Daniel Benjamin Mark, MD

Professor of Medicine
Member in the Duke Clinical Research Institute
Campus mail 2400 Pratt St, Durham, NC 27705
Phone (919) 668-8775
Email address mark0004@mc.duke.edu

Dr. Mark is a clinical cardiologist with the rank of Professor of Medicine (with tenure) as well as Vice Chief for Academic Affairs in the Division of Cardiology, Department of Medicine at Duke University Medical Center. He is also the Director of Outcomes Research at the Duke Clinical Research Institute. He has been on the full-time faculty at Duke since 1985. Prior to that he completed his cardiology fellowship at Duke, his residency and internship at the University of Virginia Hospital, and received his medical degree from Tufts University and his Master’s degree from Harvard. In 1998, he was given the honor of being elected to the American Society for Clinical Investigators and in 2002 he was honored by election to the Association of American Physicians. These organizations are the two most prestigious honor societies in academic medicine. In 2009, Dr. Mark was awarded the American College of Cardiology Distinguished Scientist Award.

Dr. Mark's major research interests include medical economics and quality of life outcomes, outcomes research, and quality of medical care. Currently, Dr. Mark is directing a number of outcomes analyses for ongoing clinical trials including PROMISE (anatomic versus functional testing for coronary artery disease, NIH), CABANA (catheter ablation versus antiarrhythmic drug therapy for atrial fibrillation, NIH), ISCHEMIA (percutaneous coronary intervention versus optimal medical therapy for moderate-severe ischemia), and STICH (CABG +/- ventricular reconstruction versus medical therapy for ischemic heart disease, NIH). He was the principal author of the AHCPR Unstable Angina Guidelines and is a co-author of both the American College of Cardiology Guideline on Exercise Testing and their Coronary Stent Consensus Guideline. He is also the Editor of the American Heart Journal. Dr. Mark has published over 270 peer-reviewed articles, two books, and 80 book chapters. He lectures widely in the US, as well as in Canada, South America, and Europe.

Keywords: cost-effectiveness analysis, disease management, quality of life assessment, resource use.

Education and Training

  • M.D., Tufts University, 1978

Publications

Pokharel, Y, Chinnakondepalli, K, Vilain, K, Wang, K, Mark, DB, Davies, G, Blazing, MA, Giugliano, RP, Braunwald, E, Cannon, CP, Cohen, DJ, and Magnuson, EA. "Impact of Ezetimibe on the Rate of Cardiovascular-Related Hospitalizations and Associated Costs Among Patients With a Recent Acute Coronary Syndrome: Results From the IMPROVE-IT Trial (Improved Reduction of Outcomes: Vytorin Efficacy International Trial)." Circulation. Cardiovascular Quality and Outcomes 10, no. 5 (May 2017).

PMID
28506979
Full Text

Cowper, PA, Sheng, S, Lopes, RD, Anstrom, KJ, Stafford, JA, Davidson-Ray, L, Al-Khatib, SM, Ansell, J, Dorian, P, Husted, S, McMurray, JJV, Steg, PG, Alexander, JH, Wallentin, L, Granger, CB, and Mark, DB. "Economic Analysis of Apixaban Therapy for Patients With Atrial Fibrillation From a US Perspective: Results From the ARISTOTLE Randomized Clinical Trial." Jama Cardiology 2, no. 5 (May 2017): 525-534.

PMID
28355434
Full Text

Fanaroff, AC, James, SK, Weisz, G, Prather, K, Anstrom, KJ, Mark, DB, Ben-Yehuda, O, Alexander, KP, Stone, GW, and Ohman, EM. "Ranolazine After Incomplete Percutaneous Coronary Revascularization in Patients With Versus Without Diabetes Mellitus: RIVER-PCI Trial." Journal of the American College of Cardiology 69, no. 18 (May 2017): 2304-2313.

PMID
28473136
Full Text

Fordyce, CB, Douglas, PS, Roberts, RS, Hoffmann, U, Al-Khalidi, HR, Patel, MR, Granger, CB, Kostis, J, Mark, DB, Lee, KL, Udelson, JE, and Prospective Multicenter Imaging Study for Evaluation of Chest Pain (PROMISE) Investigators, . "Identification of Patients With Stable Chest Pain Deriving Minimal Value From Noninvasive Testing: The PROMISE Minimal-Risk Tool, A Secondary Analysis of a Randomized Clinical Trial." JAMA cardiology 2, no. 4 (April 2017): 400-408.

PMID
28199464
Full Text

Shah, R, Yow, E, Jones, WS, Kohl, LP, Kosinski, AS, Hoffmann, U, Lee, KL, Fordyce, CB, Mark, DB, Lowe, A, Douglas, PS, and Patel, MR. "Comparison of visual assessment of coronary stenosis with independent quantitative coronary angiography: Findings from the Prospective Multicenter Imaging Study for Evaluation of Chest Pain (PROMISE) trial." American heart journal 184 (February 2017): 1-9.

PMID
27892881
Full Text

Mark, DB, Douglas, PS, and Daniels, MR. "Economic Outcomes With Anatomical Versus Functional Diagnostic Testing for Coronary Artery Disease." Annals of internal medicine 165, no. 12 (December 2016): 891-.

PMID
27992905
Full Text

Mark, DB, Lee, KL, and Harrell, FE. "Understanding the Role of P Values and Hypothesis Tests in Clinical Research." JAMA cardiology 1, no. 9 (December 2016): 1048-1054.

PMID
27732700
Full Text

Jang, J, Vemulapalli, S, Bhapkar, M, Fordyce, CB, Lee, KL, Udelson, JE, Hoffmann, U, Tardif, J-C, Jones, WS, Mark, DB, Sorrell, VL, Espinoza, A, Douglas, PS, and Patel, MR. "Predictive Model for High-Risk Coronary Artery Disease: An Analysis From PROMISE." November 11, 2016.

Scholars@Duke

Ladapo, JA, Hoffmann, U, Lee, KL, Coles, A, Huang, M, Mark, DB, Dolor, RJ, Pelberg, RA, Budoff, M, Sigurdsson, G, Severance, HW, and Douglas, PS. "Changes in Medical Therapy and Lifestyle After Anatomical or Functional Testing for Coronary Artery Disease." Journal of the American Heart Association 5, no. 10 (October 12, 2016).

PMID
27733347
Full Text

Kaul, P, Ohman, EM, Knight, JD, Anstrom, KJ, Roe, MT, Boden, WE, Hochman, JS, Gašparović, V, Armstrong, PW, McCollam, P, Fakhouri, W, Cowper, P, Davidson-Ray, L, Clapp-Channing, N, White, HD, Fox, KAA, Prabhakaran, D, Mark, DB, and TRILOGY ACS Investigators, . "Health-related quality of life outcomes with prasugrel among medically managed non-ST-segment elevation acute coronary syndrome patients: Insights from the Targeted Platelet Inhibition to Clarify the Optimal Strategy to Medically Manage Acute Coronary Syndromes (TRILOGY ACS) trial." American Heart Journal 178 (August 2016): 55-64.

PMID
27502852
Full Text

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