Gowthami Morey Arepally, MD

Associate Professor of Medicine
Associate Professor of Pathology
Campus mail Duke Box 3486, Durham, NC 27710
Phone (919) 668-3696
Email address arepa001@mc.duke.edu

Gowthami M. Arepally, M.D. is an Associate Professor in the Division of Hematology at Duke University Medical Center and the Medical Director of Therapeutic Apheresis at Duke.  Her clinical interests are in immune thrombocytopenias, thrombotic disorders, and applications of therapeutic apheresis for immunologic disorders.    Dr. Arepally’s long-standing research program investigates immunoregulatory mechanisms in HIT.  Current laboratory efforts focus on the role of complement activation in the immune pathogenesis of HIT, investigations of protamine/heparin antibodies and development of murine models for studies of the HIT immune response.  Clinical projects include applications of therapeutic apheresis, including development of a multi-site network for investigations of thrombotic microangiopathy, studies of therapeutic plasma exchange for HIT and solid organ transplantation. 

Education and Training

  • Fellow in Hematology-Oncology, Medicine, University of Pennsylvania, 1993 - 1997
  • Chief Medical Resident, Medicine, Emory University, 1992 - 1993
  • Medical Resident, Medicine, Emory University, 1989 - 1992
  • M.D., Vanderbilt University, 1989

Publications

Khandelwal, S, Lee, GM, Hester, CG, Poncz, M, McKenzie, SE, Sachais, BS, Rauova, L, Kelsoe, G, Cines, DB, Frank, M, and Arepally, GM. "The antigenic complex in HIT binds to B cells via complement and complement receptor 2 (CD21)." Blood 128, no. 14 (October 2016): 1789-1799.

PMID
27412887
Full Text

Khandelwal, S, and Arepally, GM. "Immune pathogenesis of heparin-induced thrombocytopenia." Thrombosis and haemostasis 116, no. 5 (October 2016): 792-798.

PMID
27465274
Full Text

Fountain, EM, and Arepally, GM. "THROMBOCYTOPENIA IN HOSPITALIZED NON-ICU PATIENTS." AMERICAN JOURNAL OF HEMATOLOGY 91, no. 9 (September 2016): E401-E401.

Scholars@Duke

Metjian, A, Tanhehco, Y, Pham, HP, Aqui, NA, Bhoj, V, Onwuemene, O, Marques, M, and Arepally, GM. "The Thrombotic Microangiopathy Registry of North America." December 3, 2015.

Scholars@Duke

Fountain, E, and Arepally, GM. "Thrombocytopenia in Hospitalized Non-ICU Patients." December 3, 2015.

Scholars@Duke

Lee, GM, Joglekar, M, Khandelwal, S, Qi, R, Rauova, L, and Arepally, GM. "Characterization of Human and Murine Anti-Protamine/Heparin Antibodies." December 3, 2015.

Scholars@Duke

Cai, Z, Yarovoi, SV, Zhu, Z, Rauova, L, Hayes, V, Lebedeva, T, Liu, Q, Poncz, M, Arepally, G, Cines, DB, and Greene, MI. "Atomic description of the immune complex involved in heparin-induced thrombocytopenia." Nature communications 6 (September 22, 2015): 8277-.

PMID
26391892
Full Text

Joglekar, M, Khandelwal, S, Cines, DB, Poncz, M, Rauova, L, and Arepally, GM. "Heparin enhances uptake of platelet factor 4/heparin complexes by monocytes and macrophages." Journal of thrombosis and haemostasis : JTH 13, no. 8 (August 2015): 1416-1427.

PMID
25960020
Full Text

Arepally, GM, and Ortel, TL. "Changing practice of anticoagulation: will target-specific anticoagulants replace warfarin?." Annual review of medicine 66 (January 2015): 241-253. (Review)

PMID
25587651
Full Text

Joglekar, MV, Khandelwal, S, Poncz, M, Rauova, L, and Arepally, GM. "Understanding the Underlying Immune Response in HIT: Uptake of PF4/Heparin Complexes By Monocytes & Dendritic Cells." December 6, 2014.

Scholars@Duke

Pages