Harvey Jay Cohen, MD

Professor of Medicine
Walter Kempner Professor of Medicine, in the School of Medicine
Director, Center for the Study of Aging & Human Development
Faculty Research Scholar of DuPRI's Center for Population Health & Aging
Member of the Duke Cancer Institute
Campus mail 3502 Blue Zone Duke Clinic, Center For Aging, Trent Drive, Durham, NC 27710
Phone (919) 660-7502
Email address harvey.cohen@duke.edu

Dr. Cohen's research program includes clinical research relating to aspects of the pathways to functional decline with aging, geriatric assessment, and cancer in the elderly.

Pathways to functional decline are being explored through the NIA funded Claude Pepper Older Americans Independence Center, and includes studies of the contributions of age related physiologic change, in particular changes in inflammatory parameters, comorbid diseases and conditions, environment, genetics, and the interactionas among them. Data are derived from several current studies as well as previously collected data sets from the Established Populations for Epidemiologic Studies of the Elderly (EPESE), National Long Term Care Survey, and the Chinese Longevity Study (with Dr. Zeng Yi). Previous work has demonstrated the important contributions of age related inflammation and coagulation activation to functional status.

Geriatric assessment approaches have been studied in a number of randomized and controlled studies and work is now concentrating on the application of Comprehensive Geriatric Assessment tools to the evaluation and treatment of elderly patients with cancer. This is an extension and continuation of a long standing interest in geriatric oncology. Previous studies have elucidated age-related patterns of disease presentation, treatment approaches, clinical trials, survivorship, quality of life, impact of comrobidities and functional outcomes. Dr. Cohen is co-chair of the Cancer in the Elderly Committee of Cancer and Acute Luekemia Group B (CALGB). A number of active studies and ongoing data bases aree being utilized to address these questions.

Education and Training

  • M.D., State University of New York at Brooklyn, 1965

Publications

Gajra, A, Zemla, TJ, Jatoi, A, Feliciano, JL, Wong, ML, Chen, H, Maggiore, R, McMurray, RP, Hurria, A, Muss, HB, Cohen, HJ, Lafky, J, Edelman, MJ, Lilenbaum, R, and Le-Rademacher, JG. "Time-to-Treatment-Failure and Related Outcomes Among 1000+ Advanced Non-Small Cell Lung Cancer Patients: Comparisons Between Older Versus Younger Patients (Alliance A151711)." Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer 13, no. 7 (July 2018): 996-1003.

PMID
29608967
Full Text

Tallarico, M, Foster, JC, Seisler, D, Lafky, JM, Hurria, A, Jatoi, A, Cohen, HJ, Muss, HB, Bartlett, N, Cheson, BD, Jung, S-H, Leonard, JP, Byrd, JC, and Nabhan, C. "Frequency and impact of grade three or four toxicities of novel agents on outcomes of older patients with chronic lymphocytic leukemia and non-Hodgkin lymphoma (alliance A151611)." Journal of Geriatric Oncology 9, no. 4 (July 2018): 321-328.

PMID
29673807
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Noppert, GA, Aiello, AE, O'Rand, AM, and Cohen, HJ. "Investigating pathogen burden in relation to a cumulative deficits index in a representative sample of US adults." Epidemiology and Infection (June 14, 2018): 1-9.

PMID
29898795
Full Text

Snyder, PJ, Bhasin, S, Cunningham, GR, Matsumoto, AM, Stephens-Shields, AJ, Cauley, JA, Gill, TM, Barrett-Connor, E, Swerdloff, RS, Wang, C, Ensrud, KE, Lewis, CE, Farrar, JT, Cella, D, Rosen, RC, Pahor, M, Crandall, JP, Molitch, ME, Resnick, SM, Budoff, M, Mohler, ER, Wenger, NK, Cohen, HJ, Schrier, S, Keaveny, TM, Kopperdahl, D, Lee, D, Cifelli, D, and Ellenberg, SS. "Lessons From the Testosterone Trials." Endocrine Reviews 39, no. 3 (June 2018): 369-386.

PMID
29522088
Full Text

Feliciano, JL, Le-Rademacher, JG, Gajra, A, Edelman, MJ, Zemla, T, McMurray, R, Chen, H, Hurria, A, Muss, H, Cohen, HJ, Lilenbaum, R, and Jatoi, A. "Do older patients with non-small cell lung cancer also benefit from first-line platinum-based doublet chemotherapy? Observations from a pooled analysis of 730 prospectively-treated patients (Alliance Study A151622)." Journal of Geriatric Oncology (May 27, 2018).

PMID
29848457
Full Text

Soto-Perez-de-Celis, E, Sun, C-L, Tew, WP, Mohile, SG, Gajra, A, Klepin, HD, Owusu, C, Gross, CP, Muss, HB, Lichtman, SM, Chapman, AE, Cohen, HJ, Dale, W, Kim, H, Fernandes, S, Katheria, V, and Hurria, A. "Association between patient-reported hearing and visual impairments and functional, psychological, and cognitive status among older adults with cancer." Cancer (May 24, 2018).

PMID
29797664
Full Text

Gajra, A, McCall, L, Muss, HB, Cohen, HJ, Jatoi, A, Ballman, KV, Partridge, AH, Sutton, L, Parker, BA, Magrinat, G, Klepin, HD, Lafky, JM, and Hurria, A. "The preference to receive chemotherapy and cancer-related outcomes in older adults with breast cancer CALGB 49907 (Alliance)." Journal of Geriatric Oncology 9, no. 3 (May 2018): 221-227.

PMID
29602735
Full Text

Whitson, HE, Cohen, HJ, Schmader, KE, Morey, MC, Kuchel, G, and Colon-Emeric, CS. "Physical Resilience: Not Simply the Opposite of Frailty." Journal of the American Geriatrics Society (March 25, 2018).

PMID
29577234
Full Text

Pavon, JM, Sloane, RJ, Pieper, CF, Colón-Emeric, CS, Cohen, HJ, Gallagher, D, Morey, MC, McCarty, M, Ortel, TL, and Hastings, SN. "Poor Adherence to Risk Stratification Guidelines Results in Overuse of Venous Thromboembolism Prophylaxis in Hospitalized Older Adults." Journal of hospital medicine (February 6, 2018).

PMID
29408946
Full Text

Cohen, HJ. "Evolution of Geriatric Assessment in Oncology." Journal of Oncology Practice 14, no. 2 (February 2018): 95-96.

PMID
29436305
Full Text

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