Claude Anthony Piantadosi, MD

Professor of Medicine
Interim Chief of Pulmonary, Allergy and Critical Care Medicine
Assistant Professor in Anesthesiology
Professor of Pathology
Campus mail 0570 Clin Res II, Durham, NC 27710
Phone (919) 684-6143
Email address piant001@mc.duke.edu

Dr. Piantadosi's laboratory has special expertise in the pathogenic mechanisms of acute organ failure, particularly acute lung injury (ALI), with an emphasis on the molecular regulatory roles of the physiological gases— oxygen, carbon monoxide, and nitric oxide— as they relate to the damage responses to acute inflammation. The basic science focuses on oxidative processes and redox-regulation, especially the molecular mechanisms by which reactive oxygen and nitrogen species transmit biological signals involved in the maintenance of energy metabolism and mitochondrial health, but also contribute to pathogenesis and to the resolution of tissue injury.

Clinically, ALI and the related syndrome of multiple organ failure has a high mortality, which is related to the host inflammatory response, but is not well understood scientifically; thus, the laboratory is devoted to understanding these mechanisms in the context of the host response to relevant but well-controlled experimental manipulations including hyperoxia, bacterial infections, toxic drugs, and cytokine/chemokine signals. The approach relies on animal models, mainly transgenic and knockout mice, and cell models, especially lung and heart cells to evaluate and understand the physiology, pathology, and cell and molecular biology of the injury responses, to test independent and integrated mechanisms, and to devise interventions to prevent damage.

Apart from the lung, significant work is devoted to understanding damage to the heart, brain, liver, and kidney caused by these immune mechanisms, specifically emphasizing the role of mitochondria, key targets and sources of oxidative damage. This damage compromises their ability to support energy homeostasis and advanced cellular functions, and impacts on the important roles these organelles play in cell death by apoptosis and necrosis as well as in the resolution of cellular damage and inflammation.

Education and Training

  • M.D., Johns Hopkins University, 1975

Publications

Piantadosi, CA, Sylvia, AL, and Jöbsis, FF. "Cyanide-induced cytochrome a,a3 oxidation-reduction responses in rat brain in vivo." J Clin Invest 72, no. 4 (October 1983): 1224-1233.

PMID
6313756
Full Text

BELL, DY, SPOCK, A, JOHNSON, SM, PIANTADOSI, CA, and ROGGLI, VL. "LOW OR ABSENT IMMUNOGLOBULINS AT THE BRONCHOALVEOLAR SURFACE IN PATIENTS WITH ASBESTOSIS." AMERICAN REVIEW OF RESPIRATORY DISEASE 127, no. 4 (1983): 169-169.

Scholars@Duke

JOHNSON, SM, BELL, DY, EHRIE, MG, and PIANTADOSI, CA. "LAVAGE LYMPHOCYTE DIFFERENTIAL, PHYSIOLOGIC FUNCTION, AND CORTICOSTEROID-THERAPY IN SARCOIDOSIS." AMERICAN REVIEW OF RESPIRATORY DISEASE 127, no. 4 (1983): 100-100.

Scholars@Duke

BELL, DY, SPOCK, A, PIANTADOSI, CA, and JOHNSON, SM. "SERUM IGG AND CERULOPLASMIN CONCENTRATIONS AS INDICATORS OF HIGH-INTENSITY ALVEOLITIS IN THE LUNG IN SARCOIDOSIS." AMERICAN REVIEW OF RESPIRATORY DISEASE 127, no. 4 (1983): 89-89.

Scholars@Duke

Johnson, CE, Collins, JD, and Piantadosi, CA. "Equations for predicting diver regional skin temperatures as a function of mean skin temperature." Undersea Biomed Res 9, no. 1 (March 1982): 59-74.

PMID
7090083
Scholars@Duke

Gilman, SC, Biersner, RJ, and Piantadosi, C. "Serum ferritin increases during deep saturation dives." Aviation Space and Environmental Medicine 53, no. 10 (1982): 1014-1016.

PMID
7150152
Scholars@Duke

Piantadosi, CA, Sylvia, AL, and Jobsis, FF. "Spectrophotometric monitoring of cyanide-induced cytochrome c oxidase redox responses in vivo." Clinical Research 30, no. 2 (1982): 487A-.

Scholars@Duke

Piantadosi, CA, Thalmann, ED, and Spaur, WH. "Metabolic response to respiratory heat loss-induced core cooling." Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology 50, no. 4 (April 1981): 829-834.

PMID
7263366
Full Text

Nuckols, ML, and Piantadosi, CA. "Calibration and characterization of heat flow transducers for use in hyperbaric helium." Undersea Biomed Res 7, no. 4 (December 1980): 249-256.

PMID
7233619
Scholars@Duke

Piantadosi, CA, and Thalmann, ED. "Thermal responses in humans exposed to cold hyperbaric helium-oxygen." Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology 49, no. 6 (December 1980): 1099-1106.

PMID
7440297
Full Text

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