Eric Leo Eisenstein

Associate Professor in Medicine
Associate Professor in Family Medicine and Community Health
Member in the Duke Clinical Research Institute
Campus mail 2400 Pratt St, Durham, NC 27705
Phone (919) 668-8984
Email address eisen006@mc.duke.edu

Research Interests:

Dr. Eisenstein is a member of the Duke Clinical Research Institute’s Outcomes Research and Assessment Group, with a special interest in understanding the relationships between complex interventions in health care systems and the long-term clinical and economic outcomes of patients. He has served as Principal Investigator for phase II, III, and IV economic and quality of life studies conducted alongside randomized clinical trials in cardiovascular, emergency, pulmonary, and vascular medicine and surgery. He also has conducted health technology evaluations making use of innovative research methods designed to better understand key relationships in observation (non-randomized) patient data. This work has included evaluations of the long-term clinical outcomes of coronary artery disease patients receiving drug-eluting vs. bare metal intracoronary stents, and how the use of clopidogrel changes those relationships. He also has conducted several studies assessing factors contributing to the costs of and evaluating different design considerations for multi-center randomized clinical trials.

In addition to his working in traditional health technology evaluation, Dr. Eisenstein has an interest in evaluating information technologies as interventions in health care systems. In this regard, he has collaborated in the design and conduct of large-scale, randomized clinical trials to evaluate clinical decision support systems. The research objective in these studies has been to develop methods for evaluating health information technologies in practice-based settings using a “tool kit” of inexpensive, yet highly scalable methods that make use of data sets created as a byproduct of normal clinical and administrative operations. The use of these evaluation methods has been demonstrated in four clinical trials that include care process, clinical, economic, and quality of life measurements.

Education and Training

  • D.B.A., Cleveland State University, 1995

Publications

Scott, Philip J., Angela W. Brown, Taiwo Adedeji, Jeremy C. Wyatt, Andrew Georgiou, Eric L. Eisenstein, and Charles P. Friedman. “A review of measurement practice in studies of clinical decision support systems 1998-2017..” J Am Med Inform Assoc 26, no. 10 (October 1, 2019): 1120–28. https://doi.org/10.1093/jamia/ocz035.

PMID
30990522
Full Text

Eisenstein, Eric L., Kristi Prather, Stephen J. Greene, Tina Harding, Amanda Harrington, Davera Gabriel, Ingrid Jones, Robert J. Mentz, Eric J. Velazquez, and Kevin J. Anstrom. “Death: The Simple Clinical Trial Endpoint..” Stud Health Technol Inform 257 (2019): 86–91.

PMID
30741178
Scholars@Duke

Nordo, Amy, Eric L. Eisenstein, Maryam Garza, W Ed Hammond, and Meredith Nahm Zozus. “Evaluative Outcomes in Direct Extraction and Use of EHR Data in Clinical Trials..” Stud Health Technol Inform 257 (2019): 333–40.

PMID
30741219
Scholars@Duke

Eisenstein, Eric L., Daniel Wojdyla, and David F. Kong. “Estimating Clinical Trial Bleeding Events Using Electronic Health Record Data..” Stud Health Technol Inform 257 (2019): 92–97.

PMID
30741179
Scholars@Duke

Garza, Maryam, Sahiti Myneni, Amy Nordo, Eric L. Eisenstein, W Ed Hammond, Anita Walden, and Meredith Zozus. “eSource for Standardized Health Information Exchange in Clinical Research: A Systematic Review..” Stud Health Technol Inform 257 (2019): 115–24.

PMID
30741183
Scholars@Duke

Simon, Christian M., Helen A. Schartz, Gary E. Rosenthal, Eric L. Eisenstein, and David W. Klein. “Perspectives on Electronic Informed Consent From Patients Underrepresented in Research in the United States: A Focus Group Study..” J Empir Res Hum Res Ethics 13, no. 4 (October 2018): 338–48. https://doi.org/10.1177/1556264618773883.

PMID
29790410
Full Text

Levitan, Bennett, Kenneth Getz, Eric L. Eisenstein, Michelle Goldberg, Matthew Harker, Sharon Hesterlee, Bray Patrick-Lake, Jamie N. Roberts, and Joseph DiMasi. “Assessing the Financial Value of Patient Engagement: A Quantitative Approach from CTTI's Patient Groups and Clinical Trials Project..” Ther Innov Regul Sci 52, no. 2 (March 2018): 220–29. https://doi.org/10.1177/2168479017716715.

PMID
29714515
Full Text

Nordo, Amy Harris, Eric L. Eisenstein, Jeffrey Hawley, Sai Vadakkeveedu, Melissa Pressley, Jennifer Pennock, and Iain Sanderson. “A comparative effectiveness study of eSource used for data capture for a clinical research registry..” Int J Med Inform 103 (July 2017): 89–94. https://doi.org/10.1016/j.ijmedinf.2017.04.015.

PMID
28551007
Full Text

Levitan, B., K. A. Getz, E. L. Eisenstein, M. Goldberg, M. Harker, S. E. Hesterlee, B. Patrick-Lake, J. Roberts, and J. A. DiMasi. “ASSESSING THE FINANCIAL VALUE OF PATIENT ENGAGEMENT.” In Value in Health, 20:A33–A33. ELSEVIER SCIENCE INC, 2017.

Scholars@Duke

Wagner, Marilyn, Laura Wagner, Chris Wagner, Samuel J. Bell, Brit W. Nicholson, David G. Strauss, Stafford Warren, et al. “In memory of Professor Galen S. Wagner M.D., Ph.D. (1939-2016): our mentor, colleague and friend..” J Electrocardiol 50, no. 1 (January 2017): 3–4. https://doi.org/10.1016/j.jelectrocard.2016.11.001.

PMID
27889056
Full Text

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