Daniel Benjamin Mark, MD

Professor of Medicine
Member in the Duke Clinical Research Institute
Campus mail 2400 Pratt St, Durham, NC 27705
Phone (919) 668-8775
Email address mark0004@mc.duke.edu

Dr. Mark is a clinical cardiologist with the rank of Professor of Medicine (with tenure) as well as Vice Chief for Academic Affairs in the Division of Cardiology, Department of Medicine at Duke University Medical Center. He is also the Director of Outcomes Research at the Duke Clinical Research Institute. He has been on the full-time faculty at Duke since 1985. Prior to that he completed his cardiology fellowship at Duke, his residency and internship at the University of Virginia Hospital, and received his medical degree from Tufts University and his Master’s degree from Harvard. In 1998, he was given the honor of being elected to the American Society for Clinical Investigators and in 2002 he was honored by election to the Association of American Physicians. These organizations are the two most prestigious honor societies in academic medicine. In 2009, Dr. Mark was awarded the American College of Cardiology Distinguished Scientist Award.

Dr. Mark's major research interests include medical economics and quality of life outcomes, outcomes research, and quality of medical care. Currently, Dr. Mark is directing a number of outcomes analyses for ongoing clinical trials including PROMISE (anatomic versus functional testing for coronary artery disease, NIH), CABANA (catheter ablation versus antiarrhythmic drug therapy for atrial fibrillation, NIH), ISCHEMIA (percutaneous coronary intervention versus optimal medical therapy for moderate-severe ischemia), and STICH (CABG +/- ventricular reconstruction versus medical therapy for ischemic heart disease, NIH). He was the principal author of the AHCPR Unstable Angina Guidelines and is a co-author of both the American College of Cardiology Guideline on Exercise Testing and their Coronary Stent Consensus Guideline. He is also the Editor of the American Heart Journal. Dr. Mark has published over 270 peer-reviewed articles, two books, and 80 book chapters. He lectures widely in the US, as well as in Canada, South America, and Europe.

Keywords: cost-effectiveness analysis, disease management, quality of life assessment, resource use.

Education and Training

  • M.D., Tufts University, 1978

Publications

Zeitler, Emily P., Sana M. Al-Khatib, Daniel J. Friedman, Joo Yoon Han, Jeanne E. Poole, Gust H. Bardy, J Thomas Bigger, et al. “Predicting appropriate shocks in patients with heart failure: Patient level meta-analysis from SCD-HeFT and MADIT II..” In J Cardiovasc Electrophysiol, 28:1345–51, 2017. https://doi.org/10.1111/jce.13307.

PMID
28744959
Full Text

Sharma, Abhinav, Nishant K. Sekaran, Adrian Coles, Neha J. Pagidipati, Udo Hoffmann, Daniel B. Mark, Kerry L. Lee, et al. “Impact of Diabetes Mellitus on the Evaluation of Stable Chest Pain Patients: Insights From the PROMISE (Prospective Multicenter Imaging Study for Evaluation of Chest Pain) Trial..” J Am Heart Assoc 6, no. 11 (October 31, 2017). https://doi.org/10.1161/JAHA.117.007019.

PMID
29089344
Full Text

Mark, Daniel B., Ilana Richman, and Mark A. Hlatky. “Proprotein Convertase Subtilisin/Kexin Type 9 Inhibitor Therapy-Breakthrough in Low-Density Lipoprotein Cholesterol Lowering, Breakdown in Value..” Jama Cardiol 2, no. 10 (October 1, 2017): 1066–68. https://doi.org/10.1001/jamacardio.2017.2911.

PMID
28832860
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Ladapo, Joseph A., Adrian Coles, Rowena J. Dolor, Daniel B. Mark, Lawton Cooper, Kerry L. Lee, Jonathan Goldberg, Michael D. Shapiro, Udo Hoffmann, and Pamela S. Douglas. “Quantifying sociodemographic and income disparities in medical therapy and lifestyle among symptomatic patients with suspected coronary artery disease: a cross-sectional study in North America..” Bmj Open 7, no. 9 (September 29, 2017). https://doi.org/10.1136/bmjopen-2017-016364.

PMID
28965093
Full Text

Friedman, Daniel J., Sana M. Al-Khatib, Emily P. Zeitler, JooYoon Han, Gust H. Bardy, Jeanne E. Poole, J Thomas Bigger, et al. “New York Heart Association class and the survival benefit from primary prevention implantable cardioverter defibrillators: A pooled analysis of 4 randomized controlled trials..” In Am Heart J, 191:21–29, 2017. https://doi.org/10.1016/j.ahj.2017.06.002.

PMID
28888266
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Lu, Michael T., Pamela S. Douglas, James E. Udelson, Elizabeth Adami, Brian B. Ghoshhajra, Michael H. Picard, Rhonda Roberts, et al. “Safety of coronary CT angiography and functional testing for stable chest pain in the PROMISE trial: A randomized comparison of test complications, incidental findings, and radiation dose..” J Cardiovasc Comput Tomogr 11, no. 5 (September 2017): 373–82. https://doi.org/10.1016/j.jcct.2017.08.005.

PMID
28838846
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Hess, Paul L., Hussein R. Al-Khalidi, Daniel J. Friedman, Hillary Mulder, Anna Kucharska-Newton, Wayne R. Rosamond, Renato D. Lopes, et al. “The Metabolic Syndrome and Risk of Sudden Cardiac Death: The Atherosclerosis Risk in Communities Study..” J Am Heart Assoc 6, no. 8 (August 23, 2017). https://doi.org/10.1161/JAHA.117.006103.

PMID
28835363
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Felker, G Michael, Kevin J. Anstrom, Kirkwood F. Adams, Justin A. Ezekowitz, Mona Fiuzat, Nancy Houston-Miller, James L. Januzzi, et al. “Effect of Natriuretic Peptide-Guided Therapy on Hospitalization or Cardiovascular Mortality in High-Risk Patients With Heart Failure and Reduced Ejection Fraction: A Randomized Clinical Trial..” Jama 318, no. 8 (August 22, 2017): 713–20. https://doi.org/10.1001/jama.2017.10565.

PMID
28829876
Full Text

Mark, Daniel B., and Kevin A. Schulman. “PCSK9 Inhibitors and the Choice Between Innovation, Efficiency, and Affordability..” Jama 318, no. 8 (August 22, 2017): 711–12. https://doi.org/10.1001/jama.2017.8907.

PMID
28829851
Full Text

Califf, Robert M., Jonathan McCall, and Daniel B. Mark. “Cosmetics, Regulations, and the Public Health: Understanding the Safety of Medical and Other Products..” Jama Intern Med 177, no. 8 (August 1, 2017): 1080–82. https://doi.org/10.1001/jamainternmed.2017.2773.

PMID
28655035
Full Text

Pages