Howard Allan Rockman, MD

Professor of Medicine
Edward S. Orgain Professor of Cardiology, in the School of Medicine
Professor in Molecular Genetics and Microbiology
Professor in Cell Biology
Campus mail 226 Clin Res Lab Bldg, Durham, NC 27710
Phone (919) 668-2520
Email address h.rockman@duke.edu

Rockman Lab: Molecular Mechanisms of Hypertrophy and Heart Failure

Overall Research Direction: The major focus of this laboratory is to understand the molecular mechanisms of hypertrophy and heart failure. My laboratory uses a strategy that combines state of the art molecular techniques to generate transgenic and gene targeted mouse models, combined with sophisticated physiologic measures of in vivo cardiac function. In this manner, candidate molecules are either selectively overexpressed in the mouse heart or ablated by homologous recombination, which is followed by an in-depth analysis of the physiological phenotype. To model human cardiac disease, we have created several models of cardiac overload in the mouse using both microsurgical techniques and genetic models of cardiac dysfunction.

Areas of Research
1) Signaling: G protein-coupled receptor signaling in hypertrophy and heart failure focusing on the concept of biased signaling of 7 transmembrane receptors.

2) Molecular physiology: In depth physiological analysis of cardiac function in genetically altered mice to understand the role of G protein-coupled receptor signaling pathways on the development of heart failure in vivo.

3) Deletion screens in Drosophila: To detect novel genes important for cardiac function in the adult fly .

Education and Training

  • Cardiology Fellow, Medicine, University of California at San Diego, 1987 - 1991
  • Medical Resident, Medicine, Montreal General Hospital, 1984 - 1987
  • M.D., McGill University (Canada), 1983

Publications

Rockman, HA, Knowlton, KU, Jr, JR, and Chien, KR. "In vivo murine cardiac hypertrophy: A novel model to identify genetic signaling mechanisms that activate an adaptive physiological response." Circulation 87, no. 6 SUPPL. 1 (1993): VII14-VII21.

Scholars@Duke

Kambayashi, M, Miura, T, Oh, BH, Murata, K, Rockman, HA, Parra, G, and Ross, J. "Myocardial cell hypertrophy after myocardial infarction with reperfusion in dogs." Circulation 86, no. 6 (December 1992): 1935-1944.

PMID
1451265
Scholars@Duke

Oh, BH, Volpini, M, Kambayashi, M, Murata, K, Rockman, HA, Kassab, GS, and Ross, J. "Myocardial function and transmural blood flow during coronary venous retroperfusion in pigs." Circulation 86, no. 4 (October 1992): 1265-1279.

PMID
1394933
Scholars@Duke

Lee, KJ, Ross, RS, Rockman, HA, Harris, AN, O'Brien, TX, van Bilsen, M, Shubeita, HE, Kandolf, R, Brem, G, and Price, J. "Myosin light chain-2 luciferase transgenic mice reveal distinct regulatory programs for cardiac and skeletal muscle-specific expression of a single contractile protein gene." J Biol Chem 267, no. 22 (August 5, 1992): 15875-15885.

PMID
1379240
Scholars@Duke

Kambayashi, M, Miura, T, Oh, BH, Rockman, HA, Murata, K, and Ross, J. "Enhancement of the force-frequency effect on myocardial contractility by adrenergic stimulation in conscious dogs." Circulation 86, no. 2 (August 1992): 572-580.

PMID
1353420
Scholars@Duke

Rockman, HA, and Knowlton, KU. "Peripartum vascular collapse Dissection of a genetic disease." Trends Cardiovasc Med 2, no. 4 (July 1992): 125-128.

PMID
21239257
Full Text

Miyamoto, MI, Rockman, HA, Guth, BD, Heusch, G, and Ross, J. "Effect of alpha-adrenergic stimulation on regional contractile function and myocardial blood flow with and without ischemia." Circulation 84, no. 4 (October 1991): 1715-1724.

PMID
1680577
Scholars@Duke

Rockman, HA, Ross, RS, Harris, AN, Knowlton, KU, Steinhelper, ME, Field, LJ, Ross, J, and Chien, KR. "Segregation of atrial-specific and inducible expression of an atrial natriuretic factor transgene in an in vivo murine model of cardiac hypertrophy." Proc Natl Acad Sci U S A 88, no. 18 (September 15, 1991): 8277-8281.

PMID
1832775
Scholars@Duke

Rockman, HA, Adamson, RM, Dembitsky, WP, Bonar, JW, and Jaski, BE. "Acute fulminant myocarditis: long-term follow-up after circulatory support with left ventricular assist device." Am Heart J 121, no. 3 Pt 1 (March 1991): 922-926.

PMID
2000764
Scholars@Duke

Rockman, HA, Ross, RS, Harris, AN, Knowlton, KU, Steinhelper, ME, Field, LJ, Jr, JR, and Chien, KR. "Erratum: Segregation of atrial-specific and inducible expression of an atrial natriuretic factor transgene in an in vivo murine model of cardiac hypertrophy (Proc. Natl. Acad. Sci. USA (September 1991) 88 (8277-8281))." Proceedings of the National Academy of Sciences of the United States of America 88, no. 21 (1991): 9907--.

Scholars@Duke

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