Allison Elizabeth Ashley-Koch, PhD

Professor in Medicine
Professor in Biostatistics and Bioinformatics
Research Professor in Molecular Genetics and Microbiology
Faculty Network Member of the Duke Institute for Brain Sciences
Affiliate of the Center for Child and Family Policy
Member of Duke Molecular Physiology Institute
Campus mail 300 N Duke St., Durham, NC 27701
Phone (919) 684-1805
Email address allison.ashleykoch@duke.edu

One of my major research foci is in the genetic basis of psychiatric and neurological disorders. I am currently involved in studies to dissect the genetic etiology of attention deficit hyperactivity disorder (ADHD), autism, chiari type I malformations, essential tremor, and neural tube defects. Additional research foci include genetic modifiers of sickle cell disease, and genetic contributions to birth outcomes, particularly among African American women.

Education and Training

  • Ph.D., Emory University, 1997

Publications

Aschard, H, Kang, JH, Iglesias, AI, Hysi, P, Cooke Bailey, JN, Khawaja, AP, Allingham, RR, Ashley-Koch, A, Lee, RK, Moroi, SE, Brilliant, MH, Wollstein, G, Schuman, JS, Fingert, JH, Budenz, DL, Realini, T, Gaasterland, T, Scott, WK, Singh, K, Sit, AJ, Igo, RP, Song, YE, Hark, L, Ritch, R, Rhee, DJ, Gulati, V, Haven, S, Vollrath, D, Zack, DJ, Medeiros, F, Weinreb, RN, Cheng, C-Y, Chasman, DI, Christen, WG, Pericak-Vance, MA, Liu, Y, Kraft, P, Richards, JE, Rosner, BA, and Hauser, MA et al. "Genetic correlations between intraocular pressure, blood pressure and primary open-angle glaucoma: a multi-cohort analysis." European journal of human genetics : EJHG 25, no. 11 (November 2017): 1261-1267.

PMID
28853718
Full Text

Grotegut, CA, Ngan, E, Garrett, ME, Miranda, ML, Ashley-Koch, AE, and Swamy, GK. "The association of single-nucleotide polymorphisms in the oxytocin receptor and G protein-coupled receptor kinase 6 (GRK6) genes with oxytocin dosing requirements and labor outcomes." American journal of obstetrics and gynecology 217, no. 3 (September 2017): 367.e1-367.e9.

PMID
28526450
Full Text

Ratanatharathorn, A, Boks, MP, Maihofer, AX, Aiello, AE, Amstadter, AB, Ashley-Koch, AE, Baker, DG, Beckham, JC, Bromet, E, Dennis, M, Garrett, ME, Geuze, E, Guffanti, G, Hauser, MA, Kilaru, V, Kimbrel, NA, Koenen, KC, Kuan, P-F, Logue, MW, Luft, BJ, Miller, MW, Mitchell, C, Nugent, NR, Ressler, KJ, Rutten, BPF, Stein, MB, Vermetten, E, Vinkers, CH, Youssef, NA, VA Mid-Atlantic MIRECC Workgroup, , PGC PTSD Epigenetics Workgroup, , Uddin, M, Nievergelt, CM, and Smith, AK. "Epigenome-wide association of PTSD from heterogeneous cohorts with a common multi-site analysis pipeline." American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 174, no. 6 (September 2017): 619-630.

PMID
28691784
Full Text

Duncan, LE, Ratanatharathorn, A, Aiello, AE, Almli, LM, Amstadter, AB, Ashley-Koch, AE, Baker, DG, Beckham, JC, Bierut, LJ, Bisson, J, Bradley, B, Chen, C-Y, Dalvie, S, Farrer, LA, Galea, S, Garrett, ME, Gelernter, JE, Guffanti, G, Hauser, MA, Johnson, EO, Kessler, RC, Kimbrel, NA, King, A, Koen, N, Kranzler, HR, Logue, MW, Maihofer, AX, Martin, AR, Miller, MW, Morey, RA, Nugent, NR, Rice, JP, Ripke, S, Roberts, AL, Saccone, NL, Smoller, JW, Stein, DJ, Stein, MB, Sumner, JA, and Uddin, M et al. "Largest GWAS of PTSD (N=20 070) yields genetic overlap with schizophrenia and sex differences in heritability." Molecular psychiatry (April 25, 2017).

PMID
28439101
Full Text

Jacob, SA, Novelli, EM, Isenberg, JS, Garrett, ME, Chu, Y, Soldano, K, Ataga, KI, Telen, MJ, Ashley-Koch, A, Gladwin, MT, Zhang, Y, and Kato, GJ. "Thrombospondin-1 gene polymorphism is associated with estimated pulmonary artery pressure in patients with sickle cell anemia." American journal of hematology 92, no. 3 (March 2017): E31-E34. (Letter)

PMID
28033687
Full Text

Tan, PL, Garrett, ME, Willer, JR, Campochiaro, PA, Campochiaro, B, Zack, DJ, Ashley-Koch, AE, and Katsanis, N. "Systematic Functional Testing of Rare Variants: Contributions of CFI to Age-Related Macular Degeneration." Investigative ophthalmology & visual science 58, no. 3 (March 2017): 1570-1576.

PMID
28282489
Full Text

Taylor, WD, Boyd, B, Turner, R, McQuoid, DR, Ashley-Koch, A, MacFall, JR, Saleh, A, and Potter, GG. "APOE ε4 associated with preserved executive function performance and maintenance of temporal and cingulate brain volumes in younger adults." Brain imaging and behavior 11, no. 1 (February 2017): 194-204.

PMID
26843007
Full Text

Pasquale, LR, Aschard, H, Kang, JH, Bailey, JNC, Lindström, S, Chasman, DI, Christen, WG, Allingham, RR, Ashley-Koch, A, Lee, RK, Moroi, SE, Brilliant, MH, Wollstein, G, Schuman, JS, Fingert, J, Budenz, DL, Realini, T, Gaasterland, T, Gaasterland, D, Scott, WK, Singh, K, Sit, AJ, Igo, RP, Song, YE, Hark, L, Ritch, R, Rhee, DJ, Gulati, V, Havens, S, Vollrath, D, Zack, DJ, Medeiros, F, Weinreb, RN, Pericak-Vance, MA, Liu, Y, Kraft, P, Richards, JE, Rosner, BA, Hauser, MA, Haines, JL, and Wiggs, JL. "Age at natural menopause genetic risk score in relation to age at natural menopause and primary open-angle glaucoma in a US-based sample." Menopause (New York, N.Y.) 24, no. 2 (February 2017): 150-156.

PMID
27760082
Full Text

Hauser, MA, Garrett, ME, Liu, Y, Dennis, MF, Kimbrel, NA, Veterans Affairs Mid-Atlantic Mental Illness Research Education And Clinical Center Workgroup, , Beckham, JC, and Ashley-Koch, AE. "Further evidence for a role of the ADRB2 gene in risk for posttraumatic stress disorder." Journal of psychiatric research 84 (January 2017): 59-61.

PMID
27701011
Full Text

Jacob, SA, Novelli, EM, Isenberg, JS, Garrett, ME, Chu, Y, Soldano, KL, Ataga, KI, Telen, MJ, Ashley-Koch, AE, Zhang, Y, and Kato, GJ. "Thrombospondin-1 Polymorphisms Are Associated with Chronic Kidney Disease in Sickle Cell Anemia." December 2, 2016.

Scholars@Duke

Pages