Gregory David Sempowski, PhD

Professor in Medicine
Professor of Pathology
Affiliate, Duke Global Health Institute
Member of the Duke Human Vaccine Institute
Campus mail 909 S. Lasalle St, Rm 1019 Global Health Research Building,, Durham, NC 27705
Phone (919) 684-4386
Email address greg.sempowski@duke.edu

Dr. Sempowski earned his PhD in Immunology from the University of Rochester and was specifically trained in the areas of inflammation, wound healing, and host response (innate and adaptive).  Dr. Sempowski contributed substantially to the field of lung inflammation and fibrosis defining the roles of pulmonary fibroblast heterogeneity and CD40/CD40L signaling in regulating normal and pathogenic lung inflammation.  During his postdoctoral training with Dr. Barton F. Haynes at Duke University, Dr. Sempowski focused on human immunology and more specifically immune reconstitution in settings of immune deficiency.  This resulted in publication of seminal findings regarding the cellular and molecular mechanisms that drive attenuation of immune function in the elderly. 

Since joining the Duke School of Medicine faculty in 2000, Dr. Sempowski has developed an independent research program studying immune deficiency associated with aging and radiation exposure. Dr. Sempowski is highly collaborative and works closely with investigators across the US, Europe, Australia and Japan and is internationally recognized as a thought leader in thymic aging, immunosenescence and multiplex biomarker analysis.

In 2017 Dr. Sempowski assumed Directorship of the Duke Global Health Research Building, a division of the Duke Human Vaccine Institute.  This state-of-the-art Regional Biocontainment Laboratory (RBL) was built with funding from the NIH to support basic research to develop drugs, diagnostics and vaccines for emerging/reemerging infections and biodefense.  The Duke RBL has a comprehensive safety and operations program to provide the Duke and RTP communities biocontainment facilities for BSL2, BSL3, and Select Agent research.  The facility is home to a portfolio of sponsored research programs focused on biosafety and biopreparedness, vaccine and therapeutic development, host response and immune monitoring and assay proficiency and quality assurance. 

Education and Training

  • Ph.D., University of Rochester, 1996

Publications

Packiam, Mathanraj, Roshan D. Yedery, Afrin A. Begum, Russell W. Carlson, Jhuma Ganguly, Gregory D. Sempowski, Melissa S. Ventevogel, William M. Shafer, and Ann E. Jerse. “Phosphoethanolamine decoration of Neisseria gonorrhoeae lipid A plays a dual immunostimulatory and protective role during experimental genital tract infection.” Infect Immun 82, no. 6 (June 2014): 2170–79. https://doi.org/10.1128/IAI.01504-14.

PMID
24686069
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Yan, Qin, Batu K. Sharma-Kuinkel, Hitesh Deshmukh, Ephraim L. Tsalik, Derek D. Cyr, Joseph Lucas, Christopher W. Woods, et al. “Dusp3 and Psme3 are associated with murine susceptibility to Staphylococcus aureus infection and human sepsis.” Plos Pathog 10, no. 6 (June 2014): e1004149. https://doi.org/10.1371/journal.ppat.1004149.

PMID
24901344
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Lynch, Heather E., Shelley M. Stewart, Thomas B. Kepler, Gregory D. Sempowski, and S Munir Alam. “Surface plasmon resonance measurements of plasma antibody avidity during primary and secondary responses to anthrax protective antigen.” J Immunol Methods 404 (February 2014): 1–12. https://doi.org/10.1016/j.jim.2013.11.026.

PMID
24316020
Full Text

Holmer, Stephanie M., Kathy S. Evans, Yohannes G. Asfaw, Divey Saini, Wiley A. Schell, Julie G. Ledford, Richard Frothingham, Jo Rae Wright, Gregory D. Sempowski, and John R. Perfect. “Impact of surfactant protein D, interleukin-5, and eosinophilia on Cryptococcosis.” Infect Immun 82, no. 2 (February 2014): 683–93. https://doi.org/10.1128/IAI.00855-13.

PMID
24478083
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Zhou, Xiyou, Xi Gao, Peter M. Broglie, Chahnaz Kebaier, James E. Anderson, Natalie Thom, Michael A. Apicella, Gregory D. Sempowski, and Joseph A. Duncan. “Hexa-acylated lipid A is required for host inflammatory response to Neisseria gonorrhoeae in experimental gonorrhea.” Infect Immun 82, no. 1 (January 2014): 184–92. https://doi.org/10.1128/IAI.00890-13.

PMID
24126526
Full Text

Lynch, H. E., S. M. Stewart, T. B. Kepler, G. D. Sempowski, and S. M. Alam. “Surface plasmon resonance measurements of plasma antibody avidity during primary and secondary responses to anthrax protective antigen.” Journal of Immunological Methods 404, no. 1 (2014): 1–12.

Scholars@Duke

Roberts, Lydia M., Hannah E. Ledvina, Gregory D. Sempowski, and Jeffrey A. Frelinger. “TLR2 Signaling is Required for the Innate, but Not Adaptive Response to LVS clpB.” Front Immunol 5 (2014): 426. https://doi.org/10.3389/fimmu.2014.00426.

PMID
25250027
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Cain, Derek W., Emily G. O’Koren, Matthew J. Kan, Mandy Womble, Gregory D. Sempowski, Kristen Hopper, Michael D. Gunn, and Garnett Kelsoe. “Identification of a tissue-specific, C/EBPβ-dependent pathway of differentiation for murine peritoneal macrophages.” J Immunol 191, no. 9 (November 1, 2013): 4665–75. https://doi.org/10.4049/jimmunol.1300581.

PMID
24078688
Full Text

Collins, Bradley H., Zoie E. Holzknecht, Kellie A. Lynn, Gregory D. Sempowski, Catherine C. Smith, Songling Liu, William Parker, and Don C. Rockey. “Association of age-dependent liver injury and fibrosis with immune cell populations.” Liver Int 33, no. 8 (September 2013): 1175–86. https://doi.org/10.1111/liv.12202.

PMID
23710620
Full Text

Pages