Francis Joseph Miller, MD

Professor of Medicine
Professor in Pharmacology and Cancer Biology
Campus mail 203 Research Drive, 397 MSRB1, Durham, NC 27705
Phone (919) 668-2688
Email address francis.miller@duke.edu

The central goal of my research program is to understand the molecular and cellular mechanisms that contribute to the generation of reactive oxygen species and pathophysiology of vascular disease. I am an internationally recognized expert in NADPH oxidases and detection of reactive oxygen species in blood vessels and vascular cells. As a practicing cardiologist, I strive to integrate research findings across the spectrum of molecular mechanisms to cultured cells to animal models to human disease. A secondary focus utilizes the selectivity of RNA aptamers for therapeutic targeting.

Education and Training

  • Cardiovascular Diseases Fellowship, University of Iowa Roy J. and Lucille A. Carver College of Medicine, 1992 - 1995
  • Internal Medicine Residency, University of Texas Southwestern Medical Center at Dallas Southwestern Medical School, 1989 - 1992
  • M.D., University of Iowa Roy J. and Lucille A. Carver College of Medicine, 1989

Publications

Matsuda, JJ, Filali, MS, Moreland, JG, Miller, FJ, and Lamb, FS. "Activation of swelling-activated chloride current by tumor necrosis factor-alpha requires ClC-3-dependent endosomal reactive oxygen production." The Journal of Biological Chemistry 285, no. 30 (July 2010): 22864-22873.

PMID
20479003
Full Text

Miller, FJ, Chu, X, Stanic, B, Tian, X, Sharma, RV, Davisson, RL, and Lamb, FS. "A differential role for endocytosis in receptor-mediated activation of Nox1." Antioxidants & Redox Signaling 12, no. 5 (March 2010): 583-593.

PMID
19737091
Full Text

Simons, AL, Orcutt, KP, Parsons, AD, Sibenaller, ZA, Scarbrough, PM, Sobhakumari, A, Zhu, Y, Wilke, WW, Kalen, AL, Miller, FJ, Goswami, P, and Spitz, DR. "Inhibition of EGFR Signaling Induces Metabolic Oxidative Stress in Human Head and Neck Cancer Cells." January 2010.

Full Text

Miller, FJ. "NADPH oxidase 4: walking the walk with Poldip2." Circulation Research 105, no. 3 (July 2009): 209-210.

PMID
19644055
Full Text

Lamb, FS, Moreland, JG, and Miller, FJ. "Electrophysiology of reactive oxygen production in signaling endosomes." Antioxidants & Redox Signaling 11, no. 6 (June 2009): 1335-1347. (Review)

PMID
19207039
Full Text

Xing, D, Chaudhary, AK, Miller, FJ, and Martins, JB. "Free radical scavenger specifically prevents ischemic focal ventricular tachycardia." Heart rhythm 6, no. 4 (April 2009): 530-536.

PMID
19324315
Full Text

Delfs, J, Stanic, B, and Miller, FJ. "TNF-alpha AND THROMBIN DIFFERENTIALY ACTIVATE NOX1 TRAFFICKING IN MOUSE AORTIC SMOOTH MUSCLE CELLS." JOURNAL OF INVESTIGATIVE MEDICINE 57, no. 3 (March 2009): 537-537.

Scholars@Duke

Jagadeesha, DK, Miller, FJ, and Bhalla, RC. "Inhibition of apoptotic signaling and neointimal hyperplasia by tempol and nitric oxide synthase following vascular injury." Journal of vascular research 46, no. 2 (January 2009): 109-118.

PMID
18714161
Full Text

Ashby, AR, Schmidt, GA, and Miller, FJ. "Prophylactic Beta Blockade To Prevent Peri-Extubation Cardiac Ischemia and Congestive Heart Failure." AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 179 (2009).

Scholars@Duke

Tannous, P, Zhu, H, Nemchenko, A, Berry, JM, Johnstone, JL, Shelton, JM, Jr, MFJ, Rothermel, BA, and Hill, JA. "Intracellular Protein Aggregation Is a Proximal Trigger of Cardiomyocyte Autophagy." CIRCULATION RESEARCH 103, no. 5 (August 29, 2008): E53-E53.

Scholars@Duke

Pages