David Isaias Ortiz-Melo, MD

Assistant Professor of Medicine
Campus mail DUMC Box 2747, Durham, NC 27705
Email address david.ortiz-melo@duke.edu

I enjoy practicing nephrology and taking care of patient with kidney disorders. As a clinician-educator in the Division of Nephrology, my clinical practice mainly focuses on the management of uncontrolled high blood pressure, chronic kidney disease, acute kidney injury and fluid and electrolyte disorders. I have particular interest in the evaluation and management of kidney disease affecting patients with cancer (onco-nephrology). In the inpatient setting, my clinical activities are focused on consultative nephrology and maintenance dialysis.  In the outpatient setting, I see patients two days weekly through the Private Diagnostic Clinic. In addition, I am a rounding nephrologist at three outpatient dialysis units.

Education and Training

  • Chief Medical Resident, Wayne State University, School of Medicine, 2009 - 2010
  • Resident, Wayne State University, School of Medicine, 2007 - 2009
  • Intern, Wayne State University, School of Medicine, 2006 - 2007
  • M.D., Instituto Tecnologico de Santo Domingo (Dominican Republic), 2004


Murakami, Naoka, Patrick Mulvaney, Melissa Danesh, Ala Abudayyeh, Adi Diab, Noha Abdel-Wahab, Maen Abdelrahim, et al. “A multi-center study on safety and efficacy of immune checkpoint inhibitors in cancer patients with kidney transplant.” Kidney Int 100, no. 1 (July 2021): 196–205. https://doi.org/10.1016/j.kint.2020.12.015.

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Ortiz-Melo, David I., and Robert F. Spurney. “Special deLIVERy: podocyte injury promotes renal angiotensin II generation from liver-derived angiotensinogen.” Kidney Int 85, no. 5 (May 2014): 1009–11. https://doi.org/10.1038/ki.2013.440.

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Wysocki, Jan, David I. Ortiz-Melo, Natalie K. Mattocks, Katherine Xu, Jessica Prescott, Karla Evora, Minghao Ye, et al. “ACE2 deficiency increases NADPH-mediated oxidative stress in the kidney.” Physiol Rep 2, no. 3 (2014): e00264. https://doi.org/10.1002/phy2.264.

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Lehrich, Ruediger W., David I. Ortiz-Melo, Mehul B. Patel, and Arthur Greenberg. “Role of vaptans in the management of hyponatremia.” Am J Kidney Dis 62, no. 2 (August 2013): 364–76. https://doi.org/10.1053/j.ajkd.2013.01.034.

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Corsino, Leonor, María Pilar Rocha-Goldberg, Bryan C. Batch, David I. Ortiz-Melo, Hayden B. Bosworth, and Laura P. Svetkey. “The Latino Health Project: pilot testing a culturally adapted behavioral weight loss intervention in obese and overweight Latino adults.” Ethn Dis 22, no. 1 (2012): 51–57.