New funding awards - June 2016

Sponsored Research

Hsiang-Ting Ho (Mentor: Christopher Holley) of Cardiology has received an award from the American Heart Association for a project entitled "Regulation of oxidative stress and reactive oxygen species (ROS) in heart failure." Total funding will be $34,500.

Christopher Holley of Cardiology has received an award from the American Heart Association for a project entitled "Bioactive sphingolipid signaling in cardiomyocyte mitophagy." Total funding will be $21,500.William S. Jones of Cardiology has received an award from the Doris Duke Charitable Foundation for a project entitled "DDCF 2016." Total funding will be $495,003.

Christopher Kontos of Cardiology has received an award from the American Heart Association for a project entitled "A Novel Molecular Regulator of Vascular Homeostasis." Total funding will be $77,000.

William E. Kraus of Cardiology has received an award (2P01-HL036587-25A1) from the National Institutes of Health for a project entitled "Gene x stress interactions' & responses to behavioral & drug interventions", a part of Redford B. Williams Jr.'s project entitled "Genes, environmental stressors, and the biobehavioral pathways to CVD." Total funding will be $398,343.

William E. Kraus of Cardiology has received an award (EP-16-D-000134) from the Environmental Protection Agency for a project entitled "Determine the Methylation Profile of DNA Samples." Total funding will be $144,000.

Gillian D. Schmidler of Cardiology has received an award from the Agency for Healthcare Research and Quality for a project entitled "Evidence-based Practice Centers (EPC) V TO 19 Post Myocardial Infraction Depression- Small." Total funding will be $255,000.

Svati H. Shah of Cardiology has received an award (2P01-HL036587-25A1) from the National Institutes of Health for a project entitled "Molecular mechanisms of gene x stress effects on pre-disease endophenotypes", a part of Redford B. Williams Jr.'s project entitled "Genes, environmental stressors, and the biobehavioral pathways to CVD." Total funding will be $441,544.

Mark N. Feinglos of Endocrinology, Metabolism, and Nutrition has received a sub-award through Wake Forest University School Of Medicine for a project entitled "Systolic Blood Pressure Interventional Trial (SPRINT)." Total funding will be $100,242.

Deborah Muoio of Endocrinology, Metabolism, and Nutrition has received an award from the Sanford-Burnham Medical Research Institute for a project entitled "Probing the role of Mitochondrial Short-Chain Carbon Homeostasis in the Hypertrophied and Failing Heart." Total funding will be $315,935.

Andrew J. Muir of Gastroenterology has received an award (2T32-DK007568-26) from the National Institutes of Health for a project entitled "Duke Training Grant in Digestive Diseases and Nutrition." Total funding will be $1,223,381.

Jeffrey Clough of General Internal Medicine has received an award from the American Heart Association for a project entitled "Variability in Clinician-Patient Risk Discussions for Using Statins in Primary Prevention and Association with Statin Prescription." Total funding will be $149,163.

Julia Gamble of General Internal Medicine has received an award from the Project Access of Durham County for a project entitled "Durham Medical Respite Pilot Program Expansion." Total funding will be $4,865.

Helene Vilme (Mentor: Leigh Boulware) of General Internal Medicine has received an award (3R01-DK098759-05S1) from the National Institutes of Health for a project entitled "Potential Barriers and Facilitators to Living Donor Kidney Transplantation Among Black Americans." Total funding will be $89,040.

Nelson J. Chao of Hematological Malignancies and Cellular Therapy has received an award from the Department of Health and Human Services for a project entitled "Point of Care Biodosimeter Option 5B." Total funding will be $6,900,000.

Deverick J. Anderson of Infectious Diseases has received an award (1U54-CK000483-01) from the Centers for Disease Control and Prevention for projects entitled “Core Project”, “Small Collaborative Project”, “Medium Collaborative Project”, and “Large Collaborative Project.”

Vance G. Fowler of Infectious Diseases has received a sub-award (U01-AI124319) through Harbor-UCLA Research and Education for a project entitled "Systems Immunobiology of Antibiotic-Persistent MRSA Infections." Total funding will be $612,110.

Greg Gray of Infectious Diseases has received an award from CRDF Global for a project entitled "One Health Training Program." Total funding will be $337,373.

Mehri McKellar of Infectious Diseases has received an award from the NC DHHS for a project entitled "Substance Abuse Center-5: Counseling, Testing and Referral in Durham, Caswell, Orange, Person and Wake." Total funding will be $75,000.

