Department of Medicine faculty have received notice of the following research, clinical trials, CME or other training awards.
[tabs style="vertical"][tab title="Sponsored research"]Robert M. Califf of Cardiology has received an award (1TL1-TR001116-01) from the National Institutes of Health for a project entitled "Duke CTSA (TL1)." Total funding will be $1,776,380.
Robert M. Califf of Cardiology has received an award (1KL2-TR001115-01) from the National Institutes of Health for a project entitled "Duke CTSA (KL2)." Total funding will be $5,093,759.
Robert M. Califf of Cardiology has received an award (1UL1-TR001117-01) from the National Institutes of Health for a project entitled "Duke CTSA (UL1)." Total funding will be $40,312,763.
Robert M. Califf of Cardiology has received an award (2KL2-TR000437-06A1) from the National Institutes of Health for a project entitled "Duke CTSA-KL2." Total funding will be $179,816.
Robert M. Califf of Cardiology has received an award (2UL1-TR000436-06A1) from the National Institutes of Health for a project entitled "Duke CTSA." Total funding will be $1,999,999.
Christopher Kontos of Cardiology has received an award (1R21-ES024029-01) from the National Institutes of Health for a project entitled "Tie2 Activation for the Treatment of Chemical-Induced Acute Lung Injury." Total funding will be $770,750.
James R. Bain of Endocrinology, Metabolism, and Nutrition has received a sub-award (1R01-DK095963-01A1) through Northwestern University for a project entitled "Maternal Obesity and Gestational Diabetes: Impact on the Metabolome." Total funding will be $262,568.
Matthew D. Hirschey of Endocrinology, Metabolism, and Nutrition has received an award from the Ellison Medical Foundation for a project entitled "SIRT5 Regulates Mitochondrial Metabolism in Aging and Disease." Total funding will be $398,148.
Wei Chen of Gastroenterology has received an award (1R01-CA172570-01A1) from the National Institutes of Health for a project entitled "Inhibition of Wnt/B-Catenin Signaling in Colorectal Cancer Therapy." Total funding will be $1,628,875.
Anna Mae Diehl of Gastroenterology has received an award (3U01-DK061713-12S1) from the National Institutes of Health for a project entitled "NASH Clinical Research Network." Total funding will be $88,447.
Anna Mae Diehl of Gastroenterology has received an award (3U01-DK061713-12S2) from the National Institutes of Health for a project entitled "NASH Clinical Research Network." Total funding will be $273,749.
Rodger A. Liddle of Gastroenterology has received an award (1R01-DK098796-01A1) from the National Institutes of Health for a project entitled "Receptor Regulation of CCK Cell Function." Total funding will be $1,365,900.
Heather E. Whitson of Geriatrics has received an award from the Alzheimer's Association for a project entitled "Novel Retinal Biomarkers for Early Detection of Alzheimer's Disease." Total funding will be $100,000.
John P. Chute of Hematological Malignancies and Cellular Therapy has received an award (HHSO100201000001C) from the Department of Health and Human Services for a project entitled "Point of Care Biodosimeter." Total funding will be $10,078,760.
Cristina Gasparetto of Hematological Malignancies and Cellular Therapy has received an award from the Multiple Myeloma Research Foundation for a project entitled "An Observational Study on Newly Diagnosed MM to assess the realtionship between patient outcomes, treatment regimens." Total funding will be $87,571.
Keith M. Sullivan of Hematological Malignancies and Cellular Therapy has received an award (HHSN272201100025C) from the National Institutes of Health for a project entitled "Scleroderma Cyclophosphamide or Transplantation (SCOT) Trial-Option 2." Total funding will be $852,758.
Mehri McKellar of Infectious Diseases has received an award from the Cape Fear Memorial Foundation for a project entitled "Bundled Testing and Patient navigation." Total funding will be $40,000.
Jason E. Stout of Infectious Diseases has received an award (200-2011-41276 Option 3) from the Centers for Disease Control and Prevention for a project entitled "Prospective Comparison of the Tuberculin Skin Test (TST) vs. Interferon Gamma Release Assays (IGRAs) in Diagnosing Latent Tuberculosis Infection (LTBI) and in Predicting Progression from LTBI to Active Tuberculosis Disease." Total funding will be $494,798.
Chris Woods of Infectious Diseases has received an award (HHSN272201300017I) from the National Institutes of Health for a project entitled "Vaccine and Treatment Evaluation Unit (VTEU)."
Amy P. Abernethy of Medical Oncology has received an award (1U24-NR014637-01) from the National Institutes of Health for a project entitled "Refinement and expansion of the Palliative Care Research Cooperative Group." Total funding will be $9,770,372.
