Allison Elizabeth Ashley-Koch, PhD

Professor in Medicine
Research Professor in Molecular Genetics and Microbiology
Professor in Biostatistics and Bioinformatics
Faculty Network Member of the Duke Institute for Brain Sciences
Affiliate of the Center for Child and Family Policy
Member of Duke Molecular Physiology Institute
Campus mail 300 N Duke St., Durham, NC 27701
Phone (919) 684-1805
Email address allison.ashleykoch@duke.edu

One of my major research foci is in the genetic basis of psychiatric and neurological disorders. I am currently involved in studies to dissect the genetic etiology of attention deficit hyperactivity disorder (ADHD), autism, chiari type I malformations, essential tremor, and neural tube defects. Additional research foci include genetic modifiers of sickle cell disease, and genetic contributions to birth outcomes, particularly among African American women.

Education and Training

  • Ph.D., Emory University, 1997

Publications

Kimbrel, Nathan A., Allison E. Ashley-Koch, Xue J. Qin, Jennifer H. Lindquist, Melanie E. Garrett, Michelle F. Dennis, Lauren P. Hair, et al. “A genome-wide association study of suicide attempts in the million veterans program identifies evidence of pan-ancestry and ancestry-specific risk loci.” Mol Psychiatry, March 28, 2022. https://doi.org/10.1038/s41380-022-01472-3.

PMID
35347246
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Liggett, L Alexander, Liam D. Cato, Joshua S. Weinstock, Yingze Zhang, S Mehdi Nouraie, Mark T. Gladwin, Melanie E. Garrett, et al. “Clonal hematopoiesis in sickle cell disease.” J Clin Invest 132, no. 4 (February 15, 2022). https://doi.org/10.1172/JCI156060.

PMID
34990411
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Zheng, Yuanchao, Melanie E. Garrett, Delin Sun, Emily K. Clarke-Rubright, Courtney C. Haswell, Adam X. Maihofer, Jeremy A. Elman, et al. “Trauma and posttraumatic stress disorder modulate polygenic predictors of hippocampal and amygdala volume.” Transl Psychiatry 11, no. 1 (December 16, 2021): 637. https://doi.org/10.1038/s41398-021-01707-x.

PMID
34916497
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Gamache, J., J. Barrera, D. Gingerich, M. Garrett, D. Chipman, H. Fradin, A. Ashley-Koch, G. Crawford, and O. Chiba-Falek. “Parallel single-nucleus chromatin accessibility and transcriptomic profiling of human late-onset Alzheimer's disease brains.” Alzheimer’S &Amp; Dementia : The Journal of the Alzheimer’S Association 17 (December 1, 2021): e057261. https://doi.org/10.1002/alz.057261.

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Luo, Yang, Masahiro Kanai, Wanson Choi, Xinyi Li, Saori Sakaue, Kenichi Yamamoto, Kotaro Ogawa, et al. “Author Correction: A high-resolution HLA reference panel capturing global population diversity enables multi-ancestry fine-mapping in HIV host response.” Nat Genet 53, no. 12 (December 2021): 1722. https://doi.org/10.1038/s41588-021-00979-9.

PMID
34728834
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Luo, Yang, Masahiro Kanai, Wanson Choi, Xinyi Li, Saori Sakaue, Kenichi Yamamoto, Kotaro Ogawa, et al. “A high-resolution HLA reference panel capturing global population diversity enables multi-ancestry fine-mapping in HIV host response.” Nat Genet 53, no. 10 (October 2021): 1504–16. https://doi.org/10.1038/s41588-021-00935-7.

PMID
34611364
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Cade, Brian E., Jiwon Lee, Tamar Sofer, Heming Wang, Man Zhang, Han Chen, Sina A. Gharib, et al. “Whole-genome association analyses of sleep-disordered breathing phenotypes in the NHLBI TOPMed program.” Genome Med 13, no. 1 (August 26, 2021): 136. https://doi.org/10.1186/s13073-021-00917-8.

PMID
34446064
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Barrera, Julio, Lingyun Song, Julia E. Gamache, Melanie E. Garrett, Alexias Safi, Young Yun, Ivana Premasinghe, et al. “Sex dependent glial-specific changes in the chromatin accessibility landscape in late-onset Alzheimer's disease brains.” Mol Neurodegener 16, no. 1 (August 24, 2021): 58. https://doi.org/10.1186/s13024-021-00481-0.

PMID
34429139
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Liang, Dan, Angela L. Elwell, Nil Aygün, Oleh Krupa, Justin M. Wolter, Felix A. Kyere, Michael J. Lafferty, et al. “Cell-type-specific effects of genetic variation on chromatin accessibility during human neuronal differentiation.” Nat Neurosci 24, no. 7 (July 2021): 941–53. https://doi.org/10.1038/s41593-021-00858-w.

PMID
34017130
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Hu, Benxia, Hyejung Won, Won Mah, Royce B. Park, Bibi Kassim, Keeley Spiess, Alexey Kozlenkov, et al. “Neuronal and glial 3D chromatin architecture informs the cellular etiology of brain disorders.” Nat Commun 12, no. 1 (June 25, 2021): 3968. https://doi.org/10.1038/s41467-021-24243-0.

PMID
34172755
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Pages