Erik Magnus Ohman, MBBS

Professor of Medicine
Member in the Duke Clinical Research Institute
Campus mail 7403 Duke North, Durham, NC 27710
Phone (919) 681-2069
Email address ohman001@mc.duke.edu

The main focus of my research is in the management of acute myocardial infarction. My focus has revolved around the use of interventional procedures such as balloon angioplasty, intra-aortic balloon pumping and other support devices for the management of patients with acute myocardial infarction. Through participating and designing a number of randomized trials, we have helped crystallize the management to sustain patency of the infarct-related coronary artery in acute myocardial infarction. Furthermore, I have conducted several large multi-center clinical trials on the use of intra-aortic counterpulsation and angioplasty to better understand the pathophysiology of interventional procedures. Another major focus has been in the area of risk stratification in acute myocardial infarction. Early observations done abroad have led me to use new cardiac markers to identify high and low risk patients. Further research in this area will integrate early and rapid triage along with monitoring of the effect of thrombolysis after reperfusion in patients. A patent in the latter category has already been issued. My continued focus in the performance of multi-center international clinical trials has allowed us to explore different treatment strategies for the management of acute myocardial infarction from an international prospective. We have also collected angioplasty data on nearly 6,000 patients from around North America to further explore international differences in the management of patients using percutaneous interventions.

In Their Words

Education and Training

  • M.B.B.S., Royal College of Surgeons (Ireland), 1981

Publications

Doll, JA, Neely, ML, Roe, MT, Armstrong, PW, White, HD, Prabhakaran, D, Winters, KJ, Duvvuru, S, Sundseth, SS, Jakubowski, JA, Gurbel, PA, Bhatt, DL, Ohman, EM, Fox, KAA, and TRILOGY ACS Investigators, . "Impact of CYP2C19 Metabolizer Status on Patients With ACS Treated With Prasugrel Versus Clopidogrel." Journal of the American College of Cardiology 67, no. 8 (March 2016): 936-947.

PMID
26916483
Full Text

Lopes, RD, Leonardi, S, Neely, B, Neely, ML, Ohman, EM, Ardissino, D, Hamm, CW, Goodman, SG, Bhatt, DL, White, HD, Prabhakaran, D, Martinez, F, Nicolau, JC, Winters, KJ, Fox, KAA, Armstrong, PW, and Roe, MT. "Spontaneous MI After Non-ST-Segment Elevation Acute Coronary Syndrome Managed Without Revascularization: The TRILOGY ACS Trial." Journal of the American College of Cardiology 67, no. 11 (March 2016): 1289-1297.

PMID
26988949
Full Text

Levine, GN, Bates, ER, Blankenship, JC, Bailey, SR, Bittl, JA, Cercek, B, Chambers, CE, Ellis, SG, Guyton, RA, Hollenberg, SM, Khot, UN, Lange, RA, Mauri, L, Mehran, R, Moussa, ID, Mukherjee, D, Ting, HH, O'Gara, PT, Kushner, FG, Ascheim, DD, Brindis, RG, Casey, DE, Chung, MK, de Lemos, JA, Diercks, DB, Fang, JC, Franklin, BA, Granger, CB, Krumholz, HM, Linderbaum, JA, Morrow, DA, Newby, LK, Ornato, JP, Ou, N, Radford, MJ, Tamis-Holland, JE, Tommaso, CL, Tracy, CM, Woo, YJ, and Zhao, DX. "2015 ACC/AHA/SCAI Focused Update on Primary Percutaneous Coronary Intervention for Patients With ST-Elevation Myocardial Infarction: An Update of the 2011 ACCF/AHA/SCAI Guideline for Percutaneous Coronary Intervention and the 2013 ACCF/AHA Guideline for the Management of ST-Elevation Myocardial Infarction: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Society for Cardiovascular Angiography and Interventions." Circulation 133, no. 11 (March 2016): 1135-1147.

PMID
26490017
Full Text

Ohman, EM. "CLINICAL PRACTICE. Chronic Stable Angina." The New England Journal of Medicine 374, no. 12 (March 2016): 1167-1176. (Review)

PMID
27007960
Full Text

Ohman, EM, and Roe, MT. "Excess of Solid Cancers After Prasugrel: The Food and Drug Administration Outlook." Am J Ther 23, no. 1 (January 2016): e243-e244. (Letter)

PMID
23782754
Full Text

Melloni, C, Cornel, JH, Hafley, G, Neely, ML, Clemmensen, P, Zamoryakhin, D, Prabhakaran, D, White, HD, Fox, KAA, Ohman, EM, Armstrong, PW, and Roe, MT. "Impact of chronic kidney disease on long-term ischemic and bleeding outcomes in medically managed patients with acute coronary syndromes: Insights from the TRILOGY ACS trial." European Heart Journal: Acute Cardiovascular Care 5, no. 6 (January 1, 2016): 443-454.

Full Text

Alexander, KP, Weisz, G, Prather, K, James, S, Mark, DB, Anstrom, KJ, Davidson-Ray, L, Witkowski, A, Mulkay, AJ, Osmukhina, A, Farzaneh-Far, R, Ben-Yehuda, O, Stone, GW, and Ohman, EM. "Effects of Ranolazine on Angina and Quality of Life After Percutaneous Coronary Intervention With Incomplete Revascularization: Results From the Ranolazine for Incomplete Vessel Revascularization (RIVER-PCI) Trial." Circulation 133, no. 1 (January 2016): 39-47.

PMID
26555329
Full Text

Roe, MT, Cyr, DD, Eckart, D, Schulte, PJ, Morse, MA, Blackwell, KL, Ready, NE, Zafar, SY, Beaven, AW, Strickler, JH, Onken, JE, Winters, KJ, Houterloot, L, Zamoryakhin, D, Wiviott, SD, White, HD, Prabhakaran, D, Fox, KAA, Armstrong, PW, Ohman, EM, and TRILOGY ACS Investigators, . "Ascertainment, classification, and impact of neoplasm detection during prolonged treatment with dual antiplatelet therapy with prasugrel vs. clopidogrel following acute coronary syndrome." European Heart Journal 37, no. 4 (January 2016): 412-422.

PMID
26637834
Full Text

Newby, LK, and Ohman, EM. "Biomarkers: Troponin testing--risk stratification to stratified medicine." Nature Reviews. Cardiology 12, no. 11 (November 2015): 625-626.

PMID
26440981
Full Text

Clemmensen, P, Roe, MT, Hochman, JS, Cyr, DD, Neely, ML, McGuire, DK, Cornel, JH, Huber, K, Zamoryakhin, D, White, HD, Armstrong, PW, Fox, KAA, Prabhakaran, D, Ohman, EM, and TRILOGY ACS Investigators, . "Long-term outcomes for women versus men with unstable angina/non-ST-segment elevation myocardial infarction managed medically without revascularization: insights from the TaRgeted platelet Inhibition to cLarify the Optimal strateGy to medicallY manage Acute Coronary Syndromes trial." American heart journal 170, no. 4 (October 2015): 695-705.e5.

PMID
26386793
Full Text

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