Mehri McKellar of Infectious Diseases has received an award from the NC Dept of Health and Human Services for a project entitled "Housing Opportunities for Persons with AIDS - Region Six." Total funding will be $28,076.

Mehri McKellar of Infectious Diseases has received an award from the NC Department of Health and Human Services for a project entitled "Housing Opportunities for Persons with AIDS - Region Seven." Total funding will be $75,489.

Nwora L. Okeke of Infectious Diseases has received an award from the Duke Clinical Research Institute for a project entitled "6510 HIV-HCV SWITCH (337-1834)." Total funding will be $36,168.

Nathan M. Thielman of Infectious Diseases has received a sub-award (R01MH106388) through the University of South Carolina for a project entitled "Does preference-based HIV testing increase uptake in high risk populations?" Total funding will be $564,877.

Brent A. Hanks of Medical Oncology has received an award from the Alliance for Cancer Gene Therapy for a project entitled "Metabolic Reprogramming of Dendritic Cell-based Cancer Vaccines to Enhance Anti-Tumor Immunity." Total funding will be $90,337.

Tian Zhang of Medical Oncology has received an award from the V Foundation for Cancer Research for a project entitled "Conditional lethality of copper and disulfiram as a therapeutic modality for prostate cancer." Total funding will be $400,000.

Matthew J. Ellis of Nephrology has received a sub-award (U01-MD010611) through Emory University for a project entitled "RaDIANT Community Study to Reduce Disparities in Access to Kidney Transplantation." Total funding will be $2,873.

Jamie L. Todd of Pulmonary, Allergy, and Critical Care Medicine has received an award (1K23-AI125670-01) from the National Institutes of Health for a project entitled "Immune Profiles to Better Understand Chronic Allograft Dysfunction and Successful Long-term Clinical Outcomes after Human Lung Transplantation." Total funding will be $835,465.

Virginia B. Kraus of Rheumatology and Immunology has received an award from the Arthritis Foundation for a project entitled "The Role of Low-Grade Endotoxemia in Osteoarthritis." Total funding will be $411,062.

Industry-sponsored Clinical Trials

Melvin R. Echols of Cardiology has received an award from Novartis Pharmaceuticals Corporation for a project entitled "CHAMP-HF." Total funding will be $173,000.

Gary M. Felker of Cardiology has received an award from Aries Pharmaceuticals for a project entitled "INDIE-HF-pEF." Total funding will be $105,700.

Christopher Granger of Cardiology has received an award through Harvard Pilgrim Health Care, Inc. for a project entitled "Sentinel." Total funding will be $134,035.

Christopher Granger of Cardiology has received an award from the Bristol-Myers Squibb Company for a project entitled "RENAL-AF Randomized Clinical Trial." Total funding will be $12,857,861.

Christopher Granger of Cardiology has received an award from Bayer Healthcare Pharmaceuticals Inc for a project entitled "BAY 1021189." Total funding will be $25,000.

John K. Harrison of Cardiology has received an award from Medtronic, Inc. for a project entitled "TAVR in Low Risk Patients." Total funding will be $430,964.

L. Kristin Newby of Cardiology has received an award from the Baseline Study LLC for a project entitled "The Baseline Study." Total funding will be $33,150,317.

Erik M. Ohman of Cardiology has received an award from Janssen Research & Development, LLC for a project entitled "GEMINI ACS 2: A Randomized, Double-blind, Double-dummy, Active-controlled, Parallel-group, Multicenter Study to Compare the Efficacy and Safety of Rivaroxaban versus Acetylsalicylic Acid in Addition ." Total funding will be $188,029.

Sudarshan Rajagopal of Cardiology has received an award from Eiger BioPharmaceuticals, Inc. for a project entitled "A phase 2, randomized, double-blind, placebo-controlled study of ubenimex in patients with pulmonary arterial hypertension (WHO Group 1) (LIBERTY)." Total funding will be $123,097.

Sydney G. Short of Cardiology has received an award from the Bristol-Myers Squibb Company for a project entitled "ELITE." Total funding will be $17,000.

Tracy Y. Wang of Cardiology has received an award from Novartis Pharmaceuticals Corporation for a project entitled "Novartis Rate Card Proposal 2." Total funding will be $158,400.

