Feng Gao, MD

Professor of Medicine
Member of the Duke Human Vaccine Institute
Campus mail 244 Sands Bldg, Box 102359, Durham, NC 27710
Phone (919) 668-6433
Email address feng.gao@duke.edu

Dr. Feng Gao is Professor of Medicine at Duke University. The Gao laboratory has a long-standing interest in elucidating the origins and evolution of human and simian inmmunodeficiency viruses (HIV and SIV), and in studying HIV/SIV gene function and pathogenic mechanisms from the evolutionary perspective. These studies have led to new strategies to better understand HIV origins,  biology, pathogenesis and drug resistance, and to design new AIDS vaccines.

Education and Training

  • M.D., Harbin Medical University (China), 1984

Publications

Ritchie, Adam John, Fangping Cai, Nicola M. G. Smith, Sheri Chen, Hongshuo Song, Simon Brackenridge, Salim S. Abdool Karim, et al. “Recombination-mediated escape from primary CD8+ T cells in acute HIV-1 infection..” Retrovirology 11 (September 12, 2014). https://doi.org/10.1186/s12977-014-0069-9.

PMID
25212771
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Gao, Feng, Mattia Bonsignori, Hua-Xin Liao, Amit Kumar, Shi-Mao Xia, Xiaozhi Lu, Fangping Cai, et al. “Cooperation of B cell lineages in induction of HIV-1-broadly neutralizing antibodies..” Cell 158, no. 3 (July 31, 2014): 481–91. https://doi.org/10.1016/j.cell.2014.06.022.

PMID
25065977
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Fera, Daniela, Aaron G. Schmidt, Barton F. Haynes, Feng Gao, Hua-Xin Liao, Thomas B. Kepler, and Stephen C. Harrison. “Affinity maturation in an HIV broadly neutralizing B-cell lineage through reorientation of variable domains..” Proc Natl Acad Sci U S A 111, no. 28 (July 15, 2014): 10275–80. https://doi.org/10.1073/pnas.1409954111.

PMID
24982157
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Sanchez, Ana M., C Todd DeMarco, Bhavna Hora, Sarah Keinonen, Yue Chen, Christie Brinkley, Mars Stone, et al. “Development of a contemporary globally diverse HIV viral panel by the EQAPOL program..” J Immunol Methods 409 (July 2014): 117–30. https://doi.org/10.1016/j.jim.2014.01.004.

PMID
24447533
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Haynes, Barton F., M Anthony Moody, Munir Alam, Mattia Bonsignori, Laurent Verkoczy, Guido Ferrari, Feng Gao, Georgia D. Tomaras, Hua-Xin Liao, and Garnett Kelsoe. “Progress in HIV-1 vaccine development..” J Allergy Clin Immunol 134, no. 1 (July 2014): 3–10. https://doi.org/10.1016/j.jaci.2014.04.025.

PMID
25117798
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Bonsignori, Mattia, Kevin Wiehe, Sebastian K. Grimm, Rebecca Lynch, Guang Yang, Daniel M. Kozink, Florence Perrin, et al. “An autoreactive antibody from an SLE/HIV-1 individual broadly neutralizes HIV-1..” J Clin Invest 124, no. 4 (April 2014): 1835–43. https://doi.org/10.1172/JCI73441.

PMID
24614107
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Xiang, Yue, Wei Liu, Yue Chen, Chuntao Zhang, Weiheng Su, Yan Zhang, Jiaxi Sun, Feng Gao, and Chunlai Jiang. “The variable loop 3 in the envelope glycoprotein is critical for the atypical coreceptor usage of an HIV-1 strain..” Plos One 9, no. 6 (2014). https://doi.org/10.1371/journal.pone.0098058.

PMID
24897520
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Song, Hongshuo, Bhavna Hora, Tanmoy Bhattacharya, Nilu Goonetilleke, Michael K. P. Liu, Kevin Wiehe, Hui Li, et al. “Reversion and T cell escape mutations compensate the fitness loss of a CD8+ T cell escape mutant in their cognate transmitted/founder virus..” Plos One 9, no. 7 (2014). https://doi.org/10.1371/journal.pone.0102734.

PMID
25028937
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Liu, Jia, Hongshuo Song, Donglai Liu, Tao Zuo, Fengmin Lu, Hui Zhuang, and Feng Gao. “Extensive recombination due to heteroduplexes generates large amounts of artificial gene fragments during PCR..” Plos One 9, no. 9 (2014). https://doi.org/10.1371/journal.pone.0106658.

PMID
25211143
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Liu, D., T. Zuo, B. Hora, H. Song, W. Kong, X. Yu, N. Goonetilleke, et al. “Preexisting compensatory amino acids compromise fitness costs of a HIV-1 T cell escape mutation.” Retrovirology, 2014. https://doi.org/10.1186/s12977-014-0101-0.

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