New funding awards - August 2015

Sponsored Research

Thomas J. Cahill III (Mentor: Robert J. Lefkowitz) of Cardiology has received an award (1F30-HL129803-01) from the National Institutes of Health for a project entitled "Stuctural characterization and signaling of g protein-coupled receptor-protein complexes mediate uniqd ue signaling for novel rational drug design." Total funding will be $164,454.

Carolyn L. Lekavich of Cardiology has received an award from the Heart Failure Society of America for a project entitled "Early Markers of HFpEF." Total funding will be $10,000.

Geoffrey Pitt of Cardiology has received an award from the Edna and Fred L. Mandel, Jr. Foundation for a project entitled "Pitt Lab-Mandel Foundation", a part of Victor J. Dzau's project entitled "Mandel Foundation."

Matthew T. Roe of Cardiology has received an award from the State of Texas for a project entitled "Mission Lifeline Texas State System Report." Total funding will be $4,993.

Sudha Shenoy of Cardiology has received an award (5R01-HL118369-02S1) from the National Institutes of Health for a project entitled "Regulation of B-arrestin2's pro-atherogenic activity by the deubiquitinase USP20." Total funding will be $170,925.

Sreekanth Vemulapalli of Cardiology has received an award from the American College of Cardiology Foundation for a project entitled "Quality of Care and Resource Utilization in Apparent Treatment Resistant Hypertension." Total funding will be $70,000.

Cathleen S. Colon-Emeric of Geriatrics has received an award (1K24-AG049077-01A1) from the National Institutes of Health for a project entitled "Mentoring Intervention Development in Fall and Fracture Prevention." Total funding will be $360,829.

Mitchell Heflin of Geriatrics has received an award (1-U1HP28708-01-00) from the Health Resources and Service Administration for a project entitled "Duke Geriatric Workforce Enhancement Program (GWEP): Communities Caring for Seniors." Total funding will be $749,656.

Juliessa M. Pavon of Geriatrics has received an award from the Society of Hospital Medicine for a project entitled "Adherence to Venous Thromboembolism Prophylaxis Guidelines in Hospitalized Elders." Total funding will be $50,000.

Stefanie Sarantopoulos of Hematological Malignancies and Cellular Therapy has received an award (1R01-HL129061-01) from the National Institutes of Health for a project entitled "Pathological B Cells: Novel Strategies to Prevent and Treat Chronic GVHD." Total funding will be $3,217,665.

Grace M. Lee of Hematology has received an award from the Hemostasis & Thrombosis Research Society for a project entitled "Biological Significance of Protamine/Heparin Antibodies." Total funding will be $162,000.

Deverick J. Anderson of Infectious Diseases has received an award (1R01-HS023821-01A1) from the Agency for Healthcare Research and Quality for a project entitled "Prevention of Surgical Site Infection using Statistical Process Control Charts." Total funding will be $2,472,607.

Greg Gray of Infectious Diseases has received a sub-award (S-LMAQM-14-CA-1313) through the CRDF Global for a project entitled "One Health Training Program." Total funding will be $345,923.

Nathan M. Thielman of Infectious Diseases has received a sub-award (5R25-TW009337-04) through Vanderbilt University for a project entitled "Vanderbilt-Emory-Cornell-Duke Consortium for Global Health Fellows (VECDor)." Total funding will be $43,884.

Mehri McKellar of Infectious Diseases has received an award from the NC Department of Health and Human Services for a project entitled "Housing Opportunities for Persons with AIDS - Region Seven." Total funding will be $113,234.

Mehri McKellar of Infectious Diseases has received an award through the University of North Carolina - Chapel Hill for a project entitled "IGHID 11417 - PHI 05 - The Safety and Efficacy of Fixed Dose Combination Dolutegravir/Abacavir/Lamivudine Initiated During Acute HIV Infection: Impact on the Latent HIV Reservoir and Long-Term Immunologic Effect." Total funding will be $184,489.

Nathan M. Thielman of Infectious Diseases has received a sub-award (5R25-TW009337-04) through Vanderbilt University for a project entitled "Vanderbilt-Emory-Cornell-Duke Consortium for Global Health Fellows (VECDor)." Total funding will be $43,918.

Jian Chen (Mentor: Gerard C. Blobe) of Medical Oncology has received an award from the Susan G. Komen Breast Cancer Foundation for a project entitled "A Novel Function for ALK4 in Suppressing Breast Cancer Progression." Total funding will be $60,000.

Jeffrey Crawford of Medical Oncology has received an award from the Fred Hutchinson Cancer Research Center for a project entitled "Improving Clinical Outcomes in Patients with Cancer." Total funding will be $18,376.

Michaela A. Dinan of Medical Oncology has received an award (4R00-HS022189-03) from the Agency for Healthcare Research and Quality for a project entitled "National Utilization Patterns of Oncotype DX in Early Stage Breast Cancer and its Effect on Health Disparities, Chemotherapy Utilization, and Associated Costs." Total funding will be $745,780.

Brent A. Hanks of Medical Oncology has received an award (1K08-CA191063-01A1) from the National Institutes of Health for a project entitled "Melanoma-mediated Dendritic Cell Tolerization and Immune Evasion." Total funding will be $825,660.

Victoria L. Seewaldt of Medical Oncology has received an award (1U01-CA189283-01A1) from the National Institutes of Health for a project entitled "Combined breast MRI/biomarker strategies to identify aggressive biology." Total funding will be $3,481,746.

Hongyu Tian of Medical Oncology has received an award from the HHT Foundation International, Inc. for a project entitled "Endoglin Regulates Biology and Signal Transduction in Vascular Smooth Muscle Cells." Total funding will be $30,000.

