David Michael Ashley, MBBS, PhD

Professor of Neurosurgery
Rory David Deutsch Distinguished Professor of Neuro-Oncology
Professor of Medicine
Professor in Pathology
Professor in Pediatrics
Member of the Duke Cancer Institute
Campus mail 203 Research Dr Msrb1, Box 2600, Durham, NC 27710
Phone (919) 684-4164
Email address david.ashley@duke.edu

Dr. Ashley's primary research focus is laboratory based, investigating the role of immunotherapy as a novel approach to the treatment of tumors of the central nervous system (CNS). Since beginning his appointment at the faculty level at Duke in August of 1995 his activities have centered on two main areas of investigation. The first involves both in vivo and in vitro studies of the use of molecular therapeutics to target a CNS tumor associated antigen. The second area of interest comprises a detailed analysis of the role of TGF beta, a protein messenger produced by tumors of the CNS, both in the pathogenesis of disease and as a possible target for immunotherapy.

In addition to his laboratory role Dr. Ashley is involved in the design and application of a variety of clinical research protocols in the treatment of children with malignant brain tumors.

Education and Training

  • Ph.D., University of Melbourne (Australia), 1998
  • M.B.B.S., University of Melbourne (Australia), 1994
  • F.R.A.C.P., Royal Australasian College of Physicians (Australia), 1993

Publications

Wei, Shiyou, Delong Yin, Shengnan Yu, Xiang Lin, Milan R. Savani, Kuang Du, Yin Ku, et al. “Antitumor Activity of a Mitochondrial-Targeted HSP90 Inhibitor in Gliomas.” Clin Cancer Res 28, no. 10 (May 13, 2022): 2180–95. https://doi.org/10.1158/1078-0432.CCR-21-0833.

PMID
35247901
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Low, Justin T., Vidyalakshmi Chandramohan, Michelle L. Bowie, Michael C. Brown, Matthew S. Waitkus, Aaron Briley, Kevin Stevenson, et al. “Epigenetic STING silencing is developmentally conserved in gliomas and can be rescued by methyltransferase inhibition.” Cancer Cell 40, no. 5 (May 9, 2022): 439–40. https://doi.org/10.1016/j.ccell.2022.04.009.

PMID
35487217
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Abdullah, Kalil G., Cylaina E. Bird, Joseph D. Buehler, Lauren C. Gattie, Milan R. Savani, Alex C. Sternisha, Yi Xiao, et al. “Establishment of patient-derived organoid models of lower-grade glioma.” Neuro Oncol 24, no. 4 (April 1, 2022): 612–23. https://doi.org/10.1093/neuonc/noab273.

PMID
34850183
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Singh, Kirit, Kristen A. Batich, Patrick Y. Wen, Aaron C. Tan, Stephen J. Bagley, Michael Lim, Michael Platten, et al. “Designing Clinical Trials for Combination Immunotherapy: A Framework for Glioblastoma.” Clin Cancer Res 28, no. 4 (February 15, 2022): 585–93. https://doi.org/10.1158/1078-0432.CCR-21-2681.

PMID
34561270
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Yu, Shengnan, Shiyou Wei, Milan Savani, Xiang Lin, Kuang Du, Ilgen Mender, Silvia Siteni, et al. “A Modified Nucleoside 6-Thio-2'-Deoxyguanosine Exhibits Antitumor Activity in Gliomas.” Clin Cancer Res 27, no. 24 (December 15, 2021): 6800–6814. https://doi.org/10.1158/1078-0432.CCR-21-0374.

PMID
34593527
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Johnson, Margaret, Mustafa Khasraw, Jung-Young Kim, Nicole Cort, James Herndon, Luis Ramirez, Eric Lipp, et al. “QOLP-28. COMPARING KNOWLEDGE OF AND BELIEFS ABOUT PALLIATIVE CARE AMONG NEURO-ONCOLOGY PATIENTS, CAREGIVERS, PROVIDERS AND A NATIONALLY-REPRESENTATIVE U.S. SAMPLE.” In Neuro Oncology, 23:vi189–vi189. Oxford University Press (OUP), 2021. https://doi.org/10.1093/neuonc/noab196.748.

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Peters, Katherine, Mallika Patel, Candice Alford, Gerardo Chavez, Jung-Young Kim, Jennifer Durling, Tracy Novack, et al. “INNV-20. RADIOGRAPHIC RESPONSE AND SEIZURE CONTROL IN IDH1 MUTANT GLIOMA PATIENTS USING IVOSIDENIB.” In Neuro Oncology, 23:vi109–vi109. Oxford University Press (OUP), 2021. https://doi.org/10.1093/neuonc/noab196.431.

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Peters, Katherine, Mary Affronti, Jung-Young Kim, Mallika Patel, Margaret Johnson, David Bartlett, Nicole Cort, et al. “QOLP-10. A LONGITUDINAL OBSERVATIONAL STUDY OF EXERCISE BEHAVIOR IN GLIOBLASTOMA PATIENTS TREATED WITH TUMOR-TREATING FIELDS.” In Neuro Oncology, 23:vi184–85. Oxford University Press (OUP), 2021. https://doi.org/10.1093/neuonc/noab196.731.

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Petitt, Zoey, James Herndon, Oren Gottfried, Christina Cone, Daniel Landi, Mustafa Khasraw, Henry Friedman, et al. “INNV-31. NEURO-ONCOLOGY OUTPATIENT SATISFACTION IS MAINTAINED IN THE ERA OF COVID-19 TELEMEDICINE.” In Neuro Oncology, 23:vi112–vi112. Oxford University Press (OUP), 2021. https://doi.org/10.1093/neuonc/noab196.442.

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