Harvey Jay Cohen, MD

Professor of Medicine
Walter Kempner Professor of Medicine, in the School of Medicine
Director, Center for the Study of Aging & Human Development
Faculty Research Scholar of DuPRI's Center for Population Health & Aging
Member of the Duke Cancer Institute
Campus mail 3502 Blue Zone Duke Clinic, Center for Aging, Trent Drive, Durham, NC 27710
Phone (919) 660-7502
Email address harvey.cohen@duke.edu

Dr. Cohen's research program includes clinical research relating to aspects of the pathways to functional decline with aging, geriatric assessment, and cancer in the elderly.

Pathways to functional decline are being explored through the NIA funded Claude Pepper Older Americans Independence Center, and includes studies of the contributions of age related physiologic change, in particular changes in inflammatory parameters, comorbid diseases and conditions, environment, genetics, and the interactionas among them. Data are derived from several current studies as well as previously collected data sets from the Established Populations for Epidemiologic Studies of the Elderly (EPESE), National Long Term Care Survey, and the Chinese Longevity Study (with Dr. Zeng Yi). Previous work has demonstrated the important contributions of age related inflammation and coagulation activation to functional status.

Geriatric assessment approaches have been studied in a number of randomized and controlled studies and work is now concentrating on the application of Comprehensive Geriatric Assessment tools to the evaluation and treatment of elderly patients with cancer. This is an extension and continuation of a long standing interest in geriatric oncology. Previous studies have elucidated age-related patterns of disease presentation, treatment approaches, clinical trials, survivorship, quality of life, impact of comrobidities and functional outcomes. Dr. Cohen is co-chair of the Cancer in the Elderly Committee of Cancer and Acute Luekemia Group B (CALGB). A number of active studies and ongoing data bases aree being utilized to address these questions.

Education and Training

  • M.D., State University of New York at Brooklyn, 1965

Publications

Cohen, H., A. L. Chapman, W. J. Bopp, C. E. Schmidt, C. E. Przybylski, and M. S. Mcphee. “Pathogenesis of a transplanted canine lymphocytic leukemia..” Cancer 33, no. 5 (May 1974): 1313–24.

PMID
4823481
Scholars@Duke

Cooper, M. R., H. J. Cohen, C. C. Huntley, B. M. Waite, L. Spees, and C. L. Spurr. “A monoclonal IgM with antibodylike specificity for phospholipids in a patient with lymphoma..” Blood 43, no. 4 (April 1974): 493–504.

PMID
4206077
Scholars@Duke

Johnson, J. L., H. J. Cohen, and K. V. Rajagopalan. “Studies of vanadium toxicity in the rat. Lack of correlation with molybdenum utilization..” Biochem Biophys Res Commun 56, no. 4 (February 27, 1974): 940–46.

PMID
4363644
Scholars@Duke

Johnson, J. L., K. V. Rajagopalan, and H. J. Cohen. “Molecular basis of the biological function of molybdenum. Effect of tungsten on xanthine oxidase and sulfite oxidase in the rat..” J Biol Chem 249, no. 3 (February 10, 1974): 859–66.

PMID
4359773
Scholars@Duke

Cohen, H. J., R. T. Drew, J. L. Johnson, and K. V. Rajagopalan. “Molecular basis of the biological function of molybdenum: the relationship between sulfite oxidase and the acute toxicity of bisulfite and SO2..” Proc Natl Acad Sci U S A 70, no. 12 (December 1973): 3655–59. https://doi.org/10.1073/pnas.70.12.3655.

PMID
4519654
Full Text

Cohen, H. J. “Peroxide detoxification affecting the production of immunoglobulin by mouse myeloma tumor cells in vitro..” Experientia 29, no. 10 (October 15, 1973): 1285–87.

PMID
4796641
Scholars@Duke

Cohen, H. J., and A. T. Huang. “A marker chromosome abnormality. Occurrence in chloramphenicol-associated acute leukemia..” Arch Intern Med 132, no. 3 (September 1973): 440–43.

PMID
4522023
Scholars@Duke

Cohen, H. J. “The use of diaminobenzidine for spectrophotometric and acrylamide gel detection of sulfite oxidase and its applicability to hydrogen peroxide-generating enzymes..” Anal Biochem 53, no. 1 (May 1973): 208–22.

PMID
4145739
Scholars@Duke

Cohen, H. J., S. B. Frank, W. Minkin, and R. C. Gibbs. “Subungual exostoses..” Arch Dermatol 107, no. 3 (March 1973): 431–32.

PMID
4692133
Scholars@Duke

Pages