Erik Magnus Ohman, MBBS

Professor of Medicine
Member in the Duke Clinical Research Institute
Campus mail 7403 Duke North, Durham, NC 27710
Phone (919) 681-2069
Email address ohman001@mc.duke.edu

The main focus of my research is in the management of acute myocardial infarction. My focus has revolved around the use of interventional procedures such as balloon angioplasty, intra-aortic balloon pumping and other support devices for the management of patients with acute myocardial infarction. Through participating and designing a number of randomized trials, we have helped crystallize the management to sustain patency of the infarct-related coronary artery in acute myocardial infarction. Furthermore, I have conducted several large multi-center clinical trials on the use of intra-aortic counterpulsation and angioplasty to better understand the pathophysiology of interventional procedures. Another major focus has been in the area of risk stratification in acute myocardial infarction. Early observations done abroad have led me to use new cardiac markers to identify high and low risk patients. Further research in this area will integrate early and rapid triage along with monitoring of the effect of thrombolysis after reperfusion in patients. A patent in the latter category has already been issued. My continued focus in the performance of multi-center international clinical trials has allowed us to explore different treatment strategies for the management of acute myocardial infarction from an international prospective. We have also collected angioplasty data on nearly 6,000 patients from around North America to further explore international differences in the management of patients using percutaneous interventions.

In Their Words

Education and Training

  • M.B.B.S., Royal College of Surgeons (Ireland), 1981

Publications

Husted, SE, and Ohman, EM. "Pharmacological and emerging therapies in the treatment of chronic angina." Lancet (London, England) 386, no. 9994 (August 2015): 691-701. (Review)

PMID
26334161
Full Text

Kragholm, K, Halim, SA, Yang, Q, Schulte, PJ, Hochman, JS, Melloni, C, Mahaffey, KW, Moliterno, DJ, Harrington, RA, White, HD, Armstrong, PW, Ohman, EM, Van de Werf, F, Tricoci, P, Alexander, JH, Giugliano, RP, and Newby, LK. "Sex-Stratified Trends in Enrollment, Patient Characteristics, Treatment, and Outcomes Among Non-ST-Segment Elevation Acute Coronary Syndrome Patients: Insights From Clinical Trials Over 17 Years." Circulation. Cardiovascular quality and outcomes 8, no. 4 (July 7, 2015): 357-367.

PMID
26152683
Full Text

Ben-Gal, Y, Mohr, R, Feit, F, Ohman, EM, Kirtane, A, Xu, K, Mehran, R, and Stone, GW. "Surgical versus percutaneous coronary revascularization for multivessel disease in diabetic patients with non-ST-segment-elevation acute coronary syndrome: analysis from the Acute Catheterization and Early Intervention Triage Strategy trial." Circulation. Cardiovascular interventions 8, no. 6 (June 2015).

PMID
26019142
Full Text

Thiele, H, Ohman, EM, Desch, S, Eitel, I, and de Waha, S. "Management of cardiogenic shock." European heart journal 36, no. 20 (May 2015): 1223-1230. (Review)

PMID
25732762
Full Text

Mehta, RH, Chen, AY, Alexander, KP, Ohman, EM, Roe, MT, and Peterson, ED. "Doing the right things and doing them the right way: association between hospital guideline adherence, dosing safety, and outcomes among patients with acute coronary syndrome." Circulation 131, no. 11 (March 2015): 980-987.

PMID
25688146
Full Text

Bakal, JA, Roe, MT, Ohman, EM, Goodman, SG, Fox, KAA, Zheng, Y, Westerhout, CM, Hochman, JS, Lokhnygina, Y, Brown, EB, and Armstrong, PW. "Applying novel methods to assess clinical outcomes: insights from the TRILOGY ACS trial." European heart journal 36, no. 6 (February 2015): 385-92a.

PMID
25012156
Full Text

Roy, A, Roe, MT, Neely, ML, Cyr, DD, Zamoryakhin, D, Fox, KAA, White, HD, Armstrong, PW, Ohman, EM, and Prabhakaran, D. "Impact of Human Development Index on the profile and outcomes of patients with acute coronary syndrome." Heart (British Cardiac Society) 101, no. 4 (February 2015): 279-286.

PMID
25538134
Full Text

Warren, J, Mehran, R, Yu, J, Xu, K, Bertrand, ME, Cox, DA, Lincoff, AM, Manoukian, SV, Ohman, EM, Pocock, SJ, White, HD, and Stone, GW. "Incidence and impact of totally occluded culprit coronary arteries in patients presenting with non-ST-segment elevation myocardial infarction." The American journal of cardiology 115, no. 4 (February 2015): 428-433.

PMID
25542393
Full Text

Jones, WS, Clare, RM, Chiswell, K, Perera, D, French, JK, Kumar, AS, Blaxill, J, Pijls, N, Mills, J, Ohman, EM, and Patel, MR. "The impact of processes of care on myocardial infarct size in patients with ST-segment elevation myocardial infarction: Observations from the CRISPAMI trial." Clinical Cardiology 38, no. 1 (January 1, 2015): 25-31.

Full Text

Jones, WS, Clare, RM, Chiswell, K, Perera, D, French, JK, Kumar, AS, Blaxill, J, Pijls, N, Mills, J, Ohman, EM, and Patel, MR. "The impact of processes of care on myocardial infarct size in patients with ST-segment elevation myocardial infarction: observations from the CRISP-AMI trial." Clinical cardiology 38, no. 1 (January 2015): 25-31.

PMID
25488040
Full Text

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