Daniel Benjamin Mark, MD

Professor of Medicine
Member in the Duke Clinical Research Institute
Campus mail 2400 Pratt St, Durham, NC 27705
Phone (919) 668-8775
Email address mark0004@mc.duke.edu

Dr. Mark is a clinical cardiologist with the rank of Professor of Medicine (with tenure) as well as Vice Chief for Academic Affairs in the Division of Cardiology, Department of Medicine at Duke University Medical Center. He is also the Director of Outcomes Research at the Duke Clinical Research Institute. He has been on the full-time faculty at Duke since 1985. Prior to that he completed his cardiology fellowship at Duke, his residency and internship at the University of Virginia Hospital, and received his medical degree from Tufts University and his Master’s degree from Harvard. In 1998, he was given the honor of being elected to the American Society for Clinical Investigators and in 2002 he was honored by election to the Association of American Physicians. These organizations are the two most prestigious honor societies in academic medicine. In 2009, Dr. Mark was awarded the American College of Cardiology Distinguished Scientist Award.

Dr. Mark's major research interests include medical economics and quality of life outcomes, outcomes research, and quality of medical care. Currently, Dr. Mark is directing a number of outcomes analyses for ongoing clinical trials including PROMISE (anatomic versus functional testing for coronary artery disease, NIH), CABANA (catheter ablation versus antiarrhythmic drug therapy for atrial fibrillation, NIH), ISCHEMIA (percutaneous coronary intervention versus optimal medical therapy for moderate-severe ischemia), and STICH (CABG +/- ventricular reconstruction versus medical therapy for ischemic heart disease, NIH). He was the principal author of the AHCPR Unstable Angina Guidelines and is a co-author of both the American College of Cardiology Guideline on Exercise Testing and their Coronary Stent Consensus Guideline. He is also the Editor of the American Heart Journal. Dr. Mark has published over 270 peer-reviewed articles, two books, and 80 book chapters. He lectures widely in the US, as well as in Canada, South America, and Europe.

Keywords: cost-effectiveness analysis, disease management, quality of life assessment, resource use.

Education and Training

  • M.D., Tufts University, 1978

Publications

Packer, Douglas L., Daniel B. Mark, Richard A. Robb, Kristi H. Monahan, Tristram D. Bahnson, Kathleen Moretz, Jeanne E. Poole, et al. “Catheter Ablation versus Antiarrhythmic Drug Therapy for Atrial Fibrillation (CABANA) Trial: Study Rationale and Design..” Am Heart J 199 (May 2018): 192–99. https://doi.org/10.1016/j.ahj.2018.02.015.

PMID
29754661
Full Text

Genders, Tessa S. S., Adrian Coles, Udo Hoffmann, Manesh R. Patel, Daniel B. Mark, Kerry L. Lee, Ewout W. Steyerberg, MG Myriam Hunink, Pamela S. Douglas, and Pamela S. CAD Consortium and the PROMISE Investigators. “The External Validity of Prediction Models for the Diagnosis of Obstructive Coronary Artery Disease in Patients With Stable Chest Pain: Insights From the PROMISE Trial..” Jacc Cardiovasc Imaging 11, no. 3 (March 2018): 437–46. https://doi.org/10.1016/j.jcmg.2017.02.020.

PMID
28624401
Full Text

Silva, Katia Regina da, Roberto Costa, Clarissa Garcia Rodrigues, Andi Schasechter, Moacyr Cuce Nobre, Rod Passman, and Daniel B. Mark. “Quality of life in patients with implantable cardioverter-defibrillator: systematic review of randomized controlled trials..” Eur J Cardiovasc Nurs 17, no. 3 (March 2018): 196–206. https://doi.org/10.1177/1474515117739619.

PMID
29067836
Full Text

Ferencik, Maros, Thomas Mayrhofer, Daniel O. Bittner, Hamed Emami, Stefan B. Puchner, Michael T. Lu, Nandini M. Meyersohn, et al. “Use of High-Risk Coronary Atherosclerotic Plaque Detection for Risk Stratification of Patients With Stable Chest Pain: A Secondary Analysis of the PROMISE Randomized Clinical Trial..” Jama Cardiol 3, no. 2 (February 1, 2018): 144–52. https://doi.org/10.1001/jamacardio.2017.4973.

PMID
29322167
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Issa, Omar M., Rhonda Roberts, Daniel B. Mark, Robin Boineau, Christine Goertz, Yves Rosenberg, Eldrin F. Lewis, et al. “Effect of high-dose oral multivitamins and minerals in participants not treated with statins in the randomized Trial to Assess Chelation Therapy (TACT)..” Am Heart J 195 (January 2018): 70–77. https://doi.org/10.1016/j.ahj.2017.09.002.

PMID
29224648
Full Text

Mark, Daniel B., and Manesh R. Patel. “Patient-Reported Outcomes in Revascularization Decisions for Left-Main Disease: Sharing the EXCELlence..” J Am Coll Cardiol 70, no. 25 (December 26, 2017): 3123–26. https://doi.org/10.1016/j.jacc.2017.10.059.

PMID
29097295
Full Text

Sze, Edward, Allison Dunning, Zak Loring, Brett D. Atwater, Karen Chiswell, James P. Daubert, Joseph A. Kisslo, Daniel B. Mark, Eric J. Velazquez, and Zainab Samad. “Comparison of Incidence of Left Ventricular Systolic Dysfunction Among Patients With Left Bundle Branch Block Versus Those With Normal QRS Duration..” Am J Cardiol 120, no. 11 (December 1, 2017): 1990–97. https://doi.org/10.1016/j.amjcard.2017.08.003.

PMID
28958452
Full Text

Lu, Michael T., Maros Ferencik, Rhonda S. Roberts, Kerry L. Lee, Alexander Ivanov, Elizabeth Adami, Daniel B. Mark, et al. “Noninvasive FFR Derived From Coronary CT Angiography: Management and Outcomes in the PROMISE Trial..” Jacc Cardiovasc Imaging 10, no. 11 (November 2017): 1350–58. https://doi.org/10.1016/j.jcmg.2016.11.024.

PMID
28412436
Full Text

Zeitler, Emily P., Sana M. Al-Khatib, Daniel J. Friedman, Joo Yoon Han, Jeanne E. Poole, Gust H. Bardy, J Thomas Bigger, et al. “Predicting appropriate shocks in patients with heart failure: Patient level meta-analysis from SCD-HeFT and MADIT II..” In J Cardiovasc Electrophysiol, 28:1345–51, 2017. https://doi.org/10.1111/jce.13307.

PMID
28744959
Full Text

Sharma, Abhinav, Nishant K. Sekaran, Adrian Coles, Neha J. Pagidipati, Udo Hoffmann, Daniel B. Mark, Kerry L. Lee, et al. “Impact of Diabetes Mellitus on the Evaluation of Stable Chest Pain Patients: Insights From the PROMISE (Prospective Multicenter Imaging Study for Evaluation of Chest Pain) Trial..” J Am Heart Assoc 6, no. 11 (October 31, 2017). https://doi.org/10.1161/JAHA.117.007019.

PMID
29089344
Full Text

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