Strouse Clinical Research Program in Sickle Cell Disease

Principal Investigator

John J. Strouse

Associate Professor of Medicine
Associate Professor in the Department of Pediatrics

Principal Investigator

John J. Strouse

Associate Professor of Medicine
Associate Professor in the Department of Pediatrics

Contact Information

Campus Mail
DUMC Box 3939

Physical Address
315 Trent Drive, Hanes 267
Durham, NC 27710

Phone
Office: 919-684-0628
Fax: 919-681-6174
Pager: 919-970-6081

Email
john.strouse@duke.edu

Education

Undergraduate
1987 – 1991 A.B. in Ecology and Evolutionary Biology, Princeton University, Princeton, NJ.

High honors in Ecology and Evolutionary Biology.

Met requirements for major in Molecular, Cell, and Developmental Biology.

Doctoral/Graduate
1992 – 1996 M.D., Johns Hopkins University School of Medicine, Baltimore, MD

2002 – 2009 Ph.D. in Clinical Investigation, Johns Hopkins University School of Public Health, Baltimore, MD

Postdoctoral
1996 – 2000 Resident, Combined Internal Medicine/Pediatrics Program, University of Rochester, Rochester, Rochester, NY

2000 – 2004 Fellow in Hematology, National Institutes of Health (NHLBI), Bethesda, MD

2001 – 2004 Fellow in Pediatric Oncology, NIH (NCI), Bethesda, MD

2001 – 2004 Fellow in Pediatric Hematology/Oncology, Johns Hopkins Univ., Baltimore, MD

Principal Investigator

John J. Strouse

Associate Professor of Medicine
Associate Professor in the Department of Pediatrics

Contact Information

Campus Mail
DUMC Box 3939

Physical Address
315 Trent Drive, Hanes 267
Durham, NC 27710

Phone
Office: 919-684-0628
Fax: 919-681-6174
Pager: 919-970-6081

Email
john.strouse@duke.edu

Education

Undergraduate
1987 – 1991 A.B. in Ecology and Evolutionary Biology, Princeton University, Princeton, NJ.

High honors in Ecology and Evolutionary Biology.

Met requirements for major in Molecular, Cell, and Developmental Biology.

Doctoral/Graduate
1992 – 1996 M.D., Johns Hopkins University School of Medicine, Baltimore, MD

2002 – 2009 Ph.D. in Clinical Investigation, Johns Hopkins University School of Public Health, Baltimore, MD

Postdoctoral
1996 – 2000 Resident, Combined Internal Medicine/Pediatrics Program, University of Rochester, Rochester, Rochester, NY

2000 – 2004 Fellow in Hematology, National Institutes of Health (NHLBI), Bethesda, MD

2001 – 2004 Fellow in Pediatric Oncology, NIH (NCI), Bethesda, MD

2001 – 2004 Fellow in Pediatric Hematology/Oncology, Johns Hopkins Univ., Baltimore, MD

Overview

Current Studies

1. Retrospective and prospective cohorts of children and adults with sickle cell disease to study stroke, silent cerebral infarct, and cognitive impairment.

2. The lab is optimizing pseudo continuous arterial spin labeled MRI to measure cerebral blood flow as a potential predictor of risk of future stroke and silent cerebral infarct in adults with sickle cell disease and stroke.

We also are evaluating the association between tobacco smoke and other environmental exposure and the severity of sickle cell disease in children and adults.

Dr. Strouse is on the Executive Committee and a co-investigator on the HU Prevent Study, a randomized controlled trial of hydroxyurea vs. placebo for the primary prevention of conditional or abnormal transcranial Doppler ultrasound, silent cerebral infarct, and stroke in children 12 to 48 months old with sickle cell anemia