Harvey Jay Cohen, MD

Professor of Medicine
Walter Kempner Distinguished Professor of Medicine, in the School of Medicine
Emeritus Director, Center for the Study of Aging & Human Development
Faculty Research Scholar of DuPRI's Center for Population Health & Aging
Member of the Duke Cancer Institute
Campus mail 2509 Blue Zone Duke Clinic, Center for Aging, Trent Drive, Durham, NC 27710
Phone (919) 660-7503
Email address harvey.cohen@duke.edu

Dr. Cohen's research program includes clinical research relating to aspects of the pathways to functional decline and reilience with aging, geriatric assessment, and cancer and anemia in the elderly.

Pathways to functional decline are being explored through the NIA funded Claude Pepper Older Americans Independence Center, and includes studies of the contributions of age related physiologic change, in particular changes in inflammatory parameters, comorbid diseases and conditions, environment, genetics, and the interactionas among them. Data are derived from several current studies as well as previously collected data sets from the Established Populations for Epidemiologic Studies of the Elderly (EPESE), National Long Term Care Survey, and the Chinese Longevity Study (with Dr. Zeng Yi). Previous work has demonstrated the important contributions of age related inflammation and coagulation activation to functional status. He is Co-PI of the Pepper Center Physical Performance Across the LifeSpan (PALS) study, which is a longitudinal cohort study of community dwelling adults from age 30-90+and includes functional measures and biomarkers on inflammation and metabolism.
 
Geriatric assessment approaches have been studied in a number of randomized and controlled studies and work is now concentrating on the application of Comprehensive Geriatric Assessment tools to the evaluation and treatment of elderly patients with cancer. This is an extension and continuation of a long standing interest in geriatric oncology. Previous studies have elucidated age-related patterns of disease presentation, treatment approaches, clinical trials, survivorship, quality of life, impact of comrobidities and functional outcomes. Dr. Cohen was co-chair, and now member of the Cancer in the Older Adult Committee of the Alliance for Clinical Trials in Oncology (ALLIANCE). A number of active studies and ongoing data bases aree being utilized to address these questions.

Anemia in the older adult is being addressed through an NIA funded U01 consortium (Dr. Cohen Co-PI). the current main study is an observational study followed by a pragmatic treatment trial for anemia in older adults with CHF, in collaboration with the Cardiovascular Research Network (CVRN) of the Health services research network (HSRN) 

Education and Training

  • M.D., State University of New York, Brooklyn, 1965

Publications

Klepin, Heidi D., Can-Lan Sun, David D. Smith, Rawad Elias, Kelly M. Trevino, Ashley Leak Bryant, Daneng Li, et al. “Predictors of Unplanned Hospitalizations Among Older Adults Receiving Cancer Chemotherapy.” Jco Oncol Pract, April 21, 2021, OP2000681. https://doi.org/10.1200/OP.20.00681.

PMID
33881905
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Mandelblatt, Jeanne S., Xingtao Zhou, Brent J. Small, Jaeil Ahn, Wanting Zhai, Tim Ahles, Martine Extermann, et al. “Response to Dekker, Stege, and Versteeg.” J Natl Cancer Inst, April 5, 2021. https://doi.org/10.1093/jnci/djab060.

PMID
33823011
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Van Dyk, Kathleen, Xingtao Zhou, Brent J. Small, Jaeil Ahn, Wanting Zhai, Tim Ahles, Deena Graham, et al. “Protective Effects of APOE ε2 Genotype on Cognition in Older Breast Cancer Survivors: The Thinking and Living With Cancer Study.” Jnci Cancer Spectr 5, no. 2 (April 2021): pkab013. https://doi.org/10.1093/jncics/pkab013.

PMID
33748669
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Guerard, Emily, Andrew B. Dodge, Jennifer G. Le-Rademacher, M Margaret Kemeny, Michael Ojelabi, Mina S. Sedrak, Judith Hopkins, et al. “Electronic Geriatric Assessment: Is It Feasible in a Multi-Institutional Study That Included a Notable Proportion of Older African American Patients? (Alliance A171603).” Jco Clin Cancer Inform 5 (April 2021): 435–41. https://doi.org/10.1200/CCI.20.00163.

PMID
33852323
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Wong, Melisa L., Junheng Gao, Gita Thanarajasingam, Jeff A. Sloan, Amylou C. Dueck, Paul J. Novotny, Aminah Jatoi, et al. “Expanding Beyond Maximum Grade: Chemotherapy Toxicity over Time by Age and Performance Status in Advanced Non-Small Cell Lung Cancer in CALGB 9730 (Alliance A151729).” Oncologist 26, no. 3 (March 2021): e435–44. https://doi.org/10.1002/onco.13527.

PMID
32951293
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Magnuson, Allison, Mina S. Sedrak, Cary P. Gross, William P. Tew, Heidi D. Klepin, Tanya M. Wildes, Hyman B. Muss, et al. “Development and Validation of a Risk Tool for Predicting Severe Toxicity in Older Adults Receiving Chemotherapy for Early-Stage Breast Cancer.” J Clin Oncol 39, no. 6 (February 20, 2021): 608–18. https://doi.org/10.1200/JCO.20.02063.

PMID
33444080
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Sedrak, Mina S., Canlan Sun, Hyman Muss, Rachel A. Freedman, Allison Magnuson, Cary P. Gross, William P. Tew, et al. “Inflammation and coagulation biomarkers associated with physical resilience in older women receiving chemotherapy for early breast cancer.” In Cancer Research, Vol. 81, 2021.

Scholars@Duke

Mandelblatt, Jeanne S., Xingtao Zhou, Brent J. Small, Jaeil Ahn, Wanting Zhai, Tim Ahles, Martine Extermann, et al. “Deficit Accumulation Frailty Trajectories of Older Breast Cancer Survivors and Non-Cancer Controls: The Thinking and Living with Cancer Study.” J Natl Cancer Inst, January 23, 2021. https://doi.org/10.1093/jnci/djab003.

PMID
33484565
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Huang, Qianyang, Shiying Hao, Xiaoming Yao, Jin You, Xiao Li, Donghai Lai, Chunle Han, et al. “High-throughput quantitation of serological ceramides/dihydroceramides by LC/MS/MS: Pregnancy baseline biomarkers and potential metabolic messengers.” J Pharm Biomed Anal 192 (January 5, 2021): 113639. https://doi.org/10.1016/j.jpba.2020.113639.

PMID
33017796
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Sedrak, Mina S., Rachel A. Freedman, Harvey J. Cohen, Hyman B. Muss, Aminah Jatoi, Heidi D. Klepin, Tanya M. Wildes, et al. “Older adult participation in cancer clinical trials: A systematic review of barriers and interventions.” Ca Cancer J Clin 71, no. 1 (January 2021): 78–92. https://doi.org/10.3322/caac.21638.

PMID
33002206
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