Endocrinology, Metabolism, and Nutrition

Christopher Bang Newgard, PhD

Professor of Pharmacology and Cancer Biology
W. David and Sarah W. Stedman Professor of Nutrition in the School of Medicine
Director, Sarah W. Stedman Nutrition and Metabolism Center
Professor of Biochemistry
Professor in Medicine
Affiliate, Duke Global Health Institute
Member of the Duke Cancer Institute
Campus mail 300 North Duke Street, Durham, NC 27701
Phone (919) 668-6059
Email address newga002@mc.duke.edu

Over its 16 year history, our laboratory has investigated mechanisms of metabolic regulation and fuel homeostasis in mammalian systems. Major projects include: 1) Mechanisms involved in regulation of insulin secretion from pancreatic islet β-cells by glucose and other metabolic fuels; 2) Development of methods for protection of β-cells against immune-mediated damage; 3) Studies on spatial organization and regulation of systems controlling hepatic glucose balance; 4) Studies on the mechanisms involved in lipid-induced impairment of insulin secretion and action in diabetes.

Education and Training

  • Ph.D., University of Texas at Dallas, 1984

Grants

Publications

Peterson, BS, Campbell, JE, Ilkayeva, O, Grimsrud, PA, Hirschey, MD, and Newgard, CB. "Remodeling of the Acetylproteome by SIRT3 Manipulation Fails to Affect Insulin Secretion or β Cell Metabolism in the Absence of Overnutrition." Cell Reports 24, no. 1 (July 2018): 209-223.e6.

PMID
29972782
Full Text

White, PJ, McGarrah, RW, Grimsrud, PA, Tso, S-C, Yang, W-H, Haldeman, JM, Grenier-Larouche, T, An, J, Lapworth, AL, Astapova, I, Hannou, SA, George, T, Arlotto, M, Olson, LB, Lai, M, Zhang, G-F, Ilkayeva, O, Herman, MA, Wynn, RM, Chuang, DT, and Newgard, CB. "The BCKDH Kinase and Phosphatase Integrate BCAA and Lipid Metabolism via Regulation of ATP-Citrate Lyase." Cell Metabolism 27, no. 6 (June 2018): 1281-1293.e7.

PMID
29779826
Full Text

Shantavasinkul, PC, Muehlbauer, MJ, Bain, JR, Ilkayeva, OR, Craig, DM, Newgard, CB, Svetkey, LP, Shah, SH, and Torquati, A. "Improvement in insulin resistance after gastric bypass surgery is correlated with a decline in plasma 2-hydroxybutyric acid." Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery (April 17, 2018).

PMID
29805089
Full Text

Chondronikola, M, Magkos, F, Yoshino, J, Okunade, AL, Patterson, BW, Muehlbauer, MJ, Newgard, CB, and Klein, S. "Effect of Progressive Weight Loss on Lactate Metabolism: A Randomized Controlled Trial." Obesity (Silver Spring, Md.) (February 24, 2018).

PMID
29476613
Full Text

Sugi, K, Hsieh, PN, Ilkayeva, O, Shelkay, S, Moroney, B, Baadh, P, Haynes, B, Pophal, M, Fan, L, Newgard, CB, Prosdocimo, DA, and Jain, MK. "Kruppel-like factor 15 is required for the cardiac adaptive response to fasting." PloS one 13, no. 2 (January 2018): e0192376-.

PMID
29408889
Full Text

Jensen, BC, Parry, TL, Huang, W, Beak, JY, Ilaiwy, A, Bain, JR, Newgard, CB, Muehlbauer, MJ, Patterson, C, Johnson, GL, and Willis, MS. "Effects of the kinase inhibitor sorafenib on heart, muscle, liver and plasma metabolism in vivo using non-targeted metabolomics analysis." British Journal of Pharmacology 174, no. 24 (December 2017): 4797-4811.

PMID
28977680
Full Text

Softic, S, Gupta, MK, Wang, G-X, Fujisaka, S, O'Neill, BT, Rao, TN, Willoughby, J, Harbison, C, Fitzgerald, K, Ilkayeva, O, Newgard, CB, Cohen, DE, and Kahn, CR. "Divergent effects of glucose and fructose on hepatic lipogenesis and insulin signaling." The Journal of Clinical Investigation 127, no. 11 (November 2017): 4059-4074.

PMID
28972537
Full Text

Bolton, JL, Wiley, MG, Ryan, B, Truong, S, Strait, M, Baker, DC, Yang, NY, Ilkayeva, O, O'Connell, TM, Wroth, SW, Sánchez, CL, Swamy, G, Newgard, C, Kuhn, C, Bilbo, SD, and Simmons, LA. "Perinatal western-type diet and associated gestational weight gain alter postpartum maternal mood." Brain and behavior 7, no. 10 (October 2017): e00828-.

PMID
29075574
Full Text

Jensen, MV, Gooding, JR, Ferdaoussi, M, Dai, X-Q, Peterson, BS, MacDonald, PE, and Newgard, CB. "Metabolomics applied to islet nutrient sensing mechanisms." Diabetes, obesity & metabolism 19 Suppl 1 (September 2017): 90-94. (Review)

PMID
28880482
Full Text

Stephens, SB, Edwards, RJ, Sadahiro, M, Lin, W-J, Jiang, C, Salton, SR, and Newgard, CB. "The Prohormone VGF Regulates β Cell Function via Insulin Secretory Granule Biogenesis." Cell reports 20, no. 10 (September 2017): 2480-2489.

PMID
28877479
Full Text

Pages