Eric Leo Eisenstein

Associate Professor in Medicine
Associate Professor in Community and Family Medicine
Member in the Duke Clinical Research Institute
Campus mail 2400 Pratt St, Durham, NC 27705
Phone (919) 668-8984
Email address eisen006@mc.duke.edu

Research Interests:

Dr. Eisenstein is a member of the Duke Clinical Research Institute’s Outcomes Research and Assessment Group, with a special interest in understanding the relationships between complex interventions in health care systems and the long-term clinical and economic outcomes of patients. He has served as Principal Investigator for phase II, III, and IV economic and quality of life studies conducted alongside randomized clinical trials in cardiovascular, emergency, pulmonary, and vascular medicine and surgery. He also has conducted health technology evaluations making use of innovative research methods designed to better understand key relationships in observation (non-randomized) patient data. This work has included evaluations of the long-term clinical outcomes of coronary artery disease patients receiving drug-eluting vs. bare metal intracoronary stents, and how the use of clopidogrel changes those relationships. He also has conducted several studies assessing factors contributing to the costs of and evaluating different design considerations for multi-center randomized clinical trials.

In addition to his working in traditional health technology evaluation, Dr. Eisenstein has an interest in evaluating information technologies as interventions in health care systems. In this regard, he has collaborated in the design and conduct of large-scale, randomized clinical trials to evaluate clinical decision support systems. The research objective in these studies has been to develop methods for evaluating health information technologies in practice-based settings using a “tool kit” of inexpensive, yet highly scalable methods that make use of data sets created as a byproduct of normal clinical and administrative operations. The use of these evaluation methods has been demonstrated in four clinical trials that include care process, clinical, economic, and quality of life measurements.

Education and Training

  • D.B.A., Cleveland State University, 1995

Publications

Eisenstein, EL, Sun, JL, Anstrom, KJ, DeLong, ER, Szczech, LA, and Mark, DB. "Assessing the economic attractiveness of coronary artery revascularization in chronic kidney disease patients." J Med Syst 33, no. 4 (August 2009): 287-297.

PMID
19697695
Scholars@Duke

Eisenstein, EL, Edwards, R, Cowper, PA, Kong, DF, Silverstein, MD, Mark, DB, Anstrom, KJ, and Wijns, W. "ECONOMIC ANALYSIS OF THE ENDEAVOR DRUG-ELUTING STENT VS. THE DRIVER BARE METAL STENT: RESULTS FROM THE ENDEAVOR II TRIAL." VALUE IN HEALTH 12, no. 3 (May 2009): A152-A152.

Scholars@Duke

Eisenstein, EL, Leon, MB, Kandzari, DE, Edwards, R, Cowper, PA, Kong, DF, Silverstein, MD, Mark, DB, and Anstrom, KJ. "ECONOMIC ANALYSIS OF ENDEAVOR VS. CYPHER STENTS: RESULTS FROM THE ENDEAVOR III TRIAL." VALUE IN HEALTH 12, no. 3 (May 2009): A152-A152.

Scholars@Duke

Douglas, PS, Brennan, JM, Anstrom, KJ, Sedrakyan, A, Eisenstein, EL, Haque, G, Dai, D, Kong, DF, Hammill, B, Curtis, L, Matchar, D, Brindis, R, and Peterson, ED. "Clinical effectiveness of coronary stents in elderly persons: results from 262,700 Medicare patients in the American College of Cardiology-National Cardiovascular Data Registry." Journal of the American College of Cardiology 53, no. 18 (May 2009): 1629-1641.

PMID
19406337
Full Text

Brennan, JM, Anstrom, KJ, Eisenstein, EL, Dai, D, Haque, G, Kong, DF, Brindis, RG, Sedrakyan, A, Matcher, D, Peterson, ED, and Douglas, PS. "Long-Term Outcomes of Drug-Eluting Versus Bare-Metal Stents in Underrepresented Populations: Results From the Linked NCDR and CMS Database." Journal of the American College of Cardiology 53, no. 10 (March 10, 2009): A386-A386.

Scholars@Duke

Douglas, PS, Brennan, JM, Anstrom, K, Eisenstein, EL, Dai, D, Haque, G, Kong, DF, Brindis, RG, Sedrakyan, A, Matcher, DB, and Peterson, ED. "Outcomes Following Coronary Stenting in a Linked NCDR and CMS Database: A National Study of Long-Term, Real World Outcomes of Bare Metal and Drug-Eluting Stents." Journal of the American College of Cardiology 53, no. 10 (March 10, 2009): A401-A402.

Scholars@Duke

Allen, LA, Anstrom, KJ, Horton, J, Shaw, LK, Eisenstein, EL, and Felker, GM. "Relationship Between Anemia Status and Health Care Costs in Patients With Symptomatic Heart Failure." JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY 53, no. 10 (March 10, 2009): A391-A391.

Scholars@Duke

Eisenstein, EL, Sun, JL, Anstrom, KJ, Stafford, JA, Szczech, LA, Muhlbaier, LH, and Mark, DB. "Do income level and race influence survival in patients receiving hemodialysis?." Am J Med 122, no. 2 (February 2009): 170-180.

PMID
19185093
Full Text

Eisenstein, EL, Lobach, DF, Kawamoto, K, Edwards, R, Willis, JM, Silvey, GM, and Anstrom, KJ. "A randomized clinical trial of clinical decision support in a rural community health network serving lower income individuals: study design and baseline characteristics." Studies in Health Technology and Informatics 143 (January 2009): 220-226.

PMID
19380940
Scholars@Duke

Eisenstein, EL, Ortiz, M, Anstrom, KJ, and Lobach, DF. "Health information technology economic evaluation." (December 1, 2008): 240-258. (Chapter)

Full Text

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