Mary H. Foster of Nephrology has received an award (3P30-DK096493-04S1) from the National Institutes of Health for a project entitled "George M. O'Brien Kidney Research Core Centers--Student Supplement." Total funding will be $50,418.

Rasheeda K. Hall of Nephrology has received an award (1R03-AG050834-01) from the National Institutes of Health for a project entitled "Improving Quality of Life Measurement in Older Dialysis Patients." Total funding will be $239,500.

Christopher Cox of Pulmonary, Allergy, and Critical Care Medicine has received an award (1R34-AT008819-01) from the National Institutes of Health for a project entitled "Mobile Mindfulness to Improve Psychological Distress after Critical Illness." Total funding will be $740,170.

Alice L. Gray of Pulmonary, Allergy, and Critical Care Medicine has received an award from the Cystic Fibrosis Foundation for a project entitled "CFF." Total funding will be $56,700.

Timothy J. McMahon of Pulmonary, Allergy, and Critical Care Medicine has received a sub-award (1R01-GM113838-01) through the Washington University for a project entitled "Sepsis-induced Red Cell Dysfunction (SiRD)." Total funding will be $257,176.

Megan E. Clowse of Rheumatology and Immunology has received an award (1K18-HS023443-01A1) from the Agency for Healthcare Research and Quality for a project entitled "Optimizing Lupus Management in Pregnancy." Total funding will be $449,427.

Industry-sponsored clinical trials

Tristram D. Bahnson of Cardiology has received an award from St. Jude Medical Inc. for a project entitled "Optimization of RFA Predictive Modeling Using Novel US Method of Real-Time Lesion Assessment in Humans." Total funding will be $121,263.

Robert M. Califf of Cardiology has received an award from Amgen, Inc. for a project entitled "Cardiovascular Drug Development." Total funding will be $30,000.

Renato D. Lopes of Cardiology has received an award from Theravance, Inc. for a project entitled "TD-4208 for the Treatment of Chronic Obstructive Pulmonary Disease (copd)-14." Total funding will be $203,322.

Sunil V. Rao of Cardiology has received an award from Medtronic, Inc. for a project entitled "Onyx." Total funding will be $148,349.

Manal F. Abdelmalek of Gastroenterology has received an award from Galectin Therapeutics, Inc. for a project entitled "Galectin GI-026: A Multi-Center, Randomized, Controlled, Double-blind, Parallel Group, Phase 2/3 Clinical Trial to Evaluate the Safety and Efficacy of GR-MD-02 for the Treatment of Liver Fibrosis and Resultant Portal Hypertension in Patients with NASH." Total funding will be $393,595.

Cristal Brown of Gastroenterology has received an award from Gilead Sciences, Inc. for a project entitled "A Registry for Subjects with Cirrhosis Who Achieve a Sustained Virologic Response Following Treatment with a Sofosbuvir-Based Regimen without Interferon for Chronic Hepatitis C Infection in Gilead Sponsored Trials." Total funding will be $83,639.

Stefanie Sarantopoulos of Hematological Malignancies and Cellular Therapy has received an award from Rigel Inc for a project entitled "A Phase I Trial of Fostamatinib before Chronic Graft-vs.-Host Disease Development after Allogeneic Stem Cell Transplantation."

John Perfect of Infectious Diseases has received an award from Amplyx Pharmaceuticals, Inc. for a project entitled "A Computer Modeling Approach to Create an Antifungal to Improve the Treatment of Cryptococcal Infections." Total funding will be $20,000.

Mehri McKellar of Infectious Diseases has received an award from Alliance Behavioral Healthcare for a project entitled "HIV Early Intervention Testing." Total funding will be $119,850.

Jeffrey Crawford of Medical Oncology has received an award from Clovis Oncology, Inc. for a project entitled "TIGER 1: A randomized, open-label, phase II study of CO-1686 or Erlotinib as first-line treatment of patients with EGFR-Mutant advanced non-small cell lung cancer." Total funding will be $273,531.

Frank R. Dunphy II of Medical Oncology has received an award from F. Hoffmann-La Roche Ltd for a project entitled "A Phase III, Multicenter, Rancomized Open-Label Study Evaluating the Efficacy and Safety of MPD3280A (Anti-PD-L1 Antibody)in Combination with Carboplatin + NAB-Paclitaxel for Chemotherapy-Naive Patients with Stage IV NSCLC." Total funding will be $283,757.

Stephanie Gaillard of Medical Oncology has received an award from PharmaMar USA, Inc. for a project entitled "Protocol # PM1183-C-004-14: Phase III Randomized Clinical Trial of Lurbinectedin (PM01183) versus Pegylated Liposomal Doxorubicin or Topotecan in Patients with Platinum-resistant Ovarian Cancer (CORAIL Trial)." Total funding will be $381,302.

Herbert I. Hurwitz of Medical Oncology has received an award from Novartis Pharmaceuticals Corporation for a project entitled "A Phase I/II open label multicenter study of the safety and efficacy of LAG525 single agent in combination with PDR001 adminitered to patients." Total funding will be $267,682.

Niharika B. Mettu of Medical Oncology has received an award from Incyte Corporation for a project entitled "A Phase I open label dose escalation safety and tolerability study of INCB054828 in subjects with advanced malignancies." Total funding will be $327,875.

Momen Wahidi of Pulmonary, Allergy, and Critical Care Medicine has received an award from Covidien Ltd. for a project entitled "NAVIGATE." Total funding will be $300,500.

Lisa G. Criscione-Schreiber of Rheumatology and Immunology has received an award from AbbVie Inc. for a project entitled "Support for a Clinical Fellow - 24758." Total funding will be $40,000.

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