Professor of Pharmacology and Cancer Biology
W. David and Sarah W. Stedman Distinguished Professor of Nutrition in the School of Medicine
Director, Sarah W. Stedman Nutrition and Metabolism Center
Professor in Medicine
Affiliate, Duke Global Health Institute
Member of the Duke Cancer Institute
Campus mail
300 North Duke Street, Durham, NC 27701
Phone
(919) 668-6059
Email address
newga002@mc.duke.edu
Over its 16 year history, our laboratory has investigated mechanisms of metabolic regulation and fuel homeostasis in mammalian systems. Major projects include: 1) Mechanisms involved in regulation of insulin secretion from pancreatic islet β-cells by glucose and other metabolic fuels; 2) Development of methods for protection of β-cells against immune-mediated damage; 3) Studies on spatial organization and regulation of systems controlling hepatic glucose balance; 4) Studies on the mechanisms involved in lipid-induced impairment of insulin secretion and action in diabetes.
Education and Training
- Ph.D., University of Texas at Dallas, 1984
Grants
- Duke Center for Advancement of Child Health (CAtCH).
- Engineered Glucose Metabolism in Insulin Secreting Cells
- Pharmacological Sciences Training Grant
- Role of Muscle Ketone Metabolism in Mediating the Metabolic Benefits of Weight Loss
- Quantifying Enteric Metabolism of Branched-chain Amino Acids in Relation to Other Dietary and Microbiota Nutrients
- Understanding metabolic vulnerabilities in cancer and the impact the tumor microenvironment has on cancer progression
- Studies on the Mechanisms by which SIRT5 Regulates Aging and Disease
- Mechanisms connecting dysregulated BCAA, glucose & lipid metabolism in the pathogenesis of metabolic disease
- Duke KURe Program
- Mechanisms of lipid-induced bioenergetic stress in muscle
- The Branched Chain Ketoacid Dehydrogenase Kinase-Phosphatase System as a New Regulatory Node in Myocardial Fuel Section
- Multidisciplinary Heart and Vascular Diseases
- VA Contract for MBX analyses, Chris Marx
- Serotonin as a Novel Biomarker for Progression to Type 2 Diabetes in Obese Adolescents
- Development of small molecules for islet beta-cell regeneration and diabetes therapy
- Metabolomics and Clinical Assay Core (MCAC)
- Small molecules with pleiotropic positive effects on beta-cell health
- Research Collaboration, Icagen and Duke University
- Kallyope SRA
- A comprehensive research resource to define mechanisms underlying microbial regulation of host metabolism in pediatric obesity and obesity-targeted therapeutics