Howard Allan Rockman, MD

Professor of Medicine
Edward S. Orgain Professor of Cardiology, in the School of Medicine
Professor in Molecular Genetics and Microbiology
Professor in Cell Biology
Campus mail 226 Clin Res Lab Bldg, Durham, NC 27710
Phone (919) 668-2520
Email address h.rockman@duke.edu

Rockman Lab: Molecular Mechanisms of Hypertrophy and Heart Failure

Overall Research Direction: The major focus of this laboratory is to understand the molecular mechanisms of hypertrophy and heart failure. My laboratory uses a strategy that combines state of the art molecular techniques to generate transgenic and gene targeted mouse models, combined with sophisticated physiologic measures of in vivo cardiac function. In this manner, candidate molecules are either selectively overexpressed in the mouse heart or ablated by homologous recombination, which is followed by an in-depth analysis of the physiological phenotype. To model human cardiac disease, we have created several models of cardiac overload in the mouse using both microsurgical techniques and genetic models of cardiac dysfunction.

Areas of Research
1) Signaling: G protein-coupled receptor signaling in hypertrophy and heart failure focusing on the concept of biased signaling of 7 transmembrane receptors.

2) Molecular physiology: In depth physiological analysis of cardiac function in genetically altered mice to understand the role of G protein-coupled receptor signaling pathways on the development of heart failure in vivo.

3) Deletion screens in Drosophila: To detect novel genes important for cardiac function in the adult fly .

Education and Training

  • Cardiology Fellow, Medicine, University of California at San Diego, 1987 - 1991
  • Medical Resident, Medicine, Montreal General Hospital, 1984 - 1987
  • M.D., McGill University (Canada), 1983

Publications

Tilley, DG, Nguyen, AD, and Rockman, HA. "Troglitazone stimulates beta-arrestin-dependent cardiomyocyte contractility via the angiotensin II type 1A receptor." Biochem Biophys Res Commun 396, no. 4 (June 11, 2010): 921-926.

PMID
20460106
Full Text

Rakesh, K, Yoo, B, Kim, I-M, Salazar, N, Kim, K-S, and Rockman, HA. "beta-Arrestin-biased agonism of the angiotensin receptor induced by mechanical stress. (Published online)" Sci Signal 3, no. 125 (June 8, 2010): ra46-.

PMID
20530803
Full Text

Kim, B-E, Turski, ML, Nose, Y, Casad, M, Rockman, HA, and Thiele, DJ. "Cardiac copper deficiency activates a systemic signaling mechanism that communicates with the copper acquisition and storage organs." Cell Metab 11, no. 5 (May 5, 2010): 353-363.

PMID
20444417
Full Text

Mangmool, S, Shukla, AK, and Rockman, HA. "beta-Arrestin-dependent activation of Ca(2+)/calmodulin kinase II after beta(1)-adrenergic receptor stimulation." J Cell Biol 189, no. 3 (May 3, 2010): 573-587.

PMID
20421423
Full Text

Kim, I-M, Wolf, MJ, and Rockman, HA. "Gene deletion screen for cardiomyopathy in adult Drosophila identifies a new notch ligand." Circ Res 106, no. 7 (April 16, 2010): 1233-1243.

PMID
20203305
Full Text

Bucholz, E, Ghaghada, K, Qi, Y, Mukundan, S, Rockman, HA, and Johnson, GA. "Cardiovascular phenotyping of the mouse heart using a 4D radial acquisition and liposomal Gd-DTPA-BMA." Magn Reson Med 63, no. 4 (April 2010): 979-987.

PMID
20373399
Full Text

Rockman, HA, and VanHook, AM. "Science signaling podcast: 8 June 2010." Science Signaling 3, no. 125 (2010): pc12-.

Full Text

Seth, M, Zhang, Z-S, Mao, L, Graham, V, Burch, J, Stiber, J, Tsiokas, L, Winn, M, Abramowitz, J, Rockman, HA, Birnbaumer, L, and Rosenberg, P. "TRPC1 channels are critical for hypertrophic signaling in the heart." Circ Res 105, no. 10 (November 6, 2009): 1023-1030.

PMID
19797170
Full Text

Yoo, B, Lemaire, A, Mangmool, S, Wolf, MJ, Curcio, A, Mao, L, and Rockman, HA. "β1-Adrenergic receptors stimulate cardiac contractility and CaMKII activation in vivo and enhance cardiac dysfunction following myocardial infarction." American Journal of Physiology - Heart and Circulatory Physiology 297, no. 4 (October 1, 2009).

Full Text

Yoo, B, Lemaire, A, Mangmool, S, Wolf, MJ, Curcio, A, Mao, L, and Rockman, HA. "Beta1-adrenergic receptors stimulate cardiac contractility and CaMKII activation in vivo and enhance cardiac dysfunction following myocardial infarction." Am J Physiol Heart Circ Physiol 297, no. 4 (October 2009): H1377-H1386.

PMID
19633206
Full Text

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