Allison Elizabeth Ashley-Koch, PhD

Professor in Medicine
Professor in Biostatistics and Bioinformatics
Research Professor in Molecular Genetics and Microbiology
Faculty Network Member of the Duke Institute for Brain Sciences
Affiliate of the Center for Child and Family Policy
Member of Duke Molecular Physiology Institute
Campus mail 300 N Duke St., Durham, NC 27701
Phone (919) 684-1805
Email address allison.ashleykoch@duke.edu

One of my major research foci is in the genetic basis of psychiatric and neurological disorders. I am currently involved in studies to dissect the genetic etiology of attention deficit hyperactivity disorder (ADHD), autism, chiari type I malformations, essential tremor, and neural tube defects. Additional research foci include genetic modifiers of sickle cell disease, and genetic contributions to birth outcomes, particularly among African American women.

Education and Training

  • Ph.D., Emory University, 1997

Publications

Zekavat, SM, Ruotsalainen, S, Handsaker, RE, Alver, M, Bloom, J, Poterba, T, Seed, C, Ernst, J, Chaffin, M, Engreitz, J, Peloso, GM, Manichaikul, A, Yang, C, Ryan, KA, Fu, M, Johnson, WC, Tsai, M, Budoff, M, Vasan, RS, Cupples, LA, Rotter, JI, Rich, SS, Post, W, Mitchell, BD, Correa, A, Metspalu, A, Wilson, JG, Salomaa, V, Kellis, M, Daly, MJ, Neale, BM, McCarroll, S, Surakka, I, Esko, T, Ganna, A, Ripatti, S, Kathiresan, S, Natarajan, P, Abe, N, Abecasis, G, Albert, C, Allred, NP, Almasy, L, Alonso, A, Ament, S, Anderson, P, Anugu, P, Applebaum-Bowden, D, Arking, D, Arnett, DK, Ashley-Koch, A, Aslibekyan, S, Assimes, T, Auer, P, Avramopoulos, D, Barnard, J, Barnes, K, Barr, RG, Barron-Casella, E, Beaty, T, Becker, D, Becker, L, Beer, R, Begum, F, Beitelshees, A, Benjamin, E, Bezerra, M, Bielak, L, Bis, J, and Blackwell, T. "Erratum to: Deep coverage whole genome sequences and plasma lipoprotein(a) in individuals of European and African ancestries (Nature Communications, (2018), 9, 1, (2606), 10.1038/s41467-018-04668-w)(Accepted)." Nature Communications 9, no. 1 (December 1, 2018).

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Natarajan, P, Peloso, GM, Zekavat, SM, Montasser, M, Ganna, A, Chaffin, M, Khera, AV, Zhou, W, Bloom, JM, Engreitz, JM, Ernst, J, O Connell, JR, Ruotsalainen, SE, Alver, M, Manichaikul, A, Johnson, WC, Perry, JA, Poterba, T, Seed, C, Surakka, IL, Esko, T, Ripatti, S, Salomaa, V, Correa, A, Vasan, RS, Kellis, M, Neale, BM, Lander, ES, Abecasis, G, Mitchell, B, Rich, SS, Wilson, JG, Cupples, LA, Rotter, JI, Willer, CJ, Kathiresan, S, Abe, N, Albert, C, Allred, NP, Almasy, L, Alonso, A, Ament, S, Anderson, P, Anugu, P, Applebaum-Bowden, D, Arking, D, Arnett, DK, Ashley-Koch, A, Aslibekyan, S, Assimes, T, Auer, P, Avramopoulos, D, Barnard, J, Barnes, K, Barr, RG, Barron-Casella, E, Beaty, T, Becker, D, Becker, L, Beer, R, Begum, F, Beitelshees, A, Benjamin, E, Bezerra, M, Bielak, L, Bis, J, Blackwell, T, Blangero, J, Boerwinkle, E, Borecki, I, Bowler, R, Brody, J, Broeckel, U, Broome, J, Bunting, K, Burchard, E, and Cardwell, J. "Deep-coverage whole genome sequences and blood lipids among 16,324 individuals(Accepted)." Nature Communications 9, no. 1 (December 1, 2018).

