Geoffrey Stuart Pitt, MD

Adjunct Professor in the Department of Medicine
Faculty Network Member of the Duke Institute for Brain Sciences
Campus mail 515 E. 79th Street, Pha, New York, NY 10075
Phone (919) 257-1589
Email address geoffrey.pitt@duke.edu

Our research focuses on how intracellular Ca2+, the ultimate signal of membrane excitability, regulates membrane excitability and the consequent function of excitable cells. We have discovered and described multiple mechanisms that control Ca2+ influx through voltage-gated Ca2+ channels and feedback mechanisms by which internal calcium regulates other channels that influence Ca2+ channel function. The work has entailed structure-function analyses of ion channels and their regulatory subunits and studies of mutations that lead to inherited channelopathies such as cardiac arrhythmias and epilepsy.

Education and Training

  • Fellow in Cardiovascular Medicine, Medicine, Stanford University, 1995 - 1999
  • Medical Resident, Medicine, Stanford University, 1993 - 1995
  • M.D., Johns Hopkins University, 1993

Publications

Okaichi, K., A. B. Cubitt, G. S. Pitt, and R. A. Firtel. “Amino acid substitutions in the Dictyostelium G alpha subunit G alpha 2 produce dominant negative phenotypes and inhibit the activation of adenylyl cyclase, guanylyl cyclase, and phospholipase C.” Mol Biol Cell 3, no. 7 (July 1992): 735–47. https://doi.org/10.1091/mbc.3.7.735.

PMID
1355376
Full Text

Pitt, G. S., N. Milona, J. Borleis, K. C. Lin, R. R. Reed, and P. N. Devreotes. “Structurally distinct and stage-specific adenylyl cyclase genes play different roles in Dictyostelium development.” Cell 69, no. 2 (April 17, 1992): 305–15. https://doi.org/10.1016/0092-8674(92)90411-5.

PMID
1348970
Full Text

Johnson, R. L., R. Gundersen, D. Hereld, G. S. Pitt, S. Tugendreich, C. L. Saxe, A. R. Kimmel, and P. N. Devreotes. “G-protein-linked signaling pathways mediate development in Dictyostelium.” Cold Spring Harb Symp Quant Biol 57 (1992): 169–76. https://doi.org/10.1101/sqb.1992.057.01.022.

PMID
1339656
Full Text

Pitt, G. S., R. E. Gundersen, and P. N. Devreotes. “Mechanisms of excitation and adaptation in Dictyostelium.” Semin Cell Biol 1, no. 2 (April 1990): 99–104.

PMID
2129339
Scholars@Duke

Pitt, G. S., R. E. Gundersen, P. J. Lilly, M. B. Pupillo, R. A. Vaughan, and P. N. Devreotes. “G protein-linked signal transduction in aggregating Dictyostelium.” Society of General Physiologists Series 45 (January 1, 1990): 125–31.

Scholars@Duke

Pitt, G. S., R. E. Gundersen, P. J. Lilly, M. B. Pupillo, R. A. Vaughan, and P. N. Devreotes. “G protein-linked signal transduction in aggregating Dictyostelium.” Soc Gen Physiol Ser 45 (1990): 125–31.

PMID
2116034
Scholars@Duke

Pupillo, M., A. Kumagai, G. S. Pitt, R. A. Firtel, and P. N. Devreotes. “Multiple alpha subunits of guanine nucleotide-binding proteins in Dictyostelium.” Proc Natl Acad Sci U S A 86, no. 13 (July 1989): 4892–96. https://doi.org/10.1073/pnas.86.13.4892.

PMID
2500658
Full Text

Johnson, R. L., R. Gundersen, P. Lilly, G. S. Pitt, M. Pupillo, T. J. Sun, R. A. Vaughan, and P. N. Devreotes. “G-protein-linked signal transduction systems control development in Dictyostelium.” Development 107 Suppl (1989): 75–80.

PMID
2517628
Scholars@Duke

Pitt, G. S., and P. N. Devreotes. “A simple BASIC program allows the rapid entry of DNA nucleotide sequences into personal computers.” Biotechniques 6, no. 2 (February 1988): 122–23.

PMID
3273178
Scholars@Duke

Pupillo, M., P. Klein, R. Vaughan, G. Pitt, P. Lilly, T. Sun, P. Devreotes, A. Kumagai, and R. Firtel. “cAMP receptor and G-protein interactions control development in Dictyostelium.” In Cold Spring Harb Symp Quant Biol, 53 Pt 2:657–65, 1988. https://doi.org/10.1101/sqb.1988.053.01.075.

PMID
3151181
Full Text

Pages