Francis Joseph Miller, MD

Professor of Medicine
Professor in Pharmacology and Cancer Biology
Campus mail 203 Research Drive, 397 MSRB1, Durham, NC 27705
Phone (919) 668-2688
Email address francis.miller@duke.edu

The central goal of my research program is to understand the molecular and cellular mechanisms that contribute to the generation of reactive oxygen species and pathophysiology of vascular disease. I am an internationally recognized expert in NADPH oxidases and detection of reactive oxygen species in blood vessels and vascular cells. As a practicing cardiologist, I strive to integrate research findings across the spectrum of molecular mechanisms to cultured cells to animal models to human disease. A secondary focus utilizes the selectivity of RNA aptamers for therapeutic targeting.

Education and Training

  • Cardiovascular Diseases Fellowship, University of Iowa Roy J. and Lucille A. Carver College of Medicine, 1992 - 1995
  • Internal Medicine Residency, University of Texas Southwestern Medical Center at Dallas Southwestern Medical School, 1989 - 1992
  • M.D., University of Iowa Roy J. and Lucille A. Carver College of Medicine, 1989

Publications

Tannous, P, Zhu, H, Nemchenko, A, Berry, JM, Johnstone, JL, Shelton, JM, Miller, FJ, Rothermel, BA, and Hill, JA. "Intracellular protein aggregation is a proximal trigger of cardiomyocyte autophagy." Circulation 117, no. 24 (June 9, 2008): 3070-3078.

PMID
18541737
Full Text

Roghair, RD, Miller, FJ, Scholz, TD, Lamb, FS, and Segar, JL. "Coronary constriction to angiotensin II is enhanced by endothelial superoxide production in sheep programmed by dexamethasone." Pediatric research 63, no. 4 (April 2008): 370-374.

PMID
18356741
Full Text

Filali, MS, Matsuda, JJ, Gross, JR, Storm, SK, Moreland, JG, Miller, FJ, and Lamb, FS. "ClC-3 anion current is required for superoxide production in early endosomes and subsequent NF-B-kappa activation by TNF alpha." FASEB JOURNAL 22 (April 2008).

Scholars@Duke

Roghair, RD, Miller, FJ, Scholz, TD, Lamb, FS, and Segar, JL. "Endothelial superoxide production is altered in sheep programmed by early gestation dexamethasone exposure." Neonatology 93, no. 1 (January 2008): 19-27.

PMID
17630494
Scholars@Duke

Chu, X, Sheehan, AL, Lamb, FS, and Jr, MFJ. "The chloride transporter CIC-3 is required for TNF-alpha-induced proliferation of vascular smooth muscle cells, activation of matrix metalloproteinase-9, and neointima formation." CIRCULATION 116, no. 16 (October 16, 2007): 113-113.

Scholars@Duke

Sheehan, AL, Takapoo, M, Banfi, B, and Jr, MFJ. "Role for Nox1 NADPH oxidase in atherosclerosis." CIRCULATION 116, no. 16 (October 16, 2007): 244-244.

Scholars@Duke

Miller, FJ, Filali, M, Huss, GJ, Stanic, B, Chamseddine, A, Barna, TJ, and Lamb, FS. "Cytokine activation of nuclear factor kappa B in vascular smooth muscle cells requires signaling endosomes containing Nox1 and ClC-3." Circulation research 101, no. 7 (September 2007): 663-671.

PMID
17673675
Full Text

Dammanahalli, JK, Jr, MFJ, and Bhalla, RC. "Effect of oxidative stress on apoptosis and regulation of Bax and Bel-xL in development of intimal thickening of balloon-injured rat carotid artery." April 2007.

Scholars@Duke

Miller, FJ. "Aortic aneurysms: It's all about the stress." Arteriosclerosis, thrombosis, and vascular biology 22, no. 12 (December 2002): 1948-1949. (Review)

PMID
12482817
Full Text

Xu, SP, Chamseddine, A, and Miller, FJ. "Increased expression of Nox4 is associated with increased superoxide levels and altered growth of smooth muscle cells in atherosclerosis." November 5, 2002.

Scholars@Duke

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