Harvey Jay Cohen, MD

Professor of Medicine
Walter Kempner Distinguished Professor of Medicine, in the School of Medicine
Emeritus Director, Center for the Study of Aging & Human Development
Faculty Research Scholar of DuPRI's Center for Population Health & Aging
Member of the Duke Cancer Institute
Campus mail 2509 Blue Zone Duke Clinic, Center for Aging, Trent Drive, Durham, NC 27710
Phone (919) 660-7503
Email address harvey.cohen@duke.edu

Dr. Cohen's research program includes clinical research relating to aspects of the pathways to functional decline and reilience with aging, geriatric assessment, and cancer and anemia in the elderly.

Pathways to functional decline are being explored through the NIA funded Claude Pepper Older Americans Independence Center, and includes studies of the contributions of age related physiologic change, in particular changes in inflammatory parameters, comorbid diseases and conditions, environment, genetics, and the interactionas among them. Data are derived from several current studies as well as previously collected data sets from the Established Populations for Epidemiologic Studies of the Elderly (EPESE), National Long Term Care Survey, and the Chinese Longevity Study (with Dr. Zeng Yi). Previous work has demonstrated the important contributions of age related inflammation and coagulation activation to functional status. He is Co-PI of the Pepper Center Physical Performance Across the LifeSpan (PALS) study, which is a longitudinal cohort study of community dwelling adults from age 30-90+and includes functional measures and biomarkers on inflammation and metabolism.
 
Geriatric assessment approaches have been studied in a number of randomized and controlled studies and work is now concentrating on the application of Comprehensive Geriatric Assessment tools to the evaluation and treatment of elderly patients with cancer. This is an extension and continuation of a long standing interest in geriatric oncology. Previous studies have elucidated age-related patterns of disease presentation, treatment approaches, clinical trials, survivorship, quality of life, impact of comrobidities and functional outcomes. Dr. Cohen was co-chair, and now member of the Cancer in the Older Adult Committee of the Alliance for Clinical Trials in Oncology (ALLIANCE). A number of active studies and ongoing data bases aree being utilized to address these questions.

Anemia in the older adult is being addressed through an NIA funded U01 consortium (Dr. Cohen Co-PI). the current main study is an observational study followed by a pragmatic treatment trial for anemia in older adults with CHF, in collaboration with the Cardiovascular Research Network (CVRN) of the Health services research network (HSRN) 

Education and Training

  • M.D., State University of New York, Brooklyn, 1965

Publications

Huang, Qianyang, Shiying Hao, Xiaoming Yao, Jin You, Xiao Li, Donghai Lai, Chunle Han, et al. “High-throughput quantitation of serological ceramides/dihydroceramides by LC/MS/MS: Pregnancy baseline biomarkers and potential metabolic messengers.” J Pharm Biomed Anal 192 (January 5, 2021): 113639. https://doi.org/10.1016/j.jpba.2020.113639.

PMID
33017796
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Sylvester, Karl G., Shiying Hao, Jin You, Le Zheng, Lu Tian, Xiaoming Yao, Lihong Mo, et al. “Maternal metabolic profiling to assess fetal gestational age and predict preterm delivery: a two-centre retrospective cohort study in the US.” Bmj Open 10, no. 12 (December 2, 2020): e040647. https://doi.org/10.1136/bmjopen-2020-040647.

PMID
33268420
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Huang, Jia, Le Zheng, Zhen Li, Shiying Hao, Fangfan Ye, Jun Chen, Hayley A. Gans, et al. “Kinetics of SARS-CoV-2 positivity of infected and recovered patients from a single center.” Sci Rep 10, no. 1 (October 29, 2020): 18629. https://doi.org/10.1038/s41598-020-75629-x.

PMID
33122706
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Parker, Daniel C., Bryce N. Bartlett, Harvey J. Cohen, Gerda Fillenbaum, Janet L. Huebner, Virginia Byers Kraus, Carl Pieper, and Daniel W. Belsky. “Association of Blood Chemistry Quantifications of Biological Aging With Disability and Mortality in Older Adults.” J Gerontol a Biol Sci Med Sci 75, no. 9 (September 16, 2020): 1671–79. https://doi.org/10.1093/gerona/glz219.

PMID
31693736
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Knoll, Christopher, Beth Kaufman, Sharon Chen, Jenna Murray, Harvey Cohen, Barbara M. Sourkes, David N. Rosenthal, and Seth A. Hollander. “Palliative Care Engagement for Pediatric Ventricular Assist Device Patients: A Single-Center Experience.” Asaio J 66, no. 8 (August 2020): 929–32. https://doi.org/10.1097/MAT.0000000000001092.

PMID
32740354
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Hao, Shiying, Xuefeng B. Ling, John T. Kanegaye, Emelia Bainto, Samuel R. Dominguez, Heather Heizer, Pei-Ni Jone, et al. “Multicentre validation of a computer-based tool for differentiation of acute Kawasaki disease from clinically similar febrile illnesses.” Arch Dis Child 105, no. 8 (August 2020): 772–77. https://doi.org/10.1136/archdischild-2019-317980.

PMID
32139365
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Nobuhara, Chloe K., W Michael Bullock, Thomas Bunning, Brian Colin, Mary Cooter, Michael J. Devinney, Michael N. Ferrandino, et al. “A protocol to reduce self-reported pain scores and adverse events following lumbar punctures in older adults.” J Neurol 267, no. 7 (July 2020): 2002–6. https://doi.org/10.1007/s00415-020-09797-1.

PMID
32198714
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Ambrosy, Andrew P., Jesse K. Fitzpatrick, Grace H. Tabada, Jerry H. Gurwitz, Andrew Artz, Stanley L. Schrier, Sunil V. Rao, et al. “A reduced transferrin saturation is independently associated with excess morbidity and mortality in older adults with heart failure and incident anemia.” Int J Cardiol 309 (June 15, 2020): 95–99. https://doi.org/10.1016/j.ijcard.2020.03.020.

PMID
32201101
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Kobayashi, Lindsay C., Harvey Jay Cohen, Wanting Zhai, Xingtao Zhou, Brent J. Small, George Luta, Arti Hurria, et al. “Cognitive function prior to systemic therapy and subsequent well-being in older breast cancer survivors: Longitudinal findings from the Thinking and Living with Cancer Study.” Psychooncology 29, no. 6 (June 2020): 1051–59. https://doi.org/10.1002/pon.5376.

PMID
32154959
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Sinclair, Tiffany J., Chengyin Ye, Yunliang Chen, Dongyan Zhang, Tian Li, Xuefeng Bruce Ling, Harvey J. Cohen, et al. “Progressive Metabolic Dysfunction and Nutritional Variability Precedes Necrotizing Enterocolitis.” Nutrients 12, no. 5 (April 30, 2020). https://doi.org/10.3390/nu12051275.

PMID
32365850
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