Howard Allan Rockman, MD

Professor of Medicine
Edward S. Orgain Distinguished Professor of Cardiology, in the School of Medicine
Professor in Cell Biology
Campus mail 226 Clin Res Lab Bldg, Duke Box 102151, Durham, NC 27710
Phone (919) 668-2520
Email address h.rockman@duke.edu

Rockman Lab: Molecular Mechanisms of Hypertrophy and Heart Failure

Overall Research Direction: The major focus of this laboratory is to understand the molecular mechanisms of hypertrophy and heart failure. My laboratory uses a strategy that combines state of the art molecular techniques to generate transgenic and gene targeted mouse models, combined with sophisticated physiologic measures of in vivo cardiac function. In this manner, candidate molecules are either selectively overexpressed in the mouse heart or genes ablated followed by an in-depth analysis of the physiological phenotype. To model human cardiac disease, we have created several models of cardiac overload in the mouse using both microsurgical techniques and genetic models of cardiac dysfunction.

Areas of Research
1) Signaling: G protein-coupled receptor signaling in hypertrophy and heart failure focusing on the concept of biased signaling of 7 transmembrane receptors.

2) Molecular physiology: In depth physiological analysis of cardiac function in genetically altered mice to understand the role of G protein-coupled receptor signaling pathways on the development of heart failure in vivo.

Education and Training

  • Cardiology Fellow, Medicine, University of California - San Diego, 1987 - 1991
  • Medical Resident, Medicine, Montreal General Hospital (Canada), 1984 - 1987
  • M.D., McGill University (Canada), 1983

Publications

Tang, Hao, Kunhong Xiao, Lan Mao, Howard A. Rockman, and Douglas A. Marchuk. “Overexpression of TNNI3K, a cardiac-specific MAPKKK, promotes cardiac dysfunction.” J Mol Cell Cardiol 54 (January 2013): 101–11. https://doi.org/10.1016/j.yjmcc.2012.10.004.

PMID
23085512
Full Text

Kim, Ki-Seok, Dennis Abraham, Barbara Williams, Jonathan D. Violin, Lan Mao, and Howard A. Rockman. “β-Arrestin-biased AT1R stimulation promotes cell survival during acute cardiac injury.” Am J Physiol Heart Circ Physiol 303, no. 8 (October 15, 2012): H1001–10. https://doi.org/10.1152/ajpheart.00475.2012.

PMID
22886417
Full Text

Tang, Hao, Kunhong Xiao, Lan Mao, Howard A. Rockman, and Douglas A. Marchuk. “Overexpression of Cardiac Troponin I-Interacting Kinase, a Cardiac-Specific MAPKKK, Promotes Cardiac Dysfunction.” In Circulation Research, Vol. 111. LIPPINCOTT WILLIAMS & WILKINS, 2012.

Scholars@Duke

Tang, Wei, and Howard A. Rockman. “AT1R Conformation Mediates Mechanical Stress-Induced beta-Arrestin Signaling.” In Circulation Research, Vol. 111. LIPPINCOTT WILLIAMS & WILKINS, 2012.

Scholars@Duke

Lee, Chang-Lung, Everett J. Moding, Kyle C. Cuneo, Yifan Li, Julie M. Sullivan, Lan Mao, Iman Washington, et al. “p53 functions in endothelial cells to prevent radiation-induced myocardial injury in mice.” Sci Signal 5, no. 234 (July 24, 2012): ra52. https://doi.org/10.1126/scisignal.2002918.

PMID
22827996
Full Text

Houser, Steven R., Kenneth B. Margulies, Anne M. Murphy, Francis G. Spinale, Gary S. Francis, Sumanth D. Prabhu, Howard A. Rockman, et al. “Animal models of heart failure: a scientific statement from the American Heart Association.” Circ Res 111, no. 1 (June 22, 2012): 131–50. https://doi.org/10.1161/RES.0b013e3182582523.

PMID
22595296
Full Text

Lefkowitz, Robert, Joseph Goldstein, and Michael Brown. “A conversation with Robert Lefkowitz, Joseph Goldstein, and Michael Brown. Interview by Ushma S. Neil and Howard A. Rockman.” J Clin Invest 122, no. 5 (May 2012): 1586–87. https://doi.org/10.1172/jci64244.

PMID
22690398
Full Text

Pages