
Over its 16 year history, our laboratory has investigated mechanisms of metabolic regulation and fuel homeostasis in mammalian systems. Major projects include: 1) Mechanisms involved in regulation of insulin secretion from pancreatic islet β-cells by glucose and other metabolic fuels; 2) Development of methods for protection of β-cells against immune-mediated damage; 3) Studies on spatial organization and regulation of systems controlling hepatic glucose balance; 4) Studies on the mechanisms involved in lipid-induced impairment of insulin secretion and action in diabetes.
Education and Training
- Ph.D., University of Texas at Dallas, 1984
Grants
- Duke Center for Advancement of Child Health (CAtCH).
- Engineered Glucose Metabolism in Insulin Secreting Cells
- Pharmacological Sciences Training Grant
- Role of Muscle Ketone Metabolism in Mediating the Metabolic Benefits of Weight Loss
- Quantifying Enteric Metabolism of Branched-chain Amino Acids in Relation to Other Dietary and Microbiota Nutrients
- Understanding metabolic vulnerabilities in cancer and the impact the tumor microenvironment has on cancer progression
- Studies on the Mechanisms by which SIRT5 Regulates Aging and Disease
- Mechanisms connecting dysregulated BCAA, glucose & lipid metabolism in the pathogenesis of metabolic disease
- Duke KURe Program
- Mechanisms of lipid-induced bioenergetic stress in muscle
- The Branched Chain Ketoacid Dehydrogenase Kinase-Phosphatase System as a New Regulatory Node in Myocardial Fuel Section
- Multidisciplinary Heart and Vascular Diseases
- VA Contract for MBX analyses, Chris Marx
- Serotonin as a Novel Biomarker for Progression to Type 2 Diabetes in Obese Adolescents
- Development of small molecules for islet beta-cell regeneration and diabetes therapy
- Metabolomics and Clinical Assay Core (MCAC)
- Small molecules with pleiotropic positive effects on beta-cell health
- Research Collaboration, Icagen and Duke University
- Kallyope SRA
- A comprehensive research resource to define mechanisms underlying microbial regulation of host metabolism in pediatric obesity and obesity-targeted therapeutics