Claude Anthony Piantadosi, MD

Professor of Medicine
Interim Chief of Pulmonary, Allergy and Critical Care Medicine
Professor of Pathology
Assistant Professor in Anesthesiology
Campus mail 0570 Clin Res II, Durham, NC 27710
Phone (919) 684-6143
Email address piant001@mc.duke.edu

Dr. Piantadosi's laboratory has special expertise in the pathogenic mechanisms of acute organ failure, particularly acute lung injury (ALI), with an emphasis on the molecular regulatory roles of the physiological gases— oxygen, carbon monoxide, and nitric oxide— as they relate to the damage responses to acute inflammation. The basic science focuses on oxidative processes and redox-regulation, especially the molecular mechanisms by which reactive oxygen and nitrogen species transmit biological signals involved in the maintenance of energy metabolism and mitochondrial health, but also contribute to pathogenesis and to the resolution of tissue injury.

Clinically, ALI and the related syndrome of multiple organ failure has a high mortality, which is related to the host inflammatory response, but is not well understood scientifically; thus, the laboratory is devoted to understanding these mechanisms in the context of the host response to relevant but well-controlled experimental manipulations including hyperoxia, bacterial infections, toxic drugs, and cytokine/chemokine signals. The approach relies on animal models, mainly transgenic and knockout mice, and cell models, especially lung and heart cells to evaluate and understand the physiology, pathology, and cell and molecular biology of the injury responses, to test independent and integrated mechanisms, and to devise interventions to prevent damage.

Apart from the lung, significant work is devoted to understanding damage to the heart, brain, liver, and kidney caused by these immune mechanisms, specifically emphasizing the role of mitochondria, key targets and sources of oxidative damage. This damage compromises their ability to support energy homeostasis and advanced cellular functions, and impacts on the important roles these organelles play in cell death by apoptosis and necrosis as well as in the resolution of cellular damage and inflammation.

Education and Training

  • M.D., Johns Hopkins University, 1975

Publications

Cherry, AD, Suliman, HB, Bartz, RR, and Piantadosi, CA. "Peroxisome proliferator-activated receptor γ co-activator 1-α as a critical co-activator of the murine hepatic oxidative stress response and mitochondrial biogenesis in Staphylococcus aureus sepsis." The Journal of biological chemistry 289, no. 1 (January 2014): 41-52.

PMID
24253037
Full Text

Suliman, HB, and Piantadosi, CA. "Mitochondrial biogenesis: regulation by endogenous gases during inflammation and organ stress." Current pharmaceutical design 20, no. 35 (January 2014): 5653-5662. (Review)

PMID
24606800
Full Text

Bartz, RR, Fu, P, Suliman, HB, Crowley, SD, MacGarvey, NC, Welty-Wolf, K, and Piantadosi, CA. "Staphylococcus aureus sepsis induces early renal mitochondrial DNA repair and mitochondrial biogenesis in mice." PloS one 9, no. 7 (January 2014): e100912-.

PMID
24988481
Full Text

Hampson, NB, Piantadosi, CA, Thom, SR, and Weaver, LK. "Practice recommendations in the diagnosis, management, and prevention of carbon monoxide poisoning." Diving and Hyperbaric Medicine 43, no. 3 (September 1, 2013): 172-.

Scholars@Duke

Demchenko, IT, Zhilyaev, SY, Moskvin, AN, Krivchenko, AI, Piantadosi, CA, and Allen, BW. "Baroreflex-mediated cardiovascular responses to hyperbaric oxygen." J Appl Physiol (1985) 115, no. 6 (September 2013): 819-828.

PMID
23823147
Full Text

Reynolds, JD, Bennett, KM, Cina, AJ, Diesen, DL, Henderson, MB, Matto, F, Plante, A, Williamson, RA, Zandinejad, K, Demchenko, IT, Hess, DT, Piantadosi, CA, and Stamler, JS. "S-nitrosylation therapy to improve oxygen delivery of banked blood." Proc Natl Acad Sci U S A 110, no. 28 (July 9, 2013): 11529-11534.

PMID
23798386
Full Text

Hampson, NB, Piantadosi, CA, Thom, SR, and Weaver, LK. "Reply: carbon monoxide treatment guidelines must acknowledge the limitations of the existing evidence." Am J Respir Crit Care Med 187, no. 12 (June 15, 2013): 1390-1391. (Letter)

PMID
23767904
Full Text

Hampson, NB, Piantadosi, CA, Thom, SR, and Weaver, LK. "Carbon Monoxide Treatment Guidelines Must Acknowledge the Limitations of the Existing Evidence Reply." AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 187, no. 12 (June 15, 2013): 1390-1391.

Scholars@Duke

Yu, Y-RA, Mao, L, Piantadosi, CA, and Gunn, MD. "CCR2 deficiency, dysregulation of Notch signaling, and spontaneous pulmonary arterial hypertension." Am J Respir Cell Mol Biol 48, no. 5 (May 2013): 647-654.

PMID
23492191
Full Text

Hanna, G, Fontanella, A, Palmer, G, Shan, S, Radiloff, DR, Zhao, Y, Irwin, D, Hamilton, K, Boico, A, Piantadosi, CA, Blueschke, G, Dewhirst, M, McMahon, T, and Schroeder, T. "Automated measurement of blood flow velocity and direction and hemoglobin oxygen saturation in the rat lung using intravital microscopy." Am J Physiol Lung Cell Mol Physiol 304, no. 2 (January 15, 2013): L86-L91.

PMID
23161885
Full Text

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