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Zekavat, SM, Ruotsalainen, S, Handsaker, RE, Alver, M, Bloom, J, Poterba, T, Seed, C, Ernst, J, Chaffin, M, Engreitz, J, Peloso, GM, Manichaikul, A, Yang, C, Ryan, KA, Fu, M, Johnson, WC, Tsai, M, Budoff, M, Ramachandran, VS, Cupples, LA, Rotter, JI, Rich, SS, Post, W, Mitchell, BD, Correa, A, Metspalu, A, Wilson, JG, Salomaa, V, Kellis, M, Daly, MJ, Neale, BM, McCarroll, S, Surakka, I, Esko, T, Ganna, A, Ripatti, S, Kathiresan, S, and Natarajan, P. "Deep coverage whole genome sequences and plasma lipoprotein(a) in individuals of European and African ancestries(Published online)." Nature Communications 9, no. 1 (December 2018).

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Xu, JZ, Garrett, ME, Soldano, KL, Chen, ST, Clish, CB, Ashley-Koch, AE, and Telen, MJ. "Clinical and metabolomic risk factors associated with rapid renal function decline in sickle cell disease." American Journal of Hematology (August 24, 2018).

PMID
30144150
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Ilboudo, Y, Bartolucci, P, Garrett, ME, Ashley-Koch, A, Telen, M, Brugnara, C, Galactéros, F, and Lettre, G. "A common functional PIEZO1 deletion allele associates with red blood cell density in sickle cell disease patients." American Journal of Hematology (August 13, 2018). (Letter)

PMID
30105803
Full Text

Bryois, J, Garrett, ME, Song, L, Safi, A, Giusti-Rodriguez, P, Johnson, GD, Shieh, AW, Buil, A, Fullard, JF, Roussos, P, Sklar, P, Akbarian, S, Haroutunian, V, Stockmeier, CA, Wray, GA, White, KP, Liu, C, Reddy, TE, Ashley-Koch, A, Sullivan, PF, and Crawford, GE. "Evaluation of chromatin accessibility in prefrontal cortex of individuals with schizophrenia." Nature Communications 9, no. 1 (August 7, 2018): 3121-null.

PMID
30087329
Full Text

Kimbrel, NA, Garrett, ME, Dennis, MF, VA Mid-Atlantic Mental Illness Research, Education, and Clinical Center Workgroup, , Hauser, MA, Ashley-Koch, AE, and Beckham, JC. "A genome-wide association study of suicide attempts and suicidal ideation in U.S. military veterans." Psychiatry Research 269 (July 17, 2018): 64-69.

PMID
30145303
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Wolf, EJ, Maniates, H, Nugent, N, Maihofer, AX, Armstrong, D, Ratanatharathorn, A, Ashley-Koch, AE, Garrett, M, Kimbrel, NA, Lori, A, Va Mid-Atlantic Mirecc Workgroup, , Aiello, AE, Baker, DG, Beckham, JC, Boks, MP, Galea, S, Geuze, E, Hauser, MA, Kessler, RC, Koenen, KC, Miller, MW, Ressler, KJ, Risbrough, V, Rutten, BPF, Stein, MB, Ursano, RJ, Vermetten, E, Vinkers, CH, Uddin, M, Smith, AK, Nievergelt, CM, and Logue, MW. "Traumatic stress and accelerated DNA methylation age: A meta-analysis." Psychoneuroendocrinology 92 (June 2018): 123-134.

PMID
29452766
Full Text

Gelineau-Van Waes, J, Riley, RT, Voss, K, Ashley-Koch, A, Gregory, S, Moseley, A, Soderblom, E, Maddox, J, and Merritt, N. "Fumonisin B1 (FB1) and Fingolimod (FTY720): Tortilla Toxin and Oral Therapeutic Target Sphingolipid Pathways during Neural Tube Closure.": WILEY, May 15, 2018.

Scholars@Duke

Gelineau-Van Waes, J, Riley, RT, Voss, K, Ashley-Koch, A, Gregory, S, Moseley, A, Soderblom, E, Maddox, J, and Merritt, N. "Fumonisin B1 (FB1) and Fingolimod (FTY720): Tortilla Toxin and Oral Therapeutic Target Sphingolipid Pathways during Neural Tube Closure.": WILEY, May 15, 2018.

Scholars@Duke

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