Endocrinology, Metabolism, and Nutrition

David A D'Alessio, MD

Professor of Medicine
Chief, Division of Endocrinology and Metabolism
Member of Duke Molecular Physiology Institute
Campus mail 300 North Duke Street, Durham, NC 27701
Phone (919) 684-4005
Email address david.d'alessio@duke.edu

Education and Training

  • Research Fellowship, Metabolism, Endocrinology And Nutrition, University of Washington, School of Medicine, 1987 - 1990
  • Resident, Temple University, School of Medicine, 1983 - 1986
  • M.D., University of Wisconsin - Madison, 1983

Grants

Publications

Ozer, Imran, Anna Slezak, Jeffrey Everitt, Xinghai Li, Nikita Zakharov, Joel Collier, Jonathan Campbell, David D’Alessio, and Ashutosh Chilkoti. “Injectable non-immunogenic PEG-like conjugate that forms a subcutaneous depot and enables sustained delivery of a peptide drug,” July 28, 2021. https://doi.org/10.21203/rs.3.rs-737658/v1.

Full Text

Schaffer, Anna E., David A. D’Alessio, and John R. Guyton. “Extreme elevations of low-density lipoprotein cholesterol with very low carbohydrate, high fat diets.” J Clin Lipidol 15, no. 3 (May 2021): 525–26. https://doi.org/10.1016/j.jacl.2021.04.010.

PMID
34030981
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El, K., S. M. Gray, M. E. Capozzi, E. R. Knuth, E. Jin, B. Svendsen, A. Clifford, et al. “GIP mediates the incretin effect and glucose tolerance by dual actions on α cells and β cells.” Sci Adv 7, no. 11 (March 2021). https://doi.org/10.1126/sciadv.abf1948.

PMID
33712466
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Alonge, Kimberly M., David A. D’Alessio, and Michael W. Schwartz. “Correction to: Brain control of blood glucose levels: implications for the pathogenesis of type 2 diabetes.” Diabetologia 64, no. 1 (January 2021): 259. https://doi.org/10.1007/s00125-020-05321-2.

PMID
33175179
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Riddle, Matthew C., George Bakris, Lawrence Blonde, Andrew J. M. Boulton, David D’Alessio, Linda A. DiMeglio, Linda Gonder-Frederick, et al. “A Lesson From 2020: Public Health Matters for Both COVID-19 and Diabetes.” Diabetes Care 44, no. 1 (January 2021): 8–10. https://doi.org/10.2337/dci20-0071.

PMID
33571952
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Alonge, Kimberly M., David A. D’Alessio, and Michael W. Schwartz. “Brain control of blood glucose levels: implications for the pathogenesis of type 2 diabetes.” Diabetologia 64, no. 1 (January 2021): 5–14. https://doi.org/10.1007/s00125-020-05293-3.

PMID
33043401
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Willard, Francis S., Jonathan D. Douros, Maria Bn Gabe, Aaron D. Showalter, David B. Wainscott, Todd M. Suter, Megan E. Capozzi, et al. “Tirzepatide is an imbalanced and biased dual GIP and GLP-1 receptor agonist.” Jci Insight 5, no. 17 (September 3, 2020). https://doi.org/10.1172/jci.insight.140532.

PMID
32730231
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Gray, Sarah M., Yurong Xin, Elizabeth C. Ross, Bryanna M. Chazotte, Megan E. Capozzi, Kimberley El, Berit Svendsen, et al. “Discordance between GLP-1R gene and protein expression in mouse pancreatic islet cells.” The Journal of Biological Chemistry 295, no. 33 (August 2020): 11529–41. https://doi.org/10.1074/jbc.ra120.014368.

PMID
32554468
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Buse, John B., Deborah J. Wexler, Apostolos Tsapas, Peter Rossing, Geltrude Mingrone, Chantal Mathieu, David A. D’Alessio, and Melanie J. Davies. “Erratum. 2019 Update to: Management of Hyperglycemia in Type 2 Diabetes, 2018. A Consensus Report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Diabetes Care 2020;43:487-493.” Diabetes Care 43, no. 7 (July 2020): 1670. https://doi.org/10.2337/dc20-er07.

PMID
32444453
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Capozzi, Megan E., Reilly W. Coch, Jepchumba Koech, Inna I. Astapova, Jacob B. Wait, Sara E. Encisco, Jonathan D. Douros, et al. “The Limited Role of Glucagon for Ketogenesis During Fasting or in Response to SGLT2 Inhibition.” Diabetes 69, no. 5 (May 2020): 882–92. https://doi.org/10.2337/db19-1216.

PMID
32005706
Full Text

Pages