Daniel Benjamin Mark, MD

Professor of Medicine
Member in the Duke Clinical Research Institute
Campus mail 2400 Pratt St, Durham, NC 27705
Phone (919) 668-8775
Email address mark0004@mc.duke.edu

Dr. Mark is a clinical cardiologist with the rank of Professor of Medicine (with tenure) as well as Vice Chief for Academic Affairs in the Division of Cardiology, Department of Medicine at Duke University Medical Center. He is also the Director of Outcomes Research at the Duke Clinical Research Institute. He has been on the full-time faculty at Duke since 1985. Prior to that he completed his cardiology fellowship at Duke, his residency and internship at the University of Virginia Hospital, and received his medical degree from Tufts University and his Master’s degree from Harvard. In 1998, he was given the honor of being elected to the American Society for Clinical Investigators and in 2002 he was honored by election to the Association of American Physicians. These organizations are the two most prestigious honor societies in academic medicine. In 2009, Dr. Mark was awarded the American College of Cardiology Distinguished Scientist Award.

Dr. Mark's major research interests include medical economics and quality of life outcomes, outcomes research, and quality of medical care. Currently, Dr. Mark is directing a number of outcomes analyses for ongoing clinical trials including PROMISE (anatomic versus functional testing for coronary artery disease, NIH), CABANA (catheter ablation versus antiarrhythmic drug therapy for atrial fibrillation, NIH), ISCHEMIA (percutaneous coronary intervention versus optimal medical therapy for moderate-severe ischemia), and STICH (CABG +/- ventricular reconstruction versus medical therapy for ischemic heart disease, NIH). He was the principal author of the AHCPR Unstable Angina Guidelines and is a co-author of both the American College of Cardiology Guideline on Exercise Testing and their Coronary Stent Consensus Guideline. He is also the Editor of the American Heart Journal. Dr. Mark has published over 270 peer-reviewed articles, two books, and 80 book chapters. He lectures widely in the US, as well as in Canada, South America, and Europe.

Keywords: cost-effectiveness analysis, disease management, quality of life assessment, resource use.

Education and Training

  • M.D., Tufts University, 1978

Publications

Mark, DB, Federspiel, JJ, Cowper, PA, Anstrom, KJ, Hoffmann, U, Patel, MR, Davidson-Ray, L, Daniels, MR, Cooper, LS, Knight, JD, Lee, KL, Douglas, PS, and PROMISE Investigators, . "Economic Outcomes With Anatomical Versus Functional Diagnostic Testing for Coronary Artery Disease." Annals of internal medicine 165, no. 2 (July 2016): 94-102.

PMID
27214597
Full Text

Pagidipati, NJ, Hemal, K, Coles, A, Mark, DB, Dolor, RJ, Pellikka, PA, Hoffmann, U, Litwin, SE, Udelson, J, Daubert, MA, Shah, SH, Martinez, B, Lee, KL, and Douglas, PS. "Sex Differences in Functional and CT Angiography Testing in Patients With Suspected Coronary Artery Disease." Journal of the American College of Cardiology 67, no. 22 (June 2016): 2607-2616.

PMID
27058908
Full Text

Pokorney, SD, and Mark, DB. "Cost-Effectiveness of Left Atrial Appendage Occlusion: A Case Based on Facts Not in Evidence?." Circulation. Arrhythmia and electrophysiology 9, no. 6 (June 2016).

PMID
27307520
Full Text

Mark, DB, Anstrom, KJ, Sheng, S, Baloch, KN, Daniels, MR, Hoffmann, U, Patel, MR, Cooper, LS, Lee, KL, Douglas, PS, and PROMISE Investigators, . "Quality-of-Life Outcomes With Anatomic Versus Functional Diagnostic Testing Strategies in Symptomatic Patients With Suspected Coronary Artery Disease: Results From the PROMISE Randomized Trial." Circulation 133, no. 21 (May 2016): 1995-2007.

PMID
27143676
Full Text

Lamas, GA, Navas-Acien, A, Mark, DB, and Lee, KL. "Heavy Metals, Cardiovascular Disease, and the Unexpected Benefits of Chelation Therapy." Journal of the American College of Cardiology 67, no. 20 (May 2016): 2411-2418. (Review)

PMID
27199065
Full Text

Mark, DB. "Assessing quality-of-life outcomes in cardiovascular clinical research." Nature reviews. Cardiology 13, no. 5 (May 2016): 286-308. (Review)

PMID
26888169
Full Text

Hemal, K, Pagidipati, NJ, Coles, A, Dolor, RJ, Mark, DB, Pellikka, PA, Hoffmann, U, Litwin, SE, Daubert, MA, Shah, SH, Ariani, K, Bullock-Palmer, RP, Martinez, B, Lee, KL, and Douglas, PS. "Sex Differences in Demographics, Risk Factors, Presentation, and Noninvasive Testing in Stable Outpatients With Suspected Coronary Artery Disease: Insights From the PROMISE Trial." JACC. Cardiovascular imaging 9, no. 4 (April 2016): 337-346.

PMID
27017234
Full Text

Fordyce, CB, Douglas, PS, Roberts, RS, Patel, MR, Hoffmann, U, Mark, DB, Al-Khalidi, H, Kostis, J, Lee, KL, and Udelson, JE. "IDENTIFYING STABLE CHEST PAIN PATIENTS WITH SUSPECTED CORONARY DISEASE IN WHOM NONINVASIVE TESTING MAY BE SAFELY DEFERRED: INSIGHTS FROM THE PROMISE TRIAL (PROSPECTIVE MULTICENTER IMAGING STUDY FOR EVALUATION OF CHEST PAIN)." April 2016.

Full Text

Mark, DB, and O'Connor, CM. "When Business and Science Clash, How Can We Avoid Harming Patients?: The Case of AVOID-HF." JACC. Heart failure 4, no. 2 (February 2016): 106-108.

PMID
26519994
Full Text

Krishnamoorthy, A, Peterson, ED, Knight, JD, Anstrom, KJ, Effron, MB, Zettler, ME, Davidson-Ray, L, Baker, BA, McCollam, PL, Mark, DB, and Wang, TY. "How Reliable are Patient-Reported Rehospitalizations? Implications for the Design of Future Practical Clinical Studies." Journal of the American Heart Association 5, no. 1 (January 25, 2016).

PMID
26811163
Full Text

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