Christopher Dale Kontos, MD

Professor of Medicine
Director, Medical Scientist Training Program
Professor of Pharmacology and Cancer Biology
Member of the Duke Cancer Institute
Campus mail 435 Sands Bldg, Durham, NC 27710
Phone (919) 684-2119
Email address cdkontos@duke.edu

The Kontos Lab studies the molecular mechanisms of angiogenesis and vascular remodeling. Studies are directed toward understanding how signal transduction by endothelial receptor tyrosine kinase (RTKs) regulates vascular growth in both physiological and pathological processes, including exercise, peripheral artery disease (PAD), atherosclerosis, and cancer.

Current projects include:

1. Signal transduction, mechanisms of activation, and downregulation of endothelial RTKs (mainly Tie1, Tie2, VEGFR-1, and VEGFR-2)

2. Differential effects of the Angiopoietins

3. Role of the inositol phosphatase PTEN in the regulation of vascular cell growth and remodeling

4. PTEN gene therapy for prevention of vein graft disease

5. Angiogenic signaling in skeletal muscle, including mechanisms of exercise-induced angiogenesis

6. Proteolytic cleavage and shedding of endothelial RTKs

7. Angiogenic proteins as biomarkers in peripheral artery disease

Education and Training

  • Fellow in Cardiology, Medicine, Duke University, 1993 - 1997
  • M.D., Virginia Commonwealth University, 1989

Publications

Myers, VD, Tomar, D, Madesh, M, Wang, J, Song, J, Zhang, X-Q, Gupta, MK, Tahrir, FG, Gordon, J, McClung, JM, Kontos, CD, Khalili, K, Cheung, JY, and Feldman, AM. "Haplo-insufficiency of Bcl2-associated athanogene 3 in mice results in progressive left ventricular dysfunction, β-adrenergic insensitivity, and increased apoptosis." Journal of Cellular Physiology 233, no. 9 (September 2018): 6319-6326.

PMID
29323723
Full Text

Tahrir, FG, Shanmughapriya, S, Ahooyi, TM, Knezevic, T, Gupta, MK, Kontos, CD, McClung, JM, Madesh, M, Gordon, J, Feldman, AM, Cheung, JY, and Khalili, K. "Dysregulation of mitochondrial bioenergetics and quality control by HIV-1 Tat in cardiomyocytes." Journal of Cellular Physiology 233, no. 2 (February 2018): 748-758.

PMID
28493473
Full Text

McClung, JM, McCord, TJ, Ryan, TE, Schmidt, CA, Green, TD, Southerland, KW, Reinardy, JL, Mueller, SB, Venkatraman, TN, Lascola, CD, Keum, S, Marchuk, DA, Spangenburg, EE, Dokun, A, Annex, BH, and Kontos, CD. "BAG3 (Bcl-2-Associated Athanogene-3) Coding Variant in Mice Determines Susceptibility to Ischemic Limb Muscle Myopathy by Directing Autophagy." Circulation 136, no. 3 (July 2017): 281-296.

PMID
28442482
Full Text

Feldman, AM, Kontos, CD, McClung, JM, Gerhard, GS, Khalili, K, and Cheung, JY. "Precision Medicine for Heart Failure: Lessons From Oncology." Circulation. Heart Failure 10, no. 6 (June 2017).

PMID
28611130
Full Text

Oehlers, SH, Cronan, MR, Beerman, RW, Johnson, MG, Huang, J, Kontos, CD, Stout, JE, and Tobin, DM. "Infection-Induced Vascular Permeability Aids Mycobacterial Growth." The Journal of Infectious Diseases 215, no. 5 (March 2017): 813-817.

PMID
27496976
Full Text

Fujisawa, T, Wang, K, Niu, X-L, Egginton, S, Ahmad, S, Hewett, P, Kontos, CD, and Ahmed, A. "Angiopoietin-1 promotes atherosclerosis by increasing the proportion of circulating Gr1+ monocytes." Cardiovascular Research 113, no. 1 (January 2017): 81-89.

PMID
28069704
Full Text

McClung, JM, McCord, TJ, Southerland, K, Schmidt, CA, Padgett, ME, Ryan, TE, and Kontos, CD. "Subacute limb ischemia induces skeletal muscle injury in genetically susceptible mice independent of vascular density." Journal of Vascular Surgery 64, no. 4 (October 2016): 1101-1111.e2.

PMID
26254821
Full Text

Mueller, SB, and Kontos, CD. "Tie1: an orphan receptor provides context for angiopoietin-2/Tie2 signaling." The Journal of Clinical Investigation 126, no. 9 (September 2016): 3188-3191.

PMID
27548526
Full Text

Padgett, ME, McCord, TJ, McClung, JM, and Kontos, CD. "Methods for Acute and Subacute Murine Hindlimb Ischemia." Journal of Visualized Experiments : Jove, no. 112 (June 21, 2016).

PMID
27403963
Full Text

Mofarrahi, M, McClung, JM, Kontos, CD, Davis, EC, Tappuni, B, Moroz, N, Pickett, AE, Huck, L, Harel, S, Danialou, G, and Hussain, SNA. "Angiopoietin-1 enhances skeletal muscle regeneration in mice." American Journal of Physiology Regulatory, Integrative and Comparative Physiology 308, no. 7 (April 2015): R576-R589.

PMID
25608750
Full Text

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