Amy P. Abernethy of Medical Oncology has received a sub-award (1R18-HS021951-01) through the American Society of Clinical Oncology for a project entitled "Research Dissemination through the ASCO Virtual Learning Collaborative." Total funding will be $43,586.
Uptal Patel of Nephrology has received an award (1R01-DK093938-01A1) from the National Institutes of Health for a project entitled "Multi-factorial Intervention to Slow Progression of Diabetic Kidney Disease." Total funding will be $3,413,055.
Monica Kraft of Pulmonary, Allergy, and Critical Care Medicine has received a sub-award (5U01-AI095050-03) through the Baylor College of Medicine for a project entitled "Efficacy and Safety of Beta-adrenoceptor Inverse Agonist, Nadolol, In Mild Asthma (NIMA)." Total funding will be $96,260.
Peter S. Kussin of Pulmonary, Allergy, and Critical Care Medicine has received an award from the Cystic Fibrosis Foundation for a project entitled "Duke University Medical Center CFF Center Proposal 2013-2014-Project 2." Total funding will be $19,710.[/tab][tab title="Industry-sponsored clinical trials"]
John H. Alexander of Cardiology has received an award from CSL Limited for a project entitled "CSL112 in Adults with ST Segment Elevation - LOI." Total funding will be $184,417.
Pamela S. Douglas of Cardiology has received an award from Gilead Sciences, Inc. for a project entitled "GS-US-334-0154: Sofosbuvir+RBV HCV Infected Subjects with Renal Insufficiency." Total funding will be $424,548.
Eric L. Eisenstein of Cardiology has received an award from Aptus Endosystems, Inc. for a project entitled "ANCHOR Economics." Total funding will be $398,664.
Gary M. Felker of Cardiology has received an award from Novartis Pharmaceuticals Corporation for a project entitled "Phase III study to evaluate the efficacy, safety and tolerability of Serelaxin." Total funding will be $3,048,160.
Christopher Granger of Cardiology has received an award from Daiichi Sankyo Inc for a project entitled "DCRI Learn Daiichi." Total funding will be $58,271.
William S. Jones of Cardiology has received an award from Cardiovascular Systems Inc. for a project entitled "Prospective, Observational, Multi-Center Clinical Study to Evaluate Acute and Long Term Clinical and Economic Outcomes of Endovascular Device Intervention in Patients with Distal Outflow Peripheral Arterial Disease (PAD)." Total funding will be $65,261.
William E. Kraus of Cardiology has received an award from CardioDx for a project entitled "PROMISE CardioDX Ancillary Study." Total funding will be $1,005,083.
Mitchell W. Krucoff of Cardiology has received an award from Ikaria, Inc for a project entitled "Pulmonary Hypertension (PH) Associated With Chronic Pulmonary Disease." Total funding will be $109,220.
Chetan B. Patel of Cardiology has received an award from Roche Diagnostics for a project entitled "Guiding Evidence Based Therapy Using Biomarker Intensified Treatment in Heart Failure." Total funding will be $162,001.
Manesh R. Patel of Cardiology has received an award from Cardiovascular Systems Inc. for a project entitled "Multi-center Prospective Study to Evaluate Outcomes of Moderate to Severely Calcified Coronary Lesions (MACE)." Total funding will be $41,387.
Manesh R. Patel of Cardiology has received an award from Medtronic, Inc. for a project entitled "Renal Denervation in Patients with Uncontrolled Hypertension -SYMPLICITY HTN-4." Total funding will be $667,279.
Thomas J. Povsic of Cardiology has received an award from Cytori Therapeutics, Inc. for a project entitled "Adipose-derived regenerative cells in the Treatment of patients with chronic ischemic Heart disease Not Amenable to surgical or interventional revascularization." Total funding will be $623,773.
Joseph G. Rogers of Cardiology has received an award from Cleveland Heart, Inc for a project entitled "Cleveland Heart Institute Preliminary CRA." Total funding will be $250,000.
Ara D. Metjian of Hematology has received an award from Baxter Healthcare Corporation for a project entitled "A phase 3, prospective, open-label study to evaluate safety and efficacy of recombinant activated FVII BI (rFIIa BI) in the treatment of acute bleeding per an on-demand regimen in patients with hemophilia A or B with inhibitors." Total funding will be $52,110.
Vance G. Fowler Jr. of Infectious Diseases has received an award from the Forest Research Institute for a project entitled "Comparison of Subjects with Persistent Methicillin-Resistant Staphylococcus aureus Bacteremia treated with Ceftaroline Fosamil to Historical Controls not treated with Ceftaroline Fosamil." Total funding will be $129,901.
Mehri McKellar of Infectious Diseases has received an award from Gilead Sciences, Inc. for a project entitled "Phase 3, 2-part Study to Eval Efficacy of Tenofovir Alafenamide vs Placebo Added to Failing Regimen Followed by Treatment with Elvitegravir/Cobicistat/Emtricitabine/Tenofovir Alafenamide in HIV-1 Positive Antiretroviral Treatment-Experienced Adults." Total funding will be $108,510.
