman, KM, Kraus, WE, Thurberg, BL, Corcoran, DL, Bali, D, Bursac, N, and Kishnani, PS. "Correction of Biochemical Abnormalities and Improved Muscle Function in a Phase I/II Clinical Trial of Clenbuterol in Pompe Disease." Molecular Therapy : the Journal of the American Society of Gene Therapy 26, no. 9 (September 2018): 2304-2314.

PMID
30025991
Full Text

Porter, LS, Gao, X, Lyna, P, Kraus, W, Olsen, M, Patterson, E, Puleo, B, and Pollak, KI. "Pilot randomized trial of a couple-based physical activity videoconference intervention for sedentary cancer survivors." Health Psychology : Official Journal of the Division of Health Psychology, American Psychological Association 37, no. 9 (September 2018): 861-865.

PMID
30138021
Full Text

White, JP, Billin, AN, Campbell, ME, Russell, AJ, Huffman, KM, and Kraus, WE. "The AMPK/p27Kip1 Axis Regulates Autophagy/Apoptosis Decisions in Aged Skeletal Muscle Stem Cells." Stem Cell Reports 11, no. 2 (August 2018): 425-439.

PMID
30033086
Full Text

Fudim, M, O'Connor, CM, Mulder, H, Coles, A, Bhatt, AS, Ambrosy, AP, Kraus, WE, Piña, IL, Whellan, DJ, and Mentz, RJ. "Loop diuretic adjustments in patients with chronic heart failure: Insights from HF-ACTION." American Heart Journal (July 29, 2018).

PMID
30158057
Full Text

Barber, JL, Kraus, WE, Church, TS, Hagberg, JM, Thompson, PD, Bartlett, DB, Beets, MW, Earnest, CP, Huffman, KM, Landers-Ramos, RQ, Leon, AS, Rao, DC, Seip, RL, Skinner, JS, Slentz, CA, Wilund, KR, Bouchard, C, and Sarzynski, MA. "Effects of regular endurance exercise on GlycA: Combined analysis of 14 exercise interventions." Atherosclerosis 277 (July 26, 2018): 1-6.

PMID
30170218
Full Text

Singh, A, Babyak, MA, Brummett, BH, Kraus, WE, Siegler, IC, Hauser, ER, and Williams, RB. "Developing a synthetic psychosocial stress measure and harmonizing CVD-risk data: a way forward to GxE meta- and mega-analyses." Bmc Research Notes 11, no. 1 (July 24, 2018): 504-null.

PMID
30041705
Full Text

Woessner, MN, VanBruggen, MD, Pieper, CF, Sloane, R, Kraus, WE, Gow, AJ, and Allen, JD. "Beet the Best? Dietary Inorganic Nitrate to Augment Exercise Training in Lower Extremity Peripheral Artery Disease with Intermittent Claudication." Circulation Research (July 5, 2018).

PMID
29976553
Full Text

Zuo, X, Luciano, A, Pieper, CF, Bain, JR, Kraus, VB, Kraus, WE, Morey, MC, and Cohen, HJ. "Combined Inflammation and Metabolism Biomarker Indices of Robust and Impaired Physical Function in Older Adults." Journal of the American Geriatrics Society 66, no. 7 (July 2018): 1353-1359.

PMID
29738072
Full Text

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