Eric Leo Eisenstein

Associate Professor in Medicine
Associate Professor in Family Medicine and Community Health
Member in the Duke Clinical Research Institute
Campus mail 2400 Pratt St, Durham, NC 27705
Phone (919) 668-8984
Email address eisen006@mc.duke.edu

Research Interests:

Dr. Eisenstein is a member of the Duke Clinical Research Institute’s Outcomes Research and Assessment Group, with a special interest in understanding the relationships between complex interventions in health care systems and the long-term clinical and economic outcomes of patients. He has served as Principal Investigator for phase II, III, and IV economic and quality of life studies conducted alongside randomized clinical trials in cardiovascular, emergency, pulmonary, and vascular medicine and surgery. He also has conducted health technology evaluations making use of innovative research methods designed to better understand key relationships in observation (non-randomized) patient data. This work has included evaluations of the long-term clinical outcomes of coronary artery disease patients receiving drug-eluting vs. bare metal intracoronary stents, and how the use of clopidogrel changes those relationships. He also has conducted several studies assessing factors contributing to the costs of and evaluating different design considerations for multi-center randomized clinical trials.

In addition to his working in traditional health technology evaluation, Dr. Eisenstein has an interest in evaluating information technologies as interventions in health care systems. In this regard, he has collaborated in the design and conduct of large-scale, randomized clinical trials to evaluate clinical decision support systems. The research objective in these studies has been to develop methods for evaluating health information technologies in practice-based settings using a “tool kit” of inexpensive, yet highly scalable methods that make use of data sets created as a byproduct of normal clinical and administrative operations. The use of these evaluation methods has been demonstrated in four clinical trials that include care process, clinical, economic, and quality of life measurements.

Education and Training

  • D.B.A., Cleveland State University, 1995

Publications

Eisenstein, E. L., P. A. Cowper, J. P. Bae, D. F. Kong, K. Ramaswamy, and K. J. Anstrom. “CV1 WHAT IS THE CLINICAL BENEFIT OF PREVENTING NON-FATAL MYOCARDIAL INFARCTIONS?.” Value in Health 11, no. 6 (November 2008): A341–42. https://doi.org/10.1016/s1098-3015(10)66185-2.

Full Text

Patel, Manesh R., Kevin J. Anstrom, Eric L. Eisenstein, Ralph G. Brindis, Eric D. Peterson, and Pamela S. Douglas. “Patients without obstructive coronary artery disease and stress test results: An analysis from the National Cardiovascular Data Registry.” Circulation 118, no. 18 (October 28, 2008): S1085–S1085.

Scholars@Duke

Baker-Smith, Carissa M., Daniel K. Benjamin, Henry G. Grabowski, Elizabeth D. Reid, Barry Mangum, John V. Goldsmith, M Dianne Murphy, et al. “The economic returns of pediatric clinical trials of antihypertensive drugs..” Am Heart J 156, no. 4 (October 2008): 682–88. https://doi.org/10.1016/j.ahj.2008.05.001.

PMID
18926149
Full Text

Anstrom, Kevin J., David F. Kong, Linda K. Shaw, Robert M. Califf, Judith M. Kramer, Eric D. Peterson, Sunil V. Rao, et al. “Long-term clinical outcomes following coronary stenting..” Arch Intern Med 168, no. 15 (August 11, 2008): 1647–55. https://doi.org/10.1001/archinte.168.15.1647.

PMID
18695078
Full Text

Kong, David F., Eric L. Eisenstein, and Robert Harrington. “Late adverse events after drug-eluting stent implantation..” Curr Cardiol Rep 10, no. 4 (July 2008): 253–62.

PMID
18611359
Scholars@Duke

Eisenstein, Eric L., Patricia A. Cowper, Jay Bae, David F. Kong, and Kevin J. Anstrom. “Assessing proportions of higher-risk acute coronary syndrome-percutaneous coronary intervention patients in clinical trials and clinical practice.” In Circulation, 117:E421–22. LIPPINCOTT WILLIAMS & WILKINS, 2008.

Scholars@Duke

Konstance, Richard P., Eric L. Eisenstein, Kevin J. Anstrom, Linda K. Shaw, Robert M. Califf, Robert A. Harrington, David B. Matchar, Kevin A. Schulman, and David F. Kong. “Outcomes of second revascularization procedures after stent implantation..” J Med Syst 32, no. 2 (April 2008): 177–86.

PMID
18461821
Scholars@Duke

Rao, Sunil V., Padma R. Kaul, Lawrence Liao, Paul W. Armstrong, E Magnus Ohman, Christopher B. Granger, Robert M. Califf, Robert A. Harrington, Eric L. Eisenstein, and Daniel B. Mark. “Association between bleeding, blood transfusion, and costs among patients with non-ST-segment elevation acute coronary syndromes..” Am Heart J 155, no. 2 (February 2008): 369–74. https://doi.org/10.1016/j.ahj.2007.10.014.

PMID
18215610
Full Text

Oliveira, Gustavo B. F., Eric M. Crespo, Richard C. Becker, Emily F. Honeycutt, Charles S. Abrams, Kevin J. Anstrom, Peter B. Berger, et al. “Incidence and prognostic significance of thrombocytopenia in patients treated with prolonged heparin therapy..” Arch Intern Med 168, no. 1 (January 14, 2008): 94–102. https://doi.org/10.1001/archinternmed.2007.65.

PMID
18195201
Full Text

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