Daniel Benjamin Mark, MD

Professor of Medicine
Member in the Duke Clinical Research Institute
Campus mail 2400 Pratt St, Durham, NC 27705
Phone (919) 668-8775
Email address mark0004@mc.duke.edu

Dr. Mark is a clinical cardiologist with the rank of Professor of Medicine (with tenure) as well as Vice Chief for Academic Affairs in the Division of Cardiology, Department of Medicine at Duke University Medical Center. He is also the Director of Outcomes Research at the Duke Clinical Research Institute. He has been on the full-time faculty at Duke since 1985. Prior to that he completed his cardiology fellowship at Duke, his residency and internship at the University of Virginia Hospital, and received his medical degree from Tufts University and his Master’s degree from Harvard. In 1998, he was given the honor of being elected to the American Society for Clinical Investigators and in 2002 he was honored by election to the Association of American Physicians. These organizations are the two most prestigious honor societies in academic medicine. In 2009, Dr. Mark was awarded the American College of Cardiology Distinguished Scientist Award.

Dr. Mark's major research interests include medical economics and quality of life outcomes, outcomes research, and quality of medical care. Currently, Dr. Mark is directing a number of outcomes analyses for ongoing clinical trials including PROMISE (anatomic versus functional testing for coronary artery disease, NIH), CABANA (catheter ablation versus antiarrhythmic drug therapy for atrial fibrillation, NIH), ISCHEMIA (percutaneous coronary intervention versus optimal medical therapy for moderate-severe ischemia), and STICH (CABG +/- ventricular reconstruction versus medical therapy for ischemic heart disease, NIH). He was the principal author of the AHCPR Unstable Angina Guidelines and is a co-author of both the American College of Cardiology Guideline on Exercise Testing and their Coronary Stent Consensus Guideline. He is also the Editor of the American Heart Journal. Dr. Mark has published over 270 peer-reviewed articles, two books, and 80 book chapters. He lectures widely in the US, as well as in Canada, South America, and Europe.

Keywords: cost-effectiveness analysis, disease management, quality of life assessment, resource use.

Education and Training

  • M.D., Tufts University, 1978

Publications

Pryor, DB, Califf, RM, Harrell, FE, Hlatky, MA, Lee, KL, Mark, DB, and Rosati, RA. "Clinical data bases. Accomplishments and unrealized potential." Med Care 23, no. 5 (May 1985): 623-647. (Review)

PMID
3892181
Scholars@Duke

Harrell, FE, Lee, KL, McKinnis, RA, Hlatky, MA, Mark, D, Califf, RM, and Pryor, DB. "Analysis of risk factors for sudden death after acute myocardial infarction." Am J Cardiol 55, no. 5 (February 15, 1985): 621-622. (Letter)

PMID
3969926
Scholars@Duke

Califf, RM, Hlatky, MA, Mark, DB, Lee, KL, Jr, FEH, Rosati, RA, and Pryor, DB. "Randomized trials of coronary artery bypass surgery: Impact on clinical practice at Duke University Medical Center." Circulation 72, no. 6 II MONGR. (1985): V136-V144.

Scholars@Duke

Hlatky, MA, Lee, KL, Harrell, FE, Califf, RM, Pryor, DB, Mark, DB, and Rosati, RA. "Tying clinical research to patient care by use of an observational database." Stat Med 3, no. 4 (October 1984): 375-387.

PMID
6396793
Scholars@Duke

Hlatky, MA, Pryor, DB, Harrell, FE, Califf, RM, Mark, DB, and Rosati, RA. "Factors affecting sensitivity and specificity of exercise electrocardiography. Multivariable analysis." Am J Med 77, no. 1 (July 1984): 64-71.

PMID
6741986
Scholars@Duke

Mark, DB, Califf, RM, Morris, KG, Harrell, FE, Pryor, DB, Hlatky, MA, Lee, KL, and Rosati, RA. "Clinical characteristics and long-term survival of patients with variant angina." Circulation 69, no. 5 (May 1984): 880-888.

PMID
6705163
Scholars@Duke

Mark, DB, and Gaynon, MW. "Trauma-induced endophthalmitis caused by Acinetobacter anitratus." Br J Ophthalmol 67, no. 2 (February 1983): 124-126.

PMID
6600400
Scholars@Duke

Mark, DB, and McCulley, JB. "Reiter's keratitis." Arch Ophthalmol 100, no. 5 (May 1982): 781-784.

PMID
7082208
Scholars@Duke

Mark, DB, and Beuerman, R. "Intracorneal lesions produced with focused ultrasound." Curr Eye Res 2, no. 5 (1982): 323-326.

PMID
7166050
Scholars@Duke

Mark, VH, Takada, I, Tsutsumi, H, Takamatsu, H, Toth, E, and Mark, DB. "Effect of exogenous catecholamines in the amygdala of a 'rage' cat." Appl Neurophysiol 38, no. 1 (1975): 61-72.

PMID
1211930
Scholars@Duke

Pages