Allison Elizabeth Ashley-Koch, PhD

Professor in Medicine
Professor in Biostatistics and Bioinformatics
Research Professor in Molecular Genetics and Microbiology
Faculty Network Member of the Duke Institute for Brain Sciences
Affiliate of the Center for Child and Family Policy
Member of Duke Molecular Physiology Institute
Campus mail 300 N Duke St., Durham, NC 27701
Phone (919) 684-1805
Email address allison.ashleykoch@duke.edu

One of my major research foci is in the genetic basis of psychiatric and neurological disorders. I am currently involved in studies to dissect the genetic etiology of attention deficit hyperactivity disorder (ADHD), autism, chiari type I malformations, essential tremor, and neural tube defects. Additional research foci include genetic modifiers of sickle cell disease, and genetic contributions to birth outcomes, particularly among African American women.

Education and Training

  • Ph.D., Emory University, 1997

Publications

Zekavat, SM, Ruotsalainen, S, Handsaker, RE, Alver, M, Bloom, J, Poterba, T, Seed, C, Ernst, J, Chaffin, M, Engreitz, J, Peloso, GM, Manichaikul, A, Yang, C, Ryan, KA, Fu, M, Johnson, WC, Tsai, M, Budoff, M, Ramachandran, VS, Cupples, LA, Rotter, JI, Rich, SS, Post, W, Mitchell, BD, Correa, A, Metspalu, A, Wilson, JG, Salomaa, V, Kellis, M, Daly, MJ, Neale, BM, McCarroll, S, Surakka, I, Esko, T, Ganna, A, Ripatti, S, Kathiresan, S, and Natarajan, P. "Deep coverage whole genome sequences and plasma lipoprotein(a) in individuals of European and African ancestries(Published online)." Nature Communications 9, no. 1 (December 2018).

Full Text

Wolf, EJ, Maniates, H, Nugent, N, Maihofer, AX, Armstrong, D, Ratanatharathorn, A, Ashley-Koch, AE, Garrett, M, Kimbrel, NA, Lori, A, Va Mid-Atlantic Mirecc Workgroup, , Aiello, AE, Baker, DG, Beckham, JC, Boks, MP, Galea, S, Geuze, E, Hauser, MA, Kessler, RC, Koenen, KC, Miller, MW, Ressler, KJ, Risbrough, V, Rutten, BPF, Stein, MB, Ursano, RJ, Vermetten, E, Vinkers, CH, Uddin, M, Smith, AK, Nievergelt, CM, and Logue, MW. "Traumatic stress and accelerated DNA methylation age: A meta-analysis." Psychoneuroendocrinology 92 (June 2018): 123-134.

PMID
29452766
Full Text

Gelineau-Van Waes, J, Riley, RT, Voss, K, Ashley-Koch, A, Gregory, S, Moseley, A, Soderblom, E, Maddox, J, and Merritt, N. "Fumonisin B1 (FB1) and Fingolimod (FTY720): Tortilla Toxin and Oral Therapeutic Target Sphingolipid Pathways during Neural Tube Closure.": WILEY, May 15, 2018.

Scholars@Duke

Gelineau-Van Waes, J, Riley, RT, Voss, K, Ashley-Koch, A, Gregory, S, Moseley, A, Soderblom, E, Maddox, J, and Merritt, N. "Fumonisin B1 (FB1) and Fingolimod (FTY720): Tortilla Toxin and Oral Therapeutic Target Sphingolipid Pathways during Neural Tube Closure.": WILEY, May 15, 2018.

Scholars@Duke

Nievergelt, CM, Ashley-Koch, AE, Dalvie, S, Hauser, MA, Morey, RA, Smith, AK, and Uddin, M. "Genomic Approaches to Posttraumatic Stress Disorder: The Psychiatric Genomic Consortium Initiative." Biological Psychiatry 83, no. 10 (May 2018): 831-839. (Review)

PMID
29555185
Full Text

Duncan, LE, Ratanatharathorn, A, Aiello, AE, Almli, LM, Amstadter, AB, Ashley-Koch, AE, Baker, DG, Beckham, JC, Bierut, LJ, Bisson, J, Bradley, B, Chen, C-Y, Dalvie, S, Farrer, LA, Galea, S, Garrett, ME, Gelernter, JE, Guffanti, G, Hauser, MA, Johnson, EO, Kessler, RC, Kimbrel, NA, King, A, Koen, N, Kranzler, HR, Logue, MW, Maihofer, AX, Martin, AR, Miller, MW, Morey, RA, Nugent, NR, Rice, JP, Ripke, S, Roberts, AL, Saccone, NL, Smoller, JW, Stein, DJ, Stein, MB, Sumner, JA, Uddin, M, Ursano, RJ, Wildman, DE, Yehuda, R, Zhao, H, Daly, MJ, Liberzon, I, Ressler, KJ, Nievergelt, CM, and Koenen, KC. "Largest GWAS of PTSD (N=20 070) yields genetic overlap with schizophrenia and sex differences in heritability." Molecular Psychiatry 23, no. 3 (March 2018): 666-673.

PMID
28439101
Full Text

Carnes, MU, Allingham, RR, Ashley-Koch, A, and Hauser, MA. "Transcriptome analysis of adult and fetal trabecular meshwork, cornea, and ciliary body tissues by RNA sequencing." Experimental Eye Research 167 (February 2018): 91-99.

PMID
27914989
Full Text

Bailey, JNC, Gharahkhani, P, Kang, JH, Butkiewicz, M, Sullivan, DA, Weinreb, RN, Aschard, H, Allingham, RR, Ashley-Koch, A, Lee, RK, Moroi, SE, Brilliant, MH, Wollstein, G, Schuman, JS, Fingert, JH, Budenz, DL, Realini, T, Gaasterland, T, Scott, WK, Singh, K, Sit, AJ, Igo, RP, Song, YE, Hark, L, Ritch, R, Rhee, DJ, Vollrath, D, Zack, DJ, Medeiros, F, Vajaranant, TS, Chasman, DI, Christen, WG, Pericak-Vance, MA, Liu, Y, Kraft, P, Richards, JE, Rosner, BA, Hauser, MA, Craig, JE, and Burdon, KP et al. "Testosterone Pathway Genetic Polymorphisms in Relation to Primary Open-Angle Glaucoma: An Analysis in Two Large Datasets." Investigative ophthalmology & visual science 59, no. 2 (February 2018): 629-636.

PMID
29392307
Full Text

Bundy, JL, Anderson, BR, Francescatto, L, Garrett, ME, Soldano, KL, Telen, MJ, Davis, EE, and Ashley-Koch, AE. "RNA-Sequencing of Isolated Cell Populations Expressing Human APOL1 Risk Variants Reveals Molecular Correlates of Sickle Cell Nephropathy in Zebrafish Podocytes." 59th Annual Meeting of the American-Society-of-Hematology (ASH). Atlanta, GA. December 9, 2017 - December 12, 2017.: AMER SOC HEMATOLOGY, December 7, 2017.

Scholars@Duke

Morey, RA, Davis, SL, Garrett, ME, Haswell, CC, Mid-Atlantic MIRECC Workgroup, , Marx, CE, Beckham, JC, McCarthy, G, Hauser, MA, and Ashley-Koch, AE. "Genome-wide association study of subcortical brain volume in PTSD cases and trauma-exposed controls." Translational Psychiatry 7, no. 11 (November 30, 2017): 1265-null.

PMID
29187748
Full Text

Pages