Endocrinology, Metabolism, and Nutrition

Christopher Bang Newgard, PhD

Professor of Pharmacology and Cancer Biology
W. David and Sarah W. Stedman Professor of Nutrition in the School of Medicine
Director, Sarah W. Stedman Nutrition and Metabolism Center
Professor of Biochemistry
Professor in Medicine
Affiliate, Duke Global Health Institute
Member of the Duke Cancer Institute
Campus mail 300 North Duke Street, Durham, NC 27701
Phone (919) 668-6059
Email address newga002@mc.duke.edu

Over its 16 year history, our laboratory has investigated mechanisms of metabolic regulation and fuel homeostasis in mammalian systems. Major projects include: 1) Mechanisms involved in regulation of insulin secretion from pancreatic islet β-cells by glucose and other metabolic fuels; 2) Development of methods for protection of β-cells against immune-mediated damage; 3) Studies on spatial organization and regulation of systems controlling hepatic glucose balance; 4) Studies on the mechanisms involved in lipid-induced impairment of insulin secretion and action in diabetes.

Education and Training

  • Ph.D., University of Texas at Dallas, 1984

Grants

Publications

Hohmeier, HE, An, J, and Newgard, CB. "Improving human β-cell maturation in vitro." Nature Cell Biology 21, no. 2 (February 2019): 119-121.

PMID
30710149
Full Text

Kadakia, R, Nodzenski, M, Talbot, O, Kuang, A, Bain, JR, Muehlbauer, MJ, Stevens, RD, Ilkayeva, OR, O'Neal, SK, Lowe, LP, Metzger, BE, Newgard, CB, Scholtens, DM, Lowe, WL, and HAPO Study Cooperative Research Group, . "Maternal metabolites during pregnancy are associated with newborn outcomes and hyperinsulinaemia across ancestries." Diabetologia (November 27, 2018).

PMID
30483859
Full Text

Ravi, S, Parry, TL, Willis, MS, Lockyer, P, Patterson, C, Bain, JR, Stevens, RD, Ilkayeva, OR, Newgard, CB, and Schisler, JC. "Adverse Effects of Fenofibrate in Mice Deficient in the Protein Quality Control Regulator, CHIP." Journal of Cardiovascular Development and Disease 5, no. 3 (August 15, 2018).

PMID
30111698
Full Text

Shantavasinkul, PC, Muehlbauer, MJ, Bain, JR, Ilkayeva, OR, Craig, DM, Newgard, CB, Svetkey, LP, Shah, SH, and Torquati, A. "Improvement in insulin resistance after gastric bypass surgery is correlated with a decline in plasma 2-hydroxybutyric acid." Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery 14, no. 8 (August 2018): 1126-1132.

PMID
29805089
Full Text

Bhupathiraju, SN, Guasch-Ferré, M, Gadgil, MD, Newgard, CB, Bain, JR, Muehlbauer, MJ, Ilkayeva, OR, Scholtens, DM, Hu, FB, Kanaya, AM, and Kandula, NR. "Dietary Patterns among Asian Indians Living in the United States Have Distinct Metabolomic Profiles That Are Associated with Cardiometabolic Risk." The Journal of Nutrition 148, no. 7 (July 2018): 1150-1159.

PMID
29893901
Full Text

Peterson, BS, Campbell, JE, Ilkayeva, O, Grimsrud, PA, Hirschey, MD, and Newgard, CB. "Remodeling of the Acetylproteome by SIRT3 Manipulation Fails to Affect Insulin Secretion or β Cell Metabolism in the Absence of Overnutrition." Cell Reports 24, no. 1 (July 2018): 209-223.e6.

PMID
29972782
Full Text

White, PJ, McGarrah, RW, Grimsrud, PA, Tso, S-C, Yang, W-H, Haldeman, JM, Grenier-Larouche, T, An, J, Lapworth, AL, Astapova, I, Hannou, SA, George, T, Arlotto, M, Olson, LB, Lai, M, Zhang, G-F, Ilkayeva, O, Herman, MA, Wynn, RM, Chuang, DT, and Newgard, CB. "The BCKDH Kinase and Phosphatase Integrate BCAA and Lipid Metabolism via Regulation of ATP-Citrate Lyase." Cell Metabolism 27, no. 6 (June 2018): 1281-1293.e7.

PMID
29779826
Full Text

Chondronikola, M, Magkos, F, Yoshino, J, Okunade, AL, Patterson, BW, Muehlbauer, MJ, Newgard, CB, and Klein, S. "Effect of Progressive Weight Loss on Lactate Metabolism: A Randomized Controlled Trial." Obesity (Silver Spring, Md.) 26, no. 4 (April 2018): 683-688.

PMID
29476613
Full Text

McGarrah, RW, Crown, SB, Zhang, G-F, Shah, SH, and Newgard, CB. "Cardiovascular Metabolomics." Circulation Research 122, no. 9 (April 2018): 1238-1258. (Review)

PMID
29700070
Full Text

Sugi, K, Hsieh, PN, Ilkayeva, O, Shelkay, S, Moroney, B, Baadh, P, Haynes, B, Pophal, M, Fan, L, Newgard, CB, Prosdocimo, DA, and Jain, MK. "Kruppel-like factor 15 is required for the cardiac adaptive response to fasting." Plos One 13, no. 2 (January 2018): e0192376-null.

PMID
29408889
Full Text

Pages