Allison Elizabeth Ashley-Koch, PhD

Professor in Medicine
Professor in Biostatistics and Bioinformatics
Research Professor in Molecular Genetics and Microbiology
Faculty Network Member of the Duke Institute for Brain Sciences
Affiliate of the Center for Child and Family Policy
Member of Duke Molecular Physiology Institute
Campus mail 300 N Duke St., Durham, NC 27701
Phone (919) 684-1805
Email address allison.ashleykoch@duke.edu

One of my major research foci is in the genetic basis of psychiatric and neurological disorders. I am currently involved in studies to dissect the genetic etiology of attention deficit hyperactivity disorder (ADHD), autism, chiari type I malformations, essential tremor, and neural tube defects. Additional research foci include genetic modifiers of sickle cell disease, and genetic contributions to birth outcomes, particularly among African American women.

Education and Training

  • Ph.D., Emory University, 1997

Publications

Nievergelt, CM, Ashley-Koch, AE, Dalvie, S, Hauser, MA, Morey, RA, Smith, AK, and Uddin, M. "Genomic Approaches to Posttraumatic Stress Disorder: The Psychiatric Genomic Consortium Initiative. (Accepted)" Biological psychiatry 83, no. 10 (May 2018): 831-839. (Review)

PMID
29555185
Full Text

Duncan, LE, Ratanatharathorn, A, Aiello, AE, Almli, LM, Amstadter, AB, Ashley-Koch, AE, Baker, DG, Beckham, JC, Bierut, LJ, Bisson, J, Bradley, B, Chen, C-Y, Dalvie, S, Farrer, LA, Galea, S, Garrett, ME, Gelernter, JE, Guffanti, G, Hauser, MA, Johnson, EO, Kessler, RC, Kimbrel, NA, King, A, Koen, N, Kranzler, HR, Logue, MW, Maihofer, AX, Martin, AR, Miller, MW, Morey, RA, Nugent, NR, Rice, JP, Ripke, S, Roberts, AL, Saccone, NL, Smoller, JW, Stein, DJ, Stein, MB, Sumner, JA, and Uddin, M et al. "Largest GWAS of PTSD (N=20 070) yields genetic overlap with schizophrenia and sex differences in heritability." Molecular psychiatry 23, no. 3 (March 2018): 666-673.

PMID
28439101
Full Text

Bailey, JNC, Gharahkhani, P, Kang, JH, Butkiewicz, M, Sullivan, DA, Weinreb, RN, Aschard, H, Allingham, RR, Ashley-Koch, A, Lee, RK, Moroi, SE, Brilliant, MH, Wollstein, G, Schuman, JS, Fingert, JH, Budenz, DL, Realini, T, Gaasterland, T, Scott, WK, Singh, K, Sit, AJ, Igo, RP, Song, YE, Hark, L, Ritch, R, Rhee, DJ, Vollrath, D, Zack, DJ, Medeiros, F, Vajaranant, TS, Chasman, DI, Christen, WG, Pericak-Vance, MA, Liu, Y, Kraft, P, Richards, JE, Rosner, BA, Hauser, MA, Craig, JE, and Burdon, KP et al. "Testosterone Pathway Genetic Polymorphisms in Relation to Primary Open-Angle Glaucoma: An Analysis in Two Large Datasets." Investigative ophthalmology & visual science 59, no. 2 (February 2018): 629-636.

PMID
29392307
Full Text

Wolf, EJ, Maniates, H, Nugent, N, Maihofer, AX, Armstrong, D, Ratanatharathorn, A, Ashley-Koch, AE, Garrett, M, Kimbrel, NA, Lori, A, Va Mid-Atlantic Mirecc Workgroup, , Aiello, AE, Baker, DG, Beckham, JC, Boks, MP, Galea, S, Geuze, E, Hauser, MA, Kessler, RC, Koenen, KC, Miller, MW, Ressler, KJ, Risbrough, V, Rutten, BPF, Stein, MB, Ursano, RJ, Vermetten, E, Vinkers, CH, Uddin, M, Smith, AK, Nievergelt, CM, and Logue, MW. "Traumatic stress and accelerated DNA methylation age: A meta-analysis." Psychoneuroendocrinology (December 27, 2017).

