Zainab Samad, MBBS

Associate Professor of Medicine
Campus mail DUMC - Box 3254, Durham, NC 27710
Email address zainab.samad@duke.edu

Dr. Zainab Samad is an Associate Professor of Medicine at Duke University and a cardiologist in the Division of Cardiology, Department of Medicine at Duke University Medical Center. She serves as assistant director of research at the Duke Echocardiography Laboratory and director of site-based-research in cardiovascular imaging at Duke Heart Center.

She attended Medical School at the Aga Khan University Medical College in Karachi, Pakistan and thereafter completed her residency training in Internal Medicine and fellowship in Cardiology at Duke University Medical Center in Durham, North Carolina. Additionally, she completed advanced training in cardiovascular imaging, specifically in clinical echocardiography, cardiac MRI and SPECT-myocardial perfusion imaging. She is also trained in quantitative methods with a Master of Health Sciences in Clinical Research degree from the National Institutes of Health- Duke Clinical Research Training Program. 

Since joining faculty at Duke, she has been immersed in growing the trifold mission of the academic program including education, research and clinical service. Her clinical interests include managing patients with heart failure, valvular heart disease and chemotherapy induced cardiotoxcity.
Along with her collaborators, she has developed and harnessed a unique interconnection of multiple large longitudinal imaging databases to address key questions and test hypotheses regarding heart valve disease that have led to international recognition. For example, her investigation of mitral regurgitation and left ventricular systolic dysfunction was selected in the Best of Valve Disease, European Heart Journal 2015. She has had a long-standing interest in the relationship of mental stress and cardiovascular disease. She took a leadership role from an imaging standpoint in the NHLBI funded study, the Reponses of Mental Stress induced Myocardial Ischemia to Escitalopram Treatment (REMIT) study by developing the echocardiography testing, quality control, and reading protocol. Using REMIT data she has made clinically important observations including the higher prevalence of mental stress induced left ventricular dysfunction in women compared with men.  She has published her work in high impact journals including Journal of the American Medical Association, Circulation, Journal of the American College of Cardiology, European Heart Journal and the American Heart Journal. Dr. Samad also serves as an associate Editor for the American Heart Journal. 

She has won several awards for her teaching abilities most notably The Thomas Bashore Teaching Award in 2013, The Robert Waugh Teaching Award in 2014 and The Department of Medicine Teaching Award in 2015. She was again nominated for the Thomas Bashore Teaching Award in 2016. She has actively shaped the cardiology-teaching curriculum and developed teaching methods that are currently under patent review at Duke University. She has mentored sonographers, visiting medical students, Duke residents and cardiology fellows.

Education and Training

  • Cardiology Fellowship, Medicine, Duke University, 2005 - 2009
  • Resident, Medicine, Duke University, 2002 - 2005
  • M.H.S., Duke University School of Medicine, 2009
  • M.B.B.S., Aga Khan University (Pakistan), 2000

Publications

Sze, E, Dunning, A, Loring, Z, Atwater, BD, Chiswell, K, Daubert, JP, Kisslo, JA, Mark, DB, Velazquez, EJ, and Samad, Z. "Comparison of Incidence of Left Ventricular Systolic Dysfunction Among Patients With Left Bundle Branch Block Versus Those With Normal QRS Duration." The American journal of cardiology 120, no. 11 (December 2017): 1990-1997.

PMID
28958452
Full Text

Alenezi, F, Brummett, BH, Boyle, SH, Samad, Z, Babyak, MA, Alzaeim, N, Wilson, J, Romano, MMD, Sun, JL, Ersboll, M, O'Connor, CM, Velazquez, EJ, and Jiang, W. "Usefulness of Myocardial Annular Velocity Change During Mental Stress to Predict Cardiovascular Outcome in Patients With Coronary Artery Disease (From the Responses of Mental Stress-Induced Myocardial Ischemia to Escitalopram Treatment Trial)." The American journal of cardiology 120, no. 9 (November 2017): 1495-1500.

PMID
28917493
Full Text

Samad, Z, Sivak, JA, Phelan, M, Schulte, PJ, Patel, U, and Velazquez, EJ. "Prevalence and Outcomes of Left-Sided Valvular Heart Disease Associated With Chronic Kidney Disease." Journal of the American Heart Association 6, no. 10 (October 11, 2017).

PMID
29021274
Full Text

Broderick-Forsgren, K, Davenport, CA, Sivak, JA, Hargett, CW, Foster, MC, Monteagudo, A, Armour, A, Rajagopal, S, Arges, K, Velazquez, EJ, and Samad, Z. "Improving on the diagnostic characteristics of echocardiography for pulmonary hypertension." The International Journal of Cardiovascular Imaging 33, no. 9 (September 2017): 1341-1349.

PMID
28337558
Full Text

Teeter, EG, Dakik, C, Cooter, M, Samad, Z, Ghadimi, K, Harrison, JK, Gaca, J, Stafford-Smith, M, and Bottiger, BA. "Assessment of Paravalvular Leak After Transcatheter Aortic Valve Replacement: Transesophageal Echocardiography Compared With Transthoracic Echocardiography." Journal of cardiothoracic and vascular anesthesia 31, no. 4 (August 2017): 1278-1284.

PMID
28800985
Full Text

McCartney, SL, Cooter, M, Samad, Z, Sivak, J, Castleberry, A, Gregory, S, Haney, J, Hartwig, M, and Swaminathan, M. "Mitral Regurgitation After Orthotopic Lung Transplantation: Natural History and Impact on Outcomes." Journal of cardiothoracic and vascular anesthesia 31, no. 3 (June 2017): 924-930.

PMID
28082025
Full Text

Sun, JL, Boyle, SH, Samad, Z, Babyak, MA, Wilson, JL, Kuhn, C, Becker, RC, Ortel, TL, Williams, RB, Rogers, JG, O'Connor, CM, Velazquez, EJ, and Jiang, W. "Mental stress-induced left ventricular dysfunction and adverse outcome in ischemic heart disease patients." European journal of preventive cardiology 24, no. 6 (April 2017): 591-599.

PMID
28067532
Full Text

Wyrembak, J, Campbell, KB, Steinberg, BA, Bahnson, TD, Daubert, JP, Velazquez, EJ, Samad, Z, and Atwater, BD. "Incidence and Predictors of Left Atrial Appendage Thrombus in Patients Treated With Nonvitamin K Oral Anticoagulants Versus Warfarin Before Catheter Ablation for Atrial Fibrillation." The American journal of cardiology 119, no. 7 (April 2017): 1017-1022.

PMID
28153350
Full Text

Fudim, M, Bloomfield, GS, and Samad, Z. "Transcatheter Aortic Valve Implantation Versus Surgical Aortic Valve Replacement." Annals of internal medicine 166, no. 8 (April 2017): 605-606.

PMID
28418555
Full Text

Samad, Z, Sivak, J, Phelan, M, Schulte, P, and Velazquez, E. "LOW UTILIZATION OF SURGICAL INTERVENTION TO TREAT SEVERE AORTIC STENOSIS IN PATIENTS WITH CHRONIC KIDNEY DISEASE." March 21, 2017.

Scholars@Duke

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