Harvey Jay Cohen, MD

Professor of Medicine
Walter Kempner Professor of Medicine, in the School of Medicine
Director, Center for the Study of Aging & Human Development
Faculty Research Scholar of DuPRI's Center for Population Health & Aging
Member of the Duke Cancer Institute
Campus mail 3502 Blue Zone Duke Clinic, Center for Aging, Trent Drive, Durham, NC 27710
Phone (919) 660-7502
Email address harvey.cohen@duke.edu

Dr. Cohen's research program includes clinical research relating to aspects of the pathways to functional decline with aging, geriatric assessment, and cancer in the elderly.

Pathways to functional decline are being explored through the NIA funded Claude Pepper Older Americans Independence Center, and includes studies of the contributions of age related physiologic change, in particular changes in inflammatory parameters, comorbid diseases and conditions, environment, genetics, and the interactionas among them. Data are derived from several current studies as well as previously collected data sets from the Established Populations for Epidemiologic Studies of the Elderly (EPESE), National Long Term Care Survey, and the Chinese Longevity Study (with Dr. Zeng Yi). Previous work has demonstrated the important contributions of age related inflammation and coagulation activation to functional status.

Geriatric assessment approaches have been studied in a number of randomized and controlled studies and work is now concentrating on the application of Comprehensive Geriatric Assessment tools to the evaluation and treatment of elderly patients with cancer. This is an extension and continuation of a long standing interest in geriatric oncology. Previous studies have elucidated age-related patterns of disease presentation, treatment approaches, clinical trials, survivorship, quality of life, impact of comrobidities and functional outcomes. Dr. Cohen is co-chair of the Cancer in the Elderly Committee of Cancer and Acute Luekemia Group B (CALGB). A number of active studies and ongoing data bases aree being utilized to address these questions.

Education and Training

  • M.D., State University of New York at Brooklyn, 1965


Cohen, H. J., and J. Laszlo. “Influence of trauma on the unusual distribution of metastases from carcinoma of the larynx.” Cancer 29, no. 2 (January 1, 1972): 466–71. https://doi.org/10.1002/1097-0142(197202)29:2<466::AID-CNCR2820290234>3.0.CO;2-M.

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Cohen, H. J., T. M. Harris, A. M. Geller, and W. L. Byrne. “Bovine hepatic fructose 1,6-diphosphatase: -glycerophosphate hydrolysis-evidence for a shared active site..” Archives of Biochemistry and Biophysics 146, no. 1 (September 1971): 144–52. https://doi.org/10.1016/s0003-9861(71)80050-4.

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Cohen, H. J., I. Fridovich, and K. V. Rajagopalan. “Hepatic sulfite oxidase. A functional role for molybdenum..” J Biol Chem 246, no. 2 (January 25, 1971): 374–82.


Cohen, H. J., and I. Fridovich. “Hepatic sulfite oxidase. The nature and function of the heme prosthetic groups..” The Journal of Biological Chemistry 246, no. 2 (January 1971): 367–73.