Claude Anthony Piantadosi, MD

Professor of Medicine
Interim Chief of Pulmonary, Allergy and Critical Care Medicine
Professor of Pathology
Assistant Professor in Anesthesiology
Campus mail 0570 Clin Res II, Durham, NC 27710
Phone (919) 684-6143
Email address piant001@mc.duke.edu

Dr. Piantadosi's laboratory has special expertise in the pathogenic mechanisms of acute organ failure, particularly acute lung injury (ALI), with an emphasis on the molecular regulatory roles of the physiological gases— oxygen, carbon monoxide, and nitric oxide— as they relate to the damage responses to acute inflammation. The basic science focuses on oxidative processes and redox-regulation, especially the molecular mechanisms by which reactive oxygen and nitrogen species transmit biological signals involved in the maintenance of energy metabolism and mitochondrial health, but also contribute to pathogenesis and to the resolution of tissue injury.

Clinically, ALI and the related syndrome of multiple organ failure has a high mortality, which is related to the host inflammatory response, but is not well understood scientifically; thus, the laboratory is devoted to understanding these mechanisms in the context of the host response to relevant but well-controlled experimental manipulations including hyperoxia, bacterial infections, toxic drugs, and cytokine/chemokine signals. The approach relies on animal models, mainly transgenic and knockout mice, and cell models, especially lung and heart cells to evaluate and understand the physiology, pathology, and cell and molecular biology of the injury responses, to test independent and integrated mechanisms, and to devise interventions to prevent damage.

Apart from the lung, significant work is devoted to understanding damage to the heart, brain, liver, and kidney caused by these immune mechanisms, specifically emphasizing the role of mitochondria, key targets and sources of oxidative damage. This damage compromises their ability to support energy homeostasis and advanced cellular functions, and impacts on the important roles these organelles play in cell death by apoptosis and necrosis as well as in the resolution of cellular damage and inflammation.

Education and Training

  • M.D., Johns Hopkins University, 1975

Publications

Piantadosi, CA, and Thalmann, ED. "Thermal responses in humans exposed to cold hyperbaric helium-oxygen." J Appl Physiol Respir Environ Exerc Physiol 49, no. 6 (December 1980): 1099-1106.

PMID
7440297
Scholars@Duke

Piantadosi, CA, Clinton, RL, and Thalmann, ED. "Prolonged oxygen exposures in immersed exercising divers at 25 fsw (1.76 ATA)." Undersea Biomed Res 6, no. 4 (December 1979): 347-356.

PMID
538863
Scholars@Duke

Gress, RE, Piantadosi, CA, Skubitz, KM, and Hsu, TH. "Breast carcinoma, thyroid carcinoma, and T3 thyrotoxicosis in a male cretin." Johns Hopkins Med J 140, no. 6 (June 1977): 317-324.

PMID
194082
Scholars@Duke

Piantadosi, CA, Dickerman, HW, and Spivak, JL. "Sequential activation of splenic nuclear RNA polymerases by erythropoietin." J Clin Invest 57, no. 1 (January 1976): 20-26.

PMID
1245599
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