Francis Joseph Miller, MD

Professor of Medicine
Professor in Pharmacology and Cancer Biology
Campus mail 203 Research Drive, 397 MSRB1, Durham, NC 27705
Phone (919) 668-2688
Email address francis.miller@duke.edu

The central goal of my research program is to understand the molecular and cellular mechanisms that contribute to the generation of reactive oxygen species and pathophysiology of vascular disease. I am an internationally recognized expert in NADPH oxidases and detection of reactive oxygen species in blood vessels and vascular cells. As a practicing cardiologist, I strive to integrate research findings across the spectrum of molecular mechanisms to cultured cells to animal models to human disease. A secondary focus utilizes the selectivity of RNA aptamers for therapeutic targeting.

Education and Training

  • Cardiovascular Diseases Fellowship, University of Iowa Roy J. and Lucille A. Carver College of Medicine, 1992 - 1995
  • Internal Medicine Residency, University of Texas Southwestern Medical Center at Dallas Southwestern Medical School, 1989 - 1992
  • M.D., University of Iowa Roy J. and Lucille A. Carver College of Medicine, 1989

Publications

Lentz, SR, Miller, FJ, Piegors, DJ, Erger, RA, Fernández, JA, Griffin, JH, and Heistad, DD. "Anticoagulant responses to thrombin are enhanced during regression of atherosclerosis in monkeys." Circulation 106, no. 7 (August 2002): 842-846.

PMID
12176958
Full Text

Brandes, RP, Miller, FJ, Beer, S, Haendeler, J, Hoffmann, J, Ha, T, Holland, SM, Görlach, A, and Busse, R. "The vascular NADPH oxidase subunit p47phox is involved in redox-mediated gene expression." Free Radical Biology & Medicine 32, no. 11 (June 2002): 1116-1122.

PMID
12031896
Full Text

Miller, FJ, Sharp, WJ, Fang, X, Oberley, LW, Oberley, TD, and Weintraub, NL. "Oxidative stress in human abdominal aortic aneurysms: a potential mediator of aneurysmal remodeling." Arteriosclerosis, Thrombosis, and Vascular Biology 22, no. 4 (April 2002): 560-565.

PMID
11950691
Full Text

Shihabi, A, Li, W-G, Miller, FJ, and Weintraub, NL. "Antioxidant therapy for atherosclerotic vascular disease: the promise and the pitfalls." American Journal of Physiology. Heart and Circulatory Physiology 282, no. 3 (March 2002): H797-H802. (Review)

PMID
11834471
Full Text

Hathaway, CA, Heistad, DD, Piegors, DJ, and Miller, FJ. "Regression of atherosclerosis in monkeys reduces vascular superoxide levels." Circulation Research 90, no. 3 (February 2002): 277-283.

PMID
11861415
Full Text

Miller, FJ, and Griendling, KK. "Functional evaluation of nonphagocytic NAD(P)H oxidases." Methods in Enzymology 353 (January 2002): 220-233.

PMID
12078497
Full Text

Lentz, SR, Miller, FJ, Piegors, DJ, Erger, RA, Fernandez, JA, Griffin, JH, and Heistad, DD. "Impaired anticoagulant response to thrombin improves after regression of atherosclerosis in monkeys." BLOOD 98, no. 11 (November 16, 2001): 257A-257A.

Scholars@Duke

Lentz, SR, Piegors, DJ, Fernandez, JA, Erger, RA, Malinow, MR, Griffin, JH, Haynes, WG, and Heistad, DD. "Effect of hyperhomocysteinemia on protein C activation and activity in vivo." November 16, 2001.

Scholars@Duke

Zhang, Y, Bissing, JW, Xu, L, Ryan, AJ, Martin, SM, Miller, FJ, Kregel, KC, Buettner, GR, and Kerber, RE. "Nitric oxide synthase inhibitors decrease coronary sinus-free radical concentration and ameliorate myocardial stunning in an ischemia-reperfusion model." Journal of the American College of Cardiology 38, no. 2 (August 2001): 546-554.

PMID
11499751
Full Text

Li, WG, Miller, FJ, Zhang, HJ, Spitz, DR, Oberley, LW, and Weintraub, NL. "H(2)O(2)-induced O(2) production by a non-phagocytic NAD(P)H oxidase causes oxidant injury." The Journal of Biological Chemistry 276, no. 31 (August 2001): 29251-29256.

PMID
11358965
Full Text

Pages