William Erle Kraus, MD

Professor of Medicine
Richard and Pat Johnson University Distinguished Professor
Professor in the School of Nursing
Member of Duke Molecular Physiology Institute
Member of the Duke Cancer Institute
Campus mail 300 N. Duke Street, Carmichael Building 51-201, Durham, NC 27701
Phone (919) 681-6733
Email address william.kraus@duke.edu

My training, expertise and research interests range from human integrative physiology and genetics to animal exercise models to cell culture models of skeletal muscle adaptation to mechanical stretch. I am trained clinically as an internist and preventive cardiologist, with particular expertise in preventive cardiology and cardiac rehabilitation.  My research training spans molecular biology and cell culture, molecular genetics, and integrative human exercise physiology and metabolism. I practice as a preventive cardiologist with a focus on cardiometabolic risk and exercise physiology for older athletes.  My research space has both a basic wet laboratory component and a human integrative physiology one.

One focus of our work is an integrative physiologic examination of exercise effects in human subjects in clinical studies of exercise training in normal individuals, in individuals at risk of disease (such as pre-diabetes and metabolic syndrome; STRRIDE), and in individuals with disease (such as coronary heart disease, congestive heart failure and cancer).

A second focus of my research group is exploration of genetic determinates of disease risk in human subjects.  We conduct studies of early onset cardiovascular disease (GENECARD; CATHGEN), congestive heart failure (HF-ACTION), peripheral arterial disease (AMNESTI), and metabolic syndrome.  We are exploring analytic models of predicting disease risk using established and innovative statistical methodology.

A third focus of my group’s work is to understand the cellular signaling mechanisms underlying the normal adaptive responses of skeletal muscle to physiologic stimuli, such as occur in exercise conditioning, and to understand the abnormal maladaptive responses that occur in response to pathophysiologic stimuli, such as occur in congestive heart failure, aging and prolonged exposure to microgravity.

Recently we have begun to investigate interactions of genes and lifestyle interventions on cardiometabolic outcomes.  We have experience with clinical lifestyle intervention studies, particularly the contributions of genetic variants to interventions responses.  We call this Lifestyle Medicopharmacogenetics.

KEY WORDS:

exercise, skeletal muscle, energy metabolism, cell signaling, gene expression, cell stretch, heart failure, aging, spaceflight, human genetics, early onset cardiovascular disease, lifestyle medicine

Education and Training

  • Fellow in Cardiology, Medicine, Duke University, 1986 - 1988
  • Medical Resident, Medicine, Duke University, 1983 - 1986
  • M.D., Duke University, 1982

Publications

Andonian, Brian J., Ching-Heng Chou, Olga R. Ilkayeva, Timothy R. Koves, Margery A. Connelly, William E. Kraus, Virginia B. Kraus, and Kim M. Huffman. “Plasma MicroRNAs in Established Rheumatoid Arthritis Relate to Adiposity and Altered Plasma and Skeletal Muscle Cytokine and Metabolic Profiles.” Front Immunol 10 (2019): 1475. https://doi.org/10.3389/fimmu.2019.01475.

PMID
31316517
Full Text

Smith, Patrick J., Stephanie Mabe, Andrew Sherwood, Michael A. Babyak, P Murali Doraiswamy, Kathleen A. Welsh-Bohmer, William Kraus, James Burke, Alan Hinderliter, and James A. Blumenthal. “Association Between Insulin Resistance, Plasma Leptin, and Neurocognition in Vascular Cognitive Impairment.” J Alzheimers Dis 71, no. 3 (2019): 921–29. https://doi.org/10.3233/JAD-190569.

PMID
31476159
Full Text

Andonian, Brian J., David B. Bartlett, Janet L. Huebner, Leslie Willis, Andrew Hoselton, Virginia B. Kraus, William E. Kraus, and Kim M. Huffman. “Effect of high-intensity interval training on muscle remodeling in rheumatoid arthritis compared to prediabetes.” Arthritis Res Ther 20, no. 1 (December 27, 2018): 283. https://doi.org/10.1186/s13075-018-1786-6.

PMID
30587230
Full Text

Powell, Kenneth E., Abby C. King, David M. Buchner, Wayne W. Campbell, Loretta DiPietro, Kirk I. Erickson, Charles H. Hillman, et al. “The Scientific Foundation for the Physical Activity Guidelines for Americans, 2nd Edition.” J Phys Act Health, December 17, 2018, 1–11. https://doi.org/10.1123/jpah.2018-0618.

PMID
30558473
Full Text

Mediano, Mauro F. F., Eric S. Leifer, Lawton S. Cooper, Steven J. Keteyian, William E. Kraus, Robert J. Mentz, and Jerome L. Fleg. “Influence of Baseline Physical Activity Level on Exercise Training Response and Clinical Outcomes in Heart Failure: The HF-ACTION Trial.” Jacc Heart Fail 6, no. 12 (December 2018): 1011–19. https://doi.org/10.1016/j.jchf.2018.09.012.

PMID
30497641
Full Text

Ross, Leanna M., Casey C. Kuka, Lucy W. Piner, Johanna L. Johnson, Cris A. Slentz, and William E. Kraus. “Ten-Year Legacy Effects of Previous STRRIDE Exercise Training Intervention on Measures of Cardiorespiratory Fitness.” In Circulation, Vol. 138, 2018.

Scholars@Duke

Fudim, Marat, Christopher M. O’Connor, Hillary Mulder, Adrian Coles, Ankeet S. Bhatt, Andrew P. Ambrosy, William E. Kraus, Ileana L. Piña, David J. Whellan, and Robert J. Mentz. “Loop diuretic adjustments in patients with chronic heart failure: Insights from HF-ACTION.” Am Heart J 205 (November 2018): 133–41. https://doi.org/10.1016/j.ahj.2018.06.017.

PMID
30158057
Full Text

Zhang, Siqi, Susanne Breitner, Wayne E. Cascio, Robert B. Devlin, Lucas M. Neas, David Diaz-Sanchez, William E. Kraus, et al. “Short-term effects of fine particulate matter and ozone on the cardiac conduction system in patients undergoing cardiac catheterization.” Part Fibre Toxicol 15, no. 1 (October 11, 2018): 38. https://doi.org/10.1186/s12989-018-0275-z.

PMID
30305173
Full Text

Saint-Maurice, Pedro, Richard P. Troiano, Charles E. Matthews, and William E. Kraus. “Moderate-to-vigorous intensity physical activity and all-cause mortality: Do bouts matter?” In Journal of Physical Activity & Health, 15:S37–S37. HUMAN KINETICS PUBL INC, 2018.

Scholars@Duke

Singh, Abanish, Michael A. Babyak, Beverly H. Brummett, William E. Kraus, Ilene C. Siegler, Elizabeth R. Hauser, and Redford B. Williams. “Harmonizing psychosocial stress and CVD-risk variables for developing robust estimates of GxE analyses.” In Genetic Epidemiology, 42:731–731. WILEY, 2018.

Scholars@Duke

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