Tracy Y. Wang of Cardiology has received an award from Novartis Pharmaceuticals Corporation for a project entitled "Novartis Rate Card Proposal 1." Total funding will be $218,881.

Paul S. Jowell of Gastroenterology has received an award from KC Specialty Therapeutics for a project entitled "A Phase 1, Single Dose Pk And Safety Study With Ni-03 Followed By A Phase 2, Randomized, Double-Blind, Parallel-Group Dose-Ranging Study To Evaluate The Safety And Efficacy Of Ni-03 Compared To Placebo In Subjects With Chronic Pancreatis." Total funding will be $74,394.

Hayden B. Bosworth of General Internal Medicine has received an award from Improved Patient Outcomes, Inc. for a project entitled "Utilization of an innovative intervention to improve medication adherence and clinical outcomes in gout patients." Total funding will be $135,422.

Cathleen S. Colon-Emeric of Geriatrics has received an award from Amgen, Inc. for a project entitled "A Multicenter, International, Randomized, Double-blind, Alendronate-controlled Study to Determine the Efficacy and Safety of AMG 785 in the Treatment of Postmenopausal Women With Osteoporosis at High Risk for Fracture." Total funding will be $587,914.

Gowthami Arepally of Hematology has received an award from Pfizer, Inc. for a project entitled "Pfizer preceptorship." Total funding will be $25,000.

Ara D. Metjian of Hematology has received an award from Baxalta, Inc. for a project entitled "POST-MARKETING non-interventional safety evaluation of obizur in the treatment of bleeding episodes for patients with acquired hemophilia A." Total funding will be $25,959.

John Perfect of Infectious Diseases has received an award from Amplyx Pharmaceuticals, Inc. for a project entitled "APX001 with Fluconazole in a Murine Model of Cryptococcosis." Total funding will be $22,510.

Batu Sharma Kuinkel of Infectious Diseases has received an award from Allergan, Inc. for a project entitled "Elucidating the role of Ceftaroline Fosamil in the treatment of meningitis caused by Methicillin-Resistant Staphylococcs aureus using Rabbit model." Total funding will be $229,939.

Kimberly L. Blackwell of Medical Oncology has received an award from Merrimack Pharmaceuticals for a project entitled "A Randomized, Multicenter, Open Label Study of MM-302 plus Trastuzumab vs. Chemotherapy of Physician's Choice plus Trastuzumab in Anthracycline Naive Patients with Locally Advanced/Metastatic HER2-Positive Breast Cancer." Total funding will be $1,075,247.

Herbert I. Hurwitz of Medical Oncology has received an award from Regeneron Pharmaceuticals, Inc. for a project entitled "A Companion study for patient who completed participation in a REGN2810 study." Total funding will be $122,010.

Andrew B. Nixon of Medical Oncology has received an award from MedPacto, Inc for a project entitled "First-in-Human Dose-Expansion Study of TEW-7197 Monotherapy in Subjects with Advanced Stage Solid Tumors." Total funding will be $375,492.

John H. Strickler of Medical Oncology has received an award from AbbVie Inc. for a project entitled "A Multicenter, phase I open-label dose escalation study of ABBV-085 an antibody drug conjugated in subjects with advanced solid tumors." Total funding will be $456,273.

Shelby Reed of Other Medicine has received an award from Janssen Research & Development, LLC for a project entitled "Treatment Resistant Depression - US." Total funding will be $443,671.

Njira L. Lugogo of Pulmonary, Allergy, and Critical Care Medicine has received an award from AstraZeneca AB for a project entitled "D3250C00037 A multicenter, open-label, safety extension study with benralizumab (MEDI-563) for asthmatic adults on inhaled corticosteroid plus long-acting ss2 agonist (MELTEMI)." Total funding will be $247,674.

Njira L. Lugogo of Pulmonary, Allergy, and Critical Care Medicine has received an award from GlaxoSmithKline for a project entitled "A multi-centre, open label, single arm, 32-week treatment study in subjects with severe eosinophilic asthma not optimally controlled with current omalizumab treatment who are switched from omalizumab to mepolizumab 100 mg subcutaneous-the OSMO study." Total funding will be $92,586.

Momen Wahidi of Pulmonary, Allergy, and Critical Care Medicine has received an award from Veracyte, Inc. for a project entitled "Percepta R-1 Registry." Total funding will be $142,930.

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