Cameron R. Wolfe of Infectious Diseases has received a sub-award (HHSN272200900001I ) through the Social & Scientific Systems, Inc. for a project entitled "A Randomized, Double-Blind, Phase II Study Comparing the Efficacy, Safety, and Tolerability of Combination Antivirals (Amantadine, Ribavirin, Oseltamivir) versus Oseltamivir for the Treatment of Influenza." Total funding will be $240,640.
Cameron R. Wolfe of Infectious Diseases has received a sub-award (HHSN-272200900001I-) through the Social & Scientific Systems, Inc. for a project entitled "IRC 004 A Randomized, Double-Blind Study Comparing Oseltamivir versus Placebo for the Treatment of Influenza in Low Risk Adults." Total funding will be $160,000.
Chris Woods of Infectious Diseases has received an award from the Cempra Pharmaceuticals, Inc. for a project entitled "Efficacy and Safety of Oral Solithromycin Compared to Oral Moxifloxacin in CAB Pneumonia." Total funding will be $282,403.
Amy P. Abernethy of Medical Oncology has received an award from the Opus Science for a project entitled "Assessing Variability in Multiple Myeloma Management:." Total funding will be $110,000.
Amy P. Abernethy of Medical Oncology has received an award from the GlaxoSmithKline for a project entitled "Retrospective Melanoma Registry." Total funding will be $200,050.
Jeffrey Crawford of Medical Oncology has received an award from the MedImmune, Inc. for a project entitled "A phase 2, randomized, double-blind study comparing Tremelimumab to placebo in Second- or third-line treatment of subjects with unresectable pleural or peritoneal malignant mesothelioma." Total funding will be $447,256.
Daniel J. George of Medical Oncology has received an award from the Janssen Pharmaceutica, Inc. for a project entitled "ABI-RACE: A Phase II Open Label, Parallel group study of Abiraterone Acetate in African American and Caucasian Men with Metastic Castrate Resistant Prostate Cancer." Total funding will be $747,288.
Daniel J. George of Medical Oncology has received an award from the Exelixis, Inc for a project entitled "A Phase 3, Randomized, Controlled Study of Cabozantinib (XL184) vs Everolimus in Subjects with Metastatic Renal Cell Carcinoma that has Progressed after Prior VEGFR Tyrosine Kinase Inhibitor Therapy." Total funding will be $294,867.
Daniel J. George of Medical Oncology has received an award from the Viamet Pharmaceuticals for a project entitled "A Phase 1/2 Open-Label, Multiple-Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of VT-464 in Chemotherapy-Naive Patients with Castration-Refractory Prostate Cancer." Total funding will be $273,032.
Brent A. Hanks of Medical Oncology has received an award from the Incyte Corporation for a project entitled "A phase 1 / 2 randomized, blinded, placebo controlled study of Ipilimumab in combination with INCB024360 or placebo in unresectable or metastatic melanoma." Total funding will be $321,214.
P. Kelly Marcom of Medical Oncology has received an award from the Novartis Pharmaceuticals Corporation for a project entitled "Novartis MSL Practicum: Modules for Breast Cancer, Lung Cancer, Melanoma, & Renal Cell Cancer." Total funding will be $77,600.
Michael A. Morse of Medical Oncology has received an award from the Bristol-Myers Squibb Company for a project entitled "A phase I/2 open label study of Nivolumab monotherapy or Nivolmab combined with Ipilmumab in subjects with advanced or metastatic solid tumors." Total funding will be $260,922.
Fatima A. Rangwala of Medical Oncology has received an award from the Eisai, Inc. for a project entitled "A multicenter rendomized open label phase 3 trial to compare the efficacy and safety of Lenvatinib versus Sorafenib in first line treatment of subject with unresectable hepatocellular carcinoma." Total funding will be $256,176.
Neal E. Ready of Medical Oncology has received an award from Genentech, Inc. for a project entitled "A phase II, multicenter, single-arm study of MPDL3280A in patients with advanced PD-L1_positive Locally advanced or Metastatic non-small cell lung cancer." Total funding will be $4,986,946.
John P. Middleton of Nephrology has received an award from Bristol-Myers Squibb for a project entitled "BMS CV202-010-0055." Total funding will be $43,978.
Momen Wahidi of Pulmonary, Allergy, and Critical Care Medicine has received an award from Pulmonx for a project entitled "Lung Function Improvement after Bronchoscopic Lung Volume Reduction with Pulmonx Endobronchial Valves used in Treatment of Emphysema (LIBERATE STUDY)." Total funding will be $762,692.[/tab]
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