Claude Anthony Piantadosi, MD

Professor of Medicine
Interim Chief of Pulmonary, Allergy and Critical Care Medicine
Assistant Professor in Anesthesiology
Professor of Pathology
Campus mail 0570 Clin Res II, Durham, NC 27710
Phone (919) 684-6143
Email address piant001@mc.duke.edu

Dr. Piantadosi's laboratory has special expertise in the pathogenic mechanisms of acute organ failure, particularly acute lung injury (ALI), with an emphasis on the molecular regulatory roles of the physiological gases— oxygen, carbon monoxide, and nitric oxide— as they relate to the damage responses to acute inflammation. The basic science focuses on oxidative processes and redox-regulation, especially the molecular mechanisms by which reactive oxygen and nitrogen species transmit biological signals involved in the maintenance of energy metabolism and mitochondrial health, but also contribute to pathogenesis and to the resolution of tissue injury.

Clinically, ALI and the related syndrome of multiple organ failure has a high mortality, which is related to the host inflammatory response, but is not well understood scientifically; thus, the laboratory is devoted to understanding these mechanisms in the context of the host response to relevant but well-controlled experimental manipulations including hyperoxia, bacterial infections, toxic drugs, and cytokine/chemokine signals. The approach relies on animal models, mainly transgenic and knockout mice, and cell models, especially lung and heart cells to evaluate and understand the physiology, pathology, and cell and molecular biology of the injury responses, to test independent and integrated mechanisms, and to devise interventions to prevent damage.

Apart from the lung, significant work is devoted to understanding damage to the heart, brain, liver, and kidney caused by these immune mechanisms, specifically emphasizing the role of mitochondria, key targets and sources of oxidative damage. This damage compromises their ability to support energy homeostasis and advanced cellular functions, and impacts on the important roles these organelles play in cell death by apoptosis and necrosis as well as in the resolution of cellular damage and inflammation.

Education and Training

  • M.D., Johns Hopkins University, 1975

Publications

Dalli, J, Kraft, BD, Colas, RA, Shinohara, M, Fredenburgh, LE, Hess, DR, Chiang, N, Welty-Wolf, K, Choi, AM, Piantadosi, CA, and Serhan, CN. "The Regulation of Proresolving Lipid Mediator Profiles in Baboon Pneumonia by Inhaled Carbon Monoxide." American Journal of Respiratory Cell and Molecular Biology 53, no. 3 (September 2015): 314-325.

PMID
25568926
Full Text

Cherry, AD, and Piantadosi, CA. "Regulation of mitochondrial biogenesis and its intersection with inflammatory responses." Antioxidants & Redox Signaling 22, no. 12 (April 2015): 965-976. (Review)

PMID
25556935
Full Text

Chang, AL, Ulrich, A, Suliman, HB, and Piantadosi, CA. "Redox regulation of mitophagy in the lung during murine Staphylococcus aureus sepsis." Free Radical Biology & Medicine 78 (January 2015): 179-189.

PMID
25450328
Full Text

Bartz, RR, Suliman, HB, and Piantadosi, CA. "Redox mechanisms of cardiomyocyte mitochondrial protection." Frontiers in Physiology 6 (January 2015): 291-null. (Review)

PMID
26578967
Full Text

Shinohara, M, Kibi, M, Riley, IR, Chiang, N, Dalli, J, Kraft, BD, Piantadosi, CA, Choi, AMK, and Serhan, CN. "Cell-cell interactions and bronchoconstrictor eicosanoid reduction with inhaled carbon monoxide and resolvin D1." American Journal of Physiology. Lung Cellular and Molecular Physiology 307, no. 10 (November 2014): L746-L757.

PMID
25217660
Full Text

Demchenko, IT, Gasier, HG, Zhilyaev, SY, Moskvin, AN, Krivchenko, AI, Piantadosi, CA, and Allen, BW. "Baroreceptor afferents modulate brain excitation and influence susceptibility to toxic effects of hyperbaric oxygen." Journal of Applied Physiology (Bethesda, Md. : 1985) 117, no. 5 (September 2014): 525-534.

PMID
24994889
Full Text

Schumacker, PT, Gillespie, MN, Nakahira, K, Choi, AMK, Crouser, ED, Piantadosi, CA, and Bhattacharya, J. "Mitochondria in lung biology and pathology: more than just a powerhouse." American Journal of Physiology. Lung Cellular and Molecular Physiology 306, no. 11 (June 2014): L962-L974. (Review)

PMID
24748601
Full Text

Kraft, BD, Piantadosi, CA, Benjamin, AM, Lucas, JE, Zaas, AK, Betancourt-Quiroz, M, Woods, CW, Chang, AL, Roggli, VL, Marshall, CD, Ginsburg, GS, and Welty-Wolf, K. "Development of a novel preclinical model of pneumococcal pneumonia in nonhuman primates." American journal of respiratory cell and molecular biology 50, no. 5 (May 2014): 995-1004.

PMID
24328793
Full Text

Cherry, AD, Suliman, HB, Bartz, RR, and Piantadosi, CA. "Peroxisome proliferator-activated receptor γ co-activator 1-α as a critical co-activator of the murine hepatic oxidative stress response and mitochondrial biogenesis in Staphylococcus aureus sepsis." J Biol Chem 289, no. 1 (January 3, 2014): 41-52.

PMID
24253037
Full Text

Suliman, HB, and Piantadosi, CA. "Mitochondrial biogenesis: regulation by endogenous gases during inflammation and organ stress." Current pharmaceutical design 20, no. 35 (January 2014): 5653-5662. (Review)

PMID
24606800
Full Text

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