PMID
29452766
Full Text

Morey, RA, Davis, SL, Garrett, ME, Haswell, CC, Mid-Atlantic MIRECC Workgroup, , Marx, CE, Beckham, JC, McCarthy, G, Hauser, MA, and Ashley-Koch, AE. "Genome-wide association study of subcortical brain volume in PTSD cases and trauma-exposed controls." Translational psychiatry 7, no. 11 (November 30, 2017): 1265-.

PMID
29187748
Full Text

Polimanti, R, Amstadter, AB, Stein, MB, Almli, LM, Baker, DG, Bierut, LJ, Bradley, B, Farrer, LA, Johnson, EO, King, A, Kranzler, HR, Maihofer, AX, Rice, JP, Roberts, AL, Saccone, NL, Zhao, H, Liberzon, I, Nievergelt, CM, Koenen, KC, Gelernter, J, Duncan, LE, Chen, CY, Ratanatharathorn, A, Aiello, AE, Ashley-Koch, AE, Garrett, ME, Hauser, MA, Beckham, JC, Kimbrel, NA, Bisson, J, Dalvie, S, Galea, S, Gelernter, JE, Guffanti, G, Ressler, KJ, Kessler, RC, Koen, N, Stein, DJ, Logue, MW, and Miller, MW et al. "A putative causal relationship between genetically determined female body shape and posttraumatic stress disorder." Genome Medicine 9, no. 1 (November 27, 2017).

Full Text

Aschard, H, Kang, JH, Iglesias, AI, Hysi, P, Cooke Bailey, JN, Khawaja, AP, Allingham, RR, Ashley-Koch, A, Lee, RK, Moroi, SE, Brilliant, MH, Wollstein, G, Schuman, JS, Fingert, JH, Budenz, DL, Realini, T, Gaasterland, T, Scott, WK, Singh, K, Sit, AJ, Igo, RP, Song, YE, Hark, L, Ritch, R, Rhee, DJ, Gulati, V, Haven, S, Vollrath, D, Zack, DJ, Medeiros, F, Weinreb, RN, Cheng, C-Y, Chasman, DI, Christen, WG, Pericak-Vance, MA, Liu, Y, Kraft, P, Richards, JE, Rosner, BA, and Hauser, MA et al. "Genetic correlations between intraocular pressure, blood pressure and primary open-angle glaucoma: a multi-cohort analysis." European journal of human genetics : EJHG 25, no. 11 (November 2017): 1261-1267.

PMID
28853718
Full Text

Smith, A, Ratanatharathorn, A, Boks, M, Logue, M, Maihofer, A, Kilaru, V, Stein, M, Vermetten, E, Koenen, K, Aiello, A, Baker, D, Hauser, M, Kimbrel, N, Ashley-Koch, A, Luft, B, Bromet, E, Miller, M, Ressler, K, Uddin, M, and Nievergelt, C. "Meta-Analysis of DNA Methylation and PTSD in the Psychiatric Genomics Consortium PTSD Epigenetics Workgroup." November 2017.

Scholars@Duke

Grotegut, CA, Ngan, E, Garrett, ME, Miranda, ML, Ashley-Koch, AE, and Swamy, GK. "The association of single-nucleotide polymorphisms in the oxytocin receptor and G protein-coupled receptor kinase 6 (GRK6) genes with oxytocin dosing requirements and labor outcomes." American journal of obstetrics and gynecology 217, no. 3 (September 2017): 367.e1-367.e9.

PMID
28526450
Full Text

Ratanatharathorn, A, Boks, MP, Maihofer, AX, Aiello, AE, Amstadter, AB, Ashley-Koch, AE, Baker, DG, Beckham, JC, Bromet, E, Dennis, M, Garrett, ME, Geuze, E, Guffanti, G, Hauser, MA, Kilaru, V, Kimbrel, NA, Koenen, KC, Kuan, P-F, Logue, MW, Luft, BJ, Miller, MW, Mitchell, C, Nugent, NR, Ressler, KJ, Rutten, BPF, Stein, MB, Vermetten, E, Vinkers, CH, Youssef, NA, VA Mid-Atlantic MIRECC Workgroup, , PGC PTSD Epigenetics Workgroup, , Uddin, M, Nievergelt, CM, and Smith, AK. "Epigenome-wide association of PTSD from heterogeneous cohorts with a common multi-site analysis pipeline." American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 174, no. 6 (September 2017): 619-630.

PMID
28691784
Full Text

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