Hematology

Gowthami Morey Arepally, MD

Professor of Medicine
Associate Professor of Pathology
Professor of Pathology
Campus mail Duke Box 3486, Durham, NC 27710
Phone (919) 668-3696
Email address arepa001@mc.duke.edu

Gowthami M. Arepally, M.D. is a Professor of Medicine in the Division of Hematology at Duke University Medical Center.  Her clinical interests are in immune thrombocytopenias, thrombotic disorders, and complement-mediated diseases.  Dr. Arepally’s long-standing research program investigates the immune pathogenesis of heparin induced thrombocytopenia (HIT).  Current laboratory efforts focus on the role of complement activation in antibody production and thrombosis in HIT, studies of complement inhibitors for immune-complex mediated diseases and diagnostic biomarkers of platelet activation.  

Education and Training

  • Fellow in Hematology-Oncology, Medicine, University of Pennsylvania, 1993 - 1997
  • Chief Medical Resident, Medicine, Emory University, 1992 - 1993
  • Medical Resident, Medicine, Emory University, 1989 - 1992
  • M.D., Vanderbilt University, 1989

Grants

Publications

Rondeau, Eric, Marie Scully, Gema Ariceta, Tom Barbour, Spero Cataland, Nils Heyne, Yoshitaka Miyakawa, et al. “Erratum to "Rondeau E, Scully M, Ariceta G, Barbour T, Cataland S, Heyne N, Miyakawa Y, Ortiz S, Swenson E, Vallee M, Yoon S-S, Kavanagh D, Haller H; on behalf of the 311 Study Group. The long-acting C5 inhibitor, Ravulizumab, is effective and safe in adult patients with atypical hemolytic uremic syndrome naïve to complement inhibitor treatment" Kidney Int. 2020;97:1287-1296.” Kidney Int 98, no. 6 (December 2020): 1621. https://doi.org/10.1016/j.kint.2020.11.001.

PMID
33276869
Full Text

Johnston, Ian, Amrita Sarkar, Vincent Hayes, Gavin T. Koma, Gowthami M. Arepally, Junmei Chen, Dominic W. Chung, et al. “Recognition of PF4-VWF complexes by heparin-induced thrombocytopenia antibodies contributes to thrombus propagation.” Blood 135, no. 15 (April 9, 2020): 1270–80. https://doi.org/10.1182/blood.2018881607.

PMID
32077913
Full Text

Gollomp, Kandace, Amrita Sarkar, Sanjiv Harikumar, Steven H. Seeholzer, Gowthami M. Arepally, Kristin Hudock, Lubica Rauova, M Anna Kowalska, and Mortimer Poncz. “Fc-modified HIT-like monoclonal antibody as a novel treatment for sepsis.” Blood 135, no. 10 (March 5, 2020): 743–54. https://doi.org/10.1182/blood.2019002329.

PMID
31722003
Full Text

Achey, Meredith A., Uttara P. Nag, Victoria L. Robinson, Christopher R. Reed, Gowthami M. Arepally, Jerrold H. Levy, and Elisabeth T. Tracy. “The Developing Balance of Thrombosis and Hemorrhage in Pediatric Surgery: Clinical Implications of Age-Related Changes in Hemostasis.” Clin Appl Thromb Hemost 26 (January 2020): 1076029620929092. https://doi.org/10.1177/1076029620929092.

PMID
32584601
Full Text

Gollomp, Kandace, Amrita Sarkar, Gowthami Arepally, Douglas B. Cines, M Anna Kowalska, Lubica Rauova, and Mortimer Poncz. “Understanding How Fc-Modification Transforms a Pathogenic Heparin-Induced Thrombocytopenia (HIT)-like Monoclonal Antibody into a Novel Treatment for Sepsis.” Blood 134, no. Supplement_1 (November 13, 2019): 10. https://doi.org/10.1182/blood-2019-123132.

PMID
31723995
Full Text

Pishko, Allyson M., Daniel S. Lefler, Phyllis Gimotty, Koosha Paydary, Sara Fardin, Gowthami M. Arepally, Mark Crowther, et al. “The risk of major bleeding in patients with suspected heparin-induced thrombocytopenia.” J Thromb Haemost 17, no. 11 (November 2019): 1956–65. https://doi.org/10.1111/jth.14587.

PMID
31350937
Full Text

Duarte, Madelaine, Maragatha Kuchibhatla, Sanjay Khandelwal, Gowthami M. Arepally, and Grace M. Lee. “Heterogeneity in neutrophil responses to immune complexes.” Blood Adv 3, no. 19 (October 8, 2019): 2778–89. https://doi.org/10.1182/bloodadvances.2019000235.

PMID
31554616
Full Text

Khandelwal, Sanjay, Joann Ravi, Lubica Rauova, Alexandra Johnson, Grace M. Lee, Jennifer B. Gilner, Sreenivasulu Gunti, et al. “Polyreactive IgM initiates complement activation by PF4/heparin complexes through the classical pathway.” Blood 132, no. 23 (December 6, 2018): 2431–40. https://doi.org/10.1182/blood-2018-03-834598.

PMID
30309891
Full Text

Pages