Endocrinology, Metabolism, and Nutrition

David A D'Alessio, MD

Professor of Medicine
Chief, Division of Endocrinology and Metabolism
Member of Duke Molecular Physiology Institute
Campus mail 300 North Duke Street, Durham, NC 27701
Phone (919) 684-4005
Email address david.d'alessio@duke.edu

Education and Training

  • Research Fellowship, Metabolism, Endocrinology And Nutrition, University of Washington, School of Medicine, 1987 - 1990
  • Resident, Temple University, School of Medicine, 1983 - 1986
  • M.D., University of Wisconsin - Madison, 1983

Grants

Publications

El, K., S. M. Gray, M. E. Capozzi, E. R. Knuth, E. Jin, B. Svendsen, A. Clifford, et al. “GIP mediates the incretin effect and glucose tolerance by dual actions on α cells and β cells.” Sci Adv 7, no. 11 (March 2021). https://doi.org/10.1126/sciadv.abf1948.

PMID
33712466
Full Text

Alonge, Kimberly M., David A. D’Alessio, and Michael W. Schwartz. “Brain control of blood glucose levels: implications for the pathogenesis of type 2 diabetes.” Diabetologia 64, no. 1 (January 2021): 5–14. https://doi.org/10.1007/s00125-020-05293-3.

PMID
33043401
Full Text

Alonge, Kimberly M., David A. D’Alessio, and Michael W. Schwartz. “Correction to: Brain control of blood glucose levels: implications for the pathogenesis of type 2 diabetes.” Diabetologia 64, no. 1 (January 2021): 259. https://doi.org/10.1007/s00125-020-05321-2.

PMID
33175179
Full Text

Riddle, Matthew C., George Bakris, Lawrence Blonde, Andrew J. M. Boulton, David D’Alessio, Linda A. DiMeglio, Linda Gonder-Frederick, et al. “A Lesson From 2020: Public Health Matters for Both COVID-19 and Diabetes.” Diabetes Care 44, no. 1 (January 2021): 8–10. https://doi.org/10.2337/dci20-0071.

PMID
33571952
Full Text

Willard, Francis S., Jonathan D. Douros, Maria Bn Gabe, Aaron D. Showalter, David B. Wainscott, Todd M. Suter, Megan E. Capozzi, et al. “Tirzepatide is an imbalanced and biased dual GIP and GLP-1 receptor agonist.” Jci Insight 5, no. 17 (September 3, 2020). https://doi.org/10.1172/jci.insight.140532.

PMID
32730231
Full Text

Gray, Sarah M., Yurong Xin, Elizabeth C. Ross, Bryanna M. Chazotte, Megan E. Capozzi, Kimberley El, Berit Svendsen, et al. “Discordance between GLP-1R gene and protein expression in mouse pancreatic islet cells.” J Biol Chem 295, no. 33 (August 14, 2020): 11529–41. https://doi.org/10.1074/jbc.RA120.014368.

PMID
32554468
Full Text

Buse, John B., Deborah J. Wexler, Apostolos Tsapas, Peter Rossing, Geltrude Mingrone, Chantal Mathieu, David A. D’Alessio, and Melanie J. Davies. “Erratum. 2019 Update to: Management of Hyperglycemia in Type 2 Diabetes, 2018. A Consensus Report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Diabetes Care 2020;43:487-493.” Diabetes Care 43, no. 7 (July 2020): 1670. https://doi.org/10.2337/dc20-er07.

PMID
32444453
Full Text

Capozzi, Megan E., Reilly W. Coch, Jepchumba Koech, Inna I. Astapova, Jacob B. Wait, Sara E. Encisco, Jonathan D. Douros, et al. “The Limited Role of Glucagon for Ketogenesis During Fasting or in Response to SGLT2 Inhibition.” Diabetes 69, no. 5 (May 2020): 882–92. https://doi.org/10.2337/db19-1216.

PMID
32005706
Full Text

Brehm, Bonnie, Suzanne Summer, Todd Jenkins, David D’Alessio, and Thomas Inge. “Thermic effect of food and resting energy expenditure after sleeve gastrectomy for weight loss in adolescent females.” Surg Obes Relat Dis 16, no. 5 (May 2020): 599–606. https://doi.org/10.1016/j.soard.2020.01.025.

PMID
32146085
Full Text

Aulinger, Benedikt A., Marta Perabo, Randy J. Seeley, Klaus G. Parhofer, and David A. D’Alessio. “Rapid hepatic metabolism blunts the endocrine action of portally infused GLP-1 in male rats.” Am J Physiol Endocrinol Metab 318, no. 2 (February 1, 2020): E189–97. https://doi.org/10.1152/ajpendo.00298.2019.

PMID
31743041
Full Text

Pages