Erik Magnus Ohman, MBBS

Professor of Medicine
Member in the Duke Clinical Research Institute
Campus mail 7403 Duke North, Durham, NC 27710
Phone (919) 681-2069
Email address ohman001@mc.duke.edu

The main focus of my research is in the management of acute myocardial infarction. My focus has revolved around the use of interventional procedures such as balloon angioplasty, intra-aortic balloon pumping and other support devices for the management of patients with acute myocardial infarction. Through participating and designing a number of randomized trials, we have helped crystallize the management to sustain patency of the infarct-related coronary artery in acute myocardial infarction. Furthermore, I have conducted several large multi-center clinical trials on the use of intra-aortic counterpulsation and angioplasty to better understand the pathophysiology of interventional procedures. Another major focus has been in the area of risk stratification in acute myocardial infarction. Early observations done abroad have led me to use new cardiac markers to identify high and low risk patients. Further research in this area will integrate early and rapid triage along with monitoring of the effect of thrombolysis after reperfusion in patients. A patent in the latter category has already been issued. My continued focus in the performance of multi-center international clinical trials has allowed us to explore different treatment strategies for the management of acute myocardial infarction from an international prospective. We have also collected angioplasty data on nearly 6,000 patients from around North America to further explore international differences in the management of patients using percutaneous interventions.

In Their Words

Education and Training

  • M.B.B.S., Royal College of Surgeons (Ireland), 1981

Publications

Schoos, MM, Mehran, R, Dangas, GD, Yu, J, Baber, U, Clemmensen, P, Feit, F, Gersh, BJ, Guagliumi, G, Ohman, EM, Pocock, SJ, Witzenbichler, B, and Stone, GW. "Gender Differences in Associations Between Intraprocedural Thrombotic Events During Percutaneous Coronary Intervention and Adverse Outcomes." The American Journal of Cardiology 118, no. 11 (December 2016): 1661-1668.

PMID
27836132
Full Text

Baber, U, Dangas, G, Cohen, DJ, Gibson, CM, Mehta, SR, Angiolillo, DJ, Pocock, SJ, Krucoff, MW, Kastrati, A, Ohman, EM, Steg, PG, Badimon, J, Zafar, MU, Chandrasekhar, J, Sartori, S, Aquino, M, and Mehran, R. "Ticagrelor with aspirin or alone in high-risk patients after coronary intervention: Rationale and design of the TWILIGHT study." American Heart Journal 182 (December 2016): 125-134.

PMID
27914492
Full Text

Cornel, JH, Ohman, EM, Neely, B, Jakubowski, JA, Bhatt, DL, White, HD, Ardissino, D, Fox, KAA, Prabhakaran, D, Armstrong, PW, Erlinge, D, Tantry, US, Gurbel, PA, and Roe, MT. "Relationship of Platelet Reactivity With Bleeding Outcomes During Long-Term Treatment With Dual Antiplatelet Therapy for Medically Managed Patients With Non-ST-Segment Elevation Acute Coronary Syndromes." Journal of the American Heart Association 5, no. 11 (November 4, 2016).

PMID
27815268
Full Text

Welsh, RC, Roe, MT, Steg, PG, James, S, Povsic, TJ, Bode, C, Gibson, CM, and Ohman, EM. "A critical reappraisal of aspirin for secondary prevention in patients with ischemic heart disease." American Heart Journal 181 (November 2016): 92-100. (Review)

PMID
27823698
Full Text

Ohman, EM, Douglas, PS, Dean, LB, and Ginsburg, GS. "Philanthropy for Science: Is It a Viable Option?." Circulation Research 119, no. 10 (October 2016): 1057-1059. (Review)

PMID
27789583
Full Text

Chin, CT, Boden, WE, Roe, MT, Neely, B, Neely, ML, Leiva-Pons, JL, Corbalán, R, Gottlieb, S, Dalby, AJ, Armstrong, PW, Prabhakaran, D, Fox, KAA, White, HD, Ohman, EM, Winters, KJ, and Schiele, F. "Effect of prior clopidogrel use on outcomes in medically managed acute coronary syndrome patients." Heart (British Cardiac Society) 102, no. 15 (August 2016): 1221-1229.

PMID
27030601
Full Text

Kaul, P, Ohman, EM, Knight, JD, Anstrom, KJ, Roe, MT, Boden, WE, Hochman, JS, Gašparović, V, Armstrong, PW, McCollam, P, Fakhouri, W, Cowper, P, Davidson-Ray, L, Clapp-Channing, N, White, HD, Fox, KAA, Prabhakaran, D, Mark, DB, and TRILOGY ACS Investigators, . "Health-related quality of life outcomes with prasugrel among medically managed non-ST-segment elevation acute coronary syndrome patients: Insights from the Targeted Platelet Inhibition to Clarify the Optimal Strategy to Medically Manage Acute Coronary Syndromes (TRILOGY ACS) trial." American Heart Journal 178 (August 2016): 55-64.

PMID
27502852
Full Text

Kong, DF, and Ohman, EM. "Chronic Total Coronary Occlusions, Percutaneous Coronary Intervention, and Mortality: A "Hybrid Approach" to Interpretation." Jacc. Cardiovascular Interventions 9, no. 15 (August 2016): 1545-1547.

PMID
27491604
Full Text

Ohman, EM. "Chronic Stable Angina." The New England Journal of Medicine 375, no. 3 (July 2016): 293-null. (Letter)

PMID
27468079
Full Text

Hagström, E, Roe, MT, Hafley, G, Neely, ML, Sidhu, MS, Winters, KJ, Prabhakaran, D, White, HD, Armstrong, PW, Fox, KAA, Ohman, EM, Boden, WE, and TRILOGY ACS Investigators, . "Association Between Very Low Levels of High-Density Lipoprotein Cholesterol and Long-term Outcomes of Patients With Acute Coronary Syndrome Treated Without Revascularization: Insights From the TRILOGY ACS Trial." Clinical Cardiology 39, no. 6 (June 2016): 329-337.

PMID
27177240
Full Text

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