Christopher Dale Kontos, MD

Professor of Medicine
Director, Medical Scientist Training Program
Professor of Pharmacology and Cancer Biology
Member of the Duke Cancer Institute
Campus mail 435 Sands Bldg, Durham, NC 27710
Phone (919) 684-2119
Email address cdkontos@duke.edu

The Kontos Lab studies the molecular mechanisms of angiogenesis and vascular remodeling. Studies are directed toward understanding how signal transduction by endothelial receptor tyrosine kinase (RTKs) regulates vascular growth in both physiological and pathological processes, including exercise, peripheral artery disease (PAD), atherosclerosis, and cancer.

Current projects include:

1. Signal transduction, mechanisms of activation, and downregulation of endothelial RTKs (mainly Tie1, Tie2, VEGFR-1, and VEGFR-2)

2. Differential effects of the Angiopoietins

3. Role of the inositol phosphatase PTEN in the regulation of vascular cell growth and remodeling

4. PTEN gene therapy for prevention of vein graft disease

5. Angiogenic signaling in skeletal muscle, including mechanisms of exercise-induced angiogenesis

6. Proteolytic cleavage and shedding of endothelial RTKs

7. Angiogenic proteins as biomarkers in peripheral artery disease

Education and Training

  • Fellow in Cardiology, Medicine, Duke University, 1993 - 1997
  • M.D., Virginia Commonwealth University, 1989

Publications

Shan, S, Robson, ND, Cao, Y, Qiao, T, Li, CY, Kontos, CD, Garcia Blanco, M, and Dewhirst, MW. "Responses of vascular endothelial cells to angiogenic signaling are important for tumor cell survival." The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 18, no. 2 (February 2004): 326-328. (Academic Article)

PMID
14688196
Scholars@Duke

Peters, KG, Kontos, CD, Lin, PC, Wong, AL, Rao, P, Huang, L, Dewhirst, MW, and Sankar, S. "Functional significance of Tie2 signaling in the adult vasculature." Recent Prog Horm Res 59 (2004): 51-71. (Review)

PMID
14749497
Scholars@Duke

Liu, S, Premont, RT, Kontos, CD, Huang, J, and Rockey, DC. "Endothelin-1 activates endothelial cell nitric-oxide synthase via heterotrimeric G-protein betagamma subunit signaling to protein jinase B/Akt." J Biol Chem 278, no. 50 (December 12, 2003): 49929-49935.

PMID
14523027
Full Text

Cai, J, Ahmad, S, Jiang, WG, Huang, J, Kontos, CD, Boulton, M, and Ahmed, A. "Activation of vascular endothelial growth factor receptor-1 sustains angiogenesis and Bcl-2 expression via the phosphatidylinositol 3-kinase pathway in endothelial cells." Diabetes 52, no. 12 (December 2003): 2959-2968.

PMID
14633857
Scholars@Duke

White, RR, Shan, S, Rusconi, CP, Shetty, G, Dewhirst, MW, Kontos, CD, and Sullenger, BA. "Inhibition of rat corneal angiogenesis by a nuclease-resistant RNA aptamer specific for angiopoietin-2." Proc Natl Acad Sci U S A 100, no. 9 (April 29, 2003): 5028-5033.

PMID
12692304
Full Text

Niu, X-L, Peters, KG, and Kontos, CD. "Deletion of the carboxyl terminus of Tie2 enhances kinase activity, signaling, and function. Evidence for an autoinhibitory mechanism." J Biol Chem 277, no. 35 (August 30, 2002): 31768-31773.

PMID
12082108
Full Text

Huang, J, and Kontos, CD. "Inhibition of vascular smooth muscle cell proliferation, migration, and survival by the tumor suppressor protein PTEN." Arterioscler Thromb Vasc Biol 22, no. 5 (May 1, 2002): 745-751.

PMID
12006385
Scholars@Duke

Huang, J, and Kontos, CD. "PTEN modulates vascular endothelial growth factor-mediated signaling and angiogenic effects." J Biol Chem 277, no. 13 (March 29, 2002): 10760-10766.

PMID
11784722
Full Text

Kontos, CD, Cha, EH, York, JD, and Peters, KG. "The endothelial receptor tyrosine kinase Tie1 activates phosphatidylinositol 3-kinase and Akt to inhibit apoptosis." Mol Cell Biol 22, no. 6 (March 2002): 1704-1713.

PMID
11865050
Scholars@Duke

Bussolati, B, Dunk, C, Grohman, M, Kontos, CD, Mason, J, and Ahmed, A. "Vascular endothelial growth factor receptor-1 modulates vascular endothelial growth factor-mediated angiogenesis via nitric oxide." Am J Pathol 159, no. 3 (September 2001): 993-1008.

PMID
11549592
Full Text

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