Harvey Jay Cohen, MD

Professor of Medicine
Walter Kempner Distinguished Professor of Medicine, in the School of Medicine
Emeritus Director, Center for the Study of Aging & Human Development
Faculty Research Scholar of DuPRI's Center for Population Health & Aging
Member of the Duke Cancer Institute
Campus mail 2509 Blue Zone Duke Clinic, Center for Aging, Trent Drive, Durham, NC 27710
Phone (919) 660-7503
Email address harvey.cohen@duke.edu

Dr. Cohen's research program includes clinical research relating to aspects of the pathways to functional decline and reilience with aging, geriatric assessment, and cancer and anemia in the elderly.

Pathways to functional decline are being explored through the NIA funded Claude Pepper Older Americans Independence Center, and includes studies of the contributions of age related physiologic change, in particular changes in inflammatory parameters, comorbid diseases and conditions, environment, genetics, and the interactionas among them. Data are derived from several current studies as well as previously collected data sets from the Established Populations for Epidemiologic Studies of the Elderly (EPESE), National Long Term Care Survey, and the Chinese Longevity Study (with Dr. Zeng Yi). Previous work has demonstrated the important contributions of age related inflammation and coagulation activation to functional status. He is Co-PI of the Pepper Center Physical Performance Across the LifeSpan (PALS) study, which is a longitudinal cohort study of community dwelling adults from age 30-90+and includes functional measures and biomarkers on inflammation and metabolism.
 
Geriatric assessment approaches have been studied in a number of randomized and controlled studies and work is now concentrating on the application of Comprehensive Geriatric Assessment tools to the evaluation and treatment of elderly patients with cancer. This is an extension and continuation of a long standing interest in geriatric oncology. Previous studies have elucidated age-related patterns of disease presentation, treatment approaches, clinical trials, survivorship, quality of life, impact of comrobidities and functional outcomes. Dr. Cohen was co-chair, and now member of the Cancer in the Older Adult Committee of the Alliance for Clinical Trials in Oncology (ALLIANCE). A number of active studies and ongoing data bases aree being utilized to address these questions.

Anemia in the older adult is being addressed through an NIA funded U01 consortium (Dr. Cohen Co-PI). the current main study is an observational study followed by a pragmatic treatment trial for anemia in older adults with CHF, in collaboration with the Cardiovascular Research Network (CVRN) of the Health services research network (HSRN) 

Education and Training

  • M.D., State University of New York, Brooklyn, 1965

Publications

Stinchcombe, T. E., W. Fan, S. E. Schild, E. E. Vokes, J. Bogart, Q. -. T. X. Le, C. R. Thomas, et al. “A pooled analysis of individual patient data (IPD) of concurrent chemoradiotherapy for limited-stage small cell lung cancer (LS-SCLC) in elderly compared to younger patients (pts) who participated in US National Cancer Institute cooperative group studies.” In Ann Oncol, 29 Suppl 8:viii597–98, 2018. https://doi.org/10.1093/annonc/mdy298.004.

PMID
32137590
Full Text

Wildes, Tanya M., Ronald J. Maggiore, William P. Tew, David Smith, Can-Lan Sun, Harvey Cohen, Supriya G. Mohile, et al. “Factors associated with falls in older adults with cancer: a validated model from the Cancer and Aging Research Group.” Support Care Cancer 26, no. 10 (October 2018): 3563–70. https://doi.org/10.1007/s00520-018-4212-3.

PMID
29705872
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Freedman, Rachel A., Travis J. Dockter, Jacqueline M. Lafky, Arti Hurria, Hyman J. Muss, Harvey J. Cohen, Aminah Jatoi, M Margaret Kemeny, and Kathryn J. Ruddy. “Promoting Accrual of Older Patients with Cancer to Clinical Trials: An Alliance for Clinical Trials in Oncology Member Survey (A171602).” Oncologist 23, no. 9 (September 2018): 1016–23. https://doi.org/10.1634/theoncologist.2018-0033.

PMID
29674441
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Li, Daneng, Linda M. McCall, Olwen M. Hahn, Clifford A. Hudis, Harvey J. Cohen, Hyman B. Muss, Aminah Jatoi, et al. “Identification of risk factors for toxicity in patients with hormone receptor-positive advanced breast cancer treated with bevacizumab plus letrozole: a CALGB 40503 (alliance) correlative study.” Breast Cancer Res Treat 171, no. 2 (September 2018): 325–34. https://doi.org/10.1007/s10549-018-4828-5.

PMID
29789969
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Feliciano, Josephine L., Jennifer G. Le-Rademacher, Ajeet Gajra, Martin J. Edelman, Tyler Zemla, Ryan McMurray, Hongbin Chen, et al. “Do older patients with non-small cell lung cancer also benefit from first-line platinum-based doublet chemotherapy? Observations from a pooled analysis of 730 prospectively-treated patients (Alliance Study A151622).” J Geriatr Oncol 9, no. 5 (September 2018): 501–6. https://doi.org/10.1016/j.jgo.2018.05.006.

PMID
29848457
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Soto-Perez-de-Celis, Enrique, Can-Lan Sun, William P. Tew, Supriya Gupta Mohile, Ajeet Gajra, Heidi D. Klepin, Cynthia Owusu, et al. “Association between patient-reported hearing and visual impairments and functional, psychological, and cognitive status among older adults with cancer.” Cancer 124, no. 15 (August 1, 2018): 3249–56. https://doi.org/10.1002/cncr.31540.

PMID
29797664
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Mohile, Supriya G., William Dale, Mark R. Somerfield, Mara A. Schonberg, Cynthia M. Boyd, Peggy S. Burhenn, Beverly Canin, et al. “Practical Assessment and Management of Vulnerabilities in Older Patients Receiving Chemotherapy: ASCO Guideline for Geriatric Oncology.” J Clin Oncol 36, no. 22 (August 1, 2018): 2326–47. https://doi.org/10.1200/JCO.2018.78.8687.

PMID
29782209
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Whitson, Heather E., Harvey J. Cohen, Kenneth E. Schmader, Miriam C. Morey, George Kuchel, and Cathleen S. Colon-Emeric. “Physical Resilience: Not Simply the Opposite of Frailty.” J Am Geriatr Soc 66, no. 8 (August 2018): 1459–61. https://doi.org/10.1111/jgs.15233.

PMID
29577234
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Bail, Jennifer R., Andrew D. Frugé, Mallory G. Cases, Jennifer F. De Los Santos, Julie L. Locher, Kerry P. Smith, Alan B. Cantor, Harvey J. Cohen, and Wendy Demark-Wahnefried. “A home-based mentored vegetable gardening intervention demonstrates feasibility and improvements in physical activity and performance among breast cancer survivors.” Cancer 124, no. 16 (August 2018): 3427–35. https://doi.org/10.1002/cncr.31559.

PMID
29932460
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Gajra, Ajeet, Tyler J. Zemla, Aminah Jatoi, Josephine L. Feliciano, Melisa L. Wong, Hongbin Chen, Ronald Maggiore, et al. “Time-to-Treatment-Failure and Related Outcomes Among 1000+ Advanced Non-Small Cell Lung Cancer Patients: Comparisons Between Older Versus Younger Patients (Alliance A151711).” J Thorac Oncol 13, no. 7 (July 2018): 996–1003. https://doi.org/10.1016/j.jtho.2018.03.020.

PMID
29608967
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