Daniel Benjamin Mark, MD

Professor of Medicine
Member in the Duke Clinical Research Institute
Campus mail 2400 Pratt St, Durham, NC 27705
Phone (919) 668-8775
Email address mark0004@mc.duke.edu

Dr. Mark is a clinical cardiologist with the rank of Professor of Medicine (with tenure) as well as Vice Chief for Academic Affairs in the Division of Cardiology, Department of Medicine at Duke University Medical Center. He is also the Director of Outcomes Research at the Duke Clinical Research Institute. He has been on the full-time faculty at Duke since 1985. Prior to that he completed his cardiology fellowship at Duke, his residency and internship at the University of Virginia Hospital, and received his medical degree from Tufts University and his Master’s degree from Harvard. In 1998, he was given the honor of being elected to the American Society for Clinical Investigators and in 2002 he was honored by election to the Association of American Physicians. These organizations are the two most prestigious honor societies in academic medicine. In 2009, Dr. Mark was awarded the American College of Cardiology Distinguished Scientist Award.

Dr. Mark's major research interests include medical economics and quality of life outcomes, outcomes research, and quality of medical care. Currently, Dr. Mark is directing a number of outcomes analyses for ongoing clinical trials including PROMISE (anatomic versus functional testing for coronary artery disease, NIH), CABANA (catheter ablation versus antiarrhythmic drug therapy for atrial fibrillation, NIH), ISCHEMIA (percutaneous coronary intervention versus optimal medical therapy for moderate-severe ischemia), and STICH (CABG +/- ventricular reconstruction versus medical therapy for ischemic heart disease, NIH). He was the principal author of the AHCPR Unstable Angina Guidelines and is a co-author of both the American College of Cardiology Guideline on Exercise Testing and their Coronary Stent Consensus Guideline. He is also the Editor of the American Heart Journal. Dr. Mark has published over 270 peer-reviewed articles, two books, and 80 book chapters. He lectures widely in the US, as well as in Canada, South America, and Europe.

Keywords: cost-effectiveness analysis, disease management, quality of life assessment, resource use.

Education and Training

  • M.D., Tufts University, 1978

Publications

Pryor, DB, Harrell, FE, Rankin, JS, Lee, KL, Muhlbaier, LH, Newland Oldham, H, Hlatky, MA, Mark, DB, Reves, JG, and Califf, RM. "The changing survival benefits of coronary revascularization over time." Circulation 76, no. 5 II SUPPL. (January 1, 1987): 13-21.

Scholars@Duke

Mark, DB, Hlatky, MA, Lee, KL, Harrell, FE, Califf, RM, and Pryor, DB. "Localizing coronary artery obstructions with the exercise treadmill test." Annals of Internal Medicine 106, no. 1 (January 1987): 53-55.

PMID
3789578
Full Text

Mark, DB, Hlatky, MA, and Pryor, DB. "Coronary obstructions: Location with exercise electrocardiography." Cardiology Board Review 4, no. 7 (1987): 90-99.

Scholars@Duke

Papanicolaou, MN, Califf, RM, Hlatky, MA, McKinnis, RA, Harrell, FE, Mark, DB, McCants, B, Rosati, RA, Lee, KL, and Pryor, DB. "Prognostic implications of angiographically normal and insignificantly narrowed coronary arteries." The American Journal of Cardiology 58, no. 13 (December 1986): 1181-1187.

PMID
3788805
Full Text

Hlatky, MA, Haney, T, Barefoot, JC, Califf, RM, Mark, DB, Pryor, DB, and Williams, RB. "Medical, psychological and social correlates of work disability among men with coronary artery disease." The American Journal of Cardiology 58, no. 10 (November 1986): 911-915.

PMID
3776848
Full Text

Lamas, GA, Muller, JE, Turi, ZG, Stone, PH, Rutherford, JD, Jaffe, AS, Raabe, DS, Rude, RE, Mark, DB, and Califf, RM. "A simplified method to predict occurrence of complete heart block during acute myocardial infarction." The American Journal of Cardiology 57, no. 15 (June 1986): 1213-1219.

PMID
3717016
Full Text

Califf, RM, Hlatky, MA, Mark, DB, Lee, KL, Harrell, FE, Rosati, RA, and Pryor, DB. "Randomized trials of coronary artery bypass surgery: Impact on clinical practice at Duke University Medical Center." Circulation 72, no. 6 II MONGR. (December 1, 1985).

Scholars@Duke

Califf, RM, Hlatky, MA, Mark, DB, Lee, KL, Harrell, FE, Rosati, RA, and Pryor, DB. "Randomized trials of coronary artery bypass surgery: impact on clinical practice at Duke University Medical Center." Circulation 72, no. 6 Pt 2 (December 1985): V136-V144.

PMID
2933183
Scholars@Duke

Mark, DB, Kong, Y, and Whalen, RE. "Variant angina and spontaneous coronary artery dissection." Am J Cardiol 56, no. 7 (September 1, 1985): 485-486.

PMID
4036830
Scholars@Duke

Califf, RM, Phillips, HR, Hindman, MC, Mark, DB, Lee, KL, Behar, VS, Johnson, RA, Pryor, DB, Rosati, RA, and Wagner, GS. "Prognostic value of a coronary artery jeopardy score." Journal of the American College of Cardiology 5, no. 5 (May 1985): 1055-1063.

PMID
3989116
Full Text

Pages