Guofang Zhang, PhD

Assistant Professor in Medicine
Member of Duke Molecular Physiology Institute
Campus mail 300 North Duke Street, Durham, NC 27701
Phone (919) 684-2262
Email address guofang.zhang@duke.edu

Education and Training

  • M.S., Vrije Universiteit Brussel (Belgium), 2004
  • Ph.D., Nanjing University (China), 2001

Publications

Wilson, KA, Han, Y, Zhang, M, Hess, JP, Chapman, KA, Cline, GW, Tochtrop, GP, Brunengraber, H, and Zhang, G-F. "Inter-relations between 3-hydroxypropionate and propionate metabolism in rat liver: relevance to disorders of propionyl-CoA metabolism." American journal of physiology. Endocrinology and metabolism 313, no. 4 (October 2017): E413-E428.

PMID
28634175
Full Text

Wilson, K, Hess, J, Zhang, G, Brunengraber, H, and Tochtrop, G. "Metabolism of Beta-Alanine in Rat Liver: Degradation to Acetyl-CoA and Carboxylation to 2-(aminomethyl)-malonate." April 2017.

Scholars@Duke

Sanabria, JR, Kombu, RS, Zhang, G-F, Sandlers, Y, Ai, J, Ibarra, RA, Abbas, R, Goyal, K, and Brunengraber, H. "Glutathione species and metabolomic prints in subjects with liver disease as biological markers for the detection of hepatocellular carcinoma." HPB 18, no. 12 (December 2016): 979-990.

Full Text

Guzzo, MB, Nguyen, HT, Pham, TH, Wyszczelska-Rokiel, M, Jakubowski, H, Wolff, KA, Ogwang, S, Timpona, JL, Gogula, S, Jacobs, MR, Ruetz, M, Kräutler, B, Jacobsen, DW, Zhang, G-F, and Nguyen, L. "Methylfolate Trap Promotes Bacterial Thymineless Death by Sulfa Drugs." PLoS pathogens 12, no. 10 (October 19, 2016): e1005949-.

PMID
27760199
Full Text

Li, L, Zhang, G-F, Lee, K, Lopez, R, Previs, SF, Willard, B, McCullough, A, and Kasumov, T. "A Western diet induced NAFLD in LDLR−/− mice is associated with reduced hepatic glutathione synthesis." Free Radical Biology and Medicine 96 (July 2016): 13-21.

Full Text

Marsboom, G, Zhang, G-F, Pohl-Avila, N, Zhang, Y, Yuan, Y, Kang, H, Hao, B, Brunengraber, H, Malik, AB, and Rehman, J. "Glutamine Metabolism Regulates the Pluripotency Transcription Factor OCT4." Cell reports 16, no. 2 (July 2016): 323-332.

PMID
27346346
Full Text

Hao, Y, Samuels, Y, Li, Q, Krokowski, D, Guan, B-J, Wang, C, Jin, Z, Dong, B, Cao, B, Feng, X, Xiang, M, Xu, C, Fink, S, Meropol, NJ, Xu, Y, Conlon, RA, Markowitz, S, Kinzler, KW, Velculescu, VE, Brunengraber, H, Willis, JE, LaFramboise, T, Hatzoglou, M, Zhang, G-F, Vogelstein, B, and Wang, Z. "Oncogenic PIK3CA mutations reprogram glutamine metabolism in colorectal cancer." Nature Communications 7 (June 20, 2016): 11971-11971.

Full Text

Jin, Z, Bian, F, Tomcik, K, Kelleher, JK, Zhang, G-F, and Brunengraber, H. "Compartmentation of Metabolism of the C12-, C9-, and C5-n-dicarboxylates in Rat Liver, Investigated by Mass Isotopomer Analysis: ANAPLEROSIS FROM DODECANEDIOATE." The Journal of biological chemistry 290, no. 30 (July 2015): 18671-18677.

PMID
26070565
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Li, Q, Deng, S, Ibarra, RA, Anderson, VE, Brunengraber, H, and Zhang, G-F. "Multiple mass isotopomer tracing of acetyl-CoA metabolism in Langendorff-perfused rat hearts: channeling of acetyl-CoA from pyruvate dehydrogenase to carnitine acetyltransferase." The Journal of biological chemistry 290, no. 13 (March 2015): 8121-8132.

PMID
25645937
Full Text

Anand, P, Hausladen, A, Wang, Y-J, Zhang, G-F, Stomberski, C, Brunengraber, H, Hess, DT, and Stamler, JS. "Identification of S-nitroso-CoA reductases that regulate protein S-nitrosylation." Proceedings of the National Academy of Sciences of the United States of America 111, no. 52 (December 15, 2014): 18572-18577.

PMID
25512491
Full Text

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