Eric Leo Eisenstein

Associate Professor in Medicine
Associate Professor in Family Medicine and Community Health
Member in the Duke Clinical Research Institute
Campus mail 2400 Pratt St, Durham, NC 27705
Phone (919) 668-8984
Email address eisen006@mc.duke.edu

Research Interests:

Dr. Eisenstein is a member of the Duke Clinical Research Institute’s Outcomes Research and Assessment Group, with a special interest in understanding the relationships between complex interventions in health care systems and the long-term clinical and economic outcomes of patients. He has served as Principal Investigator for phase II, III, and IV economic and quality of life studies conducted alongside randomized clinical trials in cardiovascular, emergency, pulmonary, and vascular medicine and surgery. He also has conducted health technology evaluations making use of innovative research methods designed to better understand key relationships in observation (non-randomized) patient data. This work has included evaluations of the long-term clinical outcomes of coronary artery disease patients receiving drug-eluting vs. bare metal intracoronary stents, and how the use of clopidogrel changes those relationships. He also has conducted several studies assessing factors contributing to the costs of and evaluating different design considerations for multi-center randomized clinical trials.

In addition to his working in traditional health technology evaluation, Dr. Eisenstein has an interest in evaluating information technologies as interventions in health care systems. In this regard, he has collaborated in the design and conduct of large-scale, randomized clinical trials to evaluate clinical decision support systems. The research objective in these studies has been to develop methods for evaluating health information technologies in practice-based settings using a “tool kit” of inexpensive, yet highly scalable methods that make use of data sets created as a byproduct of normal clinical and administrative operations. The use of these evaluation methods has been demonstrated in four clinical trials that include care process, clinical, economic, and quality of life measurements.

Education and Training

  • D.B.A., Cleveland State University, 1995

Publications

Eisenstein, E. L., M. B. Leon, D. E. Kandzari, R. Edwards, P. A. Cowper, D. F. Kong, M. D. Silverstein, D. B. Mark, and K. J. Anstrom. “ECONOMIC ANALYSIS OF ENDEAVOR VS. CYPHER STENTS: RESULTS FROM THE ENDEAVOR III TRIAL.” Value in Health 12, no. 3 (May 1, 2009): A152–A152.

Scholars@Duke

Brennan, J Matthew, Kevin J. Anstrom, Eric L. Eisenstein, David Dai, Ghazala Haque, David F. Kong, Ralph G. Brindis, et al. “Long-Term Outcomes of Drug-Eluting Versus Bare-Metal Stents in Underrepresented Populations: Results From the Linked NCDR and CMS Database.” Journal of the American College of Cardiology 53, no. 10 (March 10, 2009): A386–A386.

Scholars@Duke

Douglas, Pamela S., J Matthew Brennan, Kevin Anstrom, Eric L. Eisenstein, David Dai, Ghazala Haque, David F. Kong, et al. “Outcomes Following Coronary Stenting in a Linked NCDR and CMS Database: A National Study of Long-Term, Real World Outcomes of Bare Metal and Drug-Eluting Stents.” Journal of the American College of Cardiology 53, no. 10 (March 10, 2009): A401–2.

Scholars@Duke

Allen, Larry A., Kevin J. Anstrom, John Horton, Linda K. Shaw, Eric L. Eisenstein, and G Michael Felker. “Relationship Between Anemia Status and Health Care Costs in Patients With Symptomatic Heart Failure.” Journal of the American College of Cardiology 53, no. 10 (March 10, 2009): A391–A391.

Scholars@Duke

Eisenstein, Eric L., Jie L. Sun, Kevin J. Anstrom, Judith A. Stafford, Lynda A. Szczech, Lawrence H. Muhlbaier, and Daniel B. Mark. “Do income level and race influence survival in patients receiving hemodialysis?.” Am J Med 122, no. 2 (February 2009): 170–80. https://doi.org/10.1016/j.amjmed.2008.08.025.

PMID
19185093
Full Text

Eisenstein, Eric L., David F. Lobach, Kensaku Kawamoto, Rex Edwards, Janese M. Willis, Garry M. Silvey, and Kevin J. Anstrom. “A randomized clinical trial of clinical decision support in a rural community health network serving lower income individuals: study design and baseline characteristics..” Stud Health Technol Inform 143 (2009): 220–26.

PMID
19380940
Scholars@Duke

Eisenstein, Eric L. “DRIVE it home: making the case for prospective economic data collection in randomized clinical trials..” Kidney Int 74, no. 12 (December 2008): 1507–9. https://doi.org/10.1038/ki.2008.553.

PMID
19034299
Full Text

Eisenstein, Eric L., Jie L. Sun, Kevin J. Anstrom, Judith A. Stafford, Lynda A. Szczech, Lawrence H. Muhlbaier, and Daniel B. Mark. “Re-evaluating the volume-outcome relationship in hemodialysis patients..” Health Policy 88, no. 2–3 (December 2008): 317–25. https://doi.org/10.1016/j.healthpol.2008.03.017.

PMID
18502534
Full Text

Lobach, David F., Garry M. Silvey, Janese M. Willis, Kevin R. Kooy, Kensaku Kawamoto, Kevin J. Anstrom, Eric L. Eisenstein, and Fredrick Johnson. “Coupling direct collection of health risk information from patients through kiosks with decision support for proactive care management..” Amia Annu Symp Proc, November 6, 2008, 429–33.

PMID
18999181
Scholars@Duke

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