Christopher Bang Newgard, PhD

Professor of Pharmacology and Cancer Biology
W. David and Sarah W. Stedman Distinguished Professor of Nutrition in the School of Medicine
Director, Sarah W. Stedman Nutrition and Metabolism Center
Professor in Medicine
Affiliate, Duke Global Health Institute
Member of the Duke Cancer Institute
Campus mail 300 North Duke Street, Durham, NC 27701
Phone (919) 668-6059
Email address newga002@mc.duke.edu

Over its 16 year history, our laboratory has investigated mechanisms of metabolic regulation and fuel homeostasis in mammalian systems. Major projects include: 1) Mechanisms involved in regulation of insulin secretion from pancreatic islet β-cells by glucose and other metabolic fuels; 2) Development of methods for protection of β-cells against immune-mediated damage; 3) Studies on spatial organization and regulation of systems controlling hepatic glucose balance; 4) Studies on the mechanisms involved in lipid-induced impairment of insulin secretion and action in diabetes.

Education and Training

  • Ph.D., University of Texas at Dallas, 1984

Publications

Pirro, Valentina, Kenneth D. Roth, Yanzhu Lin, Jill A. Willency, Paul L. Milligan, Jonathan M. Wilson, Giacomo Ruotolo, Axel Haupt, Christopher B. Newgard, and Kevin L. Duffin. “Effects of Tirzepatide, a Dual GIP and GLP-1 RA, on Lipid and Metabolite Profiles in Subjects With Type 2 Diabetes.” J Clin Endocrinol Metab 107, no. 2 (January 18, 2022): 363–78. https://doi.org/10.1210/clinem/dgab722.

PMID
34608929
Full Text

Levine, Daniel C., Hsin-Yu Kuo, Hee-Kyung Hong, Jonathan Cedernaes, Chelsea Hepler, Alexandra G. Wright, Meredith A. Sommars, et al. “NADH inhibition of SIRT1 links energy state to transcription during time-restricted feeding.” Nat Metab 3, no. 12 (December 2021): 1621–32. https://doi.org/10.1038/s42255-021-00498-1.

PMID
34903884
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Liu, Yu, Alan Kuang, James R. Bain, Michael J. Muehlbauer, Olga R. Ilkayeva, Lynn P. Lowe, Boyd E. Metzger, Christopher B. Newgard, Denise M. Scholtens, and William L. Lowe. “Maternal Metabolites Associated With Gestational Diabetes Mellitus and a Postpartum Disorder of Glucose Metabolism.” J Clin Endocrinol Metab 106, no. 11 (October 21, 2021): 3283–94. https://doi.org/10.1210/clinem/dgab513.

PMID
34255031
Full Text

White, Phillip J., Robert W. McGarrah, Mark A. Herman, James R. Bain, Svati H. Shah, and Christopher B. Newgard. “Insulin action, type 2 diabetes, and branched-chain amino acids: A two-way street.” Mol Metab 52 (October 2021): 101261. https://doi.org/10.1016/j.molmet.2021.101261.

PMID
34044180
Full Text

Truby, Lauren K., Jessica A. Regan, Stephanie N. Giamberardino, Olga Ilkayeva, James Bain, Christopher B. Newgard, Christopher M. O’Connor, et al. “Circulating long chain acylcarnitines and outcomes in diabetic heart failure: an HF-ACTION clinical trial substudy.” Cardiovasc Diabetol 20, no. 1 (August 3, 2021): 161. https://doi.org/10.1186/s12933-021-01353-z.

PMID
34344360
Full Text

Lee, Jennifer, Archana Vijayakumar, Phillip J. White, Yuping Xu, Olga Ilkayeva, Christopher J. Lynch, Christopher B. Newgard, and Barbara B. Kahn. “BCAA Supplementation in Mice with Diet-induced Obesity Alters the Metabolome Without Impairing Glucose Homeostasis.” Endocrinology 162, no. 7 (July 1, 2021). https://doi.org/10.1210/endocr/bqab062.

PMID
33765118
Full Text

Chang, Hao-Wei, Nathan P. McNulty, Matthew C. Hibberd, David O’Donnell, Jiye Cheng, Vincent Lombard, Bernard Henrissat, et al. “Gut microbiome contributions to altered metabolism in a pig model of undernutrition.” Proc Natl Acad Sci U S A 118, no. 21 (May 25, 2021). https://doi.org/10.1073/pnas.2024446118.

PMID
34001614
Full Text

Zhang, Guo-Fang, Mette V. Jensen, Sarah M. Gray, Kimberley El, You Wang, Danhong Lu, Thomas C. Becker, Jonathan E. Campbell, and Christopher B. Newgard. “Reductive TCA cycle metabolism fuels glutamine- and glucose-stimulated insulin secretion.” Cell Metab 33, no. 4 (April 6, 2021): 804-817.e5. https://doi.org/10.1016/j.cmet.2020.11.020.

PMID
33321098
Full Text

Walejko, Jacquelyn M., Bridgette A. Christopher, Scott B. Crown, Guo-Fang Zhang, Adrian Pickar-Oliver, Takeshi Yoneshiro, Matthew W. Foster, et al. “Branched-chain α-ketoacids are preferentially reaminated and activate protein synthesis in the heart.” Nat Commun 12, no. 1 (March 15, 2021): 1680. https://doi.org/10.1038/s41467-021-21962-2.

PMID
33723250
Full Text

McCann, Jessica R., Nathan A. Bihlmeyer, Kimberly Roche, Cameron Catherine, Jayanth Jawahar, Lydia Coulter Kwee, Noelle E. Younge, et al. “The Pediatric Obesity Microbiome and Metabolism Study (POMMS): Methods, Baseline Data, and Early Insights.” Obesity (Silver Spring) 29, no. 3 (March 2021): 569–78. https://doi.org/10.1002/oby.23081.

PMID
33624438
Full Text

Pages