Harvey Jay Cohen, MD

Professor of Medicine
Walter Kempner Professor of Medicine, in the School of Medicine
Director, Center for the Study of Aging & Human Development
Faculty Research Scholar of DuPRI's Center for Population Health & Aging
Member of the Duke Cancer Institute
Campus mail 3502 Blue Zone Duke Clinic, Center For Aging, Trent Drive, Durham, NC 27710
Phone (919) 660-7502
Email address harvey.cohen@duke.edu

Dr. Cohen's research program includes clinical research relating to aspects of the pathways to functional decline with aging, geriatric assessment, and cancer in the elderly.

Pathways to functional decline are being explored through the NIA funded Claude Pepper Older Americans Independence Center, and includes studies of the contributions of age related physiologic change, in particular changes in inflammatory parameters, comorbid diseases and conditions, environment, genetics, and the interactionas among them. Data are derived from several current studies as well as previously collected data sets from the Established Populations for Epidemiologic Studies of the Elderly (EPESE), National Long Term Care Survey, and the Chinese Longevity Study (with Dr. Zeng Yi). Previous work has demonstrated the important contributions of age related inflammation and coagulation activation to functional status.

Geriatric assessment approaches have been studied in a number of randomized and controlled studies and work is now concentrating on the application of Comprehensive Geriatric Assessment tools to the evaluation and treatment of elderly patients with cancer. This is an extension and continuation of a long standing interest in geriatric oncology. Previous studies have elucidated age-related patterns of disease presentation, treatment approaches, clinical trials, survivorship, quality of life, impact of comrobidities and functional outcomes. Dr. Cohen is co-chair of the Cancer in the Elderly Committee of Cancer and Acute Luekemia Group B (CALGB). A number of active studies and ongoing data bases aree being utilized to address these questions.

Education and Training

  • M.D., State University of New York at Brooklyn, 1965

Publications

Wong, ML, and Cohen, HJ. "Going Far Together: A Tribute to Arti Hurria, MD." Journal of the American Geriatrics Society 67, no. 3 (March 2019): 620-621. (Letter)

PMID
30707760
Full Text

Ganti, AK, Wang, X, Stinchcombe, TE, Wang, Y, Bradley, J, Cohen, HJ, Kelly, K, Paulus, R, Ramalingam, SS, Vokes, EE, and Pang, H. "Clinical prognostic model for older patients with advanced non-small cell lung cancer." Journal of Geriatric Oncology (February 20, 2019).

PMID
30797707
Full Text

Parker, D, Sloane, R, Pieper, CF, Hall, KS, Kraus, VB, Kraus, WE, Huebner, JL, Ilkayeva, OR, Bain, JR, Newby, LK, Cohen, HJ, and Morey, MC. "Age-Related Adverse Inflammatory and Metabolic Changes Begin Early in Adulthood." February 2019.

PMID
29985987
Full Text

Stinchcombe, TE, Fan, W, Schild, SE, Vokes, EE, Bogart, J, Le, Q-T, Thomas, CR, Edelman, MJ, Horn, L, Komaki, R, Cohen, HJ, Kishor Ganti, A, Pang, H, and Wang, X. "A pooled analysis of individual patient data from National Clinical Trials Network clinical trials of concurrent chemoradiotherapy for limited-stage small cell lung cancer in elderly patients versus younger patients." Cancer 125, no. 3 (February 2019): 382-390.

PMID
30343497
Full Text

Berger, M, Oyeyemi, D, Olurinde, MO, Whitson, HE, Weinhold, KJ, Woldorff, MG, Lipsitz, LA, Moretti, E, Giattino, CM, Roberts, KC, Zhou, J, Bunning, T, Ferrandino, M, Scheri, RP, Cooter, M, Chan, C, Cabeza, R, Browndyke, JN, Murdoch, DM, Devinney, MJ, Shaw, LM, Cohen, HJ, Mathew, JP, and INTUIT Investigators, . "The INTUIT Study: Investigating Neuroinflammation Underlying Postoperative Cognitive Dysfunction." Journal of the American Geriatrics Society (January 23, 2019).

PMID
30674067
Full Text

Kaufman, BD, Hollander, SA, Zhang, Y, Chen, S, Bernstein, D, Rosenthal, DN, Almond, CS, Murray, JM, Burgart, AM, Cohen, HJ, Kirkpatrick, JN, and Blume, ED. "Compassionate deactivation of ventricular assist devices in children: A survey of pediatric ventricular assist device clinicians’ perspectives and practices." Pediatric Transplantation (January 1, 2019).

Full Text

Barginear, M, Dueck, AC, Allred, JB, Bunnell, C, Cohen, HJ, Freedman, RA, Hurria, A, Kimmick, G, Le-Rademacher, JG, Lichtman, S, Muss, HB, Shulman, LN, Sitiki Copur, M, Biggs, D, Ramaswamy, B, Lafky, JM, and Jatoi, A. "Age and the Risk of Paclitaxel-Induced Neuropathy in Women with Early-Stage Breast Cancer (Alliance A151411): Results from 1,881 Patients from Cancer and Leukemia Group B (CALGB) 40101." The Oncologist (November 8, 2018).

PMID
30409792
Full Text

Noppert, GA, Aiello, AE, O'Rand, AM, and Cohen, HJ. "Investigating pathogen burden in relation to a cumulative deficits index in a representative sample of US adults." Epidemiology and Infection 146, no. 15 (November 2018): 1968-1976.

PMID
29898795
Full Text

Wildes, TM, Maggiore, RJ, Tew, WP, Smith, D, Sun, C-L, Cohen, H, Mohile, SG, Gajra, A, Klepin, HD, Owusu, C, Gross, CP, Muss, H, Chapman, A, Lichtman, SM, Katheria, V, Hurria, A, and Cancer and Aging Research Group, . "Factors associated with falls in older adults with cancer: a validated model from the Cancer and Aging Research Group." Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer 26, no. 10 (October 2018): 3563-3570.

PMID
29705872
Full Text

Li, D, McCall, LM, Hahn, OM, Hudis, CA, Cohen, HJ, Muss, HB, Jatoi, A, Lafky, JM, Ballman, KV, Winer, EP, Tripathy, D, Schneider, B, Barry, W, Dickler, MN, and Hurria, A. "Identification of risk factors for toxicity in patients with hormone receptor-positive advanced breast cancer treated with bevacizumab plus letrozole: a CALGB 40503 (alliance) correlative study." Breast Cancer Research and Treatment 171, no. 2 (September 2018): 325-334.

PMID
29789969
Full Text

Pages