Claude Anthony Piantadosi, MD

Professor of Medicine
Interim Chief of Pulmonary, Allergy and Critical Care Medicine
Assistant Professor in Anesthesiology
Professor of Pathology
Campus mail 0570 Clin Res II, Durham, NC 27710
Phone (919) 684-6143
Email address piant001@mc.duke.edu

Dr. Piantadosi's laboratory has special expertise in the pathogenic mechanisms of acute organ failure, particularly acute lung injury (ALI), with an emphasis on the molecular regulatory roles of the physiological gases— oxygen, carbon monoxide, and nitric oxide— as they relate to the damage responses to acute inflammation. The basic science focuses on oxidative processes and redox-regulation, especially the molecular mechanisms by which reactive oxygen and nitrogen species transmit biological signals involved in the maintenance of energy metabolism and mitochondrial health, but also contribute to pathogenesis and to the resolution of tissue injury.

Clinically, ALI and the related syndrome of multiple organ failure has a high mortality, which is related to the host inflammatory response, but is not well understood scientifically; thus, the laboratory is devoted to understanding these mechanisms in the context of the host response to relevant but well-controlled experimental manipulations including hyperoxia, bacterial infections, toxic drugs, and cytokine/chemokine signals. The approach relies on animal models, mainly transgenic and knockout mice, and cell models, especially lung and heart cells to evaluate and understand the physiology, pathology, and cell and molecular biology of the injury responses, to test independent and integrated mechanisms, and to devise interventions to prevent damage.

Apart from the lung, significant work is devoted to understanding damage to the heart, brain, liver, and kidney caused by these immune mechanisms, specifically emphasizing the role of mitochondria, key targets and sources of oxidative damage. This damage compromises their ability to support energy homeostasis and advanced cellular functions, and impacts on the important roles these organelles play in cell death by apoptosis and necrosis as well as in the resolution of cellular damage and inflammation.

Education and Training

  • M.D., Johns Hopkins University, 1975

Publications

Piantadosi, CA. "Cardioprotective role of S-nitrosylated hemoglobin from rbc." The Journal of Clinical Investigation 126, no. 12 (December 2016): 4402-4403.

PMID
27841761
Full Text

Mahmood, K, Kraft, BD, Glisinski, K, Hartwig, MG, Harlan, NP, Piantadosi, CA, and Shofer, SL. "Safety of hyperbaric oxygen therapy for management of central airway stenosis after lung transplant." Clinical transplantation 30, no. 9 (September 2016): 1134-1139.

PMID
27410718
Full Text

Suliman, HB, Zobi, F, and Piantadosi, CA. "Heme Oxygenase-1/Carbon Monoxide System and Embryonic Stem Cell Differentiation and Maturation into Cardiomyocytes." Antioxid Redox Signal 24, no. 7 (March 1, 2016): 345-360.

PMID
26725491
Full Text

Kraft, BD, Suliman, HB, Colman, EC, Mahmood, K, Hartwig, MG, Piantadosi, CA, and Shofer, SL. "Hypoxic Gene Expression of Donor Bronchi Linked to Airway Complications after Lung Transplantation." American Journal of Respiratory and Critical Care Medicine 193, no. 5 (March 2016): 552-560.

PMID
26488115
Full Text

Suliman, HB, and Piantadosi, CA. "Mitochondrial Quality Control as a Therapeutic Target." Pharmacol Rev 68, no. 1 (January 2016): 20-48. (Review)

PMID
26589414
Full Text

Hull, TD, Boddu, R, Guo, L, Tisher, CC, Traylor, AM, Patel, B, Joseph, R, Prabhu, SD, Suliman, HB, Piantadosi, CA, Agarwal, A, and George, JF. "Heme oxygenase-1 regulates mitochondrial quality control in the heart." Jci Insight 1, no. 2 (2016): e85817-null.

PMID
27110594
Full Text

Gasier, HG, Demchenko, IT, Allen, BW, and Piantadosi, CA. "Effects of striatal nitric oxide production on regional cerebral blood flow and seizure development in rats exposed to extreme hyperoxia." Journal of Applied Physiology (Bethesda, Md. : 1985) 119, no. 11 (December 2015): 1282-1288.

PMID
26338456
Full Text

Medford, MA, and Piantadosi, CA. "Oxygen toxicity: From cough to convulsion." In Studies on Experimental Toxicology and Pharmacology, 427-447. October 14, 2015.

Full Text

Pecorella, SRH, Potter, JVF, Cherry, AD, Peacher, DF, Welty-Wolf, KE, Moon, RE, Piantadosi, CA, and Suliman, HB. "The HO-1/CO system regulates mitochondrial-capillary density relationships in human skeletal muscle." American Journal of Physiology. Lung Cellular and Molecular Physiology 309, no. 8 (October 2015): L857-L871.

PMID
26186946
Full Text

Fredenburgh, LE, Kraft, BD, Hess, DR, Harris, RS, Wolf, MA, Suliman, HB, Roggli, VL, Davies, JD, Winkler, T, Stenzler, A, Baron, RM, Thompson, BT, Choi, AM, Welty-Wolf, KE, and Piantadosi, CA. "Effects of inhaled CO administration on acute lung injury in baboons with pneumococcal pneumonia." American Journal of Physiology. Lung Cellular and Molecular Physiology 309, no. 8 (October 2015): L834-L846.

PMID
26320156
Full Text

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