Harvey Jay Cohen, MD

Professor of Medicine
Walter Kempner Distinguished Professor of Medicine, in the School of Medicine
Emeritus Director, Center for the Study of Aging & Human Development
Faculty Research Scholar of DuPRI's Center for Population Health & Aging
Member of the Duke Cancer Institute
Campus mail 2509 Blue Zone Duke Clinic, Center for Aging, Trent Drive, Durham, NC 27710
Phone (919) 660-7503
Email address harvey.cohen@duke.edu

Dr. Cohen's research program includes clinical research relating to aspects of the pathways to functional decline and reilience with aging, geriatric assessment, and cancer and anemia in the elderly.

Pathways to functional decline are being explored through the NIA funded Claude Pepper Older Americans Independence Center, and includes studies of the contributions of age related physiologic change, in particular changes in inflammatory parameters, comorbid diseases and conditions, environment, genetics, and the interactionas among them. Data are derived from several current studies as well as previously collected data sets from the Established Populations for Epidemiologic Studies of the Elderly (EPESE), National Long Term Care Survey, and the Chinese Longevity Study (with Dr. Zeng Yi). Previous work has demonstrated the important contributions of age related inflammation and coagulation activation to functional status. He is Co-PI of the Pepper Center Physical Performance Across the LifeSpan (PALS) study, which is a longitudinal cohort study of community dwelling adults from age 30-90+and includes functional measures and biomarkers on inflammation and metabolism.
 
Geriatric assessment approaches have been studied in a number of randomized and controlled studies and work is now concentrating on the application of Comprehensive Geriatric Assessment tools to the evaluation and treatment of elderly patients with cancer. This is an extension and continuation of a long standing interest in geriatric oncology. Previous studies have elucidated age-related patterns of disease presentation, treatment approaches, clinical trials, survivorship, quality of life, impact of comrobidities and functional outcomes. Dr. Cohen was co-chair, and now member of the Cancer in the Older Adult Committee of the Alliance for Clinical Trials in Oncology (ALLIANCE). A number of active studies and ongoing data bases aree being utilized to address these questions.

Anemia in the older adult is being addressed through an NIA funded U01 consortium (Dr. Cohen Co-PI). the current main study is an observational study followed by a pragmatic treatment trial for anemia in older adults with CHF, in collaboration with the Cardiovascular Research Network (CVRN) of the Health services research network (HSRN) 

Education and Training

  • M.D., State University of New York at Brooklyn, 1965

Publications

Wong, Melisa L., Stuart M. Lichtman, Gary R. Morrow, John Simmons, Tomma Hargraves, Cary P. Gross, Jennifer L. Lund, et al. “Geriatric oncology health services research: Cancer and Aging Research Group infrastructure core.” Journal of Geriatric Oncology 11, no. 2 (March 2020): 350–54. https://doi.org/10.1016/j.jgo.2019.07.012.

PMID
31326392
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Hao, Shiying, Jin You, Lin Chen, Hui Zhao, Yujuan Huang, Le Zheng, Lu Tian, et al. “Changes in pregnancy-related serum biomarkers early in gestation are associated with later development of preeclampsia.” Plos One 15, no. 3 (January 2020): e0230000. https://doi.org/10.1371/journal.pone.0230000.

PMID
32126118
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Tremoulet, Adriana H., Sonia Jain, Pei-Ni Jone, Brookie M. Best, Elizabeth H. Duxbury, Alessandra Franco, Beth Printz, et al. “Phase I/IIa Trial of Atorvastatin in Patients with Acute Kawasaki Disease with Coronary Artery Aneurysm.” J Pediatr 215 (December 2019): 107-117.e12. https://doi.org/10.1016/j.jpeds.2019.07.064.

PMID
31561960
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Ambrosy, Andrew P., Jerry H. Gurwitz, Grace H. Tabada, Andrew Artz, Stanley Schrier, Sunil V. Rao, Huiman X. Barnhart, et al. “Incident anaemia in older adults with heart failure: rate, aetiology, and association with outcomes.” Eur Heart J Qual Care Clin Outcomes 5, no. 4 (October 1, 2019): 361–69. https://doi.org/10.1093/ehjqcco/qcz010.

PMID
30847487
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Deardorff, William James, Phillip L. Liu, Richard Sloane, Courtney Van Houtven, Carl F. Pieper, Susan Nicole Hastings, Harvey J. Cohen, and Heather E. Whitson. “Association of Sensory and Cognitive Impairment With Healthcare Utilization and Cost in Older Adults.” J Am Geriatr Soc 67, no. 8 (August 2019): 1617–24. https://doi.org/10.1111/jgs.15891.

PMID
30924932
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Walston, Jeremy, Karen Bandeen-Roche, Brian Buta, Howard Bergman, Thomas M. Gill, John E. Morley, Linda P. Fried, et al. “Moving Frailty Toward Clinical Practice: NIA Intramural Frailty Science Symposium Summary.” J Am Geriatr Soc 67, no. 8 (August 2019): 1559–64. https://doi.org/10.1111/jgs.15928.

PMID
31045254
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Ganti, Apar Kishor, Xiaofei Wang, Thomas E. Stinchcombe, Yinpeng Wang, Jeffrey Bradley, Harvey J. Cohen, Karen Kelly, et al. “Clinical prognostic model for older patients with advanced non-small cell lung cancer.” J Geriatr Oncol 10, no. 4 (July 2019): 555–59. https://doi.org/10.1016/j.jgo.2019.02.007.

PMID
30797707
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Dao, Dyda, Tyler Zemla, Aminah Jatoi, Rachel A. Freedman, Arti Hurria, Hyman Muss, Harvey Jay Cohen, et al. “Older-Patient-Specific Cancer Trials: A Pooled Analysis of 2,277 Patients (A151715).” Oncologist 24, no. 6 (June 2019): e284–91. https://doi.org/10.1634/theoncologist.2018-0803.

PMID
30975921
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Hurria, Arti, Enrique Soto-Perez-de-Celis, Jacob B. Allred, Harvey Jay Cohen, Anait Arsenyan, Karla Ballman, Jennifer Le-Rademacher, et al. “Functional Decline and Resilience in Older Women Receiving Adjuvant Chemotherapy for Breast Cancer.” J Am Geriatr Soc 67, no. 5 (May 2019): 920–27. https://doi.org/10.1111/jgs.15493.

PMID
30146695
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Barginear, Myra, Amylou C. Dueck, Jacob B. Allred, Craig Bunnell, Harvey J. Cohen, Rachel A. Freedman, Arti Hurria, et al. “Age and the Risk of Paclitaxel-Induced Neuropathy in Women with Early-Stage Breast Cancer (Alliance A151411): Results from 1,881 Patients from Cancer and Leukemia Group B (CALGB) 40101.” Oncologist 24, no. 5 (May 2019): 617–23. https://doi.org/10.1634/theoncologist.2018-0298.

PMID
30409792
Full Text

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